Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm nafarelin ntsiav tshuaj hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo nafarelin ntsiav tshuaj muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Nafarelin ntsiav tshuajyog ib qho hluavtaws gonadotropin- tso cov tshuaj hormone (GnRH) agonist. Nws lub luag haujlwm tseem ceeb ntawm kev ua haujlwm yog ua kom tsis tu ncua thiab muaj zog qhib pituitary GnRH receptors, induce receptor desensitization, yog li inhibiting qhov tso tawm ntawm pituitary gonadotropins (luteinizing hormone thiab follicle-stimulating hormone). Thaum kawg, nws txo qis cov qib ntawm gonadal cov tshuaj hormones (estrogen thiab testosterone), ua tiav lub hom phiaj kho mob rau cov kab mob cuam tshuam nrog cov tshuaj hormones- nyob ntawm qhov txawv txav hyperplasia lossis secretion.
Peb Cov Khoom Muag Khoom
NafarelinCOA
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| Certificate of Analysis | ||
| Compound npe | Nafarelin | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 76932-56-4 | |
| Ntau | 23g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090056 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.26% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.17% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib qho impurity | <0.8% | 0.45% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 426 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 618ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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| Tshuaj Formula | C66H83N17O13 |
| Exact Mass | 1321.64 |
| Molecular Luj | 1322.50 |
| m/z | 1321.64(100.0%), 1322.64(71.4%), 1323.64(25.1%), 1322.63(5.9%), 1324.65(5.8%), 1323.64(4.5%), 1323.64(2.7%), 1324.64(1.9%), 1324.64(1.5%) |
| Elemental Analysis | C,59.94; H,6.33; N,18.01; O,15.73 |
Kev kho mob endometriosis
Endometriosis yog ib hom kab mob benign gynecological hauv cov poj niam uas muaj hnub nyoog me nyuam yaus, nrog qhov tshwm sim ntawm kwv yees li 1/15 thiab feem ntau ntawm 10% -15% ntawm cov poj niam muaj hnub nyoog - cov poj niam muaj hnub nyoog. Nws cov tsos mob tseem ceeb xws li mob plab, dysmenorrhea, dyspareunia, mob pelvic mob thiab infertility, uas cuam tshuam rau cov neeg mob lub cev thiab lub hlwb thiab lub neej zoo. Lub pathogenesis zoo sib xws nrog cov tshuaj estrogen; kev loj hlob, proliferation thiab infiltration ntawm ectopic endometrial lesions vam khom rau estrogen stimulation. Cov kab mob tuaj yeem cuam tshuam ntau qhov chaw xws li lub plab peritoneum, zes qe menyuam thiab cov hlab ntsha hauv plab, ua rau muaj teeb meem xws li adhesions thiab cysts.
Raws li ib tug hluavtaws GnRH agonist,ntsiav tshuaj nafarelintsis tu ncua thiab ua tau zoo activates pituitary GnRH receptors kom induce desensitization, yog li ntawd muaj zog suppressing lub secretion ntawm pituitary gonadotropins (luteinizing hormone thiab follicle-stimulating hormone). Qhov no ua rau muaj kev poob qis hauv cov tshuaj estrogen endogenous, depriving ectopic endometrial lesions ntawm hormonal txhawb thiab ua rau gradual atrophy thiab regression. Nws muaj txiaj ntsig zoo txo cov tsos mob ntawm ntau yam mob, txo qhov mob loj thiab txhim kho pelvic adhesions, tsis muaj kev cuam tshuam rau kev rov qab los ntawm fertility. Tus nqi cev xeeb tub tom qab kev kho mob yog piv rau cov tshuaj ib txwm siv danazol.
Daim ntawv thov hauv Assisted Reproductive Technology
Hauv kev pabcuam kev ua menyuam yaus xws li In Vitro Fertilization thiab Embryo Transfer (IVF-ET) thiab Intracytoplasmic Sperm Injection (ICSI), down-txoj cai yog kauj ruam tseem ceeb hauv kev kho ovulation induction. Nws lub hom phiaj tseem ceeb yog txhawm rau txo qis pituitary gonadotropin secretion, zam kev loj hlob ntawm follicle ntxov ntxov, ua tiav cov kev cai ntawm follicular kev loj hlob, thiab txhim kho ovulation induction efficiency thiab oocyte zoo.
Nrog rau nws qhov ruaj khov GnRH agonistic nyhuv, nws yog ib qho ntawm cov tshuaj uas nquag siv rau kev txo qis -txoj cai hauv kev pab tsim tawm.
Los ntawm kev pheej hmoo inhibiting pituitary gonadotropin secretion, nws zoo tiv thaiv qhov ntxov ntxov luteinizing hormone (LH) surge thiab ntxov ovulation, xyuas kom synchronous txoj kev loj hlob ntawm ntau lub hauv paus, ua rau kom tus naj npawb ntawm siab - zoo follicles thiab elevates oocyte retrieval npaum li cas .Meanwhile }kev txhim khu kev qha cov nyhuv. Lub voj voog tshem tawm cov nqi tshwm sim los ntawm asynchronous follicular kev loj hlob thiab ovulation ntxov ntxov.
Nws tsis muaj qhov cuam tshuam tsis zoo rau oocyte zoo thiab embryo implantation muaj peev xwm, txhim kho embryo implantation tus nqi thiab soj ntsuam cev xeeb tub tus nqi, thiab optimizing tag nrho cov kev pab cuam ntawm kev yug me nyuam.
Tsis tas li ntawd, nws txoj kev tswj hwm qhov ncauj yog qhov yooj yim dua piv nrog rau kev txhaj tshuaj - cov neeg ua haujlwm tswj hwm, txo qhov mob thiab txhim kho kev ua raws li cov tshuaj, tshwj xeeb tshaj yog tsim nyog rau cov neeg mob txhaj tshuaj phobia lossis kev kho mob tsis zoo.
Lwm Daim Ntawv Thov
Dhau li ntawm cov lus qhia tseem ceeb saum toj no, nws kuj tseem siv tau rau kev kho mob ntawm uterine fibroids, tshwj xeeb tshaj yog rau cov neeg mob uas muaj cov fibroids me me, cov tsos mob me, tsis kam phais, lossis kev xav tau kev xeeb tub ua ntej kev phais tam sim. Kev loj hlob ntawm uterine fibroids kuj yog nyob ntawm estrogen stimulation. Los ntawm inhibiting endogenous estrogen secretion, nws zoo suppresses proliferation ntawm uterine leiomyoma hlwb thiab maj mam txo cov fibroid ntim. Nws txo qis cov tsos mob xws li menorrhagia, ua rau lub cev ntev, mob plab plab thiab qis plab, muab cov neeg mob rau txoj hauv kev rau kev kho mob thiab zam kev phais mob thiab teeb meem.
Ntxiv mus, nws tuaj yeem ua kev kho mob ntxiv rau benign prostatic hyperplasia hauv cov txiv neej. Qhov tshwm sim ntawm benign prostatic hyperplasia yog cuam tshuam nrog testosterone qib. Los ntawm kev txo qis testosterone concentration, nws inhibits qhov txawv txav ntawm cov nqaij mos prostatic hyperplasia thiab txo qis cov tsos mob ntawm cov zis nrog rau nquag micturition, ceev micturition, dysuria thiab nocturia, txhim kho cov neeg mob cov voiding muaj nuj nqi thiab lub neej zoo. Txawm li cas los xij, nws daim ntawv thov kev kho mob tam sim no kuj tsis tshua muaj, feem ntau yog siv los ua qhov thib ob - kab kev kho mob thaum kho phais lossis thawj zaug - cov tshuaj tau txais txiaj ntsig tsis zoo.
Tsis tas li ntawd, ntau qhov kev tshawb fawb soj ntsuam tau pom tiasntsiav tshuaj nafarelintuaj yeem siv rau kev kho mob palliative ntawm qee yam tshuaj hormones - cov qog noj ntshav (piv txwv li, mob qog noj ntshav endometrial thiab prostate cancer). Los ntawm muaj zog suppressing poj niam txiv neej secretion, nws ua tau zoo ncua cov qog cell loj hlob thiab metastasis, alleviates qog-cov tsos mob, txhim kho cov neeg mob lub neej zoo, ncua sij hawm ciaj sia taus, thiab muab ib tug tshiab kev xaiv rau cov neeg mob uas muaj cov tshuaj hormones siab heev- cov qog nyob ntawm seb.
Cov Ntaub Ntawv Keeb Kwm: Tuam Tshoj Pharmaceutical Information Query Platform, Pfizer Medical Prescribing Information, Medscape Reference, PubMed Clinical Research Literature, Ketai Biotech Pharmaceutical Research Report.
Pharmacokinetics
Pharmacokinetic yam ntxwv ntawm nws tsuas yog npog plaub txheej txheem: nqus, faib, metabolism thiab excretion. Nws lub qhov ncauj nqus tus nqi, bioavailability, plasma protein binding tus nqi thiab metabolic excretion txoj kev ncaj qha txiav txim qhov kev kho mob ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj, raws li cov lus qhia hauv qab no:
Kev nqus
Tom qab kev tswj hwm qhov ncauj, nws tau nqus los ntawm txoj hnyuv. Raws li peptide compound, nws yooj yim degraded los ntawm plab hnyuv peptidases, uas ua rau cov bioavailability tsis tshua muaj, nrog rau qhov nruab nrab ntawm 2.8% -8% thiab ntau ntawm 1.2% -5.6%. Cov tshuaj yog absorbed sai heev, ncav cuag lub siab tshaj plaws plasma concentration (Cmax) nyob rau hauv 10-40 feeb tom qab noj qhov ncauj, thiab Cmax yog zoo correlated nrog muab tshuaj. Ib koob tshuaj ntawm 0.2 mg yields Cmax ntawm kwv yees li 0.6 ng / mL, thaum ib koob tshuaj 0.4 mg ua rau Cmax txog 1.8 ng / mL. Cov zaub mov muaj kev cuam tshuam tsawg rau nws qhov nqus, thiab cov tshuaj tuaj yeem noj ua ntej lossis tom qab noj mov; Txawm li cas los xij, kev siv tshuaj tas sijhawm yog pom zoo kom tswj hwm cov tshuaj plasma ruaj khov.
Tshwj xeeb, kab mob plab (xws li gastritis, gastric ulcer, enteritis, thiab lwm yam) tuaj yeem cuam tshuam kev nqus tshuaj thiab txo qis bioavailability, yuav tsum tau hloov kho koob tshuaj raws li kev saib xyuas kho mob.
Kev faib tawm
Tom qab nkag mus rau hauv cov ntshav ncig, nws tau nrawm nrawm rau ntau cov ntaub so ntswg thiab cov khoom nruab nrog cev thoob plaws hauv lub cev, nrog rau cov ntsiab lus siab hauv lub hom phiaj hauv nruab nrog cev nrog rau pituitary thiab gonads, uas yog ze rau nws cov hom phiaj tshuaj. Nws cov plasma protein khi tus nqi yog kwv yees li 80% (ntawm 4 degree), feem ntau khi rau plasma albumin; cov protein- daim ntawv khij yog cov tshuaj tsis muaj zog, thaum daim ntawv pub dawb ua rau muaj txiaj ntsig zoo.
Cov tshuaj tuaj yeem hla cov ntshav- lub hlwb thaiv thiab faib me ntsis hauv cov ntaub so ntswg ntawm lub paj hlwb ntawm qhov tsis tshua muaj siab, ua rau tsis muaj kev cuam tshuam tsis zoo rau lub hauv paus paj hlwb. Tsis tas li ntawd, ib qho me me ntawm cov tshuaj tau tso rau hauv cov kua mis, yog li nws yog contraindicated rau cov poj niam lactating.
Metabolism
Nws yog feem ntau metabolized los ntawm peptidases ntau dua li cytochrome P450 enzyme system, ua rau tsawg dua kev cuam tshuam tshuaj nrog lwm tus neeg ua haujlwm metabolized ntawm cytochrome P450. Nws cov metabolites loj muaj xws li luv peptide fragments, naphthylalanine thiab 2-naphthoacetic acid, tag nrho cov uas yog pharmacologically inactive yam uas tsis muaj tshuaj pharmacological ntxiv.
Tom qab txhaj tshuaj subcutaneous hauv cov txiv neej, ib nrab - lub neej ntawm metabolites yog kwv yees li 85.5 teev; tom qab kev tswj hwm qhov ncauj, ib nrab - lub neej ntawm niam txiv cov tshuaj thiab cov tshuaj metabolites yog li 2.5-3.0 teev, luv luv me ntsis ntawm kev tswj hwm intranasal (ib nrab- lub neej: 3-4 teev), uas cuam tshuam nrog qhov ncauj bioavailability tsawg. Hauv cov poj niam noj qab haus huv noj 0.2 mg lossis 0.4 mg ob zaug ib hnub rau 22 hnub sib law liag, tsis pom muaj cov tshuaj sib xyaw kom pom tseeb, qhia tau tias muaj kev nyab xeeb siab ntev - kev tswj hwm ntawm cov tshuaj ib txwm siv.
Kev tso tawm
Cov khoom thiab nws cov metabolites tsuas yog tawm ntawm lub raum thiab cov hnyuv. Ntawm cov koob tshuaj, 44% -55% raug tso tawm hauv cov zis, nrog rau cov tshuaj niam txiv tsis hloov pauv tsuas yog kwv yees li 3% ntawm cov zis tso zis thiab tus so yog metabolites; 18.5% - 44.2% yog tawm hauv cov quav nrog ib tus nqi qis qis.
Tom qab ib koob tshuaj ib zaug, cov tshuaj thiab nws cov metabolites tseem nyob hauv lub cev rau ib lub sijhawm kom paub meej tias ntev - ua haujlwm tau zoo. Hauv cov neeg mob lub raum tsis txaus, txo cov zis tso zis tuaj yeem ua rau muaj cov tshuaj thiab cov metabolites, uas yuav tsum tau txo cov koob tshuaj kom tsim nyog. Hauv cov neeg mob uas muaj kab mob siab tsis txaus, kev ua haujlwm tsis zoo ntawm cov enzymes metabolic tseem yuav tsum tau hloov kho koob tshuaj raws li kev saib xyuas kev kho mob kom tsis txhob muaj kev cuam tshuam tsis zoo.
Cov Ntaub Ntawv Keeb Kwm: Tuam Tshoj Pharmaceutical Information Query Platform, NCBI Research Literature, DrugBank Database.
Contraindications
Hypersensitivity rau gonadotropin- tso tawm cov tshuaj hormones (GnRH), GnRH agonist analogs, los yog tshuaj excipients ntawm kev npaj.
Cov neeg mob uas tsis tau kuaj pom qhov txawv txav ntawm qhov chaw mos los ntshav.
Cov poj niam cev xeeb tub lossis cov poj niam npaj cev xeeb tub (cov tshuaj yuav ua rau muaj kev phom sij rau fetal).
Cov poj niam lactating (cov tshuaj yuav tso rau hauv cov kua mis thiab cuam tshuam rau cov menyuam mos).
Cov ntaub ntawv Source: FDA Cov Lus Qhia Tshuaj (SYNAREL®, nafarelin acetate nasal solution), 2025.
FAQ
Dab tsi yog nacenyl siv rau?
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Nacenyl nasal spray yog sivlos tswj endometriosis(ib yam mob uas cov ntaub so ntswg uas kab lub tsev menyuam [mob] loj hlob nyob rau hauv lwm qhov chaw ntawm lub cev thiab ua rau infertility, mob ua ntej thiab thaum lub sij hawm cev xeeb tub, mob thaum lub sij hawm thiab tom qab kev sib deev kev ua si, thiab hnyav los yog tsis meej pem) thiab kho central ...
Nacenyl ua dab tsi hauv IVF?
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Nacenyl muaj nafarelin acetate thiab ua haujlwm los ntawmtxo cov lus teb ib txwm ntawm koj lub cev rau ib qho tshuaj hormone hu ua GnRH (gonadotrophin tso cov tshuaj hormones). Yog li ntawd, koj lub zes qe menyuam tsim tsawg dua lwm cov tshuaj hu ua estrogen.
Cim npe nrov: Nafarelin ntsiav tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom