Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm SS-31 Capsules hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo SS-31 Capsules rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Raws li lub hnub qub molecule tsom rau mitochondria, qhov tseem ceeb ntawm qhov zooSS-31 tsidag nyob rau hauv lawv cov meej mechanism ntawm kev txiav txim thiab hom me me ntawm kev ua haujlwm. Los ntawm kev ua kom zoo dua lawv cov kev ua tau zoo los ntawm kev hloov kho tshuaj thiab kev sib koom ua ke nrog lwm cov kev kho mob, qhov no tuaj yeem kov yeej cov kev txwv uas twb muaj lawm, ua kom muaj ntau txoj hauv kev tshiab rau kev kho mob ntawm mitochondrial-cov kab mob ntsig txog thiab ua kom pom kev loj hlob dav dav.
Product Overview
TSI-31 COA
Txoj kev loj hlob muaj peev xwm ntawm Elamipretide
Expansion of Application Scenarios thiab Performance Enhancement Mediated by Chemical Modifications
Los ntawm lub hom phiaj kev hloov kho tshuaj, cov tshuaj pharmacokinetic ntawm Elamipretide tuaj yeem ua kom zoo dua qub thiab nws txoj haujlwm ua haujlwm tau nthuav dav thaum khaws cia nws cov txheej txheem tseem ceeb ntawm kev ua, ua rau nws tsim nyog rau ntau yam kev kho mob thiab kev tshawb fawb xav tau:
(I) Fluorescent Labeling Modification: Ua kom pom tseeb thiab kev tshawb fawb txog tshuab
Covalent hloov kho ntawm Elamipretide nrog fluorescent molecules xws li fluorescein los yog rhodamine tuaj yeem tsim cov cuab yeej pom kev. Cov kev sojntsuam no ua rau muaj tseeb -lub sijhawm taug qab cov tshuaj faib hauv vivo, lub hom phiaj ua kom muaj txiaj ntsig zoo, thiab kev sib koom ua ke nrog mitochondria hauv cellular lossis tsiaj qauv, muab cov ntaub ntawv pov thawj zoo rau kev siv cov tshuaj lub hom phiaj hauv cov qauv ntawm cov kab mob neurodegenerative, kab mob plawv, thiab lwm yam.
Tsis tas li ntawd, lawv tuaj yeem siv los tshuaj xyuas lub hom phiaj kev ua haujlwm ntawm kev xa tshuaj, pab rau kev txhim kho ntev - ua cov qauv tsim thiab txhawb kev sib sib zog nqus ntawm kev tshawb fawb hauv paus thiab kev txhais lus kho mob.
(II)Long-Kev Hloov Kho Kev Ua Haujlwm: Hais Txog Kev Tsis Txaus Siab hauv Ib Nrab-Lub Neej
Nws muaj ib nrab luv luv - lub neej, xav tau kev tswj hwm ntau zaus, uas txwv nws qhov yooj yim kho mob. Kev hloov kho xws li polyethylene glycol (PEG) conjugation, liposomal encapsulation, los yog serum albumin binding tuaj yeem txuas ntxiv lub sijhawm ntawm cov tshuaj hauv vivo thiab txo cov koob tshuaj ntau zaus.
Tsis tas li ntawd, cov tshuaj hloov kho tuaj yeem ua rau lub raum tsis ua haujlwm qeeb thiab txhim kho bioavailability, ua rau lawv tshwj xeeb rau kev cuam tshuam ntev - cov kab mob mitochondrial xws li mob ntshav qab zib nephropathy thiab hnub nyoog - ntsig txog sarcopenia.
(III) Lub Hom Phiaj Hloov Kho Kev Xa Tshuaj: Txhim kho cov ntaub so ntswg -Kev Txhim Kho Tshwj Xeeb
Kev hloov kho nrog tus kab mob- cuam tshuam txog lub hom phiaj molecules tuaj yeem txhim kho kev ua kom zoo ntawm Elamipretide hauv cov ntaub so ntswg. Piv txwv li, txhawm rau hais txog mitochondrial dysfunction nyob rau hauv cov qog, nws tuaj yeem ua ke nrog cov qog cell- tshwj xeeb antigen antibodies kom ua tiav cov tshuaj xa mus rau cov qog nqaij hlav, txhim kho mitochondrial dysfunction hauv qog hlwb thaum txo cov teebmeem ntawm cov ntaub so ntswg.
Rau cov kab mob hauv lub hlwb, kev hloov kho nrog cov ntshav- hlwb barrier- nkag mus rau peptides tuaj yeem txhim kho nws lub peev xwm hla cov ntshav- hlwb teeb meem, ua rau cov tshuaj ntau ntxiv hauv cov hlwb hlwb thiab ntxiv dag zog rau nws txoj kev kho mob ntawm Alzheimer's kab mob thiab mob stroke.
(IV) Kev Hloov Kho Kev Ua Haujlwm Zoo: Kev nthuav dav ntawm Kev Ua Haujlwm
Qhia cov pab pawg antioxidant (xws li glutathione fragments) los yog los tiv thaiv - cov kab mob inflammatory active fragments rau hauv cov qauv molecular ntawmSS31 tabtuaj yeem txhim kho nws lub peev xwm los tswj oxidative kev ntxhov siab thiab txo qhov mob, tsim kom muaj kev sib txuas ntawm "mitochondrial kho + antioxidant + anti-inflammatory" cov teebmeem. Xwb, kev hloov kho tuaj yeem ntxiv dag zog rau nws txoj kev sib raug zoo rau cardiolipin, txhim kho lub hom phiaj kev sib khi ua haujlwm nyob rau hauv cov kab mob pathological (xws li oxidized cardiolipin) thiab txhim kho kev kho cov mitochondria puas.
Multi domain application of This tshuaj
Agricultural thiab Tsiaj Husbandry
Siv nws cov khoom tseem ceeb ntawm mitochondrial- lub hom phiaj kho thiab oxidative kev nyuaj siab, Elamipretide tuaj yeem hais txog cov teeb meem tseem ceeb hauv kev ua liaj ua teb thiab tsiaj txhu, xws li "kev nyuaj siab- raug cuam tshuam, txo cov khoom tsim tau, thiab tsis zoo," ua rau nws tsim nyog rau ntau yam xwm txheej xws li tsiaj txhu, nqaij qaib, aquaculture, thiab qoob loo. Cov ntawv thov tshwj xeeb yog raws li hauv qab no:
(I) Kev Tiv Thaiv Kev Nyuaj Siab thiab Kev Txhim Kho Kev Ciaj sia nyob hauv Kev Ua Tsiaj Tsiaj thiab Nqaij qaib:
Cov xwm txheej xws li qhov kub thiab txias, siab - kev ua liaj ua teb ceev, thiab kev ntxhov siab hauv kev thauj mus los tuaj yeem ua rau mitochondrial dysfunction thiab reactive oxygen hom (ROS) surges nyob rau hauv cov tsiaj txhu thiab nqaij qaib hlwb, ua rau txo kev tiv thaiv kab mob, raws plab, thiab tuag sai sai. Nws tuaj yeem siv los ntawm cov dej haus lossis cov khoom noj khoom haus los kho cov mitochondrial muaj nuj nqi hauv lub cev tiv thaiv kab mob (xws li, macrophages) thiab plab hnyuv epithelial hlwb, txo oxidative kev nyuaj siab puas.
Tsis tas li ntawd, nws txhawb kev ua haujlwm ntawm cov enzymes antioxidant xws li SOD thiab GPx, inhibits qhov kev tso tawm ntawm pro- cov kab mob inflammatory, thiab txhim kho lub cev muaj zog tiv thaiv. Hauv kev ua liaj ua teb broiler nyob rau hauv siab - qhov kub thiab txias, qhov tshuaj ntxiv no tuaj yeem ua rau kom muaj sia nyob li 10% -15%, txo cov hnyuv mucosal, thiab txo qis qhov tshwm sim ntawm raws plab.
(II) Optimization ntawm nqaij zoo thiab ntau lawm Efficiency:
Qhov zoo ntawm cov nqaij tsiaj nyeg yog ncaj qha ntsig txog mitochondrial zog metabolism. Nyob rau hauv kev ntxhov siab, mitochondrial tsis ua haujlwm tuaj yeem ua rau lactic acid tsub zuj zuj thiab cov nqaij fiber ntau degeneration, cuam tshuam rau nqaij rhiab thiab tsw. SS31 txhim kho cov oxidative phosphorylation efficiency ntawm skeletal leeg mitochondria, tsub kom ATP ntau lawm, txo lactic acid tsub zuj zuj, thiab tswj cov nqaij fiber ntau transformation (nce qhov feem ntawm oxidative nqaij fibers).
Qhov no ua rau 8% -12% txo cov nqaij shear quab yuam, ntau xim nqaij tawv, thiab txo qis poob. Hauv kev ua liaj ua teb mis nyuj, SS31 tuaj yeem kho mitochondrial muaj nuj nqi hauv cov qog mammary, txhim kho lub zog thaum lub sij hawm tsim cov mis nyuj, nce mis nyuj ntau dua 5% -8%, thiab txhim kho cov txiaj ntsig zoo xws li mis nyuj protein thiab rog.
(III) Environmental Stress Management nyob rau hauv Aquaculture:
Hauv aquaculture, kev ntxhov siab xws li dej tsis zoo (piv txwv li, ntau dhau ammonia nitrogen, hypoxia) thiab qhov kub thiab txias hloov pauv tuaj yeem ua rau mitochondrial membrane muaj peev xwm vau thiab lub zog metabolism stagnation hauv cov ntses thiab cw, ua rau surfacing thiab tuag. SS-31 tuaj yeem nqus tau sai thiab ua kom muaj txiaj ntsig hauv mitochondria ntawm cov kabmob tseem ceeb xws li gills thiab hepatopancreas los ntawm txoj kev xws li dej dispersion lossis pub supplementation. Nws kho cov txheej txheem mitochondrial puas, tswj lub zog metabolism hauv kev ua haujlwm, thiab txhim kho lub peev xwm antioxidant ntawm gill cells, txo kev puas tsuaj los ntawm cov khoom tsis zoo. Raws li kev ntxhov siab hypoxic, nws tuaj yeem ua rau kom muaj sia nyob ntawm cov ntses thiab cw los ntawm 15% -20% thiab txo qis qhov tshwm sim ntawm cov kab mob hemorrhagic.
(IV) Cov cuab yeej los pab cov qoob loo Stress-Resistance Breeding:
Hauv kev tshawb fawb qoob loo, qhov no tuaj yeem ua cov cuab yeej reagent kom muaj txiaj ntsig kev sib raug zoo ntawm mitochondrial muaj nuj nqi thiab kev ntxhov siab. Los ntawm kev kho cov qoob loo ntawm cov qoob loo xws li pob kws thiab nplej nrogSS31 tab, puas mitochondria nyob rau hauv kev ntxhov siab (xws li, drought, kub kub, hnyav hlau paug) tuaj yeem kho. Kev soj ntsuam ntawm cov kev hloov pauv hauv photosynthetic efficiency, biomass, thiab qhia txog kev ntxhov siab-cov noob muaj feem xyuam (xws li DREB2A) tuaj yeem qhia meej txog kev sib raug zoo ntawm mitochondrial muaj nuj nqi thiab qoob loo kev ntxhov siab.
Tsis tas li ntawd, Elamipretide tuaj yeem siv los tshuaj xyuas cov qoob loo uas muaj zog tiv thaiv kev ntxhov siab.Los ntawm kev sib piv ntau yam kev ua haujlwm ua ntej thiab tom qab kev cuam tshuam ntawm Elamipretide, cov kab mob zoo tshaj plaws nrog kev ruaj khov mitochondrial muaj nuj nqi tuaj yeem txheeb xyuas sai, ua kom lub voj voog me me.
Ndustrial Biocatalysis
Kev lag luam biocatalysis tso siab rau kev ua haujlwm zoo ntawm cov khoom siv roj ntsha xws li enzymes thiab cov kab mob. Txawm li cas los xij, yam xws li oxidative kev nyuaj siab thiab kub hloov pauv hauv cov tshuaj tiv thaiv kab mob tuaj yeem yooj yim ua rau lub deactivation ntawm cov biocatalysts. Nws tuaj yeem ua kom zoo dua catalytic efficiency thiab cov txheej txheem kev ruaj ntseg los ntawm kev tiv thaiv mitochondrial - ntsig txog cov qauv ua haujlwm. Cov ntawv thov tshwj xeeb yog raws li hauv qab no:
(I) Txhim kho Enzyme Catalyst Stability thiab Catalytic Efficiency:
Redox enzymes thiab dehydrogenases feem ntau siv hauv biocatalysis feem ntau yog los ntawm mitochondria los yog nyob ntawm mitochondrial -txog cov txheej txheem. Reactive oxygen hom (ROS) thiab kub siab nyob rau hauv cov tshuaj tiv thaiv kab mob tuaj yeem ua rau cov spatial qauv ntawm cov enzymes thiab oxidize lawv cov chaw ua haujlwm. Nws tuaj yeem ua kom zoo dua qhov no hauv ob txoj hauv kev: Ua ntej, los ntawm kev ntxiv ncaj qha rau cov tshuaj tiv thaiv kab mob los khi nrog mitochondrial - muab cov qauv ntawm cov enzymes.
Tiv thaiv cov chaw ua haujlwm los ntawm oxidation thiab txo cov enzyme aggregation-induced deactivation.Second, los ntawm chemically conjugating cov tshuaj no nrog enzyme molecules los tsim ib qho "enzyme-SS31" kev sib xyaw ua ke, uas tuaj yeem txuas ntxiv ib nrab - lub neej ntawm cov enzymes nyob rau hauv cov xwm txheej ntawm 63ytic℃los ntawm kev ua kom zoo dua qub 15% -25%. Qhov no yog tshwj xeeb tshaj yog haum rau siab -kub tshuaj tiv thaiv scenarios xws li cov synthesis ntawm kws tshuaj intermediates thiab zoo tshuaj cov khoom.
(II) Optimizing Microbial Fermentation Txheej txheem:
Thaum lub sij hawm siab - ntom microbial fermentation, lub zog microbial metabolism tuaj yeem ua rau mitochondrial overload thiab ROS tsub zuj zuj, ua rau stagnation hauv microbial kev loj hlob thiab txo cov khoom siv hluavtaws. Qhov no tuaj yeem ntxiv rau qhov nruab nrab fermentation los kho mitochondrial muaj nuj nqi hauv cov kab mob (xws li cov poov xab, cov kab mob lactic acid, Escherichia coli), txhim kho cov metabolism hauv lub zog thiab nce microbial biomass los ntawm 10% -18%.
Tsis tas li ntawd, nws txo qis qhov sib xyaw ntawm - cov khoom xws li lactic acid thiab acetic acid thaum lub sij hawm fermentation, optimizing cov khoom synthesis txoj kev. Hauv kev tsim ethanol los ntawm cov poov xab fermentation, nws tuaj yeem nce ethanol tawm los ntawm 8% -12% thiab txo lub voj voog fermentation los ntawm 10% -15%. Hauv kev tsim cov tshuaj probiotics los ntawm cov kab mob lactic acid fermentation, nws tuaj yeem txhim kho microbial ciaj sia taus, nce tus naj npawb ntawm cov kab mob siv tau ntau dua 20%.
(III) Txhim kho Biofuel Production Efficiency
Kev tsim cov biofuels xws li biodiesel thiab bioethanol tso siab rau kev hloov pauv ntawm cov roj thiab cov suab thaj los ntawm cov kab mob, nrog mitochondria ua qhov chaw tseem ceeb ntawm cov txheej txheem metabolic. SS31 tuaj yeem cuam tshuam cov txheej txheem metabolic ntawm cov kab mob xws li oleaginous poov xab thiab algae, kho cov haujlwm ntawm cov enzymes koom nrog hauv mitochondrial fatty acid oxidation.
Qhov no txhim kho kev ua haujlwm ntawm cov roj degradation thiab hloov pauv, nce biodiesel tawm los ntawm 12% -18%. Nws kuj txhim khu microbial kam rau ua nyob rau hauv siab substrate concentrations (xws li, siab qab zib los yog roj siab), txo mitochondrial puas los ntawm substrate inhibition, stabilizes lub efficiency ntawm lub fermentation system, thiab txo cov nqi raw khoom.
(IV) Kev txhim kho ntsuab ntawm Bioconversion txheej txheem:
Hauv cov txheej txheem bioconversion ntawm cov tshuaj xws li cov tshuaj hormones steroid thiab tshuaj tua kab mob, cov txheej txheem ib txwm muaj cov kev sib tw xws li cov khoom lag luam qis thiab siab los ntawm - cov khoom tsim, uas muaj feem cuam tshuam rau mitochondrial dysfunction hauv cov kab mob.SS31 tabtuaj yeem txhim kho qhov ua tau zoo ntawm cov khoom siv hluav taws xob thauj khoom hauv microbial mitochondria, txhim kho qhov tshwj xeeb ntawm cov substrate hloov dua siab tshiab thiab txo los ntawm - cov khoom tsim (los ntawm - cov khoom cov ntsiab lus txo los ntawm 10% -15%). Nws kuj tseem txo qhov kev xav tau ntawm cov tshuaj tiv thaiv antioxidants hauv cov tshuaj tiv thaiv kab mob, txo qis ib puag ncig cov pa phem los ntawm cov tshuaj reagents thiab ua rau cov txheej txheem ntau ntxiv nrog cov kev cai ntsuab ntau lawm. Qhov no tshwj xeeb tshaj yog muaj feem xyuam rau cov tshuaj synthesis scenarios uas vam khom microbial hydroxylation thiab txo cov tshuaj tiv thaiv.
FAQ
Q: Dab tsi yog qhov kev loj hlob muaj peev xwm ntawm SS31 hauv kev lag luam biocatalysis?
A: Yuav txhim khu kev ruaj ntseg thiab catalytic efficiency ntawm biocatalysts xws li oxidoreductases, thiab ncua lub voj voog cov tshuaj tiv thaiv; Optimize lub siab - ceev fermentation txheej txheem ntawm cov kab mob, ua kom cov kab mob biomass thiab cov khoom synthesis tus nqi, thaum txo cov tsub zuj zuj ntawm los ntawm - khoom.
Q: Puas muaj lwm lub npe rau Elamipretide?
A: SS-31 peptide; Bendavia; MTP-131.
Cim npe nrov: SS-31 Capsules, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom