Afoxolaner Thiab Milbemycin Oxime Chewable Tablets

Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj, muag raws li lub npe NexGard Spectra®, yog dav-spectrum anthelmintic khoom tsim tshwj xeeb rau cov dev. Lub formulation muab cov kev tswj hwm sab hauv thiab sab nraud los ntawm kev ua haujlwm ntawm ob lub tswv yim. Afoxolaner, ib qho tshuaj tua kab isoxazoline thiab acaricide, ua los ntawm inhibiting gamma-aminobutyric acid (GABA)-gated chloride channel hauv cov kab mob parasites. Qhov no inhibition cuam tshuam cov paj hlwb ib txwm muaj teeb liab kis tau tus mob, ua rau hyperexcitation, tuag tes tuag taw, thiab kev tuag ntawm cov kab mob sab nraud nrog rau fleas thiab ixodid. Cov tshuaj no yog macrolide anthelmintic, exerts nws cov nyhuv los ntawm activating glutamate-gated chloride raws, uas induces hyperpolarization ntawm neuromuscular hlwb nyob rau hauv cov kab mob uas raug kab mob. Qhov no hyperpolarization ua rau tuag tes tuag taw thiab tuag ntawm cov kab mob sab hauv xws li kab mob plawv thiab plab hnyuv nematodes. Ua ke, ob qho khoom xyaw nquag xa tawm dav dav, ob qho kev tiv thaiv tawm tsam ntau yam kab mob sab hauv thiab sab nraud hauv dev.

 

Peb cov khoom

 

Cov tshuaj yog nyob rau hauv daim ntawv ntawm lub teeb liab mus rau reddish xim av ntsiav tshuaj, nrog specifcations npog cov kev xav tau ntawm cov dev uas hnyav 2-50kg, nrog rau tsib combinions: 9.375mg+1.875mg txog 150mg+30mg. Cov kev tshawb fawb Pharmacokinetic tau pom tias Aflana nce mus txog qhov siab tshaj 2-4 teev tom qab kev saib xyuas qhov ncauj thiab muaj ib nrab-lub neej ntawm kwv yees li 2 lub lis piam; Milbeixime A3 / A4 Cheebtsam ncav cuag lawv qhov siab tshaj plaws nyob rau hauv 1-2 teev, nrog ib nrab ntawm lub neej ntawm 1.6 thiab 3.3 hnub, raws li, ua kom muaj kev tiv thaiv ntev.

Cov ntaub ntawv tseem ceeb ntawm cov tshuaj

Hom npe:

Aflanamir Beixime Chewable ntsiav tshuaj

01

Khoom npe:

NexGard Spectra ®), Fuweien ® (FRONTPRO)

02

Lub npe Askiv:

Afoxolaner thiab Milbemycin Oxime Chewable Tablets

03

Chaw tsim tshuaj paus:

Boehringer Ingelheim Tsiaj Health Co., Ltd., Toulouse, Fabkis

04

Dosage form thiab cov yam ntxwv:

Lub teeb liab mus rau reddish- xim av puag ncig (tsawg spec) lossis square (siab spec) ntsiav tshuaj, palatable rau dev.

05

Specification system:

Ultra trustworthy series:

Afurana 9.375mg + Milberoxime 1.875mg
Aflana 18.75mg + Milberoxime 3.75mg
Aflana 37.50mg + Milberoxime 7.50mg
Afurana 75.00mg + Milberoxime 15.00mg
Afurana 150.00mg + Milberoxime 30.00mg

Fuweien ® Series:

Afurana 11.3 mg
Afurana 28.3 mg
Afurana 68 mg
Afurana 136 mg

Ntshuam cov ntaub ntawv sau npe:

Raws li tsab ntawv tshaj tawm ntawm Ministry of Agriculture thiab Rural Affairs, cov tshuaj yuav raug sau npe rau xyoo 2023, thiab daim ntawv pov thawj tus lej rau cov tshuaj kws kho tsiaj tuaj txawv teb chaws suav nrog (2018) Daim Ntawv Pov Thawj Tshuaj Kho Mob Txawv Tebchaws No. 19-23, siv tau txog thaum Lub Ib Hlis 16, 2028.

Afoxolaner thiab Milbemycin Oxime Chewable Tabletsyog ib qho dav -spectrum deworming pharmaceuticals tsim tshwj xeeb rau cov dev, ua lag luam raws li NexGard Spectra ®. Cov tshuaj no ua tiav kev tsav tsheb sab hauv thiab sab nraud los ntawm ob lub tshuab ua haujlwm, suav nrog kev tiv thaiv thiab kho cov kab mob sab nraud xws li fleas, ixodid, mites, nrog rau cov kab mob sab hauv xws li hertworms thiab gastroitestinal nemtodes. Nws txoj kev siv tuaj yeem raug sau ua ke rau hauv cov hauv qab no tseem ceeb:

1. Adjuvant kev kho mob rau cov kab mob parasitic tshwj xeeb

 

Pob ntseg kab mob:
Txawm hais tias tsis tau teev meej meej raws li qhov taw qhia, milberoxime muaj cov nyhuv tua ntawm cov larvae thiab cov neeg laus ntawm Otodectes cynotis. Hauv kev kho mob, cov kws kho tsiaj tuaj yeem siv nws ua ib feem ntawm kev kho mob pob ntseg (xws li kev sib xyaw nrog cov tshuaj pleev xim), tshwj xeeb tshaj yog rau cov kab mob mite los yog rov tshwm sim.
Kev tiv thaiv thiab kho ectoparasites hauv miv (siv dhau cov lus qhia):
Txawm hais tias cov tshuaj tau sau npe rau cov dev, Aflana muaj txiaj ntsig zoo tiv thaiv miv dev (cav flea). Hauv ntau tsev neeg tsiaj, yog tias tus miv tau noj cov tshuaj zom cov dev los yog tom qab kev soj ntsuam kws kho tsiaj ntawm qhov kev pheej hmoo, yuav tsum tau ceev faj thaum siv lawv rau kev tswj fleas hauv miv (kev kho tshuaj nruj yog tsim nyog kom tsis txhob muaj tshuaj lom ntau dhau los ntawm Mirbesime).

2. Tiv thaiv kev siv nyob rau hauv siab - ib puag ncig muaj kev pheej hmoo rau kab mob parasitic

 

Stray animal cawm chaw nres tsheb:
Nyob rau hauv cov chaw rau cov tsiaj nyaum uas muaj qhov tshwm sim ntawm fleas thiab ixodid, cov tshuaj no tuaj yeem siv los ua pab pawg tiv thaiv kev tiv thaiv kom tsis txhob muaj kab mob kis tau tus kab mob, tshwj xeeb tshaj yog tsim rau cov xwm txheej uas nws nyuaj rau kev deworming sab nraud txhua tus neeg.
Kev txuag tsiaj qus:
Kev tiv thaiv thiab tswj cov kab mob parasitic nyob rau hauv cov tsiaj txhu uas muaj kab mob xws li hma thiab jackals yuav tsum tau siv ceev faj tom qab kev soj ntsuam kws kho tsiaj, uas tej zaum yuav muaj kev hloov ntau npaum li cov lus qhia lossis kev sib xyaw ua ke.

3. Cov ntawv thov tshwj xeeb hauv kev sib cuam tshuam tshuaj

 

Ua ke nrog P-glycoprotein inhibitors:
Milberoxime yog ib qho substrate ntawm P-glycoprotein (P-gp), thiab thaum siv ua ke nrog P-gp inhibitors xws li ketoconazole, nws tuaj yeem txhim kho nws cov tshuaj ntshav siab thiab ua kom nws ntev. Cov yam ntxwv no tuaj yeem siv los kho cov tshuaj - tiv thaiv kab mob nemtode, tab sis yuav tsum tau saib xyuas nruj ntawm cov tshuaj toxicity.
Cov xwm txheej ntawm kev kho tsis tau tiav:
Milberoxime tej zaum yuav yog lwm txoj hauv kev rau cov kab mob nemtode lossis mite tiv taus cov tshuaj tua kab xws li ivermectin, tab sis nws cov txiaj ntsig yuav tsum tau lees paub los ntawm kev sim tshuaj rhiab heev.

4. Adjuvant therapy for non parasitic disease (theoretical possibility)

 

Immune regulatory effect:
Kab mob parasitic tuaj yeem ua rau muaj kev cuam tshuam ntau dhau ntawm tus dev lub cev tiv thaiv kab mob, ua rau tawv nqaij o lossis ua xua. Cov tshuaj tuaj yeem txo qis cov tsos mob cuam tshuam los ntawm kev tshem cov kab mob cab, tab sis tsis muaj pov thawj ncaj qha los txhawb nws txoj kev tiv thaiv kab mob.
Kev tiv thaiv kab mob Postoperative:
Cov dev tom qab phais yog raug kab mob parasitic vim tsis muaj zog tiv thaiv kab mob. Cov tshuaj no tuaj yeem siv los ua kev tiv thaiv kev tiv thaiv, tab sis hom kev phais thiab kev pheej hmoo ntawm kev siv tshuaj yuav tsum tau soj ntsuam.

1. Kev siv tshuaj ntau npaum li cas

Super trustworthy series: Xaiv cov kev qhia tshwj xeeb raws li tus dev qhov hnyav thiab noj qhov ncauj ib hlis ib zaug.
2-4kg: 9.375mg Aflana+1.875mg Milberoxime
4.1-10kg: 18.75mg Aflana +3.75mg Milberoxime
10.1-25kg: 37.5mg Aflana +7.5mg Milbeixime
25.1-50kg: 75mg Aflana +15mg Milberoxime
＞ 50kg: Siv cov ntsiav tshuaj tshwj xeeb hauv kev sib xyaw kom ntseeg tau tias qhov ntau npaum li cas ntawm 2.5-6.9mg / kg.
Afoxolaner thiab milbemycin oxime chewable ntsiav tshuajseries: koob tshuaj xam raws li cov ntsiab lus ntawm Afurana, xws li 2.7-7.0mg / kg, ib hlis ib zaug.

2. Kev hloov kho rau cov xwm txheej tshwj xeeb

Collie: Vim yog MDR1 cov noob tsis xws luag, cov tshuaj tsub zuj zuj tuaj yeem tshwm sim, thiab kev hloov pauv ntau npaum li cas lossis kev zam ntawm kev siv yuav tsum yog raws li cov lus qhia kws kho tsiaj.
Cov dev cev xeeb tub / lactating dev: Cov ntaub ntawv kev nyab xeeb yog txwv thiab yuav tsum tau siv nrog ceev faj raws li kev qhia kws kho tsiaj.
Cov menyuam dev: Cov dev hnub nyoog qis dua 8 lub lis piam lossis hnyav dua 2kg raug txwv.

3. Pharmaceuticals saib xyuas cov txheej txheem

Nws tuaj yeem pub ncaj qha lossis sib xyaw rau hauv cov zaub mov kom ntseeg tau tias kev noj zaub mov tiav rau cov dev.
Cov tshuaj ntxiv yuav tsum tau xa rov qab mus rau lawv lub ntim qub kom tsis txhob sib cuag nrog menyuam yaus.
Ntxuav tes tom qab siv los tiv thaiv kab mob plab los ntawm kev noj tsis haum.

2. Milbemycin Oxime

Qeb

 

 

Macrolide Antiparasitic Tshuaj

Kev sib xyaw

 

 

Milberoxime A3 (20%) thiab A4 (80%)

Hom phiaj

 

 

Chloride ion channel tswj los ntawm glutamate nyob rau hauv invertebrate paj hlwb thiab cov leeg hlwb

Mechanim

Tom qab khi nrog chloride ion channels, nws txhim kho cov membrane permeability, ua rau cov cell hyperpolarization, thiab ua rau cov kab mob tuag tes tuag taw thiab tuag.

Kev nyab xeeb kom zoo dua

Cov ntshav- lub paj hlwb teeb meem ntawm cov tsiaj muaj tsawg permeability rau milberoxime, thiab kev faib ntawm GABA receptors nyob rau hauv lub hauv paus paj hlwb yog txwv, yog li nws tsis muaj kev cuam tshuam rau paj hlwb nyob rau hauv dev.

2. Milberoxime

Absorption:

Tom qab kev saib xyuas ntawm qhov ncauj, qhov nqus tau nrawm, thiab qhov tseeb bioavailability ntawm Milbeixime A3 thiab A4 yog 81% thiab 65%, feem, nrog lub sijhawm siab tshaj ntawm 1-2 teev.

Kev faib tawm:

Cov ntaub so ntswg faib tawm yog 2.7 ± 0.4L / kg (A3) thiab 2.6 ± 0.6L / kg (A4), feem, nrog cov ntshav plasma tsawg (A3: 75 ± 22ml / h / kg, A4: 41 ± 12ml / h / kg).

Ib nrab neej:

A3 yog 1.6 ± 0.4 hnub, A4 yog 3.3 ± 1.4 hnub, thiab qhov ntev - ua yeeb yam ua kom muaj txiaj ntsig ntawm kev saib xyuas txhua hli.

Milbeixime yog ib qho substrate ntawm P-glycoprotein (P-gp), thiab nws kev sib xyaw nrog P-gp substrates xws li digoxin thiab doxorubicin, lossis tshuaj macrolide, tuaj yeem txhim kho toxicity. Yog li ntawd, kev sib xyaw ua ke yuav tsum zam.

Cim npe nrov: afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom