Milbemycin Oxime Thiab Praziquantel Tablets

Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm milbemycin oxime thiab praziquantel ntsiav tshuaj nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo milbemycin oxime thiab praziquantel ntsiav tshuaj muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Milbemycin Oxime thiab Praziquantel ntsiav tshuajyog ib tug broad-spectrum antiparasitic formulation tshwj xeeb tsim rau dev thiab miv, muab kev parasite tswj los ntawm kev sib koom ua ke ntawm ob yam khoom xyaw nquag. Qhov kev sib xyaw ua ke ntawm ob hom no muab ntau hom kev tiv thaiv tawm tsam ntau yam kab mob sab hauv, suav nrog nematodes, cestodes, thiab theem kev loj hlob ntawm cov kab mob plawv. Milbemycin oxime exerts nws cov nyhuv anthelmintic los ntawm kev khi rau gamma-aminobutyric acid (GABA) receptors thiab glutamate-gated chloride raws ntawm daim nyias nyias ntawm cov kab mob parasitic paj hlwb thiab cov leeg hlwb. Qhov kev khi no inhibits qhov kaw ntawm chloride ion channel, ua rau muaj cov tshuaj chloride ion influx, neuronal hyperpolarization, thiab blockade ntawm kev ua tau zoo. Raws li qhov tshwm sim, kev sib kis ntawm neuromuscular cuam tshuam, ua rau tuag tes tuag taw thiab poob ntawm kev ua haujlwm hauv lub cev-phab ntsa cov leeg ntawm cov nematodes raug mob. Tsis muaj peev xwm tswj tau lub cev-cav siab li qub lossis kev sib koom ua ke, cov kab mob ua rau tsis tuaj yeem thiab raug tshem tawm. Tsis tas li ntawd, milbemycin oxime muaj txiaj ntsig zoo rau lub hom phiaj microfilariae thiab theem peb (L3) larvae hauv cov hlab ntsha, cuam tshuam lub neej voj voog ntawm * Dirofilaria immitis * thiab pab tiv thaiv kab mob plawv hauv cov dev. Praziquantel ua feem ntau tawm tsam cestodes (tapeworms) los ntawm kev ua kom nrawm nrawm, ua kom muaj zog thiab ua kom tsis muaj zog ntawm cov kab mob hauv lub cev-phab ntsa musculature. Qhov kev cuam tshuam ntawm cov leeg tam sim no ua rau kev puas tsuaj ntawm cov txheej txheem, vacuolar degeneration ntawm tesument, thiab raug tus kab mob parasite deg antigens. Lub cev puas tsuaj tsis tsuas yog cuam tshuam cov kab mob parasite kev ncaj ncees tab sis kuj ua rau lub cev tiv thaiv kab mob los ntawm tus tswv tsev, ntxiv rau kev puas tsuaj rau cov kab mob cab. Praziquantel tseem cuam tshuam nrog nucleic acid synthesis thiab impairs glycogen uptake thiab lub zog metabolism, ua rau muaj zog zuj zus lawm thiab irreversible puas. Thaum kawg, cov kab mob tapeworms cuam tshuam thiab raug tshem tawm ntawm lub plab zom mov hauv cov quav. Ua ke, milbemycin oxime thiab praziquantel muab cov kev ua ub no ntxiv tawm tsam nematodes, cestodes, thiab txhim kho cov kab mob plawv, ua rau kev sib xyaw ua ke no tau siv dav thiab muaj txiaj ntsig zoo rau kev siv dav dav hauv cov kab mob cab hauv cov tsiaj ua ke.

Certificate of Analysis
Compound npe	Milbemycin Oxime Thiab Praziquantel
Qib	Pharmaceutical qib
Ntau	35g
Ntim txheem	PE hnab + Al foil hnab
Chaw tsim tshuaj paus	Shaanxi BLOOM TECH Co., Ltd
Ntau No.	202501090052
MFG	Peb 9, 2025
EXP	Peb 8, 2028
Yam khoom	Enterprise txheem	Kev txheeb xyuas qhov tshwm sim
Qhov tshwm sim	Dawb los yog yuav luag dawb hmoov	Ua raws
Cov ntsiab lus dej	Tsawg dua lossis sib npaug li 5.0%	0.46%
Poob rau ziab	Tsawg dua lossis sib npaug li 1.0%	0.34%
Hnyav Hlau	Pb Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Hg Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Cd Tsawg dua lossis sib npaug li 0.5ppm	N.D.
Purity (HPLC)	Ntau dua lossis sib npaug li 99.0%	99.90%
Ib leeg impurity	<0.8%	0.47%
Tag nrho microbial suav	Tsawg dua lossis sib npaug li 750cfu / g	80
E. Coli	Tsawg dua lossis sib npaug li 2MPN / g	N.D.
Salmonella	N.D.	N.D.
Ethanol (los ntawm GC)	Tsawg dua lossis sib npaug li 5000ppm	500 ppm
Cia	Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree

Milbemycin Oxime Thiab Praziquantel Tabletsyog ib qho dav -spectrum antiparasitic tshuaj tsim tshwj xeeb rau cov dev thiab miv, ua tiav ntau hom kev pab cuam los ntawm kev sib txuas ob yam khoom xyaw. Nws cov ntawv thov tseem ceeb suav nrog kev tiv thaiv kab mob plawv, tshem tawm cov nematodes thiab tapeworms, thiab tswj cov kab mob ectoparasites.

 

 

Kev ntsuam xyuas tseem ceeb

01.

Milbemycin Oxime

Raws li macrolide tshuaj tua kab mob derivatives, nws cuam tshuam cov kab mob neural kis kab mob ntawm nematodes thiab arthropods los ntawm kev cuam tshuam nrog kev tso tawm cov kab mob parasitic neurotransmitter gamma aminobutyric acid (GABA). Nws lub hom phiaj yog cov tshuaj chloride ion channel tswj los ntawm glutamate, uas txhim kho cov permeability ntawm cell membrane rau chloride ions, ua rau hyperpolarization ntawm kab cov kab mob neuromuscular thiab thaum kawg ua rau tuag tes tuag taw thiab tuag. Cov khoom xyaw no muaj peev xwm tua tau cov kab mob nematodes xws li cov kab mob plawv, kab mob sib kis, thiab cov kab mob sib kis, thiab muaj kev nyab xeeb rau cov tsiaj txhu (raws li GABA tsuas muaj nyob rau hauv nruab nrab lub paj hlwb thiab muaj kev cuam tshuam tsawg kawg nkaus hauv lub paj hlwb peripheral).

02.

Praziquantel

Raws li ib tug derivative ntawm isoquinoline, nws nce permeability ntawm kab cell membranes rau calcium ions, ua rau cov leeg rigidity thiab cortical puas. Nws muaj 100% kev kho mob tus nqi rau tapeworms (xws li canine tapeworm thiab tapeworm) thiab flukes (xws li schistosomiasis), thiab nws cov txheej txheem ntawm kev ua muaj xws li:
Cov leeg nqaij rigidity: Tsis pub dhau 20 vib nas this tom qab tau txais cov tshuaj, qhov nro ntawm cov kab mob hauv lub cev nce, thiab qhov concentration ntawm 1mg / L tuaj yeem ua rau muaj zog contraction.
Cortical cuam tshuam cov nyhuv: tshuaj ua rau vacuolar degeneration ntawm kab kab epidermis, o ntawm daim tawv nqaij ntawm lub cev, thaum kawg ua rau epidermal yaig thiab rupture, exposing nto antigens thiab activating tus tswv lub cev tiv thaiv kab mob.

Cov nyhuv neuroblocking: Milbeixime khi rau GABA receptors ntawm daim nyias nyias ntawm cov kab mob parasitic paj hlwb, inhibiting qhov kaw ntawm chloride ion channels, ua rau muaj kev cuam tshuam hyperpolarization ntawm neurons thiab thaiv qhov kev ua tau zoo. Lub nematode lub cev phab ntsa cov leeg poob lawv lub peev xwm los cog lus vim kev cuam tshuam ntawm cov paj hlwb, thiab nws thiaj li tawg thiab tuag vim tsis muaj peev xwm tswj tau lub cev kab noj hniav.

Txoj kev ntawm kev ua ntawm milberoxime

 

Kev tiv thaiv kab mob plawv: Los ntawm kev tua microfilaments thiab L3 theem larvae hauv cov ntshav, lub neej voj voog ntawm lub plawv yog thaiv. Kev sim tau pom tias kev tua tus kab mob plawv tuaj yeem ncav cuag ntau dua 98% tom qab kev tswj hwm ib leeg.
Kev tswj cov kab mob sab nraud: Nws muaj kev tua cov kab mob sab nraud xws li cov kab mob hauv cov plaub hau, kab mob mites, nab, fleas, thiab lwm yam, los ntawm kev cuam tshuam cov paj hlwb ntawm arthropods.

Dual insecticidal mechanism ntawm praziquantel

 

Cov nyhuv rigidity: Praziquantel ua rau muaj kev nruj nruj thiab kev cog lus ntawm tapeworm lub cev phab ntsa cov leeg, ua rau cov kab mob rupture thiab nws excretion nrog quav. Piv txwv li, nyob rau hauv 1 feeb ntawm kev siv tshuaj, tus kab mob canine tapeworm tsim muaj zog contractions.
Cortical cuam tshuam cuam tshuam: tshuaj induce vacuolar degeneration ntawm kab kab epidermis, nthuav tawm antigens saum npoo thiab ua kom lub cev tiv thaiv kab mob rau kev tawm tsam . 15 feeb tom qab noj cov tshuaj, vacuolar degeneration ntawm txheej txheej ntawm cov cab tuaj yeem pom, thiab hauv 24 teev, txheej txheej sab hauv yog ruptured.
Metabolic cuam tshuam cuam tshuam: inhibits cov synthesis ntawm nucleic acid thiab glycogen uptake hauv kab.

Qhov zoo ntawm kev sib xyaw ua ke

 

Cov kab sib txuas ntxiv: Milberoxime npog nematodes thiab kab mob plawv, thaum praziquantel tsom rau cov kab mob kab mob thiab cov kab mob flukes, ua tiav kev tiv thaiv triple ntawm nematodes tapeworms heartworms. Piv txwv li, rau cov dev uas muaj kab mob sib kis thiab kab mob tapeworms, ib koob tshuaj tuaj yeem tshem tawm cov kab mob cab.
Lub sij hawm siv tau: Milbeixime ncav cuag nws cov nqi tshuaj ntshav siab tshaj plaws hauv 2.6 teev tom qab kev tswj hwm qhov ncauj, thiab praziquantel nce mus txog qhov siab tshaj plaws hauv 1.1 teev. Kev siv ua ke tuaj yeem ua rau lub voj voog deworming luv. Qhov kev sim tau pom tias kev tua tus kab mob roundworms yog 100% hauv 24 teev tom qab kev kho ua ke, thiab qhov tshem tawm ntawm tapeworms yog 95% hauv 48 teev.
Tshuaj tiv thaiv thiab tswj kev tiv thaiv: Los ntawm kev tsom cov tshuaj sib txawv, peb tuaj yeem txo qhov siab ntawm kev xaiv tshuaj ib leeg thiab ncua kev txhim kho cov tshuaj tiv thaiv kab mob. Tam sim no, tsis muaj lus ceeb toom txog kev tiv thaiv kev sib xyaw ua ke ntawm Mirxexime thiab Praziquantel.

Milbemycin Oxime Thiab Praziquantel Tabletsyog ib qho dav -spectrum antiparasitic tshuaj feem ntau yog siv los tiv thaiv thiab kho cov kab mob cab hauv cov tsiaj (xws li dev thiab miv) ob sab hauv thiab sab nraum lub cev. Milbemycin Oxime belongs rau cov chav kawm ntawm cov tshuaj tua kab mob macrolide, uas muaj txiaj ntsig tua cov kab mob nematodes, mites, thiab kab mob plawv los ntawm kev cuam tshuam nrog kev sib kis ntawm cov kab mob parasitic neurotransmitter gamma aminobutyric acid (GABA); Praziquantel ua rau cov nqaij ntshiv thiab tuag los ntawm kev cuam tshuam cov calcium ion channels ntawm cov kab mob cab, tshwj xeeb tshaj yog tiv thaiv kab mob thiab kab mob. Kev sib xyaw ua ke ntawm ob tuaj yeem ua tiav qhov dav -spectrum anti parasitic teebmeem

 

 

Raw khoom npaj

01.

Kev npaj ntawm Milbemycin Oxime

Kev npaj ntawm Milbemycin Oxime feem ntau pib los ntawm cov khoom fermentation ntawm Streptomyces hygroscopicus var. aureolacerimosus kev kho mob. Cov txheej txheem fermentation yuav tsum tswj hwm qhov kub thiab txias, pH tus nqi, thiab cov pa yaj kom tau txais qhov siab -purity sib tov ntawm Milbemycin A3 thiab A4 (nrog rau qhov sib piv ntawm kwv yees li 30:70). Tom qab ntawd, Milbemycin A3 thiab A4 tau hloov mus rau Milbemycin Oxime los ntawm cov tshuaj oxidation thiab oximation tshua. Cov kauj ruam no yuav tsum tau siv cov oxidants (xws li hydrogen peroxide) thiab oxime reagents (xws li hydroxylamine), thiab cov tshuaj tiv thaiv yuav tsum tau tswj xyuas kom meej kom tsis txhob muaj cov khoom tsim los ntawm - khoom.

02.

Kev npaj ntawm Praziquantel

Kev sib xyaw ntawm Praziquantel siv cyclohexanediamine ua cov khoom siv raw thiab ua rau lub hom phiaj molecule los ntawm ntau - cov kauj ruam hloov pauv. Cov kauj ruam tshwj xeeb suav nrog:

Cov tshuaj tiv thaiv Acylation: Cyclohexanediamine reacts nrog chloroacetyl chloride los tsim cov nruab nrab N, N '- bis (chloroacetyl) cyclohexanediamine.
Cyclization cov tshuaj tiv thaiv: Qhov nruab nrab yog cyclized nyob rau hauv alkaline tej yam kev mob los tsim ib tug pyrazine isoquinoline skeleton.
Cov tshuaj tiv thaiv oxidation: Cov khoom lag luam cyclization yog oxidized thiab nkag mus rau hauv pawg carbonyl los tsim Praziquantel.

 

Kev npaj cov ntsiav tshuaj sib xyaw

 

Sib tov Milbemycin Oxime thiab Praziquantel active cov khoom xyaw nrog excipients (xws li hmoov txhuv nplej siab, lactose, microcrystalline cellulose, ntoo khaub lig- txuas carboxymethyl cellulose sodium) nyob rau hauv ib qho kev faib ua feem kom ntseeg tau tias muaj kev faib ua feem.

Tom qab ntawd, cov nplaum (xws li polyvinylpyrrolidone) thiab tus neeg sawv cev ntub dej (xws li dej los yog ethanol) tau ntxiv rau cov khoom siv los ntawm cov tshuab ntub dej granulation. Cov txheej txheem granulation yuav tsum muaj kev tswj ntawm stirring ceev thiab kom qhuav kub kom tsis txhob hais tias ua heev nyuaj los yog mos heev.

Qhuav thiab tag nrho cov granules: Muab cov khoom ntub rau hauv lub tshuab ntxhua khaub ncaws thiab tshem tawm cov dej noo los ntawm cov cua kub kom tau cov khoom qhuav. Cov particles qhuav yuav tsum tau sieved los xyuas kom meej qhov sib xws particle loj thiab pab txhawb compression.

Ntim thiab Cia: Muab cov ntsiav tshuaj ua tiav rau hauv cov ntawv ntim txhuas ntawv ci lossis lub raj mis yas, foob thiab khaws cia. Cov khoom ntim yuav tsum ua raws li cov qauv ntim tshuaj kom ntseeg tau tias cov tshuaj tsis txhob ntub los yog lwj thaum khaws cia

 

 

Tablet nias thiab txheej

Cim npe nrov: Milbemycin Oxime Thiab Praziquantel Tablets, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom