Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm praziquantel paste hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo praziquantel paste rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Praziquantel (PZQ) tseem yog lub hauv paus ntawm kev kho cov kab mob parasitic, nrog rau dav -spectrum kev ua tau zoo tiv thaiv trematodes thiab tapeworms. Thaum cov ntsiav tshuaj ntawm qhov ncauj thiab cov tshuaj txhaj tshuaj tseem siv tshuaj kho mob,praziquantel muab tshuaj txhuamtau tshwm sim los ua ntau yam kev xaiv, tshwj xeeb tshaj yog nyob rau hauv veterinary tshuaj thiab aquaculture. Cov qauv no hais txog cov kev txwv ntawm cov ntaub ntawv noj tshuaj uas twb muaj lawm, xws li tsis zoo palatability, kev noj tshuaj tsis raug thiab ib puag ncig, thaum txhim kho bioavailability thiab yooj yim ntawm kev tswj hwm. Daim ntawv no tshuaj xyuas txoj kev loj hlob, pharmacokinetics, kev siv tshuaj kho mob, kev nyab xeeb thiab cov lus qhia yav tom ntej ntawm praziquantel muab tshuaj txhuam, tsom rau nws lub luag haujlwm hauv kev txhim kho cov kab mob parasite hauv ntau hom.
Praziquantel muab tshuaj txhuam, ib nrab- cov qauv tsim khoom sib xyaw ua ke nrog cov tshuaj tsw qab thiab cov tshuaj tsw qab, muab cov neeg mob - tus phooj ywg zoo, raug, thiab tus nqi- siv tau zoo. Qhov kev tshuaj xyuas no tshawb txog nws lub hauv paus kws tshuaj, tiag tiag -cov ntawv thov hauv ntiaj teb, thiab kev tsim kho tshiab tsim nws lub neej yav tom ntej.
1. Kev qhia dav dav
(1) Txhaj tshuaj
Customizable
(2) Muab tshuaj txhuam
Customizable
(3) Sib
Customizable
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Tus Qauv Zauv: BM-3-045
Praziquantel CAS 55268-74-1
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4
Cov ntaub ntawv ntxiv ntawm chemical compound:
praziquantel+. COA
Formulation Science ntawm Praziquantel Paste
Kev sib xyaw thiab kev tsim khoom
Praziquantel paste feem ntau muaj xws li:
1) Cov khoom xyaw tshuaj nquag (API): 5-10% w/w praziquantel (nyob ntawm hom hom phiaj thiab kab mob cab).
2) Base: Hydrophilic lossis lipophilic nqa khoom (piv txwv li, polyethylene glycol, glycerin) los txhim kho solubility.
3) Flavoring agents: Molasses, ntses pluas mov, los yog khoom qab zib los npog qhov iab.
4) Stabilizers: Benzoic acid los yog sodium benzoate los tiv thaiv degradation.
5) Thickeners: Silica dioxide lossis cellulose derivatives kom tswj tau qhov sib xws.
Kev tsim khoom:
1) Kev sib xyaw qhuav: Praziquantel hmoov yog tov nrog stabilizers thiab thickeners.
2) ntub granulation: Lub hauv paus thiab cov tshuaj tsw qab tau ntxiv los ua homogeneous muab tshuaj txhuam.
3) Deaeration: Lub tshuab nqus tsev ua haujlwm tshem tawm cov npuas npuas kom ntseeg tau tias kev siv tshuaj zoo ib yam.
4) Ntim: Muab tshuaj txhuam rau hauv ua ntej - cov koob txhaj tshuaj lossis cov raj rau kev tswj xyuas meej.
Overcoming Solubility Challenges
Praziquantel cov dej tsis zoo solubility (0.04 g / 100 mL) keeb kwm txwv tsis pub muab tshuaj ntxiv. Innovations muaj xws li:
1) Khoom siv tshuab dispersion: Co- sib tsoo praziquantel nrog polyvinylpyrrolidone (PVP) nce tus nqi tawg los ntawm 300%.
2) Nanocrystallization: Txo particle loj rau<200 nm enhances surface area and bioavailability.
3) Cyclodextrin inclusion complexes: -Cyclodextrin forms water-soluble complexes with praziquantel, txhim kho stability thiab palatability.
Stability thiab Txee Lub neej
Praziquantel muab tshuaj txhuam yog rhiab rau lub teeb, tshav kub, thiab av noo. Kev tshawb fawb txog kev ruaj ntseg qhia tias:
1) Cia tej yam kev mob: 2-8℃(tub yees) ncua lub neej txee rau 36 lub hlis; chav sov (25 degree) txo nws mus rau 12-18 lub hlis.
2) Ntim: Opaque, airtight tubes txo qis degradation.
3) pH rhiab heev: Kev ruaj ntseg zoo tshwm sim ntawm pH 4-6; alkaline tej yam kev mob accelerate hydrolysis
Lub tswv yim zoo ntawm Paste Dosage Forms
Cov tshuaj ntau npaum li cas ntawm praziquantel (piv txwv li, ntsiav tshuaj, txhaj tshuaj) raug kev txom nyem los ntawm kev tsis zoo palatability thiab tsawg npaum li cas precision. Paste dosage form ua tiav kev kho mob los ntawm kev txhim kho hauv qab no:
Palatability optimization
Ntxiv cov khoom qab zib (xws li molasses) thiab cov tshuaj tsw qab (xws li cov ntses ntses) los npog qhov iab saj ntawm praziquantel thiab kom nce tus nqi ntawm kev yeem los ntawm cov tsiaj.
Cov kev ntsuam xyuas pom tau tias qhov kev lees paub ntawm kev muab tshuaj rau hauv nyuj thiab yaj yog ntau dua 90%, uas yog 40% siab dua li cov ntsiav tshuaj.
Precise Dose Control
Nws tau ntim rau hauv cov koob txhaj tshuaj prefilled lossis cov tub ntxhais kawm tiav uas txhawb nqa 0.1mL- qib kev hloov tshuaj, txo qhov kev pheej hmoo ntawm ntau dua - lossis qis dua - noj.
Kev noj tshuaj rau tus kheej rau cov tsiaj sib txawv ntawm lub cev hnyav (piv txwv li, tsiaj dev vs. tsiaj txhu loj).
Txhim khu kev ruaj ntseg
Txuas ntxiv hnub tas sij hawm ntawm cov tshuaj nyob rau hauv qhov kub thiab txias qhov chaw ib puag ncig mus txog 24-36 lub hlis nrog ntxiv cov antioxidants (xws li, Vitamin E) thiab pH modifiers.
Lub teeb- ntim khoom nyab xeeb yog tsim los tiv thaiv photolysis, kom ntseeg tau tias cov ntsiab lus ntawm cov khoom muaj nyob ruaj khov ntawm 98%-102%.
Clinical application scenarios thiab kev ua tau zoo
Parasitic kab mob ntawm cov tsiaj nyeg
Schistosomiasis: ib koob tshuaj ntawm qhov ncauj ntawm 10-20mg / kg, tus nqi ntawm cov qe qe hloov hauv 48 teev nce mus txog 98.7% (cov ntaub ntawv kuaj nyuj ua liaj ua teb).
Hepatic schistosomiasis: kev kho mob ntawm Suav daim siab mob npaws, kho tus nqi ntawm 99.4% tom qab kawm 7 hnub, rov tshwm sim tsawg dua 1%.
Kab mob Tapeworm: qhov tsawg kawg nkaus zoo concentration (MEC) ntawm 0.5mg / L rau tapeworm Schizothoracini, thiab 100% clearance twb pom tau hais tias thaum lub ncov ntshav cov tshuaj muaj nqis mus txog 1.2mg / L.
Cov tsiaj txhu
Canine Diphyllobothrium: ntshav siab siab tshaj 1 teev tom qab kev tswj hwm qhov ncauj ntawm cov tshuaj nplaum, 100% tshem tawm hauv 24 teev.
Miv Ascaris lumbricoides: Piv nrog rau cov ntsiav tshuaj praziquantel, bioavailability ntawm cov qab zib yog nce 25% thiab qhov pib ntawm kev txiav txim yog luv luv rau 30 feeb.
Aquaculture
Ntses Fingerling Worm Disease: Da dej concentration 0.05mg/L, 99.9% tua tus nqi nyob rau hauv 30 feeb, thiab tsis muaj kev pheej hmoo ntawm cov tshuaj residue.
Shrimp microsporidiosis: qhov ncauj muab tshuaj txhuam (5mg / kg) noj tas li rau 7 hnub, tus kab mob no txo qis los ntawm 82%.
Dosage form innovation zoo ntawm praziquantel cream
Los ntawm kev tsim kho tshiab ntawm daim ntawv ntau npaum, praziquantel qab zib qhia tau hais tias muaj txiaj ntsig zoo nyob rau hauv cov nqe lus ntawm palatability, ntau npaum li cas, ruaj khov thiab bioavailability, uas tau txheeb xyuas hauv qab no:
Optimization ntawm palatability: daws qhov teeb meem ntawm "tshuaj tsis kam" nyob rau hauv ib txwm noj tshuaj
Keeb kwm: Praziquantel iab hauv saj, thiab cov ntsiav tshuaj feem ntau ua rau tsis kam noj zaub mov los ntawm cov tsiaj vim tsis zoo palatability, tshwj xeeb tshaj yog tsawg dua 50% kev lees txais hauv cov ruminants (xws li nyuj, yaj) thiab cov tsiaj txhu (xws li miv).
Txoj kev daws teeb meem: Muab tshuaj txhuam los ntawm kev ntxiv cov khoom qab zib (xws li molasses, fishmeal) thiab cov tshuaj tsw qab los npog qhov iab saj ntawm cov tshuaj. Piv txwv li, ib qho tshuaj praziquantel muab tshuaj txhuam muaj 92% kev txaus siab lees txais hauv kev sim nyuj, kev txhim kho 40% ntawm cov ntsiav tshuaj.
Cov nqi kho mob: txhim kho kev ua raws li kev kho mob thiab txo qis kev kho mob vim tsis kam siv tshuaj, tshwj xeeb tshaj yog haum rau pab pawg deworming scenarios (xws li ua liaj ua teb).
Precise dose control: ua tau raws li tus kheej xav tau kev kho mob
Teeb meem keeb kwm yav dhau: cov ntsiav tshuaj ib txwm muaj cov koob tshuaj tas li, uas yog qhov nyuaj rau kev ua kom raug raws li cov kev xav tau ntawm cov tsiaj uas muaj qhov sib txawv ntawm lub cev hnyav, thiab yooj yim ua rau overdose lossis underdose.
Kev daws teeb meem tshiab: Cov tshuaj nplaum tau ntim rau hauv ua ntej - cov koob txhaj tshuaj lossis cov tub ntxhais kawm tiav, txhawb nqa 0.1mL- theem koob tshuaj. Piv txwv li, thaum kho tus kab mob canine tapeworm, cov koob tshuaj tuaj yeem suav tau raws li qhov hnyav ntawm lub cev (xws li . 10mg / kg), zam qhov yuam kev ntawm cov ntsiav tshuaj tig- tawm.
Tus nqi kho mob: Ua kom muaj txiaj ntsig kho tau zoo thiab txo qhov kev pheej hmoo ntawm kev siv tshuaj tiv thaiv, thaum txo tus nqi ntawm kev siv tshuaj.
Txhim khu kev ruaj ntseg: Kho kom yooj yim rau ib puag ncig cia thiab kev thauj mus los
Cov teeb meem keeb kwm yav dhau: Praziquantel rhiab heev rau lub teeb, cua sov thiab av noo, thiab cov ntsiav tshuaj ib txwm ua rau degradation nyob rau hauv qhov kub thiab txias ib puag ncig, uas cuam tshuam rau kev kho mob.
Cov kev daws teeb meem tshiab:
Kev ntim khoom kom zoo: siv lub teeb- zam lub raj txhuas lossis cov ntawv ntim cov yeeb yaj kiab los tiv thaiv photolysis thiab oxidation.
Ntxiv kev txhim kho: ntxiv cov tshuaj antioxidants (xws li vitamin E) thiab pH adjusters kom ncua hnub tas sij hawm mus rau 24-36 lub hlis (12-18 lub hlis ntev dua li cov ntsiav tshuaj).
Tus nqi kho mob: Tiv thaiv cov tshuaj zoo, tshwj xeeb tshaj yog tsim nyog rau lub sijhawm ntev - xav tau kev khaws cia hauv cov chaw sov lossis cov peev txheej - thaj chaw txwv.
Keeb kwm ntawm qhov teeb meem: Vim thawj zaug - kis tau tus mob thiab kev cuam tshuam ceev txwv, bioavailability ntawm praziquantel ntsiav tshuaj tsuas yog 35% -50%, uas cuam tshuam rau kev tua cov kab mob xws li Schistosoma haematobium thiab lwm yam kab mob.
Kev daws teeb meem tshiab:
Micronization thev naus laus zis: cov khoom siv tshuaj raug txo mus rau 1-5 μm los ntawm nano-milling kom nce thaj tsam ntawm qhov chaw thiab txhim kho kev solubility. Kev ntsuam xyuas pom tau tias bioavailability ntawm micronized cream yog nce los ntawm 20% -30% piv nrog cov ntsiav tshuaj.
Liposome encapsulation: Encapsulate cov tshuaj nyob rau hauv liposomes los txhawb txoj hnyuv mucosal absorption thiab txo qhov pib ntawm lub sij hawm ua hauj lwm (xws li, nyob rau hauv kev kho mob schistosomiasis, lub sij hawm rau cov ntshav siab concentration yog luv ntawm 2 teev mus rau 1 teev).
Tus nqi kho mob: rau mob schistosomiasis thiab lwm yam kab mob hnyav, nws tuaj yeem tswj tau tus kab mob sai dua thiab txo qhov kev pheej hmoo ntawm cov teeb meem.
Multi-scenario applicability: suav nrog ntau yam kev xav tau los ntawm kev yug me nyuam mus rau cov tsiaj sib luag
Kev yug me nyuam: cov tshuaj muab tshuaj tuaj yeem siv los ntawm kev sib xyaw pub mis lossis ncaj qha ntawm qhov ncauj, ua kom yooj yim ntawm cov txheej txheem ntawm pab pawg kho mob. Piv txwv li, nyob rau hauv cov ntses pas dej, sib tov cov muab tshuaj txhuam nrog pub tuaj yeem kho tus kab mob ntiv tes zoo yam tsis muaj kev pheej hmoo ntawm cov tshuaj seem.
Tus khub tsiaj scenarios: rau miv, dev, thiab lwm yam, lub qab zib tuaj yeem tsim nrog nqaij qaib lossis ntses tsw los txhim kho kev yeem txais.
Ib hom tshuaj praziquantel rau cov miv qhia hauv cov neeg siv cov lus qhia tias 90% ntawm cov miv yuav yaim nws yeem, txo qhov kev ntxhov siab ntawm kev quab yuam- pub.
Cov xwm txheej tshwj xeeb: Rau cov tsiaj qus lossis tsiaj txhu uas nyuaj rau ntes (xws li noog), cov tshuaj nplaum tuaj yeem siv rau saum npoo ntawm cov khoom noj los yog siv los ntawm kev pub noj, nthuav dav kev kho mob.
Teeb meem keeb kwm yav dhau: Cov tshuaj ntsiav tshuaj tuaj yeem ua rau tsiaj ntuav lossis nqus tau los ntawm kev ua yuam kev vim kev noj tshuaj tsis raug lossis tsis zoo palatability, ua rau muaj kev pheej hmoo ntawm kev mob ntsws.
Kev daws teeb meem tshiab: Cov kev ntxhib los mos ntawm cov nplaum yog mos thiab yooj yim kom nqus tau los ntawm qhov ncauj mucosa, txo cov plab hnyuv. Piv txwv li, hauv kev sim canine, qhov tshwm sim ntawm ntuav tau qis dua hauv cov tshuaj nplaum (3%) dua li hauv pawg ntsiav tshuaj (15%).
Tus nqi kho mob: Tshwj xeeb yog tsim rau cov menyuam yaus, laus lossis cov tsiaj muaj mob, txo kev pheej hmoo ntxiv thaum kho.
Txoj hauv kev thiab kev pheej hmoo ntawm cov pa phem hauv ib puag ncig
Dej muaj kuab paug:
Tshem tawm cov dej khib nyiab pov tseg: Praziquantel siv rau hauv aquaculture tuaj yeem nkag mus rau hauv lub cev dej hauv lub cev los ntawm kev sib pauv dej lossis xau, uas yog tshuaj lom rau cov kab mob hauv dej (xws li ntses thiab invertebrates).
Cov dej ntws tawm: Cov tshuaj seem hauv cov quav ntawm cov tsiaj hauv av tuaj yeem raug ntxuav rau hauv cov dej ntws thiab cov pas dej uas muaj nag, cuam tshuam rau cov dej hauv dej.
Av paug:
Kev siv quav nyab: thaum tsiaj quav tsiaj siv los ua chiv, cov tshuaj uas tsis muaj metabolized tuaj yeem nkag mus rau hauv av, inhibit av microbial kev ua haujlwm thiab cuam tshuam rau cov khoom noj.
Tshuaj spillage: kev siv yeeb tshuaj tsis zoo (xws li kev nchuav ncaj qha rau ib puag ncig) tuaj yeem ua rau cov tshuaj tsub zuj zuj hauv av thiab ua rau muaj kev hem thawj rau av biodiversity.
Biological enrichment thiab amplification:
Praziquantel thiab nws cov metabolites tej zaum yuav enriched nyob rau hauv cov kab mob los ntawm cov khoom noj khoom haus saw, tshwj xeeb tshaj yog cov derivatives uas muaj roj solubility, uas yuav ua rau muaj kev pheej hmoo rau sab saum toj predators (xws li noog thiab tsiaj txhu).
Cov lus nug nquag
praziquantel paste yog dab tsi?
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Praziquantel yogCov tshuaj anthelmintic siv los kho cov kab mob cab kab mob xws li schistosomiasis, clonorchiasis, thiab opisthorchiasis.. Biltricide. Lub Npe Lub Npe Praziquantel.
Dab tsi yog praziquantel siv los kho?
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Kev piav qhia. Praziquantel yog siv los khoschistosomiasis, tseem hu ua snail fever los yog bilharzia, ib tug kab mob ntawm lub urinary ib ntsuj av los yog plab hnyuv, tshwm sim los ntawm schistosoma (ntshav fluke), ib tug flatworm parasite..
Puas yog ivermectin zoo dua li praziquantel?
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Sib piv Ivermectin vs Praziquantel
Ivermectin muaj qhov ntsuas nruab nrab ntawm 7.8 tawm ntawm 10 los ntawm tag nrho ntawm 55 kev ntsuam xyuas ntawm Drugs.com.69% ntawm cov neeg soj ntsuam tau tshaj tawm cov txiaj ntsig zoo, thaum 15% qhia txog qhov tsis zoo. Praziquantel muaj qhov ntsuas nruab nrab ntawm 5.8 tawm ntawm 10 los ntawm tag nrho ntawm 5 qhov kev ntaus nqi ntawm Drugs.com.
Yuav ua li cas tib neeg tau txais tapeworms?
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Qhov tseem ceeb ntawm kev pheej hmoo rau kab mob tapeworm yognoj nqaij nyoos los yog ua tsis tau noj thiab ntses. Cov ntses qhuav thiab haus luam yeeb kuj yuav muaj cov kab mob larval nyob rau hauv lawv. Kev tu cev tsis zoo. Kev ntxuav tes tsis zoo ua rau muaj kev pheej hmoo kis tus kab mob.
Kab mob tapeworm puas yuav ploj mus?
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Yuav ua li cas kom tshem tau tus kab mob tapeworm?Koj tuaj yeem tua kab kab mob tau yooj yim nrog cov tshuaj anthelmintic, suav nrog praziquantel (Biltricide®), albendazole (Albenza®) thiab nitazoxanide (Alinia®). Cov kws kho mob feem ntau pom zoo praziquantel vim nws kuj ua rau tus kab mob tuag tes tuag taw, yuam kom nws tawm ntawm koj lub plab hnyuv.
Cim npe nrov: praziquantel paste, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom