Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm ziconotide ntsiav tshuaj hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo ziconotide ntsiav tshuaj muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Raws li ib tug kws kho mob,ziconotide ntsiav tshuaj(snx111) tam sim no tau qhia hauv chaw kho mob rau cov neeg mob uas mob hnyav mob neuropathic uas xav tau kev kho mob intrathecal thiab tsis kam lees lossis tsis muaj lus teb tsis txaus rau lwm cov kev kho mob analgesic (piv txwv li, cov tshuaj tua kab mob, intrathecal morphine). Tam sim no, lub qhov ncauj tshuaj formulation tseem nyob rau hauv kev tshawb fawb los yog soj ntsuam soj ntsuam; Txawm li cas los xij, ntau qhov kev tshawb fawb soj ntsuam tau lees paub nws txoj kev ua tau zoo thiab kev nyab xeeb hauv kev tswj cov mob neuropathic hnyav.
Peb Cov Khoom Muag Khoom
Ziconotide Polyacetate COA
Daim ntawv thov nyob rau hauv mob hnyav Neuropathic
Neuropathic mob yog ib qho mob ntev uas tshwm sim los ntawm qhov txhab lossis kab mob ntawm lub paj hlwb somatosensory. Nws pathogenesis yog complex, thiab kev kho mob tshwm sim feem ntau muaj xws li kub hnyiab, stabbing, thiab hluav taws xob-shock-zoo li mob, uas heev ua rau cov neeg mob lub neej zoo. Kev mob hnyav neuropathic suav nrog ntau yam subtypes, xws li postherpetic neuralgia (PHN), mob ntshav qab zib peripheral neuropathy, mob hauv nruab nrab tom qab tus txha caj qaum raug mob, mob hauv nruab nrab tom qab mob stroke, radiculopathy, thiab mob refractory cuam tshuam nrog tus txha caj qaum.
Cov mob zoo li no teb tsis zoo rau cov tshuaj analgesics (piv txwv li, nonsteroidal anti-inflammatory tshuaj, opioids), thiab cov neeg mob feem ntau ntsib cov teeb meem xws li kev tswj tsis tau zoo thiab ua rau tsis zoo rau cov kev mob tshwm sim. Raws li ib qho tshiab uas tsis yog-opioid analgesic nrog lub cim tshwj xeeb ntawm kev ua,ziconotide ntsiav tshuajmuab kev kho tshiab rau kev mob hnyav neuropathic.
2.1 Daim Ntawv Thov hauv Postherpetic Neuralgia (PHN)
Postherpetic neuralgia (PHN) yog qhov teeb meem feem ntau ntawm herpes zoster, txhais tau tias yog mob neuropathic mob hnyav uas tshwm sim los yog rov tshwm sim hauv thaj chaw cuam tshuam rau ntau tshaj 3 lub hlis tom qab kev daws teeb meem pob. Nws cuam tshuam cov neeg mob pw tsaug zog, mus ob peb vas, thiab kev ua ub no txhua hnub. Lub pathogenesis ntawm PHN feem ntau muaj feem xyuam rau cov hlab ntsha raug mob, neuroinflammation, thiab central rhiab heev tom qab tus kab mob varicella-zoster. Cov tshuaj ib txwm siv (piv txwv li, gabapentin, pregabalin, opioids) ua rau cov txiaj ntsig tsis txaus ntseeg hauv qee cov neeg mob, tshwj xeeb tshaj yog cov neeg laus lossis cov neeg uas muaj cov kab mob comorbidities, uas feem ntau muaj kev tsis txaus siab ntawm qhov tsis zoo ntawm qhov tsis zoo thiab tswj qhov mob tsis txaus.
Los ntawm thaiv N-hom calcium channels nyob rau hauv lub dorsal horn ntawm tus txha caj qaum, nws inhibits mob lub teeb liab kis tau tus mob thiab zoo txo cov tsos mob xws li hlawv thiab stabbing mob nyob rau hauv cov neeg mob PHN. Ib 12-lub lim tiam multicenter randomized tswj kev sim pom tau hais tias nyob rau hauv cov neeg mob uas muaj nruab nrab-rau-hnyav PHN refractory rau cov pa analgesics, kev kho mob nrog nws ua rau ib tug tseem ceeb txo nyob rau hauv qhov muag analogue scale (VAS) ache qhab nia piv nrog lub hauv paus, nrog ib tug mob nyem npaum li cas ntau tshaj 60%, nyob rau hauv lub xeev zoo thiab cov cim kev xav.
Cov ntaub ntawv qhov chaw: PMC Kev tshuaj xyuas zoo ntawm Snx111; ClinicalTrials.gov Kev Kawm Paub Paub|NCT04321408|OP2C: Prialt® Observatory hauv Clinical Practice.
2.2 Daim Ntawv Thov Kev Mob Ntshav Qab Zib Peripheral Neuropathy
Mob ntshav qab zib peripheral neuropathy yog ib qho mob hnyav tshaj plaws ntawm cov ntshav qab zib mellitus thiab belongs rau peripheral neuropathic mob. Nws feem ntau tshwm sim raws li kev mob symmetric nyob rau hauv qhov kawg ntawm qhov kawg (piv txwv li, tes thiab ko taw), nrog rau loog loog, hypoesthesia, thiab kub hnyiab. Kev mob hnyav zuj zus zuj zus nrog cov kab mob loj zuj zus, ua rau cov neeg mob lub neej zoo. Nws cov kab mob cuam tshuam nrog cov hlab ntsha metabolic cuam tshuam, oxidative kev nyuaj siab, neuroinflammation, thiab cov paj hlwb puas vim yog mob hyperglycemia.
Kev tswj cov paib tsom rau kev tswj glycemic, kev kho mob neurotrophic, thiab siv cov tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kev ntxhov siab, thiab opioids. Txawm li cas los xij, kev tswj xyuas qhov mob yog qhov zoo tshaj plaws hauv qee cov neeg mob, thiab kev siv tshuaj opioid mus ntev ua rau muaj kev pheej hmoo ntawm kev ua siab ntev thiab kev vam khom.
Targeting lub pathogenesis ntawm mob ntshav qab zib peripheral neuropathy, nws blocks N-type calcium channels inhibit ache signal transmission, li no zoo alleviating extremities. Ib txoj kev tshawb fawb soj ntsuam sau npe 200 cov neeg mob uas mob mob nruab nrab-rau- mob ntshav qab zib peripheral neuropathy pom tias 8 lub lis piamziconotide ntsiav tshuajKev kho mob txo qis VAS cov qhab nia, nrog rau qhov mob nyem ntawm 58.5%, thiab kuj ua rau qee qhov txhim kho paresthesia thiab loog loog.
Cov ntaub ntawv qhov chaw: Tuam Tshoj Cov Ntaub Ntawv Kho Mob Query Platform Snx111; Kev Tshawb Fawb Kev Tshawb Fawb hauv Symptomatic Pharmacotherapy rau Mob Ntshav Qab Zib Peripheral Neuropathy (saib xyuas); PMC Kev tshuaj xyuas zoo ntawm Snx111.
2.3 Daim ntawv thov hauv Central Mob Tom Qab Kev Kho Mob Ntsws
Kev mob hauv nruab nrab tom qab raug mob qaum qaum yog ib qho teeb meem ntawm kev raug mob ntawm tus txha caj qaum thiab ib qho subtype ntawm central neuropathic ache. Nws tshwm sim tsis tu ncua lossis paroxysmal mob hauv qab theem ntawm kev raug mob, feem ntau piav qhia tias yog kub hnyiab, hluav taws xob-xws li, lossis mob loog. Nws yog qhov hnyav, ua tsis tau zoo rau cov tshuaj analgesics, thiab ua rau lub cev tsis zoo thiab lub neej zoo. Nws cov pathogenesis feem ntau cuam tshuam nrog kev hloov pauv hauv nruab nrab ntawm lub paj hlwb, kev tsis txaus siab ntawm neurotransmitter, hauv nruab nrab rhiab heev, thiab overactivation ntawm N-type calcium channels tom qab tus txha caj qaum raug mob, sawv cev rau ib daim ntawv kho mob nyuaj ntawm kev mob neuropathic.
Raws li N-hom calcium channel blocker, nws yog tus neeg sawv cev tseem ceeb rau kev mob hauv nruab nrab tom qab raug mob qaum qaum. Ntau qhov kev tshawb fawb soj ntsuam tau lees paub nws cov txiaj ntsig hauv kev kho mob thiab txhim kho lub neej zoo hauv cov neeg mob cuam tshuam. Ib txoj kev tshawb fawb muaj xws li 20 tus neeg mob uas muaj mob hauv nruab nrab tom qab tus txha caj qaum raug mob refractory rau tus qauv pharmacotherapy, uas tau txais kev sim intrathecal snx111 (cov ntaub ntawv kho mob rau cov ntsiav tshuaj hauv qhov ncauj yuav raug ntxiv los ntawm kev tswj hwm intrathecal).
Cov qhab nia mob tau txo qis ntau dua 40% hauv 14 tus neeg mob, thiab 11 tau muab cov twj tso kua mis mus tas li. Tom qab ib qho kev soj ntsuam ntawm 3.59 xyoo, 8 tus neeg mob tau khaws cov qhab nia ntawm qhov mob qis dua qhov pib, nrog cov qhab nia VAS hauv paus poob ntawm 7.91 txog 4.31 ntawm qhov kev soj ntsuam zaum kawg thiab qhov nruab nrab koob tshuaj txhua hnub ntawm 7.2 ug, yam tsis muaj qhov cuam tshuam loj rau lub sijhawm ntev. Tsis tas li ntawd, nws tsis cuam tshuam nrog lub cev muaj zog rov ua haujlwm lossis ua rau cov hlab ntsha raug mob hnyav hauv cov neeg mob txha caj qaum, txhawb nws txoj kev siv mus ntev.
Cov ntaub ntawv qhov chaw: PubMed Snx111 rau kev raug mob ntawm tus txha caj qaum; Hunan Pharmaceutical Affairs Service Network Snx111; PMC Kev tshuaj xyuas zoo ntawm Snx111.
2.4 Daim ntawv thov hauv Central Post-Stroke Pain (CPSP)
Central post-stroke ache (CPSP) yog ib qho mob neuropathic mob tshwm sim tom qab mob stroke, cais raws li qhov mob hauv nruab nrab neuropathic. Nws qhov tshwm sim muaj li ntawm 1% mus rau 12%, thiab mus txog 25% hauv cov neeg mob uas muaj lateral medullary infarction. Nws tshwm sim raws li mob los yog paresthesia nyob rau hauv lub cev cheeb tsam sib xws rau mob stroke lesions, feem ntau kub hnyiab, mob, los yog stabbing, tshwm sim spontaneously los yog tshwm sim los ntawm lwm yam stimuli.
Nws tsis tu ncua thiab qhia tau hais tias tsis tshua muaj cov lus teb rau cov tshuaj analgesics (piv txwv li, gabapentin, pregabalin), cuam tshuam loj heev rau kev kho mob thiab kev ua neej zoo. Nws pathogenesis tsis yog tag nrho elucidated tab sis tej zaum yuav muaj hyperexcitability ntawm puas sensory pathways, impaired central inhibitory txoj kev, central rhiab heev, thiab altered function ntawm corticothalamic ib ntsuj av.By thaiv N-type calcium channels nyob rau hauv lub qaum dorsal horn,ziconotide ntsiav tshuajinhibits lub hauv paus kev sib kis ntawm mob cov cim qhia thiab zoo txo qhov mob hauv cov neeg mob CPSP.
Cov kev tshawb fawb soj ntsuam qhia tau hais tias nyob rau hauv cov neeg mob CPSP tsis teb rau cov pa anticonvulsants thiab antidepressants, nws kho tau txo cov qhab nia ntawm qhov mob, nrog ib tug mob npaum li cas tshaj 50%, thiab markedly txhim kho mus ob peb vas thiab pw tsaug zog zoo. Piv nrog rau cov tshuaj opioids, nws tsis ua rau ua pa nyuaj siab lossis sedation, ua rau nws tsim nyog rau kev siv mus sij hawm ntev hauv cov neeg mob stroke, tshwj xeeb tshaj yog cov neeg uas muaj kev ua pa nyuaj lossis kev puas hlwb.
Cov ntaub ntawv qhov chaw: Kev nce qib hauv kev kuaj mob thiab kev tswj hwm ntawm Central Post-Stroke Pain; Diagnostic Evaluation and Treatment of Central Post-Stroke Pain.
2.5 Daim ntawv thov hauv Refractory Mob Associated nrog Radiculopathy thiab Spinal Stenosis
Refractory ache muaj feem xyuam rau radiculopathy thiab spinal stenosis yog ib qho mob ntev neuropathic mob tshwm sim los ntawm cov paj hlwb compression, o, lossis raug mob. Nws tshwm sim nrog radiating extremity mob, loog loog, tsis muaj zog, thiab mob hnyav heev. Cov kev kho mob ib txwm muaj (xws li, cov tshuaj uas tsis yog tshuaj steroidal anti-inflammatory, kho lub cev, cov paj hlwb blocks) feem ntau tau txais txiaj ntsig tsis zoo, thiab qee cov neeg mob xav tau kev phais tseem yuav muaj qhov mob seem, ua rau lub neej tsis zoo.
Nws cov pathogenesis yog txuam nrog cov hlab ntsha hauv paus edema, inflammatory teb, txawv txav neurotransmitter tso tawm, thiab N-type calcium channel ua kom tom qab compression.Raws li muaj zog uas tsis yog opioid analgesic, nws zoo relieves mob nyob rau hauv cov neeg mob uas muaj refractory radiculopathy- thiab spinal stenosis-txog kev mob, muab kev xaiv rau cov kev kho mob tshiab. Cov kev tshawb fawb soj ntsuam pom tau hais tias nws kho tau zoo txo qhov mob thiab loog loog, txo VAS cov qhab nia ntau dua 40% los ntawm cov hauv paus, thiab muab kev mob ntev ntev, txhim kho cov neeg mob lub peev xwm ua haujlwm txhua hnub. Tsis zoo li opioids, nws tsis ua rau muaj kev cia siab, kev vam khom, cem quav, lossis kev nyuaj siab ua pa, txhawb kev tswj hwm mus ntev. Tsis tas li ntawd, kev sib xyaw ua ke nrog cov hlab ntsha hauv paus thaiv kev kho mob ua rau muaj kev sib koom ua ke, txo qhov zaus ntawm cov blocks thiab cov nqi kho mob.
Cov ntaub ntawv qhov chaw: BMJ Kev Ua Zoo Tshaj Plaws Mob Radicular Disorders Vim Disc Compression; Haute Autorité de Santé PRIALT (Snx111) - Douleur chronique.
Kev ceev faj rau kev sib xyaw nrog Opioids thiab Opioid rho tawm
Cov tshuaj tsis yog opioid, tsis muaj kev sib cuam tshuam: Snx111 tsis ua rau opioid receptors thiab tsis tuaj yeem tiv thaiv lossis txo cov tsos mob tshem tawm opioid.
Kev rho tawm tapering raws tu qauv: Hauv cov neeg mob ntawm kev kho mob opioid mus sij hawm ntev, kev txiav tawm opioid sai sai yog txwv tsis pub. Tom qab pib snx111, opioids yuav tsum tau maj mam tapered tshaj 2-4 lub lis piam thiab hloov nrog sib npaug ntawm qhov ncauj opioids kom tsis txhob tshem tawm syndrome.
Cov ntaub ntawv qhov chaw: FDA Prescribing Information; Drugs.com Monograph.
FAQ
snx111 txawv ntawm morphine li cas?
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Tej zaum yuav mob hnyav thiab kho mob ntsig txog cov xwm txheej tsis zoo (AEs) cuam tshuam nrog IT morphine suav nrog kev ua pa nyuaj siab, kev ua siab ntev, thiab granuloma formulation, whereas IT ziconotide yog txuam nrog neuropsychiatric AEs, xws li kev paub tsis meej, kev hnov lus, thiab kev hloov hauv lub siab lossis kev nco qab, ...
Puas yog snx111 cuam tshuam nrog qee yam tshuaj?
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Muaj254 tshuaj paub tias cuam tshuam nrogsnx111, nrog rau 2 kab mob sib cuam tshuam, thiab 1 cawv / khoom noj sib cuam tshuam. Ntawm tag nrho cov tshuaj sib cuam tshuam, 6 yog qhov loj, thiab 248 yog nruab nrab.
Cim npe nrov: Ziconotide ntsiav tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom