Clascoterone hmoovyog ib hom tshuaj muaj npe tshuaj 17- (1-oxopropyl) -17-hydroxyandrost-4-, 16-en-3-one. Dawb los yog tawm dawb crystalline hmoov, molecular mis C24H34O5, CAS 19608-29-8. Solubility tsawg heev nyob rau hauv dej, tab sis zoo solubility nyob rau hauv cov organic solvents xws li methanol, chloroform, ethanol, ether, thiab lwm yam. Nws yog ib qho tseem ceeb organic compound nrog ntau yam kev ua lom lom. Nws yog ib qho khoom siv hluavtaws adrenergic 2 receptor agonist siv los ua cov tshuaj hluavtaws rau kev kho mob hawb pob, mob ntsws ntsws ntev (COPD), thiab lwm yam kab mob ua pa. Nws tuaj yeem ua rau cov nqaij ntshiv du, txo bronchial spasms, thiab txo cov tsos mob hawb pob. Nws yuav tsum raug sau tseg tias tam sim no siv los kho cov kab mob ntawm daim tawv nqaij xws li pob txuv, nws tsuas yog siv tau raws li kev qhia ntawm tus kws kho mob. Tab sis cov khoom muab los ntawm lub chaw kuaj sim yog cov khoom siv tshuaj lom neeg thiab tsuas yog siv rau hauv chav kuaj.
Nws feem ntau muaj nyob rau hauv daim ntawv ntawm dawb los yog tawm dawb crystals los yog crystalline hmoov. Cov tsos mob no qhia tau hais tias nws cov qauv molecular muaj kev txiav txim siab thiab ruaj khov. Cov xim dawb lossis xim dawb feem ntau txhais tau hais tias cov khoom sib xyaw tsis muaj cov impurities lossis chromophores. Crystallinity qhia tau hais tias clavulane molecules tuaj yeem tsim cov qauv lattice tsis tu ncua hauv cov khoom hauv lub xeev, uas muaj feem cuam tshuam nrog lawv cov kev sib cuam tshuam hauv nruab nrab.
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Tshuaj Formula |
C24H34O5 |
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Exact Mass |
402 |
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Molecular Luj |
403 |
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m/z |
402 (100.0%), 403 (26.0%), 404 (2.7%), 404 (1.0%) |
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Elemental Analysis |
C, 71.61; H, 8.51; O, 19.87 |
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Raws li ib tug compound nrog ntau yam kev ua ub no lom,clascoterone hmoovtau pom dav daim ntawv thov kev cia siab nyob rau hauv ntau lub teb.
Kev kho mob teb
1. Kev kho pob txuv vulgaris
Pob txuv vulgaris yog ib hom kab mob ntawm daim tawv nqaij uas muaj ntau dhau ntawm sebum secretion, hyperkeratosis, colonization ntawm pob txuv kab mob, thiab o. Raws li ib qho tshiab hauv zos androgen receptor inhibitor, nws muaj cov qauv steroid zoo ib yam li dihydrotestosterone thiab tuaj yeem cuam tshuam kev khi ntawm dihydrotestosterone rau androgen receptors hauv vitro. Cov nyhuv inhibitory no ua rau nws muaj txiaj ntsig zoo hauv kev kho pob txuv vulgaris. Kev tshawb fawb tau pom tias 1% ntawm nws pom muaj kev nyab xeeb zoo thiab ua tau zoo hauv kev kho mob ntawm cov neeg mob pob txuv mob hnyav. Cov tshuaj no tuaj yeem txo tus naj npawb thiab qhov mob ntawm pob txuv thiab txhim kho cov tawv nqaij ntawm cov neeg mob. Yog li ntawd, nws yuav tsum dhau los ua qhov kev xaiv tshiab rau kev kho pob txuv vulgaris.
2. Kev kho mob ntawm cov kab mob ua pa
Nws kuj qhia tau tias muaj peev xwm kho tau rau cov kab mob ua pa. Nws tuaj yeem siv los ua ib qho adrenergic 2 receptor agonist los ua kom cov nqaij ntshiv du, txo bronchial spasms, thiab txo cov tsos mob hawb pob. Klaustone khi rau adrenergic 2 receptor nyob rau hauv daim nyias nyias ntawm bronchial smooth nqaij hlwb, ua kom adenylate cyclase nyob rau hauv lub hlwb, nce cAMP theem, thiab tom qab activating protein kinase A kom txo tau Ca2+concentration nyob rau hauv bronchial smooth nqaij hlwb, ua tiav cov nyhuv ntawm so lub bronchi. Tsis tas li ntawd, nws muaj peev xwm inhibit inflammatory thiab tsis haum tshuaj, txo edema thiab o ntawm pa mucosa, thiab ntxiv txhim kho cov tsos mob hawb pob. Qhov no ua rau nws muaj peev xwm siv dav hauv kev kho cov kab mob ua pa xws li mob hawb pob thiab mob ntsws ntsws ntev (COPD).
3. Lwm hom tshuaj
Ntxiv nrog rau cov kev siv tseem ceeb uas tau hais los saum no, nws kuj tseem muaj lwm yam kev siv tshuaj. Piv txwv li, nws tuaj yeem ua tus kws kho mob nruab nrab thiab koom nrog kev sib txuas ntawm lwm cov tshuaj lom neeg lom neeg. Tsis tas li ntawd, nws kuj tseem tuaj yeem muaj cov haujlwm lom neeg xws li tshuaj tua kab mob, tiv thaiv -inflammatory, thiab antioxidant zog, uas ua rau nws muaj txiaj ntsig zoo hauv kev txhim kho tshuaj. Txawm li cas los xij, kev siv cov peev txheej no tseem xav tau kev tshawb fawb ntxiv thiab siv tau.
Aquaculture teb
Hauv kev lag luam aquaculture, nws kuj tau pom nws qhov tshwj xeeb bioactive siv. Nws muaj lub luag haujlwm ntawm kev txhawb nqa kev loj hlob ntawm cov kab mob hauv dej thiab txuag cov khoom noj, thaum tseem tiv thaiv cov kab mob hauv dej. Qhov kev siv no qhia txog nws lub peev xwm los txhawb kev noj qab haus huv lom neeg thiab txhim kho kev tsim khoom.
1. Txhawb kev loj hlob
Nws tuaj yeem txhawb kev loj hlob thiab kev loj hlob ntawm cov kab mob hauv dej los ntawm kev tswj hwm lawv cov haujlwm physiological. Nws tuaj yeem ua rau nce qhov kev loj hlob thiab kev ciaj sia ntawm cov kab mob hauv dej los ntawm kev cuam tshuam rau lawv cov kab mob endocrine, txoj hauv kev metabolic, lossis kev tiv thaiv kab mob. Qhov no ua rau nws muaj ntau yam kev cia siab rau hauv aquaculture, uas pab txhim kho kev ua tau zoo thiab nyiaj txiag txiaj ntsig ntawm aquaculture.
2. Txuag pub
Nws kuj tseem tuaj yeem txo cov khoom pov tseg los ntawm kev nce kev siv cov kab mob hauv dej rau kev pub. Nws tuaj yeem txhim kho kev zom zaub mov thiab kev nqus dej ntawm cov kab mob hauv dej lossis tswj lawv txoj kev qab los noj mov, ua rau lawv siv cov khoom noj muaj txiaj ntsig zoo hauv kev pub noj. Qhov no tsis yog tsuas yog pab txo tus nqi yug me nyuam xwb, tab sis kuj txo cov pa phem ib puag ncig.
3. Kev tiv thaiv kab mob thiab kab tsuag
Nws kuj muaj kev ua haujlwm ntawm kev tiv thaiv kab mob hauv dej. Nws tuaj yeem txo qhov tshwm sim thiab kis kab mob los ntawm kev txhim kho kev tiv thaiv ntawm cov kab mob hauv dej los yog inhibiting kev loj hlob thiab kev loj hlob ntawm cov kab mob. Qhov no yog qhov tseem ceeb heev rau kev ua kom muaj kev noj qab haus huv ntawm aquaculture thiab txhim kho cov khoom hauv dej kom zoo.
Clascoterone hmoovyog ib yam tshiab ntawm qhov ncauj thiab tshuaj pleev pob txuv tshuaj kho mob nrog cov tshuaj hauv qab no:
1. Inhibition ntawm secretion ntawm sebaceous qog: Clascoterone, raws li ib tug hauv zos androgen receptor antagonist, yuav inhibit qhov secretion ntawm sebaceous qog, yog li txo qhov mob ntawm pob txuv.
2. Inflammatory effect: Clascoterone tuaj yeem cuam tshuam cov tshuaj tiv thaiv inflammatory thiab alleviate cov tsos mob ntawm pob txuv o.
3. Antimicrobial nyhuv: Clascoterone kuj tuaj yeem cuam tshuam kev loj hlob thiab kev loj hlob ntawm cov kab mob pob txuv, yog li txo qhov mob ntawm pob txuv.
4. Tiv thaiv cov plaub hau follicle hlwb: Clascoterone tuaj yeem tiv thaiv cov plaub hau follicle thiab txo qhov kev puas tsuaj ntawm pob txuv rau cov plaub hau follicle hlwb.
Nyob rau hauv dav dav, lub pharmacological kev txiav txim ntawm Clascoterone yog tsuas yog los txhim kho cov mob ntawm pob txuv los ntawm inhibiting lub secretion ntawm sebaceous qog, txo inflammatory tshuaj, inhibiting kev loj hlob ntawm pob txuv kab mob thiab tiv thaiv cov plaub hau follicle hlwb.
Clascoterone yog ib yam tshuaj rau qhov ncauj thiab sab nraud kho pob txuv. Nws cov yam ntxwv pharmacokinetic yog raws li nram no:
1. Kev nqus: Clascoterone tuaj yeem nqus tau sai tom qab kev tswj hwm qhov ncauj, thiab lub sijhawm kom ncav cuag qhov siab tshaj plaws yog 2.5 teev. Tom qab siv sab nraud, Clascoterone tuaj yeem nqus tau los ntawm daim tawv nqaij, tab sis nws qhov nqus tau qeeb.
2. Kev faib tawm: Clascoterone tuaj yeem faib thoob plaws hauv lub cev thiab tuaj yeem nkag mus rau ntawm daim tawv nqaij thiab cov qog sebaceous.
3. Metabolism: Clascoterone feem ntau yog metabolized nyob rau hauv daim siab los tsim ntau yam metabolites, ntawm uas 3-OH-Classcoterone yog cov metabolite tseem ceeb tshaj plaws.
4. Kev tso tawm: Clascoterone thiab nws cov metabolites feem ntau yog tawm los ntawm daim siab thiab lub raum.
5. Dose dependence: Cov ntshav concentration ntawm Clascoterone yog zoo correlated nrog nws koob. Nyob rau hauv qhov kev nyab xeeb, qhov ntau dua ntawm cov koob tshuaj Clascoterone, qhov pom tseeb dua nws inhibition ntawm sebaceous qog secretion thiab tiv thaiv - cov nyhuv inflammatory.
Feem ntau, Clascoterone muaj qhov nqus tau zoo, kev faib tawm thiab cov metabolism, thiab muaj qee yam tshuaj nyob hauv vivo. Cov yam ntxwv no muaj qhov cuam tshuam tseem ceeb ntawm nws txoj kev kho pob txuv.
Clascoterone hmoov(17-(1-oxopropyl)-17-hydroxyandro-4,16-en-3-one) yog cov khoom siv hluavtaws. Nws txoj kev hluavtaws yog raws li nram no:
1. 3-hydroxy-1-propenol tau tsim los ntawm propenol los ntawm hydroxylation.
2. 1,3-dimethoxy-5-hydroxy-7,8-dihydro-4H-2-benzopyran-4-one tau tsim los ntawm 3-hydroxy-1-propanol los ntawm ntau cov tshuaj tiv thaiv.
3. Clascoterone tau tsim los ntawm 1,3-dimethoxy-5-hydroxy-7,8-dihydro-4H-2-benzopyran-4-one los ntawm ntau cov tshuaj tiv thaiv.
Txoj kev hluavtaws ntawm Clascoterone yog qhov nyuaj, xav tau cov cuab yeej siv tshuaj zoo tshaj plaws thiab kev tswj hwm nruj ntawm cov tshuaj tiv thaiv. Tsis tas li ntawd, tus nqi, tawm los, purity thiab lwm yam yuav tsum tau xav txog nyob rau hauv industrial ntau lawm.
Clascoterone yog ib qho khoom siv hluavtaws, thiab nws txoj kev kuaj kev sib txuas yog raws li hauv qab no:
1. 4-en-3,17-dione thiab vinyl methyl ether raug txo thiab cawv nyob rau hauv muaj sodium acetate los tsim 17-hydroxy-4-enone.
2. 17-(1-bromopropyloxy)-4-enone yog synthesized los ntawm reacting 17-hydroxy-4-enone nrog 3-bromopropylic acid.
3. Lub 17-(1-bromopropyloxy)-4-enone thiab benzyltrimethylammonium ntsev yog raug rau bromination cov tshuaj tiv thaiv nyob rau hauv lub catalysis ntawm alkali los tsim 17-(1-oxopropyl)-4-enone.
4. Ib nrab hydrolysis ntawm 17-(1-oxopropyl)-4-enone nyob rau hauv catalysis ntawm sodium hydroxide thiab esterification cov tshuaj tiv thaiv ntawm acetic anhydride tau nqa tawm los tsim Clascoterone.
Nws yuav tsum raug sau tseg tias thaum cov tshuaj tiv thaiv tshuaj no tau ua nyob rau hauv chav kuaj, cov tshuaj tiv thaiv thiab kev nyab xeeb ntawm kev ua haujlwm yuav tsum tau tswj nruj me ntsis kom ntseeg tau tias cov txiaj ntsig siab thiab purity ntawm cov tshuaj tiv thaiv.
Clascoterone hmoovyog ib qho khoom siv hluavtaws nrog qee yam tshuaj tiv thaiv. Cov hauv qab no yog qee cov tshuaj tiv thaiv ntawm Clascoterone:
Cov tshuaj tiv thaiv oxidation:
Clascoterone yooj yim rau oxidized, thiab tuaj yeem oxidized rau cov carboxylic acid los yog keto acid los ntawm ntau yam oxidants (xws li hydrogen peroxide, benzoyl peroxide, thiab lwm yam).
Txo cov tshuaj tiv thaiv:
Clascoterone tuaj yeem txo qis rau nws cov cawv sib xws los ntawm ntau yam kev txo qis (xws li sodium sulfite, hydrogen, aluminium, thiab lwm yam).
Cov tshuaj tiv thaiv thermal decomposition:
Clascoterone dhau los ua cov tshuaj tiv thaiv decomposition ntawm qhov kub siab (txog 200 degree) los tsim ntau yam khoom sib txawv.
Lwm cov tshuaj tiv thaiv:
Clascoterone kuj tuaj yeem hloov pauv los ntawm cua sov, kho alkali, kho cov kua qaub thiab lwm yam kev cuam tshuam.
Nws yuav tsum raug sau tseg tias hauv chav kuaj lossis kev lag luam, cov tshuaj tiv thaiv ntawm Clascoterone yuav tsum muaj kev tswj hwm nruj thiab kev nyab xeeb ua haujlwm kom tsis txhob muaj kev nyab xeeb. Tsis tas li ntawd, Clascoterone yog tam sim no siv los kho cov kab mob ntawm daim tawv nqaij xws li pob txuv, thiab tsuas yog siv tau raws li kev qhia ntawm tus kws kho mob.
Cov lus nug nquag
Puas yog clascoterone tib yam li spironolactone?
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Spironolactone tau ntev lawm tsuas yog androgen receptor inhibitor siv rau kev kho pob txuv. Qhov sib txawv tseem ceeb ntawm clascoterone thiab spironolactone yog tias spironolactone yog tus neeg sawv cev ntawm qhov ncauj, thiab qhov no tuaj yeem ua rau muaj kev phiv ntau dua.
Puas yog clascoterone cream yog steroid?
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Clascoterone yog steroidal antiandrogen, los yog antagonist ntawm androgen receptor (AR), lub hom phiaj lom neeg ntawm androgens xws li testosterone thiab dihydrotestosterone (DHT).
Kuv yuav tsum zam dab tsi thaum siv clascoterone cream?
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Tsis txhob siv WINLEVI Cream rau cov tawv nqaij puas (xws li kev txiav, abrasions), eczematous cheeb tsam, thiab sunburned ntawm daim tawv nqaij. Tsis txhob siv lwm yam khoom uas muaj peev xwm ua rau khaus khaus (tshuaj lossis tsis yog). Cov ntaub ntawv tseem ceeb: WIN LEVI cream yog siv rau ntawm daim tawv nqaij nkaus xwb (tshuaj pleev).
Cim npe nrov: Clascoterone hmoov CAS 19608-29-8, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom