Enclomiphene Citrate ntsiav tshuaj

Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm enclomiphene citrate ntsiav tshuaj nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo enclomiphene citrate ntsiav tshuaj muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Enclomiphene citrate ntsiav tshuajyog qhov ncauj nonsteroidal xaiv estrogen receptor modulator (SERM) nrog cov qauv tshuaj ntawm (E) -2- [p - (2-chloro-1,2-diphenylethenyl) phenoxy] triethylamine citrate. Raws li tus nquag isomer ntawm Clomiphene Citrate, nws ua tiav purity siab dua los ntawm kev tshem tawm cov cis isomer (Zuclomiphene) los ntawm Clomiphene, yog li txo qhov muaj peev xwm mus ntev estrogen receptor antagonists thiab cov kev mob tshwm sim uas yav tas los yuav coj. Cov tshuaj no yog tsim los ntawm FDA pom zoo cov khoom siv tshuaj ua lag luam xws li Seqens thiab Suanfarma, ua kom muaj kev ruaj ntseg zoo ntawm nws cov khoom siv thoob ntiaj teb.

Khoom npe	Enclomiphene Citrate ntsiav tshuaj	Enclomiphene Citrate Capsules	Enclomiphene Citrate hmoov
Yam khoom	Tablet	Capsules	Hmoov
Khoom Purity	Ntau dua lossis sib npaug li 99%	Ntau dua lossis sib npaug li 99%	Ntau dua lossis sib npaug li 99%
Khoom Specifications	Customizable	Customizable	Customizable
Daim ntawv khoom	Customizable	Customizable	Organic synthesis

 

Peb cov khoom

 

Enclomiphene Citrate COA

Certificate of Analysis
Compound npe	Enclomiphene Citrate
Qib	Pharmaceutical qib
CAS Nr.	7599-79-3
Ntau	3 37,3kg
Ntim txheem	25kg / nruas
Chaw tsim tshuaj paus	Shaanxi BLOOM TECH Co., Ltd
Ntau No.	202501090045
MFG	Peb 9, 2025
EXP	Peb 8, 2028
Yam khoom	Enterprise txheem	Kev txheeb xyuas qhov tshwm sim
Qhov tshwm sim	Dawb los yog yuav luag dawb hmoov	Ua raws
Cov ntsiab lus dej	Tsawg dua lossis sib npaug li 5.0%	0.47%
Poob rau ziab	Tsawg dua lossis sib npaug li 1.0%	0.28%
Hnyav Hlau	Pb Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Hg Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Cd Tsawg dua lossis sib npaug li 0.5ppm	N.D.
Purity (HPLC)	Ntau dua lossis sib npaug li 99.0%	99.90%
Ib leeg impurity	<0.8%	0.47%
Tag nrho microbial suav	Tsawg dua lossis sib npaug li 750cfu / g	70
E. Coli	Tsawg dua lossis sib npaug li 2MPN / g	N.D.
Salmonella	N.D.	N.D.
Ethanol (los ntawm GC)	Tsawg dua lossis sib npaug li 5000ppm	500 ppm
Cia	Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree

Enclomiphene citrate ntsiav tshuajyog lub qhov ncauj nonsteroidal xaiv cov tshuaj estrogen receptor modulator (SERM), uas yog tus nquag isomer ntawm Clomiphene Citrate. Nws cov qauv tshuaj yog (E) -2- [p - (2-chloro-1,2-diphenylethenyl) phenoxy] triethylamine citrate, uas tshwj xeeb thaiv cov tshuaj estrogen receptors ntawm qib hypothalamic thiab pituitary, inhibits kev tawm tswv yim tsis zoo ntawm cov tshuaj estrogen, thiab txhawb nqa cov tshuaj hormones trophinrelation. Kev tso tawm ntawm luteinizing hormone (LH) thiab follicle stimulating hormone (FSH) los ntawm lub caj pas pituitary. Cov txheej txheem no thaum kawg ua rau muaj kev nce hauv testosterone synthesis hauv testicular interstitial hlwb, thaum txhawb cov phev ntau lawm.
Piv nrog rau clomiphene, nws tshem tawm cov cis isomer (Zuclomiphene), zam qhov tsis tu ncua estrogen receptor antagonistic cov teebmeem thiab cov kev mob tshwm sim (xws li kev xav hloov pauv thiab qhov pom kev txawv txav) uas tom kawg yuav ua rau, thiab muaj siab dua purity thiab ntau dua cov tshuaj pharmacological.

Core soj ntsuam indications

 

1. Txiv neej theem nrab hypogonadism
Txhais thiab etiology: Secondary hypogonadism yog ib qho mob uas muaj cov qib testosterone qis vim yog hypothalamic pituitary tsis ua haujlwm. Feem ntau ua rau muaj xws li kev rog, metabolic syndrome, postoperative pituitary adenoma, hyperprolactinemia, thiab lwm yam. Tsis zoo li thawj hypogonadism (testicular pathology), cov noob qes ntawm cov neeg mob no tseem muaj peev xwm tsim cov testosterone, tab sis cuam tshuam los ntawm cov kev cai hauv nruab nrab.
Kev kho cov txheej txheem: Los ntawm stimulating endogenous testosterone synthesis, serum testosterone yog rov qab mus rau qhov qub ntau yam (300-1000 ng / dL), thaum tsis txhob muaj cov nyhuv inhibitory ntawm exogenous testosterone hloov kho (TRT) ntawm cov phev ntau lawm.

 

Cov ntaub ntawv pov thawj ntawm kev kho mob:
Testosterone elevation: Ib ob - qhov muag tsis pom kev randomized tswj kev sim suav nrog 120 tus txiv neej cov neeg mob uas tau noj qhov ncauj 25mg txhua hnub. Tom qab 8 lub lis piam, cov piam thaj tag nrho cov testosterone nce los ntawm lub hauv paus 280 ng / dL rau 580 ng / dL (p<0.001), and LH and FSH levels significantly increased.
Kev txhim kho cov phev zoo: Hauv cov neeg mob uas muaj oligospermia concomitant, kev kho mob 6 lub hlis nce phev concentration ntawm 8 × 10 ⁶ / mL rau 22 × 10 ⁶ / mL thiab motility ntawm 35% mus rau 58%.
Kev txhim kho metabolic index optimization: Cov kev tshawb fawb tau pom tias cov tshuaj tuaj yeem txo cov qib insulin sai (12.3 → 9.1 μ IU/mL), txhim kho HOMA-IR Performance index, thiab qhia txog cov txiaj ntsig zoo rau cov tshuaj insulin.

Qhov zoo:
Kev Tiv Thaiv Fertility: Tsis zoo li TRT, nws tsis cuam tshuam cov phev ntau lawm thiab tsim nyog rau cov txiv neej uas xav tau fertility.
Zam kev pheej hmoo ntawm cov tshuaj hormones exogenous: txo TRT cov teeb meem xws li prostate hyperplasia thiab polycythemia.
Yooj Yim: Kev tswj qhov ncauj nrog cov neeg mob ua raws siab.

 

2. Txiv neej infertility (oligospermia/asthenozoospermia)
Pathophysiology: Kwv yees li 40% ntawm txiv neej infertility yog txuam nrog hypogonadism los yog tsis txaus tso tawm ntawm gonadotropins. Los ntawm kev nce qib FSH, txhawb cov qog nqaij hlav Sertoli cell muaj nuj nqi, thiab txhawb cov phev ntau lawm; Ib txhij nce qib testosterone thiab txhim kho ib puag ncig rau cov phev maturation.

Kev tshawb fawb soj ntsuam:
Kev txhim kho cov phev tsis zoo: Ib qho kev sim nrog 60 tus neeg mob uas muaj oligospermia tau pom tias tom qab 6 lub hlis ntawm kev kho mob txhua hnub nrog 25mg, cov phev concentration tau nce ntawm (10.2 ± 3.5) × 10 ⁶ / mL rau (28.4 ± 6.7) × 10 L (⁶ / mL)<0.01), and the normal morphology rate increased from 12% to 22%.

 

Kev txhim kho kev xeeb tub: Hauv cov niam txiv nrog cov neeg koom tes uas muaj kev tsis sib haum xeeb ntawm ovulation, kev sib xyaw ua ke yuav ua rau muaj kev xeeb tub ntawm 15% mus rau 28%.

npaj rau:
Idiopathic oligospermia / asthenozoospermia.
Secondary hypogonadism ua ke nrog infertility.
Cov neeg mob uas tsis kam lossis tsis kam lees rau TRT.

 

3. Hypotestosterone cuam tshuam rau metabolic syndrome
Kab mob sib kis: Kwv yees li 30% ntawm cov txiv neej rog rog muaj cov hypogonadism theem nrab, uas muaj cov testosterone tsawg, cov tshuaj estrogen siab, thiab insulin tsis kam. Los ntawm kev nce qib testosterone, cov ntsuas metabolic tuaj yeem txhim kho.

Kev tshawb nrhiav tshuab:
Insulin rhiab heev: Tsiaj thwmsim tau pom tias cov tshuaj tuaj yeem ua rau kom cov leeg nqaij pob txha glut4 (GLUT4) thiab txhim kho cov tshuaj insulin.

 

Kev faib tawm rog: Cov kev tshawb fawb soj ntsuam tau pom tias tom qab 6 lub hlis ntawm kev kho mob, cov neeg mob lub duav ncig tau txo qis los ntawm 3.2 cm (p=0.02) thiab visceral rog hauv cheeb tsam txo los ntawm 15%.
Cov pov thawj kho mob: Ib qho kev sim nrog 80 cov neeg mob rog rog uas muaj qib testosterone qis tau pom tias tom qab 12 lub hlis ntawm kev kho mob niaj hnub nrog 25mg Enclomiphene Citrate, cov ntshav qabzib yoo mov poob ntawm (10.2 ± 1.8) mmol / L rau (8.9 ± 1.5) mmol / L (p{{7}0.1)), thiab trigly los ntawm trigly. mmol / L rau (1.6 ± 0.5) mmol / L (p=0.01).

Tshawb nrhiav kev siv dhau ntawm phau ntawv qhia

 

1. Poj niam infertility (kev tshawb fawb theem)
Keeb kwm:Enclomiphene citrate ntsiav tshuajtau txais kev pom zoo rau poj niam anovulatory infertility, tab sis E, raws li nws cov isomer nquag, yuav muaj kev ua tau zoo thiab kev nyab xeeb.
Cov ntaub ntawv tshawb fawb:
Ovulation tus nqi: Ib qho kev sim sib piv suav nrog 200 tus neeg mob uas muaj polycystic zes qe menyuam syndrome (PCOS), thiab ovulation tus nqi ntawm pawg Enclomiphene Citrate yog 72%, uas tsis txawv txav ntawm pawg clomiphene (75%), tab sis qhov tshwm sim ntawm qhov pom kev txawv txav tau qis dua (3% vs. 15%).
Kev pheej hmoo ntawm ntau lub cev xeeb tub: Tsis muaj qhov sib txawv tseem ceeb tau pom, qhia tias nws cov yam ntxwv monomeric tuaj yeem txo qhov kev pheej hmoo ntawm zes qe menyuam hyperstimulation.
Cov xwm txheej tam sim no: Tam sim no tsis pom zoo siv rau cov poj niam, tab sis qee qhov kev tshawb fawb soj ntsuam txhawb nws cov txiaj ntsig zoo.

 

2. Adjuvant kev kho mob ntawm txiv neej hom 2 mob ntshav qab zib
Hypothesis mechanism: Hypotestosterone muaj feem cuam tshuam nrog insulin tsis kam, thiab Enclomiphene Citrate tuaj yeem txhim kho cov piam thaj metabolism los ntawm kev nce qib testosterone.
Cov pov thawj ua ntej: kev sim nrog 40 tus neeg mob uas muaj ntshav qab zib hom 2 ua ke nrog hypotestosterolemia pom tau tias tom qab 25 mg kev kho mob txhua hnub rau 6 lub hlis, HbA1c txo qis los ntawm (8.2 ± 1.1)% mus rau (7.5 ± 0.9)% (p=0.02), uas xav tau kev tshawb fawb loj ntxiv kom paub tseeb.

 

3. Txiv neej menopausal Syndrome (kev ncua hypogonadism)
Txhais: Cov txiv neej testosterone qib qis ib xyoos ib zaug tom qab muaj hnub nyoog 40 xyoo, nrog rau cov tsos mob xws li qaug zog, tsis tshua muaj siab, thiab txo libido.
Tej yam tshwm sim: Nws tuaj yeem txhim kho lub neej zoo los ntawm kev nce qib testosterone. Ib qho kev sim qhib uas muaj 50 tus neeg mob tau pom tias tom qab 3 lub hlis ntawm kev kho mob, tus txiv neej cov tsos mob tshwm sim (AMS) poob ntawm 42 cov ntsiab lus mus rau 28 cov ntsiab lus (p<0.001).

Cov khoom siv tshuaj lom neeg ntawmEnclomiphene Citrate ntsiav tshuajyog raws li nram no:

Lub cev lub xeev thiab tsos

 

Daim ntawv anhydrous crystalline yog cov hmoov dawb nrog lub iab saj. Nws daim ntawv citrate feem ntau yog siv rau hauv kev tsim kho kom zoo dua solubility thiab stability.

 

Cov yam ntxwv ntawm solubility

 

Solubility yog cuam tshuam los ntawm pH:
Nyob rau hauv ib puag ncig acidic (xws li 0.1 N hydrochloric acid, pH 1.2), solubility siab heev, ncav cuag 52.3 mg / mL;
Hauv qhov chaw nruab nrab (xws li phosphate buffer tov, pH 7.4), solubility txo qis, tsuas yog 0.12 mg / mL.
Cov yam ntxwv no ua rau muaj qhov sib txawv ntawm kev nqus tus cwj pwm ntawm cov tshuaj nyob rau hauv qhov sib txawv pH nyob rau hauv lub plab zom mov, yuav tsum tau optimization ntawm formulation tsim los txhim kho bioavailability.

 

Thermal stability

 

Sib txawv scanning calorimetry (DSC) tsom xam qhia tau hais tias qhov decomposition pib kub yog 218 ± 3 degree. Cov ntaub ntawv no muab qhov tseem ceeb rau kev tswj qhov kub thiab txias thaum lub sij hawm ua tshuaj, thiab siab -kub yuav tsum tau zam kom tsis txhob degradation.

 

Chemical structure yam ntxwv

 

Raws li trans isomer ntawm clomiphene, nws belongs rau ib qho tsis yog -steroidal triphenyl ether derivative. Nws cov qauv molecular muaj peb lub nplhaib benzene, txuas nrog cov hlua khi hlua khi, tsim cov qauv nruj. Qhov kev sib haum xeeb no ua rau nws tshwj xeeb khi rau cov tshuaj estrogen receptors thiab siv los tiv thaiv - cov teebmeem estrogenic.

 

pH-nyob ntawm tus cwj pwm

 

Nyob rau hauv acidic media, nws muaj nyob rau hauv ib tug ionized daim ntawv, nrog rau ntau zog solubility; Nyob rau hauv nruab nrab tej yam kev mob, nws yog tsuas yog nyob rau hauv ib tug molecular daim ntawv, nrog txo solubility. Cov yam ntxwv no cuam tshuam rau kev nqus ntawm cov tshuaj ntawm cov chaw sib txawv hauv lub plab zom mov, thiab yuav tsum muaj cov txheej txheem tsim (xws li microsphere txheej) kom ua tiav cov phiaj xwm tso tawm.

 

Cia ruaj khov

 

Cov tshuaj ntsiav tshuaj hauv qhov ncauj tuaj yeem tswj kev ruaj ntseg rau 24 lub hlis ntawm qhov kub qis dua 25 degree. Nws yog ib qho tsim nyog yuav tsum siv lub teeb - cov ntaub ntawv pov thawj (xws li lub raj mis xim av) txhawm rau tiv thaiv kev ua kom pom tseeb thiab tswj cov av noo kom tsis txhob nqus cov dej noo thiab caking.

1. Lub hom phiaj tseem ceeb yog dab tsi?
Siv rau kev kho txiv neej hypogonadism, tshwj xeeb tshaj yog nyob rau hauv cov mob tshwm sim los ntawm theem nrab gonadal tsis ua haujlwm.
2. Yuav ua li cas coj nws kom raug?
Ua raws li tus kws kho mob cov lus qhia nruj me ntsis. Feem ntau, noj nws ib hnub ib zaug ntawm lub sijhawm teem tseg. Nws tuaj yeem noj nrog lossis tsis muaj zaub mov.
3. Cov kev phiv tshwm sim yog dab tsi?
Nws yuav muaj xws li mob taub hau, xeev siab, yaug, thiab cov tshuaj tiv thaiv ntawm qhov chaw txhaj tshuaj. Yog tias muaj kev xav hloov pauv, hloov pauv hauv qhov pom, lossis mob hauv cov noob qes, nrhiav kev kho mob tam sim ntawd.
4. Cov kev ceev faj tseem ceeb yog dab tsi?
Rau txiv neej siv xwb. Thaum lub sij hawm siv tshuaj, yuav tsum tau saib xyuas ntawm testosterone thiab qib estrogen. Tsis haum rau cov neeg mob uas muaj cov qog ntshav tsis ua haujlwm lossis mob qog nqaij hlav prostate.
Lus Cim Tseem Ceeb: Qhov no yog ib qho tshuaj noj. Nws yuav tsum tau muab tshuaj los ntawm tus kws kho mob tshwj xeeb tom qab kuaj mob, thiab yuav tsum tau siv raws li kev saib xyuas tas li ntawm tus kws kho mob. Cov ntaub ntawv muab yog rau siv xwb. Thov ua raws li tus kws kho mob cov lus qhia rau kev siv tshwj xeeb.

Cim npe nrov: enclomiphene citrate ntsiav tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom