Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov neeg xa khoom ntawm Ivermectin thiab Pyrantel Pamoate hauv Suav teb. Txais tos rau kev lag luam wholesale tej zoo zoo ivermectin thiab pyrantel paoate kev muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Ivermectin thiab Pyrantel Pamoateyog cov tshuaj tiv thaiv kev sib xyaw ua ke siv hauv cov dev thiab miv, muab cov ntsiav tshuaj chewable (chewable lossis mos chewable) ib hlis twg los tiv thaiv thiab tswj xyuas ntau yam kab mob cab. Cov tub ntxhais kawm tseem ceeb ntawm cov yeeb tshuaj sib xyaw ua ke ntawm ob qho kev tiv thaiv kev tiv thaiv sab nraud (xws li heedworms sab nraud (xws li cov radworms thiab hookworms). Nws yog rau chav kawm ntawm macrolide Antiparasitic Antamate gated chloride ion channel, ua rau cell hyasisсivy tuag tes tuag taw, thiab kev tuag. Kev Deefofaria immitis tuaj yeem tiv thaiv kev txhim kho ntawm nws cov menyuam kab (L3, L4) hauv dev. Cov cab sab nraud xws li mites (cov pa taws mites, pob ntseg mites) thiab cov tsiaj dev mub) thiab txhawb nqa los ntawm kev tshawb fawb). Endoparasites yuav muaj inhibitos cuam tshuam rau cov menyuam ntawm tej nematodes, xws li cov hloov chaw. Nws kuj yog rau lub TetraYdropyrimidididididididididididididididididididididididididididididididididididididididididididy Helmints. Raws li Acetylcholine Receptor agonist, nws ua rau muaj kev sib txuas lus txuas ntxiv ntawm Parasite, uas yog qhov kawg tau ua los ntawm tus tswv lub plab hnyuv sab nrauv. Lub Hom Phiaj Cov Neeg Loj Hlob thiab L4 theem larvae; Cov laus thiab theem varval ntawm hookworms (ancylostoma canninum, uncinaria stenocephala); Taenia (ib nrab ntxiv rau compound npaj) xws li kev sib xyaw ntawm Thiametoxam thiab Prazatasantel tuaj yeem hom kev sib tw.
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| Daim Ntawv Pov Thawj Kev Ntsuam Xyuas | ||
| Compound npe | Ivermectin thiab Pyrantel Pamoate | |
| Teem nqi | Kws Tshuaj Ntsuam Xyuas | |
| Qho ntau | 337.3kg | |
| Ntim txheem ntim | 25Kg / nruas | |
| Tus tsim | Shaanxi Bloom Tech Co., Ltd. | |
| Lauj tsis tau. | 202501090051 | |
| Mfg | Jan 9 9 2025 | |
| Tus txeeb | Jan 8-1 2028 | |
| Yam | Kev Lag Luam Kev Lag Luam | Kev tsom xam tau |
| Kev tshwm sim | Dawb lossis yuav luag dawb hmoov | Hloov |
| Dej Cov Ntsiab Lus | Tsawg dua los yog sib npaug rau 5.0% | 0.45% |
| Poob rau ziab | Tsawg dua los yog sib npaug rau 1.0% | 0.33% |
| Cov hlau hnyav | PB tsawg dua lossis sib npaug rau 0.5ppm | N.D. |
| Tsawg tsawg dua li lossis sib npaug rau 0.5ppm | N.D. | |
| Hg tsawg dua lossis sib npaug rau 0.5ppm | N.D. | |
| CD tsawg dua lossis sib npaug rau 0.5ppm | N.D. | |
| Purity (hplc) | Ntau dua los yog sib npaug rau 99.0% | 99.90% |
| Ib Leeg Cav | <0.8% | 0.48% |
| TAG NRHO LICBIAL COUNT | Tsawg dua li lossis sib npaug rau 750cfu / g | 70 |
| E. coli | Tsawg dua los yog sib npaug rau 2mpn / g | N.D. |
| Tus ntses siav | N.D. | N.D. |
| Ethanol (los ntawm gc) | Tsawg dua los yog sib npaug rau 5000ppm | 400ppm |
| Chaw ntim khoom | Khw muag khoom hauv ib lub cim, tsaus, thiab qhuav qhov chaw hauv qab 2-8 degree | |
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Parasitic kab mob yog ib qho teeb meem kev noj qab haus huv hauv kev kho mob tsiaj thiab tsiaj muaj kev cuam tshuam loj rau kev loj hlob, kev txhim kho, thiab kev noj qab haus huv ntawm cov tsiaj.Ivermectin thiab Pyrantel Pamoate, feem ntau hu ua prazatquantel, yog ob tus siv tshuaj tiv thaiv antiparasitic uas ua rau muaj kev tswj hwm cov txiaj ntsig ntawm cov tsiaj ua haujlwm hauv cov tsiaj ua haujlwm hauv particological thiab cov khoom siv tshwj xeeb.
Cov kev sib sau ua ke ntawm Ivermectin thiab Pyrante Pamoate
- Qhov zoo ntawm kev kho kev kho mob
Kev cuam tshuam dav: Ivermectin yog siv rau kev tiv thaiv thiab kev tiv thaiv parasitic cov cua nab, thaum pyraante paoate tsom rau kev tshem tawm ntawm cov plab hnyuv nematodes. Kev sib xyaw ntawm ob qho tuaj yeem ua tiav ib qho "dual sab hauv thiab sab nraud" cov nyhuv.
Txo kev siv tshuaj tiv thaiv: Hloov kev siv cov tshuaj uas muaj cov txheej txheem sib txawv ntawm kev nqis tes ua tau ncua kev txhim kho ntawm parasite kev tiv thaiv.
Kev yooj yim: Kev lag luam muaj compound formulations (xws li ordhart ntxiv, healhart ntxiv) muab ob yam tshuaj, txhim kho tsiaj tswv raws tus tsiaj ua raws cai.
- Chaw soj ntsuam kev tshawb fawb
Ntau cov kev tshawb fawb tau lees tias kev sib xyaw ntawm Ivermectin (6 μ. ancylia PamoTsy (5Mg / kg) Tsis tas li ntawd, kev sib xyaw ua ke muaj 100% tiv thaiv cov nyhuv rau cov tub rog ntawm cov menyuam kab mob ntawm cov menyuam menyuam yaus, kav ntev rau 30 hnub.
- Muaj cov xwm txheej muaj feem xyuam
Kev tiv thaiv ib txwm muaj: Kev npaj qhov ncauj npaj ib hlis ib zaug ib lub hlis ib lub hlis ib zaug ib lub hlis ib txhij los tiv thaiv kab mob ntawm cov neeg mob hlwb, cov hookworms, thiab cov hloov hloov.
Kho cov khoom: Ua ke siv tuaj yeem tshem tawm cov cab thiab tiv thaiv kev mob siab rau cov tsiaj txhu.
Ib puag ncig muaj kev pheej hmoo: hauv cov tsiaj cov tsiaj stray thiab thaj chaw muaj cov kab ke siab, kev siv tau tuaj yeem txo cov nqi tus kab mob.
Ivermectin thiab Pyrante Pamoate's 'Collateral puas tsuaj' rau cov tsis tau hom phiaj eukaryotes
Ivermectin thiab Pyrantel Pamoateyog ob tug tseem ceeb antiparasitic cov tshuaj siv dav siv hauv kev teb veterinary thiab pej xeem kev noj qab haus huv. Cov yav dhau los ua rau parasitic neuromuscular tuag tes tuag taw los ntawm kev ua haujlwm glutamate spastic tuag los ntawm kev ua haujlwm nicotinic acetylcholine recetors (Nachr). Txawm hais tias ob qho tib si muaj kev phom sij uas muaj txiaj ntsig tua cov cab, xws li cov tshuaj tua tsiaj, thiab lwm yam) tau nyiam cov koomhaum scientific thiab cov koom haum tswj hwm.
Kev siv yeeb quav tshuaj ntawm kev ua thiab muaj peev xwm txaus ntshai ntawm cov kab mob tsis muaj kab mob
Hom phiaj thiab tsis sib haum ntawm kev cuam tshuam ntawm Ivermectin
Cov tub ntxhais mechanism ntawm Ivermectin yog kom qhib invertebrate gucls, ua rau chloride ion thiab ua rau neuromuscular zoo hyperpolarization. Txawm li cas los xij, txawm tias cov tsiaj txhu tsis muaj glucls hauv lawv lub cev, cov tshuaj yuav ua rau cov teebmeem hauv qab no:
Gaba receptor ntoo khaub lig hla kev cuam tshuam: cov tshuaj highes ntawm Ivermectin tuaj yeem txhim kho cov kev ua si ntawm gamma dev acid (GAMA) cov kua ntxwv hauv cov tsiaj muaj sia, cuam tshuam rau nruab nrab ntawm cov hlab hlwb ua haujlwm. Kev tshawb fawb tau pom tias kev sib tsoo muaj p - glycoptein (P} GPRETIPS sib hloov, uas tiv thaiv cov leeg ntawm lub hlwb thiab tuaj yeem ua rau Neurotoxicity xws li ataxia thiab tshee.
Mitochondrial kawg li: Hauv cov kev sim vitro tau pom tias Ivermectin tuaj yeem tsoo lub nroog AMPK / MTOR
Ib puag ncig tsis tu ncua: cov lus qhia txog kev tawm tsam tsiaj tuaj yeem ua rau muaj kev pheej hmoo ntev ntev, nyob rau hauv lub nroog tsis muaj mob xws li cov hlab ntsha thiab dej hauv av.
Lub hom phiaj thiab tsis sib haum ntawm cov teebmeem ntawm pyrante Pamoate
Pyrantel Pamoate induces tuag tes tuag taw los ntawm kev txhawb nqa tus cab Nachr, tab sis nws cov kev cuam tshuam rau cov khoom muaj sia uas tsis yog hom phiaj hauv:
Machmalian Nachr Hla Assivity: Txawm hais tias muaj cov txheej txheem sib txawv ntawm cov leeg nqaij cov leeg tuaj yeem ua rau mob pob txha overstimulation, ua rau cov leeg tsis muaj zog lossis ua pa nyuaj.
Microbial zej zog kev ntxhov siab: pyrantel seem nyob rau hauv av yuav inhibit cov kev ua ntawm nitrogen cycling kev ua cycling.
Tshaj tawm tshuaj tiv thaiv noob: ntev ntev tsawg {{0} Daim duab tshuaj sib hloov hauv Nachr Gene kuj cuam tshuam thiab tsis ncaj rau kev ua kom muaj kev sib txuam ntawm cov kab mob ecological.
Tsis yog hom phiaj lom roj ntsha raug thiab noj txoj hauv kev thiab koob -} teb cov lus sib raug zoo
Mammalian raug txoj kev
Kev noj khoom haus ncaj qha: Tsiaj noj ntawm cov quav tshuaj lossis licking ntawm lub vev xaib siv tshuaj yuav ua rau muaj kev thab plaub. Piv txwv li, kev sib tsoo tuaj yeem muaj cov tsos mob neurological los ntawm kev siv 0.1mg / kg Ivermectin, thaum qhov koob tshuaj muaj kev nyab xeeb tsuas yog 6 μ g / kg.
Kev Hloov Paus Tsev Kawm Ntawv Hloov Chaw: Ivermectin nkag mus rau hauv ib puag ncig tsiaj los ntawm cov zis tsiaj / quav thiab yuav cuam tshuam cov tsiaj qus tom qab siv cov khoom noj khoom haus. Kev tshawb fawb tau pom tias kev tshaj tawm tus nqi ntawm cov quav nqaij ntses uas tsawg los ntawm 40% thaum raug rau 0.01 μ g / l kaus ntxhw.
Kev Raug Mob Ua Haujlwm: Lub sijhawm ntev ntawm cov kws kho tsiaj thiab cov tsiaj ua haujlwm rau cov tshuaj yuav ua rau muaj kev fab tshuaj lossis ua pa ua pa lossis ua pa ua pa.
Kev Kho Mob Kev Mob Mob Ovanevological
Cov av microorganisms: Ivermectin muaj ib nrab - lub neej ntawm 30 hnub nyob rau hauv av, thiab ib qho koob tshuaj ntawm 0.1mg / kg tuaj yeem inhibit pub thiab lub zog ntawm cov huab cua.
Cov tsiaj muaj sia: Pyrante Pamoate muaj ib lc50 (ua kom siab ntsws) 50%) ntawm 0.5mg / l nyob rau hauv dej tshiab, uas muaj teratogenic nyhuv rau nees dam embryo loj hlob.
Kab Zej Zog: Qaub Dose Ivermectin (0.001Mg / kg) tuaj yeem txo qis kev ua haujlwm ntawm bees thiab cuam tshuam pollination cov kev pabcuam.
Tsis yog hom phiaj lom neeg lom zem thiab cov txheej txheem
Mammalian Toxicity
Neurotoxicity: ivermectin induces gaba kho mob neural inhibition nyob rau MDR1 mutant dev, manifested li ataxia thiab nystagmus. Tib neeg EX Vivo kev sim tau qhia tias 10 μ m m Ivermectin tuaj yeem txo cov synaptic kis tau kev ua tau zoo hauv hippocampal neurons.
Kev ua me nyuam toxicity: Tom qab kev txuas ntxiv mus ntxiv ntawm 5mg / kg Ivermectin rau 30 hnub hauv nas, cov tshuaj loog uas muaj kev sib tw tau nce 30%.
Immunosupression: pyrantel
Kev ntsuas kev lom neeg lom neeg lom neeg
Av biota: Ivermectin txo qhov sib txawv ntawm cov av ntiaj teb plab zom mov
Cov tsiaj muaj sia: Pyrantel Pamoate Alters kev coj ua luam dej ntawm Daphawj
Kev cog qoob loo: Muaj kev kub ntxhov rau Ivermectin (10mg / kg av) inhibits Arabidopsis txoj kev loj hlob hauv paus hniav thiab txo cov phoedynthetic efficiency.
Molecular Txheej Txheem Kev Ntsuas
Oxidative kev ntxhov siab: H Hela hlwb los tsim 8-hydroxydeoxyguanoine (8-oxodg), taw qhia DNA oxidative puas.
Mitochondrial Mitochondrial Membrane Muaj peev xwm poob siab: Pyrantel Pamoate ua rau 60% txo qis hauv cov nematescence mitochondria ntawm nematode mitochondria ntawm nematode mitochondria ntawm nematode mitochondria ntawm nematode mitochondria ntawm nematode mitochondria
Kev kho mob epigenetic kev hloov kho: raug rau Ivermectin ua rau hloov pauv hauv cov qib methylation, cuam tshuam rau cov thawj coj qhia kev cai.
Kev Tshuaj Ntsuam Xyuas Kev Nyab Xeeb thiab Kev Tiv Thaiv Kev Tiv Thaiv
Cov Qauv Kev Ntsuam Xyuas Kev pheej hmoo
Cov nyhuv raug cov nyhuv pib pib: tsim kom muaj tshuaj lom neeg lom neeg -}} teb cov lus nkhaus kom txiav txim siab tsis pom zoo (tsis muaj kev pom zoo. Piv txwv li, Ivermectin muaj Nowec ntawm 0.05Mg / Kg rau Englworms.
Ecological risk index: Combining drug environmental persistence (DT50), bioaccumulation (BCF), and toxicity (EC50), calculate the environmental risk quotient (RQ). When RQ>1, tswj kev ntsuas yuav tsum tau ua kom tau txais.
Kev nkag siab cov qhab nia: Tsim cov lus qhia sib txawv sib txawv rau cov tsiaj sib txawv (xws li Collies vs. ib txwm muaj).
Kev Tiv Thaiv thiab Tswj Tshuab Technology
Precision cov tshuaj thev naus laus zis: kev tsim qhov hnyav / yug tshwj xeeb cov dosing Regimens, xws li tshuaj xyuas MDR1 mutant dev los ntawm kev kuaj dev caj ces.
Kev Kho Mob Ib Cheeb Tsam Kev Kho Mob Ib Cheeb Tsam: Siv ozone oxidation lossis microbial degradation kom txo qis cov tshuaj seem.
Lwm yam kev kho mob kho mob: Tshawb cov khoom ntuj (xws li Melia Azedarach extract) lossis cov noob kom muaj kev cuam tshuam RNA) los txo cov tshuaj lom neeg siv tshuaj.
Kev cai tswjfwm thiab cov lus pom zoo
Cov Qauv Txwv Tsis Txaus Siab: Tsim kom muaj qhov siab tshaj plaws txwv (MRL) rau Ivermectin hauv cov tsiaj muab cov zaub mov, xws li EU kev cai ntawm 10 μ G / kg rau nqaij nyuj.
Kev tswj hwm ib puag ncig tswj: Nws yog qhov yuav tsum tau tias kev yug me nyuam ua liaj ua teb nqa tawm cov quav quav thiab txwv tsis pub tawm mus rau hauv dej lub cev.
Tshuaj Yeeb Tshuaj Xyuas Kev Lag Luam Network: Tsim Lub Ntiaj Teb Parasite Yeeb Tshuaj Tsis kam lees cov ntaub ntawv los qhia cov tshuaj kho mob kho mob.
Kev Tshawb Fawb Yav Tom Ntej
- Kev Tshawb Fawb Ua Ntej
Application of omics technology: Revealing the molecular network disruption of drugs on non targeted organisms through transcriptomics and metabolomics.
Kev tsim kho Ecological muaj: Siv Systems Kev Siv Biology los simulate cov kev sib kis tau ntawm cov tshuaj hauv cov khoom noj khoom noj.
- Cov Qauv Tshuaj Tshiab
Lub hom phiaj xa khoom: Tsim Nanocarrior kom ua tiav cov tshuaj tso tawm los ntawm kev ua cab thiab ua kom muaj zog ib puag ncig.
Cov qauv kev ua kom zoo: txo kev sib raug zoo ntawm cov tshuaj rau cov tshuaj siv tsiaj rau tsiaj rau cov tsiaj txhu cov tshuaj rau cov tshuaj lom neeg.
- Kev ntsuam xyuas kev tshuaj ntsuam xyuas
Tag nrho lub neej ntsuas kev txheeb xyuas: seb puas muaj nyiaj txiag los ntawm kev cuam tshuam ib puag ncig ntawm cov tshuaj, muab ib lub hauv paus rau txoj cai tsim.
Pej xeem kev paub tseeb: ntsuas qhov kev paub txog cov kev pheej hmoo ntawm cov tshuaj muaj kev pheej hmoo ntawm cov thawj coj science thiab tsim kho cov tswv yim science science.
Cim npe nrov: Ivermectin Thiab Pyrantel Pamoate, Lwm tus neeg, Chaw tsim khoom, Hoobkas, lag luam Wholesale, yuav, nqe, loj, loj, rau muag