Plecanatide ntsiav tshuaj

Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm plecanatide ntsiav tshuaj nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo plecanatide ntsiav tshuaj muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Plecanatide ntsiav tshuajyog cov tshuaj tshiab qhov ncauj uas siv los kho cov neeg laus mob chronic idiopathic constipation (CIC) thiab cem quav mob plab plob tsis so tswj (IBS-C). Txij li thaum tau txais kev pom zoo rau kev lag luam los ntawm US Food and Drug Administration (FDA) hauv xyoo 2017, nws tau maj mam dhau los ua ib qho kev xaiv tseem ceeb hauv kev kho cem quav vim nws cov txheej txheem tshwj xeeb ntawm kev ua thiab ua tau zoo. Plecanatide yog ib qho kev sib xyaw ua ke receptor agonist rau guanylate cyclase C (GC-C), nrog cov qauv tshuaj zoo ib yam li cov tshuaj endogenous uroguanylin hauv tib neeg lub cev. Qhov zoo sib xws no ua rau Plecanatide tshwj xeeb khi rau thiab qhib plab hnyuv GC-C receptors, yog li ua rau nws cov teebmeem physiological. Txhua ntsiav tshuaj muaj 3mg ntawm Plcanatide. Qhov koob tshuaj no yog txiav txim siab los ntawm ntau qhov kev sim tshuaj ntsuam xyuas, uas tuaj yeem txo cov tsos mob cem quav thiab tswj qhov tshwm sim ntawm qhov tshwm sim tsis zoo ntawm qib qis.

Plecanatide COA

Certificate of Analysis
Compound npe	Plecanatide
Qib	Pharmaceutical qib
CAS Nr.	467426-54-6
Ntau	3 37,3kg
Ntim txheem	25kg / nruas
Chaw tsim tshuaj paus	Shaanxi BLOOM TECH Co., Ltd
Ntau No.	202501090028
MFG	Peb 9, 2025
EXP	Peb 8, 2028
Qauv
Yam khoom	Enterprise txheem	Kev txheeb xyuas qhov tshwm sim
Qhov tshwm sim	Dawb los yog yuav luag dawb hmoov	Ua raws
Cov ntsiab lus dej	Tsawg dua lossis sib npaug li 5.0%	0.34%
Poob rau ziab	Tsawg dua lossis sib npaug li 1.0%	0.28%
Hnyav Hlau	Pb Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Hg Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Cd Tsawg dua lossis sib npaug li 0.5ppm	N.D.
Purity (HPLC)	Ntau dua lossis sib npaug li 99.0%	99.90%
Ib leeg impurity	<0.8%	0.47%
Tag nrho microbial suav	Tsawg dua lossis sib npaug li 750cfu / g	97
E. Coli	Tsawg dua lossis sib npaug li 2MPN / g	N.D.
Salmonella	N.D.	N.D.
Ethanol (los ntawm GC)	Tsawg dua lossis sib npaug li 5000ppm	400ppm ua
Cia	Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree

Lub plab microenvironment yog ib qho kev sib txawv thiab sib txawv, nrog rau cov kab mob hauv plab hnyuv, lub cev tiv thaiv kab mob, plab microbiota, thiab ntau yam bioactive tshuaj uas lawv tso tawm. Kev ruaj ntseg ntawm microenvironment no yog qhov tseem ceeb rau kev tswj lub plab hnyuv ua haujlwm, tiv thaiv kab mob ntxeem tau, thiab tswj cov kab mob hauv lub cev. Txawm li cas los xij, ntau yam xws li kev hloov pauv ntawm cov qauv kev noj haus, kev ua neej nyob, kev siv tshuaj, thiab cov kab mob tuaj yeem cuam tshuam qhov sib npaug ntawm cov hnyuv microenvironment, ua rau lub plab zom mov thiab lwm yam kab mob.Plecanatide ntsiav tshuaj, raws li ib qho tshiab GC-C receptor agonist, tau pib tsim kho rau cov neeg laus mob chronic idiopathic cem quav (CIC) thiab cem quav cem quav (IBS-C). Nrog rau kev tshawb fawb tob zuj zus, nws tau maj mam pom tias Plecanatide muaj lub luag haujlwm tshwj xeeb hauv kev kho cov hnyuv microenvironment, muab cov tswv yim kho mob tshiab rau txoj hnyuv.

Cov ntaub ntawv yooj yim

 

Plecanatide yog cyclic peptide tsim los ntawm 16 amino acids, thiab nws cov qauv tshuaj zoo ib yam li cov tshuaj endogenous uroguaniln hauv tib neeg lub cev. Plecanatide exerts nws cov teebmeem lom los ntawm tshwj xeeb khi rau GC-C receptors nyob rau saum npoo ntawm lub plab hnyuv epithelial hlwb, ua kom cov kev taw qhia downstream.

Mechanism ntawm Action

 

Tom qab khi rau GC-C receptors, Plecanatide txhawb kev tsim ntawm intracellular cGMP. CGMP, raws li ib qho tseem ceeb ntawm cov xov tooj ntawm tes taw qhia molecule, activates lub cystic fibrosis transmembrane regulator (CFTR) ion channel, stimulating lub tso zis ntawm chloride thiab bicarbonate rau hauv plab hnyuv lumen, ua rau cov dej cov ntsiab lus ntawm cov hnyuv, yog li softening quav thiab txhawb nqa defecation. Lub caij no, cGMP tseem txhawb nqa kev cog lus ntawm txoj hnyuv du, txhim kho plab hnyuv peristalsis, thiab ntxiv dag zog rau cov tsos mob cem quav.

Kev tswj cov dej hauv plab hnyuv thiab electrolyte tshuav nyiaj li cas: Plecanatide activates GC-C receptors, txhawb kev tso dej thiab electrolytes los ntawm cov qog plab hnyuv, thiab ua kom cov dej hauv cov hnyuv. Qhov kev ua haujlwm no tsis tsuas yog pab ua kom cov quav mos thiab txo cov tsos mob cem quav, tab sis kuj tseem tswj xyuas qhov sib npaug ntawm cov kua dej hauv cov hnyuv, tiv thaiv plab hnyuv qhuav thiab puas.
Txhim kho plab hnyuv muaj nuj nqi: Lub plab hnyuv barrier yog ib qho tseem ceeb tiv thaiv kab uas tiv thaiv cov khoom tsis zoo thiab cov kab mob nkag mus rau hauv cov ntaub so ntswg. Plecanatide activates GC-C receptors, txhawb kev loj hlob thiab kho cov hnyuv epithelial hlwb, txhim khu kev sib txuas ntawm cov hlwb, thiab yog li txhim kho kev ncaj ncees ntawm txoj hnyuv. Cov nyhuv no pab txo cov plab hnyuv permeability, tiv thaiv plab hnyuv microbiota translocation, thiab tiv thaiv endotoxemia.

Kev tswj cov hnyuv tiv thaiv kab mob: Cov hnyuv yog ib qho ntawm cov kab mob loj tshaj plaws hauv tib neeg lub cev, thiab kev ruaj ntseg ntawm cov hnyuv tiv thaiv kab mob yog qhov tseem ceeb rau kev tswj cov kab mob hauv lub cev. Plecanatide activates GC-C receptors, tswj kev ua haujlwm ntawm cov hnyuv hauv lub cev tiv thaiv kab mob, txo qhov tso tawm ntawm cov kab mob inflammatory, thiab yog li txo cov kab mob plab hnyuv. Cov nyhuv no muaj peev xwm siv tau rau hauv kev kho cov kab mob hauv plab hnyuv xws li kab mob plab hnyuv (IBD).
Inhibition ntawm pro-inflammatory cytokine ntau lawm: Nyob rau hauv txoj hnyuv inflammatory teb, pro-inflammatory cytokines xws li qog necrosis factor - (TNF - ), interleukin-6 (IL-6), thiab lwm yam. ua lub luag haujlwm tseem ceeb. Plecanatide txo cov hnyuv o los ntawm kev tswj cov kev ua haujlwm ntawm cov kab mob hauv plab hnyuv thiab inhibiting zus tau tej cov pro-inflammatory cytokines.

Txhawb kev tsim cov tshuaj tiv thaiv - inflammatory cytokines: Hauv kev sib piv rau cov pro-inflammatory cytokines, anti-inflammatory cytokines xws li interleukin-10 (IL-10) muaj peev xwm inhibit inflammatory teb. Plecanatide tuaj yeem txhawb kev tsim cov tshuaj tiv thaiv kab mob cytokines los ntawm cov kab mob hauv plab hnyuv, ntxiv dag zog rau cov hnyuv tiv thaiv kab mob, thiab tswj cov hnyuv.

Kev cuam tshuam rau lub plab microbiota muaj pes tsawg leeg: Lub plab microbiota yog ib qho tseem ceeb ntawm lub plab microenvironment, thiab nws cov muaj pes tsawg leeg thiab kev ua haujlwm yog qhov tseem ceeb rau kev noj qab haus huv ntawm plab. Plecanatide cuam tshuam qhov muaj pes tsawg leeg thiab ntau haiv neeg ntawm plab microbiota los ntawm kev tswj cov hnyuv ib puag ncig.

Txhawb kev loj hlob ntawm cov kab mob uas muaj txiaj ntsig: Plecanatide tuaj yeem tsim ib qho chaw zoo rau kev loj hlob ntawm cov kab mob muaj txiaj ntsig, txhawb kev loj hlob ntawm cov kab mob muaj txiaj ntsig xws li lactobacilli thiab bifidobacteria. Cov kab mob muaj txiaj ntsig zoo no ntxiv tswj cov kab mob hauv plab hnyuv thiab txhim kho plab hnyuv ua haujlwm los ntawm kev tsim cov metabolites xws li luv saw fatty acids (SCFAs).

inhibiting kev loj hlob ntawm cov kab mob phem: Hauv qhov sib piv rau cov kab mob uas muaj txiaj ntsig, cov kab mob tsis zoo xws li Escherichia coli thiab Salmonella tuaj yeem tsim cov co toxins thiab cov teeb meem metabolites, cuam tshuam cov kab mob hauv plab hnyuv, thiab ua rau mob plab hnyuv. Plecanatide tswj cov hnyuv ib puag ncig, inhibits kev loj hlob ntawm cov kab mob phem no, thiab txo lawv txoj kev puas tsuaj rau cov hnyuv.

Txo qhov mob plab hnyuv: Hauv cov kab mob hauv plab hnyuv xws li IBS-C, cov neeg mob feem ntau ntsib cov tsos mob xws li mob plab thiab tsam plab. Plecanatide alleviates cov tsos mob ntawm plab hnyuv los ntawm activating GC-C receptors, txo cov nqaij mob plab, thiab txo cov hnyuv rhiab heev rau qhov mob. Qhov kev ua haujlwm no pab txhim kho lub neej zoo ntawm cov neeg mob thiab txo lub nra ntawm cov kab mob.

Kev kho mob plab idiopathic constipation (CIC): CIC yog ib qho kev mob plab hnyuv qis, uas muaj feem xyuam rau cov plab hnyuv siab raum, lub plab zom mov, thiab kev puas siab puas ntsws. Plecanatide tau zoo txo ​​cov tsos mob cem quav hauv cov neeg mob CIC los ntawm kev ua kom cov dej hauv plab hnyuv thiab txhawb plab hnyuv peristalsis. Ntau qhov kev sim tshuaj ntsuam xyuas tau pom tias piv rau cov placebo, Plecanatide tuaj yeem ua rau cov neeg mob 'spontaneous bowel movements (SBM), txhim kho cov quav hauv quav, thiab txo qhov kev xav ntawm qhov nyuaj hauv qhov quav.

Kev kho cem quav uas muaj feem cuam tshuam rau plab hnyuv siab raum (IBS-C): IBS-C yog ib hom kab mob plab hnyuv siab raum, uas cov neeg mob feem ntau muaj mob plab thiab tsam plab ntxiv rau cov tsos mob cem quav. Plecanatide tuaj yeem tsis tsuas yog txo cov tsos mob cem quav hauv IBS-C cov neeg mob, tab sis kuj txo qhov mob plab thiab tsam plab los ntawm kev tswj cov hnyuv. Kev sim tshuaj 12 lub lis piam tau pom tias piv rau cov placebo, Plecanatide tau nce ntau ntawm cov plab hnyuv siab raum (CSBM) hauv IBS-C cov neeg mob thiab txhim kho mob plab thiab plab hnyuv.

Kev kho mob ntawm plab hnyuv kab mob (IBD): Txawm hais tias Plecanatide tau pib tsim los kho cov kab mob cem quav, nws cov peev xwm hauv kev kho cov kab mob plab hnyuv tau maj mam tshwm sim. Plecanatide xav tias yuav dhau los ua cov tshuaj tshiab los kho IBD los ntawm kev tswj cov kab mob hauv plab hnyuv thiab txhim kho txoj hnyuv ua haujlwm. Tam sim no, cov kev tshawb fawb tau lees paub qhov kev tiv thaiv kev ua haujlwm ntawm Plecanatide hauv tus qauv nas colitis, muab lub hauv paus theoretical rau nws daim ntawv thov hauv kev kho IBD.

Tiv thaiv cov kab mob hauv plab: Plecanatide yuav tsum ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv cov kab mob hauv plab los ntawm kev txhim kho microenvironment ntawm txoj hnyuv lumen. Piv txwv li, los ntawm kev tswj hwm qhov sib npaug ntawm plab microbiota thiab txhim kho txoj hnyuv ua haujlwm, Plecanatide tuaj yeem pab tiv thaiv qhov tshwm sim ntawm cov kab mob xws li kab mob plab hnyuv thiab qog.

Cim npe nrov: plecanatide ntsiav tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom