4,4 '{{- diaminodiphenylriffone CASE 80-08-0

Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab lwm tus neeg ntawm 4,4 '{}}}}} 08-0 hauv Suav teb. Txais tos rau kev lag luam wholesale ntau yam zoo 4,4'-diaminodiphenylriffone CASE 80-08-0 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.

4,4 '{- diamondiphenylipsulfone, Nrog cov tshuaj noj tshuaj c12h12n2o2s, muaj ob lub npe benzene thiab ib pawg sulfone. Cov pab pawg Sulfone tau txuas nrog ob lub pob tw benzene dhau los ntawm cov sulphur atoms. Cov molecule no muaj cov qauv phom sij thiab yog li ntawd muaj qee qhov kev ruaj ntseg ntawm kev ruaj ntseg. Nws yog cov khoom dawb dawb khov kho uas tshwm hauv cov hmoov hmoov ntawm chav tsev kub. Nws melting point yog hais txog 168-} 172 degree, thiab nws lub ntsiab lus npau npau yog li 350 degree. Nws qhov ceev yog kwv yees li 1.42 g / cm, zoo solubents, solublef, thiab dimethyl sulfoxide, tab sis muaj solubility tsis tshua muaj, tab sis muaj solubility tsis tshua muaj, As an important monomer for synthesizing polymers, it can be used to prepare various high-performance polymer materials, such as polyamide, polyester, and polyimide. Cov polymers tau siv dav hauv kev lag luam thiab muaj cov tshuab ua haujlwm zoo, muaj kub ua kom muaj zog, rwb thaiv tsev, thiab tus kheej lubrication cov khoom. Lawv tau dav siv nyob rau hauv engineering plastics, fiber ntau cov ntaub ntawv siv, tsho xim, thiab lwm thaj teb.

4,4 '{- diamondiphenylipsulfoneMuaj ntau cov kev siv hauv cov synthesis thiab tuaj yeem siv ua cov monomer tseem ceeb rau synthesizing ntau polymers.

1. Hluavtaws polyamide:

 

Nws tuaj yeem raug siv los ua ib qho ntawm monomers kom hnov ​​mob nrog dicarboxylic acids los synthesize polyamide. Polyamide yog cov khoom siv polymer nrog cov khoom siv tshuab zoo nkauj, cov tshuaj tiv thaiv zoo, muaj kub ua tsis kam, thiab corrosion tsis kam. Nws yog dav siv nyob rau hauv engineering reastics, fiber ntau cov ntaub ntawv, hnav- cov ntaub ntawv resistant, thiab lwm thaj teb.

Thaum synthesizing polyamide, 4,4 '- diam acid, thiab lwm yam ntawm cov tshuaj yej, thiab cov tshuaj tiv thaiv tsim cov polyamide. Qhov hnyav molecular thiab kev ua tau zoo ntawm cov polymers tuaj yeem hloov kho los ntawm kev tswj cov tshuaj tiv thaiv thiab monomer piv.

2. Khoom cua polyester:

 

Nws tuaj yeem raug siv los ua ib qho ntawm cov monomers kom hnov ​​mob nrog cov diols mus rau synthesize polyester. Polyester yog cov khoom siv polymer nrog cov khoom siv kho kom zoo nkauj, kub tsis kam, thiab huab cua tsis kam. Nws yog dav siv nyob rau hauv cov ntaub ntawv ntim khoom, fiber ntau cov ntaub ntawv, txheej, thiab lwm thaj teb.

Thaum synthesizing polyester, nws yog tov nrog lwm cov cawv binary (xws li ethylene glycol, etced rau ib qho kub, thiab siv tau los tsim polyester. Qhov hnyav molecular thiab kev ua tau zoo ntawm cov polymers tuaj yeem hloov kho los ntawm kev tswj cov tshuaj tiv thaiv thiab monomer piv.

3. Khoom cua polyimide:

 

Nws tuaj yeem raug siv los ua ib qho ntawm cov monomers kom hnov ​​mob nrog binary acyl cyloride kom synthesize polyimide. Cov khoom siv polyimide nrog cov khoom siv polymer nrog cov tshuab hluav taws xob zoo heev, rwb thaiv tsev, thiab tus kheej {1} lubricating zog. Nws yog dav siv hauv teb xws li engineering plastics, cov ntaub ntawv rwb thaiv tsev, thiab cov ntaub ntawv lubricating.

Thaum synthesizing polyimide, 4,4 '{- PhthalylRide (xws li phelaloyl chloride (thiab cov tshuaj tiv thaiv ua rau muaj zog polyimide. Qhov hnyav molecular thiab kev ua tau zoo ntawm cov polymers tuaj yeem hloov kho los ntawm kev tswj cov tshuaj tiv thaiv thiab monomer piv.

 

4,4 '{- diamondiphenylipsulfone, tseem hu ua diamodiphenyliphenyl sulkone, yog cov khoom siv hluav taws xob nrog tshuaj tua kab mob nrog cov tshuaj tua kab mob, tiv thaiv {}} mob, thiab immunomomodulatory. Nws cov qauv tshuaj zoo ib yam li cov tshuaj sulfonamide, thiab nws tau tawm tsam cov kabmob tshuaj tua kab mob los ntawm kev cuam tshuam nrog cov kab mob hauv cov metabolism. Txij li nws tau qhia rau hauv kev tshawb fawb hauv chaw kho mob thaum xyoo 1940, aminobenzene tau nyob nrog cov kab mob tseem ceeb hauv kev kho mob, kis tau cov kab mob thiab lwm daim teb.

Core Siv: CornerSone tshuaj rau kev kho mob ruas

 

1. Mechanism ntawm kev kho mob lprosy
Aminopheniramine yog cov tshuaj uas zoo tshaj plaws rau kev kho hanansen tus kab mob, tshwj xeeb yog rau kev kho mob reprosy (MB). Nws cov tshuab ntawm kev ua yog:

Inhibition ntawm cov metabolism: aminobenenzoic acid tau sib tw nrog para aminobenzoic acid (paba) rau DNAHYRRY BARTHENTESY thiab tom qab ntawd muaj prohyin synthesis.
DUAL kev txiav txim hom: tsawg dua tsoos inhibits cov kab mob (ntau dua los yog sib xyaw ua ke nrog lwm cov tshuaj (xws li Rifampicin, Clofazimine) los tiv thaiv tshuaj yeeb.

 

2. Cov Tswv Yim Thov Kev Npaj

Kev ua ke Kev Siv Tshuaj Kho Mob (MDT): Cov qauv kev cai pom zoo los ntawm lub Koom Haum Ntiaj Teb Rau cov kab mob qis (pb), amoxicillin (100mg / hnub) ua ke nrog Rifampicin (600mg / hli) yog siv rau 6 lub hlis.
Kev ua tau zoo thiab kev kho mob: Aminopheniramine tuaj yeem daws cov tsos mob me me (xws li not {{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{{ Kev tshawb fawb qhia tau tias kev kho qauv tau txo qhov kev rov ua dua tus nqi ntawm kev ua si kom qis dua 0.02%.

 

3. Kev tswj hwm kev tiv thaiv

Hematotoxicity: Txog 20% ​​ntawm cov neeg mob muaj kev mob hemolytic (tshwj xeeb yog G6PD tsis txaus), thiab cov ntshav tsis tu ncua yog qhov tsim nyog.
Cov tawv nqaij tiv thaiv: suav nrog cov pob xoo, kev coj noj coj ua kom zoo nkauj (hnav ris tsho), cov ntaub ntawv hnyav yuav tsum tau ua haujlwm ntawm cov tshuaj thiab kev tswj hwm ntawm corticosteroids.
Hepatotoxicity: Kev siv lub sijhawm ntev yuav ua rau nce qib siab. Nws raug nquahu kom sim ua kom lub siab ua haujlwm txhua 3 lub hlis.

Kev Kho Mob Daim Kab Mob Daim tawv nqaij: Dav npog dav los ntawm cov mob o mus rau kev mob autoimmune

 

1. Dermatitis Herpetiformis

Mechanism ntawm Kev Ua: Aminopheniramine txo cov tawv nqaij hlwv thiab khaus los ntawm inhibing neibrophil chemotaxis thiab 5-lipoxyenasing kev ua.
Kev Kho Mob Lub Hom Phiaj: Thawj zaug koob tshuaj yog 50-100mg / hnub, maj mam nce mus rau ib qho kev saib xyuas tsawg kawg nkaus (feem ntau 50-100mg / hnub) tom qab tswj tau.
Kev Kho Mob: Gluten Kev Noj Haus Dawb (GFD) yuav tsum tau txwv tsis pub muaj plab hnyuv etigens, thiab qee tus neeg mob yuav tsis ua tiav kev siv paracupamol.
2. Lwm cov kab mob tawv nqaij

 

Neutrophil daim tawv nqaij kab mob, xws li pyodrenosum thiab Sweet Syndrome, tuaj yeem kho nrog paracetamol kom inhibit neutrophil infiltration, txo cov mob ulcers thiab mob.

Visculit cov kab mob, xws li tawv nqaij ua xua ulasculitis thiab nodular erityiritis, txo qis erythema thiab o los ntawm anti {{incammatory teebmeem.
Psoriasis thiab ntxau: nws muaj qee yam kev kho mob ntawm pustular pustular potoriasis thiab pob txuv txwv, tab sis ceev faj yuav tsum tau coj tawm tsam tshuaj phiv.
3. Autoimmune Cov Kab Mob Ntawm Cov tawv nqaij

Dag tawm dag lipus erythematosus (dle): aminopheniramine tuaj yeem txo cov tawv nqaij erythema thiab kev ceev faj, rau lub ntsej muag) raws li nws yuav tsis muaj kev hemolysis).
Bullous daim tawv nqaij kab mob, xws li Pemphigus thiab cov pakpigoid, txo qhov kev tsim ntawm hlwv los ntawm inhibiting rau cov teb chaws offiated los ntawm Authantibodies.

Cov kab mob sib kis: los ntawm cab los rau cov kab mob tshwm sim

 

1. Pneumocystis carinii pneumonia (PCP)

Mechanism ntawm Kev Ua:4,4 '{- diamondiphenylipsulfoneInhibits cov neeg metabolism hauv pneumocydis carini thiab block nws proliferation.
Kev Siv Tshuaj Siv Ua Si: Siv hauv kev sib xyaw nrog Trimethoprim (TMP 15MG / KG / DMAC / KG / HNUB, muab faib ua 3 qhov ncauj), rau ib chav ntawm 14-21 hnub.
Cov neeg muaj feem: high - muaj kev pheej hmoo ntawm cov tib neeg (cd {{1} t cell suav<200/μ L) or organ transplant recipients.
2. Kev Tiv Thaiv Malaria thiab Kev Kho Mob

Tshuaj Tiv Thaiv Cov Tshuaj Malaria: aminophenol yog siv los tiv thaiv chloroquine resistant malaria (xws li ib qho koob tshuaj ntawm 100 mg / lub lim tiam ntawm aminopheniramine thiab 12.5 mg / lub lim tiam ntawm ethambutol.
Triple Edapy: Hauv cov cheeb tsam uas muaj peev xwm siab heev, chloroquine (300mg / lub lim tiam) tuaj yeem ua ke los txhim kho cov nyhuv tiv thaiv.

Daim ntawv thov hauv cov xwm txheej tshwj xeeb: kev tshawb nrhiav los ntawm cov kab mob tsis tshua muaj mob rau kev mob hnyav

 

1. Cov polychondritis recreuritis (RP)

Mechanism ntawm Kev Ua: Aminopheniramine Alleviates pob ntseg, qhov ntswg, thiab sib ntaus sib tua los ntawm kev tiv thaiv kab mob pob txha mos rhuav tshem.
Kev Kho Mob Lub Tswv Yim: thawj koob tshuaj yog 100mg / hnub, kho rau 200mg / hnub raws li cov xwm txheej, feem ntau siv hauv kev sib xyaw nrog glucocorticoids.
2. Granuloma Anuule

Cov Txiaj Ntsig: Rau cov khoom siv dav dav lossis cov lus qhia tawm tsam tau txhawb nqa kev deb ntawm cov nqaij ntshiv, tab sis ntev {}} lub hlis) yuav tsum muaj.
3. Cov kev kho mob tseem ceeb

Cov neeg mob hlawv: aminobenzene tuaj yeem txo qhov kev pheej hmoo ntawm pseudomonas Aeruginosa kis mob hauv hlawv cov tshuaj hlawv hemolytic.
Cov kab mob ua yeeb yam: rau kev kis mob tawv nqaij los ntawm kev ua yeeb yam ntawm kev ua yeeb yam, paracunamolol tuaj yeem siv ua cov tshuaj kho kom zoo.

 

Synthetic Diphenylsulfone: Lub molten {{0} {{{{} {} {} {} {} {}}}}}}} {}}}}}}}}}}}}}}}}}}}}}}}}}} {} {}}}}}}}}}}}}}}}}}}}}}}}}} Kev sib xyaw ua ke yog tso rau hauv cov pipeline reactor los ntawm a high {{5} Kev kub siab ntawm tus nqi ntawm 14 MPA, thiab qhov chaw nyob ntawm cov khoom siv uas txaus ntshai Tom qab decompression thiab tawm los ntawm lub siab txo lub siab, thiab cov khoom lag luam chromatography, thiab cov khoom noj kua roj muaj 4,4 '{14}} dichlorodiphenyl sulfone 0.1%. Qhov tawm tawm mus rau chav ua haujlwm rov qab, cov lus hais dhau los yog cov neeg nyoos, thiab cov neeg nyoos 4,4 '{{19} Txoj kev diamodiphenyliphenyliphenyliphenyliphenyliphenyliphenyliphenyliphenyliphenyliphenyliphenyliphenyliphenyliphenyliphenyliphylip Cov khoom lag luam uas yog yaj nyob hauv cov roj ntsha uas muaj 10 tus lej tag nrho Sulfone nrog kev coj dawb huv ntawm 99.5% (ua kua chromatography kev txheeb xyuas), nrog rau tag nrho cov txiaj ntsig ntawm 9,4 '{- dichlorodiphenyl sulfone).

4,4 '{- diamondiphenylipsulfoneYog tus neeg sawv cev ntawm Sulfone, uas muaj cov tshuaj tua kab mob muaj zog ntawm kev ua kom muaj mob ruas bacilli, thiab qhia cov nyhuv cov nyhuv loj. Nws cov tshuab ntawm kev ua yog zoo li cov tshuaj sulfonamide. Nws ua raws li cov synthetase synthetase ntawm cov kab mob thiab cuam tshuam nrog cov synthesis ntawm FULTE. Cov tshuaj tua kab mob antibacterial ntawm ob qho tib si yog zoo sib xws, thiab ob leeg yog txwv los ntawm aminobenzoic acid. Cov khoom no tseem tuaj yeem siv raws li Dihydroralate reductase inhibitor. Ib qho ntxiv, cov khoom no muaj imunosuppressive nyhuv, uas yuav cuam tshuam nrog kev cuam tshuam ntawm Herpetiform dermatitis. Yog tias nws siv nws nyob ib leeg ntev, lom ruas bacilli feem ntau yog tus tsim cov tshuaj tiv thaiv no.

Cov khoom no yog nqus tau sai thiab ua tiav tom qab kev tswj hwm qhov ncauj. Tus nqi protein khi yog 50% ~ 90%. Tom qab nqus tau, nws yog dav faib hauv cov ntaub so ntswg thiab dej ntawm lub cev ntawm tag nrho lub cev. Cov kev xav ntawm daim siab thiab raum yog qhov siab tshaj plaws. Cov concentration ntawm daim tawv nqaij puas yog 10 zaug siab dua li ntawm cov tawv nqaij ib txwm. Cov khoom no yog metabolized los ntawm n- acetyltranserase nyob rau lub siab. Cov neeg mob tuaj yeem muab faib ua hom mob qeeb thiab hom kev ua kom ceev acetylation hom dapsone. Cov qub muaj qhov siab dua cov tshuaj pleev xim rau tom qab noj, uas yog qhov tshwm sim ntshav, tab sis cov kev tsis sib haum hluav taws xob tsis tau nce ntxiv. Cov neeg mob uas muaj kev txhawb nqa ceev yuav tau kho qhov tshuaj thaum noj tshuaj. Cov khoom yuav ntsuas tau hauv cov ntshav li ob peb feeb tom qab kev tswj hwm qhov ncauj. Lub sijhawm siab kawg yog 2 txog 6 teev, qee zaum 4 txog 8 teev. Cov khoom muaj kev sib tw hepatobiary, yog li lub excretion yog qeeb, thiab tshem tawm ib nrab ntawm {19} Lub neej yog 10 txog 50 teev (nruab nrab 28 teev). Tom qab siv cov tshuaj, cov khoom tseem tuaj yeem muaj nyob hauv cov ntshav li ntau lub lis piam. Txog 70% ~ 85% ntawm cov koob tshuaj yog excreted los ntawm cov zis raws li cov qauv thiab cov hws me, qaub ncaug, cov qaub ncaug, cov qaub ncaug thiab mis nyuj.

Aminobenesulfone, raws li cov tshuaj tua kab mob ob tog, feem ntau yog siv los kho ntau yam kev mob ruas es tsis los ntawm mycobacterium leprae. Nws tseem siv rau kev kho ntawm ntau yam kab mob ntawm cov tawv nqaij, xws li tus mob tshuaj ntsuab Dermatitis thiab pustular dermatitis. Txawm li cas los xij, txhua yam tshuaj siv los kho tus kab mob kuj tseem tuaj yeem nrog qee yam tshuaj lom. Cov tshuaj lom ntawm dapsone tuaj yeem ua tau raws li kev nthuav dav los ntawm cov hauv qab no:

Cim npe nrov: 4,4 '{{- diamodiphenylipsulfone CASE 80-08- cov chaw tsim khoom, chaw tsim khoom, yuav khoom, khoom, rau muag