Shaanxi Bloom Tech Co., Ltd. yog ib qho kev paub txog tshaj plaws thiab cov neeg xa khoom ntawm Ivermectin thiab Pyrantel Pausoate ntsiav tshuaj nyob hauv Suav teb. Txais tos rau kev lag luam wholesale tej zoo zoo ivermectin thiab pyrantel paoate ntsiav tshuaj rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Ivermectin thiab Pyrantel Pausoate ntsiav tshuajYog qhov ncauj tshuaj tiv thaiv cov tshuaj uas tsim tshwj xeeb rau cov dev thiab miv, ua tiav broad - spectrum kev txiav txim siab los ntawm kev sib txuas ob lub zog. Nws cov tub ntxhais sib xyaw, Ivermectin, belongs rau Macrolide cov chav kawm ntawm cov tshuaj tua kab mob thiab ua rau tuag tes tuag taw thiab tuag los ntawm kev sib cuam tshuam ntawm cov kab mob parasitic hlab; Pyrantel namoate, raws li ib tug tetrahydropyridine anthelmintic, induces cov leeg tuag tes tuag tes tuag taw los ntawm kev ua haujlwm ntawm parasitic acetylcinesters. Cov nyhuv synergistic ntawm ob qho tuaj yeem ua ke lub hom phiaj ntau hom ntawm ob sab hauv thiab sab nraum lub cev, sib sau ua peb {{}} qhov chaw tiv thaiv network. Nws tsuas yog lub hom phiaj roundworms (xws li canine roundworm), xws li Canine Hookworm, Brazilian Hookworm), thiab tseem muaj qee qhov cuam tshuam ntawm cov lus ntuas. Raws li cov cholineterase inhibitor, nws block qhov kev ua phem ntawm acetylcholine ntawm kev sib tshuam ntawm neuromuscular ntawm kev cog lus thiab tuag tes tuag taw ua tuag rau hauv cab. Lub qhov ncauj nqus tus nqi yog tsawg (li 10%), feem ntau yog ua hauv txoj hnyuv, thiab cov kev tsis sib haum xeeb tau tawm nrog cov quav, txo qhov kev pheej hmoo ntawm cov kev pheej hmoo ntawm cov kev mob tshwm sim.
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Kev tab kaum ntawm cov hnyuv ecosystem los ntawm ntsiav tshuaj
Lub plab ecosystem yog ib qho kev sib cuam tshuam tseem ceeb rau kev sib cuam tshuam ntawm tib neeg lub cev thiab cov chaw sab nraud, suav nrog cov zej zog sab nraud, cov tswv yim uas muaj zog tiv thaiv microbial, thiab metabolites. Nyob rau hauv xyoo tsis ntev los no, nrog rau kev nce qib ntau rau Parasitic Kev Tiv Thaiv thiab Tswj, cov ntsiav tshuaj sib xyaw ua ke nyob ib puag ncigIvermectin thiab Pyrantel Pausoate ntsiav tshuajtau siv dav siv nyob rau hauv tus khub tsiaj xws li dev thiab miv.
Muaj peev xwm cuam tshuam ntawm kev siv yeeb tshuaj ntawm kev nqis tes ua thiab kev ua yeeb yam ntshav
Ivermectis: Neuroinhhibition thiab Cell membrane Kev Cai
Ivermectin belongs rau Macrolide cov chav kawm ntawm cov tshuaj tua kab mob, thiab nws cov tub ntxhais kev ua yeeb yam yog ua kom cov kab mob mem thiab cov kab mob siab phem thiab kev ua kom tuag tes tuag taw thiab kev tuag. Txawm hais tias tus txheej txheem no hom phiaj cab no, tej zaum nws yuav cuam tshuam nrog cov ecology los ntawm txoj kev hauv qab no:
Microbial metrolic cuam tshuam: Ivermectin tsis muaj {{0} ion cov kab mob zoo rau chloride ion cov me nyuam yaus, uas tuaj yeem ua rau lawv cov kev ua haujlwm metabolic.
Kev tiv thaiv kab mob tiv thaiv kab mob: Tshuaj ua rau cov khoom siv tuag ntau dua ntawm cov plab hnyuv, ua kom cov hnyuv nyob rau hauv lub plab zom mov, yog li hloov kho cov kab hauv cov microbiota.
Thiopyrimidine DihydroxynShalene: cholinergic thaiv thiab leeg maub los
Thiamethozole, raws li tus neeg hais txog kev ntseeg tsis tu ncua, triggers spastic tuag tes tuag taw los ntawm kev ua tsis tu ncua kom ua kom zoo nkauj icotinic acetylcholine receptor (Nachr). Qhov cuam tshuam loj ntawm nws txoj hnyuv ecology yog xav txog hauv:
Direct bactericidal effect: In vitro experiments have shown that high concentrations of thiamethoxam (>100 μ m) tuaj yeem cuam tshuam qhov tsim ntawm Escherichia coli biofilm, uas yuav cuam tshuam nrog kev puas tsuaj rau cov tshuaj rau cov kab mob ntawm cov kab mob ntawm cov kab mob.
Cov khoom siv metabolite: cov khoom lag luam hydroxylation tsim los ntawm cov metabolism hauv plab yuav koom nrog cov khoom siv microbolism tseem ceeb xws li Butyrate tsim cov kab mob.
Kev cuam tshuam ntawm cov qauv microbiota los ntawm cov tshuaj
Poob qis dua hauv microbial ntau yam thiab tsis txaus nyob hauv kev sib xyaw
Preclinical kev tshawb fawb tau pom tias tom qab kev tswj hwm ntawm qhov ncaujIvermectin thiab Pyrantel Pausoate ntsiav tshuajrau peb hnub sib law liag nyob rau hauv cov dev thiab miv, eprersity index (Shannon Performance index) ntawm plab microbiota txo qis (p<0.05), and the ratio of Firmicutes/Bacteroidetes decreased from 3.2 ± 0.8 to 1.7 ± 0.5. Specific changes include:
Txo cov kab mob muaj txiaj ntsig: Cov muaj ntau ntawm Bifidobacterium txo qis los ntawm 68%, uas yuav cuam tshuam nrog cov tshuaj tiv thaiv ntawm gram cov kab mob zoo.
Cov Kab Mob Kev nthuav dav Pathogenic Propacteria: cov txheeb ze ntawm tus entercheriae (xws li Escherichia coli thiab Kleetiella) nce ntxiv los ntawm 3.1 tsub, uas yuav ua rau cov hnyuv.
Cov neeg tsis muaj kev cuam tshuam metabolic inhibition ntawm cov tseem ceeb ua haujlwm microbial
Luv saw rog fatty acid tsim cov kab mob: Repburia thiab faecalibacterium muaj cov khoom siv hluav taws xob 5,
Bile acid metabolizing cov kab mob: kev ua si ntawm 7 - DROSDOXLOUR) yog txo, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas tuaj yeem cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam, uas tuaj yeem cuam tshuam, uas yuav cuam tshuam, uas yuav cuam tshuam rau cov metabolism hauv lub cev thiab cov kev tiv thaiv kab mob.
Kev xaiv siab ntawm cov tshuaj -} tiv taus
Lub sij hawm ntev tsawg - kev siv koob tshuajIvermectin thiab Pyrantel Pausoate ntsiav tshuajtej zaum yuav ua rau cov kev hloov pauv ntawm plab microbiota kuj. Piv txwv li, hauv kev kawm ntawm cov neeg ua liaj ua teb Canadian, tom qab siv Ivermertive cov tshuaj tua kab mob nce ntxiv los ntawm cov noob kab rov tav ntawm cov noob kab rov tav.
Tshuaj tsis txaus cuam tshuam kev cuam tshuam ntawm txoj haujlwm hnyuv
Lub cev lub cev puas tsuaj
Tshuaj ntxias Parasite tuag tawm ib qho ntau ntawm cov proteolytic cov enzymes, cuam tshuam cov kev sib tw nruj ntawm cov hnyuv hnyuv. Cov kev sim tau qhia tau tias 24 teev tom qab kev tswj hwm, cov cim pob txha pob txha (xws li cov dev lactulose) hauv cov dev nce ntxiv los ntawm 2.3 zaug
Kev tiv thaiv tsis muaj zog tiv thaiv
TH1 / Th2 Tsis txaus ntseeg: Aunermectic Dendrit Cell TLR4 recetors, insibees il-12 cov kev tiv thaiv kab mob hauv plab hnyuv thiab muaj kev pheej hmoo ntau ntawm kev ua xua tom ntej.
Txo cov kev cai t hlwb: Tom qab 7 hnub ntawm kev tswj hwm, kev sib koom tes ntawm foxp3+ kev ua si ntawm lub plab (Galt) poob qis ntawm kev ua haujlwm Lympho
Tsis muaj zog ntawm kev tshuaj lom neeg
Metabolites yuav cuam tshuam nrog cov hnoos qeev txheej synthesis. Piv txwv li, cov khoom lag luam hydroxylation ntawm thiazide tuaj yeem inhibit tus- glycusylation hloov kho tuab thiab muaj kev pheej hmoo ntawm pathogen Colonization.
Kev cuam tshuam tsis ncaj ncees ntawm cov tshuaj ntawm cov metabolism hauv tsev
Kev cuam tshuam ntawm lub zog metabolism hauv lub zog
Dysbiosis ntawm microbiotsa ua rau ib qho kev txo qis hauv cov roj ntsha, uas yuav cuam tshuam rau cov rog rog, uas yuav cuam tshuam rau cov roj ntsha ua kom muaj zog, nrog rau cov g protein txuas ntxiv receptor (GPR43) kev qhia txoj hauv kev. Cov neeg kuaj mob tau pom tias cov dev nyob ntev {}}}}}}} Kev nce qib qis (ib hlis nruab nrab txo qis ntawm 0.3kg) thiab hloov pauv hauv cov ntshav qab zib.
Vitamin synthesis tsis sib xws
Qhov kev txo tus bifidobacteria thiab Lactobacacteri ua rau ib qho kev txo qis hauv cov xwm txheej ntawm cov vitamin K thiab B vitamins. Piv txwv li, ib qib 4% txo qis hauv cov qib B12 yuav ua rau ntshav thiab cov tsos mob neuralological.
Cov metabiota metabiota metabolite sib cuam tshuam
Ivermectin tuaj yeem yog cov plab zom mov los ntawm cov plab me microbiota rau hauv cov khoom siv dej hauv hydroxylated yog qhov cuam tshuam txog kev nplua mais (r =-0.72, p<0.01), suggesting that microbiota composition may affect drug bioavailability.
Kev Cuam Tshuam ecological hauv cov xwm txheej tshwj xeeb 马线虫感染
Txoj kev cuam tshuam nyuaj hauv Co Co Cous
Nyob rau hauv ntau MultiMary Mas xyaum nyob rau hauv Tanzania, txawm hais tias kev sib xyaw ntawm Ivermectin thiab Thiametoxam tau txo tus kab mob nematodeeode ntawm Morv tus kab mob thiab Bartonella. Qhov no qhia tau tias kev pom zoo ntawm macro parasites los ntawm cov tshuaj muaj kev cuam tshuam rau kev sib kis micro kev tiv thaiv kab tiv thaiv kab mob, tab sis cov txheej txheem tshwj xeeb tseem yuav tsum tau tshawb fawb ntxiv.
Xaiv cov tshuaj pleev ntawm cov tshuaj -} tiv taus cab
Kev tshawb fawb los ntawm Canadian nees ua liaj ua teb pom tias kev tawm tsam kev ua haujlwm ntawm Ivermectis tawm tsam Parentcaris sib npaug ntawm 92.5%, thaum Thiamethoxam tseem ua tau zoo ntawm 97.6%. Qhov sib txawv no yuav ua rau cov tshuaj coevolution -}} Tus kab mob tsis kam thiab cab, exacerbating qhov tsis txaus ntseeg ntawm ecology.
Qhov sib txawv ntawm tus tswv hnub nyoog thiab ntau yam
Cov tsiaj me (<6 months old) have incomplete colonization of their gut microbiota, and the recovery time of the microbiota after medication is extended to 21 days, while adult animals only need 7 days. In addition, the sensitivity of short haired cats to thiacloprid is 1.8 times that of long haired cats, which may be related to differences in the structure of the microbiota associated with their hair type.
Cov tswv yim rau kev cuam tshuam ecological ecological tshwm sim los ntawm cov tshuaj
Kev Kho Mob Cov Tswv Yim
Koob tshuaj optimization: Kho cov koob tshuaj raws li lub cev hnyav (dev, Thonmetoxam / kg, Thiametoxam 20mg / kg), kom tsis txhob muaj kev lom zem.
Kev Tsim Qauv Qeb: Noj tshuaj txhua 3 lub hlis kom txo qis lub siab xaiv.
Microbial Kho Kev Tiv Thaiv
Probiotic Ntxiv: Kev siv kev siv Lactobacillus sib xyaw ua ke (10 ⁹ CFU hauv ib hnub) thiab BIFU
Probiotic Siv: Ntxiv OLGOFRITOSE (FOS, 2G / kg txhua hnub) tuaj yeem txhawb kev loj hlob ntawm scfa ua cov kab mob mucosal teeb meem.
Kev Tiv Thaiv Kev Tiv Thaiv Kab Mob
Omega-3 fatty acid exterementation: txhua hnub ntawm EPA + DHA 200MG / kg tau tuaj yeem tiv thaiv th1 yam tsis muaj kev phom sij thiab txo qhov kev pheej hmoo ntawm cov hnyuv sab.
Vitamin D3 supplementation: Maintain serum 25 (OH) D levels>30NG / ml thiab txhim kho cov kev qhia ntawm kev sib tshuam cov protein nruj hauv plab hnyuv mucosa.
Cim npe nrov: Ivermectin thiab Pyrantel Pamoate ntsiav tshuaj, lwm tus neeg, chaw tsim khoom, Hoobkas, lag luam Wholesale, yuav, nqe, loj, loj, rau muag