Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab cov khoom lag luam ntawm notadrenaline acid tartrristine CAS 69815-49-2 hauv Suav teb. Txais tos rau kev lag luam wholesale mis zoo tsis zoo notadrenine acid tartrenine CAS 69815-49-2 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Noradristaline acid tartrat(L-4- (2-amino-1-hydroxyethyl) -1,2-benzeniol bitartrate), tshuaj mis nyuj c8h11no6.hmo6.hmo6.hu wb dawb lossis yuav luag dawb crystalline hmoov. Tsis meej, iab, huab cua lwj, soluble hauv dej, soluble me ntsis hauv ethanol, insoluble hauv chloroform lossis ether. L-4- (2-amino-1-hydroxyethyl) -1,2-benzeniol tartrate, tshuaj siv tshuaj mis nyuj c8h11111111) yog cov tshuaj hu ua bisoprolol pub dawb lub hauv paus tartrate. Nws yog dawb lossis yuav luag dawb crystalline hmoov, feem ntau nyob rau hauv daim ntawv ntawm amorphous lossis crystalline cov khib nyiab. Nws muaj solubility nyob hauv dej thiab tuaj yeem yaj sai. Nws kuj tseem tuaj yeem yaj nyob rau hauv cov kuab tshuaj yeeb yaj kiab xws li ethanol, methanol, thiab ether. Kuj tsis muaj qhov ruaj khov nyob rau hauv ib qho kev kub siab, tab sis decomposition yuav tshwm sim nyob rau hauv cov kev mob siab. Tus nqi PH yog nyob ntawm cov concentration ntawm nws cov kev daws teeb meem thiab kev sib cais nruab nrab. Feem ntau hais lus, nws cov kua aqueous yog acidic. Tso cov kev nqus tau peaks nyob rau hauv UV pom kev zoo heev wavelengths uas tuaj yeem siv rau kev tsom xam thiab kev txiav txim siab kom paub.
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Tshuaj Cov Qauv |
C12h17No9 |
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Muaj pes tsawg leej |
319 |
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Molecular hnyav |
319 |
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m/z |
319 (100.0%), 320 (13.0%), 321 (1.8%) |
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Kev Ntsuam Xyuas |
C, 45.14; H, 5.37; N, 4.39; O, 45.10 |
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Melting taw tes |
102-105℃c |
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Kub taw tes |
360℃c |
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Ceev |
1.082 ± 0.06 g / cm3 (kwv yees) |
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Kev Cia |
2-8℃c |
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Kev Sib Hloov Tshwj Xeeb |
- 46} º (c=0.5}, hcl) |
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Solubility H2o |
50 mg / ml |
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Lub ntsiab tivthaiv ntawm hnyavNoradristaline acid tartratyog norpinephrine, uas yog alpha receptor thiab beta 1 receptor agonist. Nyob rau hauv cov nqe lus ntawm cov khoom noj khoom muag, nws muaj cov txiaj ntsig zoo ntawm Alpha cov receptors dua li adrenaline, tab sis yuav luag tsis muaj kev cuam tshuam rau Beta 2 receptors. Qhov no ua rau norpinephrine bitartrate muaj cov khoom siv hluav taws xob tseem ceeb hauv vasoconstriction thiab burpertension.
Norepinephrine bitartrate tuaj yeem ua rau vasoconstrict dav, uas yog ib qho ntawm nws cov khoom siv tseem ceeb. Tshwj xeeb, nws ua haujlwm rau alpha 1 tus neeg txais khoom ntawm daim nyias nyias ntawm vascrane du cov leeg hlwb, ua rau cov hlab ntshav tawm tsam, ua rau muaj ntshav nce ntxiv. Qhov no Vasoconstrictive effic tsis yog txwv rau daim tawv nqaij, lub cev nqaij daim tawv, thiab kuj suav nrog cov hlab ntsha thiab corebral hlab ntsha.
Nyob rau hauv cov nqe lus ntawm coronary arteries, txawm hais tias norepinephrine tuaj yeem ua rau cov vasoconsction, nws tuaj yeem ua rau kev mob ntshav plab thiab nce cov ntshav ntws. Qhov no tuaj yeem yog vim muaj kev sib txawv ntawm cov kev sib txawv ntawm cov sib txawv ntawm cov leeg ntshav, lossis nws sib cuam tshuam nrog lwm cov tshuaj vasoactive.
Nyob rau hauv cov nqe lus ntawm cerebral cov hlab ntsha, norpinephrine tuaj yeem txo cov ntshav hauv cov ntshav hauv lub hlwb, nws kuj tseem siv cov ntshav siab ua haujlwm los ntawm cov ntshav hauv lub hlwb ua haujlwm.
2. TSIM NTSHAV NTSHAV TXIV
Norepinephrine betartrate tuaj yeem sai thiab ua kom muaj zog diatsolic ntshav siab thiab cov mem tes siab, uas yog qhov tseem ceeb tshaj cov tshuaj. Nws txhawb nqa Alpha cov receptors los tsim vasoconstriction, nce lub rooj ntev ntxiv tsis kam thiab yog li nce ntshav siab. Nyob rau tib lub sijhawm, Norepinephrine tuaj yeem ua kom muaj 1 tus kheej, ua rau lub siab tso zis nrawm dua, thiab kev kub siab ntxiv.
Hauv kev tshawb nrhiav kev coj ua, namespinephrine me ntsis yog feem ntau siv los kho ntau yam tsis zoo, thiab kev xav tsis thoob los ntawm cov dej sib tw, thiab poob siab los ntawm cov ntshav tsis txaus. Hauv cov xwm txheej no, Norepinephrine tuaj yeem nce ntshav nce ntxiv, txhawm rau kom muaj ntshav ntxiv rau cov cim tseem ceeb thiab tswj cov phiajcim tseem ceeb.
3. Txhim khu myocardial cov phiaj xwm
Tartrate norpinephrine tuaj yeem txhim kho kev sib koom ua ke ntawm myocardial hlwb thiab txhim kho lub plawv dhia los ntawm kev lom zem 1 receptors. Cov nyhuv no yog qhov tshwj xeeb tshaj yog nyob rau hauv kev rov ua haujlwm plawv. Thaum twg tus neeg mob paub kev mob plawv them, ntxiv rau kev siv plawv, thiab lwm yam kev ua pa tawm hws, nws tseem siv zog nrog lub cev muaj roj, thiab txhaj lawv ncaj qha rau kev nkag siab ncaj qha. Los ntawm kev txhawb nqa alpha thiab beta receptors, ua haujlwm tau nce, uas tau txais txiaj ntsig zoo rau kev them nqi plawv thiab ua tiav txoj kev vam meej ntawm kev cawm.
4. Txhim kho lub xeev poob siab
Kev poob siab yog lub xeev pathohysiological uas muaj tus cwj pwm tsis txaus, tsis muaj cov ntaub so ntswg tsis txaus, thiab hloov chaw ua si. Norepinephrine bitartrate tuaj yeem txhim kho lub xeev kev chim siab los ntawm cov hlab ntshav siab, ua kom ntshav nce siab dua, thiab txhim kho myocardial kev ua haujlwm myocardial, thiab txhim kho myocardial pab nyiaj txiag. Nws tsis tuaj yeem tsuas yog nce lub sijhawm ua kom ntshav tiv thaiv thiab nce ntshav ntshav thiab ua kom cov ntshav tawm tsam, pab kom tswj cov ntshav tawm tsam, pab kom tswj ntshav rau cov kabmob tseem ceeb xws li lub hlwb thiab lub siab.
5. Tswj cov cim tseem ceeb
Tom qab them lub plawv ploj, norpinepinephrine bitartrate tuaj yeem siv cov ntshav siab, siv cov cim tseem ceeb uas muaj nqi. Ib qho ntxiv, nws kuj tseem tuaj yeem siv rau kev kho mob hypotaction thaum lub siab phem los ntawm cov ntshav tsis txaus los ntawm cov ntshav tsis muaj ntshav lossis tsis txaus tom qab kev sib kho mob phahechnocytoma.
Nov yog peb cov khoom lag luam tshaj plawsNoradristaline acid tartrat
Cov lus hais: Bloom Tech (Txij xyoo 2008), ua tiav chem - tech yog cov neeg pabcuam ntawm peb.
Lub sim synthesis ntawm L-4- amino-1-hydroxyethyl) -1,2-benzenediol bitartrate tuaj yeem nqa tawm los ntawm cov kauj ruam hauv qab no:
Tshuaj Muaj Tshuaj:
C8h8o {2+ Phenylhydredrazine mesylate → p}} hydroylhacetophenophenazenone
P - hydroxyacetophenone Penyyl Hydazine + h2+ catalyst → L-4- (2-amino-1-hydroxyethyl) -1,2-benzeniol
Tshuaj Muaj Tshuaj:
L-4- (2-amino-1-hydroxyethyl) -1,2-benzeniol + cl2OS + PAST → L-4- (2-AMINO-1-Hydroxyethyl) -1,2-Benzeniol Penyylhydrazine Sulfite
Tshuaj Muaj Tshuaj:
L-4- (2-amino-1 hydroxyethyl) -1,2-benzeniol penyylhydrazine sulfite + c8H11Tsis muaj → l-4- (2-amino-1 hydroxyethyl) -1,2-benzeniol penyylhydrrazine
Tshuaj Muaj Tshuaj:
L-4- (2-amino-1 hydroxyethyl) -1,2-benzeniol phenylhydrazine + c4H6O6→ L-4- (2-amino-1 hydroxyethyl) -1,2-benzeniol bitartrate
Thov nco ntsoov tias cov saum toj no tsuas yog cov kauj ruam yooj yim thiab coj cov tshuaj sib txig sib luag rau L-4- Hydroxyethyl) -1,2-benzeniol bitartrate. Hauv cov xwm txheej tiag tiag, nws yuav tsim nyog los ua kom zoo thiab kho cov tshuaj tiv thaiv, cov kuab tshuaj, thiab catalysts. Ib qho ntxiv, kom muaj kev nyab xeeb thiab ua tiav tus nqi, thov ua raws cov txheej txheem kev tshawb fawb kom raug thiab ua cov qauv ntaub ntawv uas muaj kev sim raws li kev sim tshwj xeeb.
Tsuas yog ib tus pab pawg carboxyl hauv cov molecule ntawm tartaric acid yog dehydogenated thiab salted nrog norepinephrine, uas yog lub npe hu ua bariterate lossis bitartrate. Cov kua aqueous muaj qee cov acidity. Qhov laj thawj ntawm kev siv Tartaric acid rau ntsev norpinephrine yog cov khoom ntawm chairal daws teeb meem.
Noradrenle Acid Tartrate txoj kev - neutralization tort txoj kev. Txoj kev ntsuas cov ntsiab lus: cov ntsuas ntsuas tau muab tso rau hauv cov tshuaj accetic, txuas nrog cov tshuaj acchloric viet, 0.1 mol / l) kom txog rau thaum txoj kev daws teeb meem xiav thiab ntsuab. Nyeem tawm cov nyiaj ntawm perchloric acid titration daws thiab laij cov ntsiab lus ntawm norspinephrine tartrate.
L-4- (2-amino-1-hydroxyethyl) -1,2-Benzenediol tartrate yog qhov sib txuas txuas dav hauv cov chaw muag tshuaj.
L-4- (2-amino-1-hydroxyethyl) -1,2-benzeniol bowers yog siv los ua cov kab mob plawv yog feem ntau siv los ua cov kab mob plawv, arhythermia, mob plawv, thiab lub plawv tsis ua haujlwm. Nws suppresses cov kev ua si ntawm cov neeg txais txo cov kev ua lag ua thiab lub plawv dhia ntawm lub plawv, yog li txo lub nra rau lub siab.
Bisoprolol Free Base Tartrate tuaj yeem siv ua thawj - kab tshuaj rau tswj ntshav siab. Nws pab txo qis cov ntshav siab qib siab thiab txo qhov kev pheej hmoo ntawm cov kev phom sij plawv los ntawm kev txo cov kev cog lus thiab lub plawv dhia ntawm lub plawv, txo cov ntshav siab.
L-4- (2-amino-1-hydroxyethyl) -1,2-benzeniol bitartrate yog dav siv nyob rau hauv kev kho mob ntawm myocardial infarction. Nws tuaj yeem txo qhov kev pheej hmoo ntawm kev rov muaj dua los ntawm myocardial infarction thiab txo qhov tshwm sim ntawm cov xwm txheej plawv.
Qhov no yuav siv tau los daws cov tsos mob ntawm angina (ib hom mob hauv siab los ntawm kev ua txhaum kev cai lij choj ntshav). Los ntawm kev txo cov kev thauj neeg lub npav thiab txo cov pa oxygen xav tau, nws tuaj yeem pab txo qhov mob hauv siab thiab tsis xis nyob los ntawm angina.
Bisoprolol Free Base Tarstrate muaj qee yam kev kho mob ntawm kev tswj hwm arrhythmia xws li ventricular fibrillation. Nws suppresses cov kev ua ntawm cov receptors tswj cov kev ua haujlwm hauv plawv, thiab ua tiav cov nyhuv ntawm kev kho arrhythmia.
L-4- (2-amino-1-hydroxyethyl) -1,2-benzeniol Bitartrate tuaj yeem siv los ntawm cov tshuaj tiv thaiv thiab mob hnyav ntawm migraine tawm tsam hauv cov neeg mob. Nws plays lub luag haujlwm hauv kev txo tus mob migraine los ntawm kev tswj hwm cov neurotransmitters thiab ua rau cov hlab ntshav lawj.
Bisoprolol Free Base Tarstrate yog qee zaum siv los kho hyperthyroidism. Nws tuaj yeem tiv thaiv cov teebmeem ntawm cov thyroid hormones ntawm cov nyhuv txhawb nqa cov kev ua haujlwm ntawm cov hlab plawv thiab cuam tshuam ntawm cov thyroid hormones.
Ntxiv rau cov ntawv thov tseem ceeb tau hais los saum toj no, Noradrenline Acid Tartrate tseem tau siv rau lwm cov kev ntxhov siab thiab kev kawm ntawm neuroprotecive cuam tshuam.
Cov molecular qauv ntawmNoradristaline acid tartratYog C8H11PENO3 · C4HH6O6, muaj qhov hnyav molecular ntawm 337.28. Nws muaj ob ntu: norepinephrine thiab bitartrate. Norepinephrine yog lub ntsiab bioctive sib zog, thaum tartaric acid ua raws li ib qho kua qaub ua kom nws cov dej solubility.
Los ntawm cov qauv tshuaj kho cov qauv siv tshuaj, norpinephrine bitartrate muaj ib pawg banzene, uas tau txuas nrog ob pawg hydroxyl ({}}}}}}}}}}}}}}} nh2). Tsis tas li ntawd, nws tseem muaj ib sab saw nrog lub methyl pawg ({4}}}}} h h h h h h h h h h h h h h h h h h h h h h h Cov pab pawg ua tiav no Xaus Norepinephrine bitartrate nrog cov khoom ua haujlwm tshwj xeeb thiab cov khoom siv pharmacological.
2, molecular qauv txheeb xyuas
1. Benzene Ring qauv: Lub nplhaib Benzene yog tus tseem ceeb ntawm cov qauv molecular ntawm norepinephrine bitartrate. Lub Π Electron huab ntom rau ntawm Benzene Ring yog siab, uas muab lub nplhaib Benzene muaj txiaj ntsig zoo thiab cov nyhuv sib txuas. Cov yam ntxwv no ua rau norepinephrine bitartrate rau khi rau ntau tus neeg txais hauv cov kab mob hauv lub cev, ua ntau yam kev cuam tshuam ntawm lub cev.
2. Cov pab pawg ua haujlwm tau:
Hydroxyl (- hhok):
Cov molecule ntawm norepinephrine bitartrate muaj ob pawg hydroxyl, nyob ntawm lub nplhaib Benzene thiab sab caj npab, feem. Cov pab pawg hydroxyl tuaj yeem tsim cov hlua dej hydrogen nrog cov roj av hauv cov tsiaj muaj sia, yog li nce lawv cov dej solubility. Nyob rau tib lub sijhawm, cov pab pawg hydroxyl kuj muaj qee cov txheej txheem acidity thiab tuaj yeem yeb cov tshuaj uas muaj cov tshuaj lom neeg hauv cov kab mob, txuas ntxiv ua lawv cov kev ua haujlwm.
Amino pab pawg (- nh2):
Cov pab pawg amino yog ib pab pawg tseem ceeb hauv cov molecule ntawm norpinephrine bitartrate. Cov pab pawg amino tuaj yeem hnov mob muaj ntau yam tshuaj nyob rau hauv cov muaj sia, xws li cov protons nrog cov protons nrog cov neeg ua yeeb yam ammonium, thiab sib sau cov roj ntsha nrog cov roj carboxylic. Cov kev tawm tsam no tsis yog cuam tshuam rau cov chaw muag tshuaj ntawm cov kws tshuaj noopinephrine bitartrate, tab sis kuj tseem muaj cov metabolism me ntsis rau nws cov kab mob.
Methyl (-} ch3):
Methyl yog ib pawg hydrocarbon yooj yim ntawm ib sab saw. Nws muaj qhov txawv ntawm Norepinephrine Bitharfate los ntawm catcholine compounds xws li adrenaline xws li adrenaline. Lub xub ntiag ntawm cov pab pawg methyl yuav cuam tshuam kev sib txuam ntawm norepinephrine bitartrate nrog cov receptors, nrog rau nws qhov ruaj khov thiab metabolism hauv cov tsiaj muaj sia.
Cov Qauv Txheej Txheem:
Lub stereostructure ntawm norepinephrine bitartrate muaj qhov cuam tshuam tseem ceeb ntawm nws cov kev ua haujlwm roj ntsha. Piv txwv li, cov txheeb ze cov haujlwm ntawm cov chaw nyob ntawm lub nplhaib Benzene thiab cov pab pawg ua haujlwm ntawm cov saw hauv chaw nyob hauv qhov chaw muaj kev cuam tshuam nrog lawv cov khoom siv. Yog li ntawd, txoj kev kawm ntawm stereostructure ntawm norepinepinephrine me ntsis ua rau muaj kev nkag siab tob ntawm nws txoj kev ua.
Cim npe nrov: Nororrenaline Acud Sartritures Cas 69815-49-2, Tus neeg muab khoom, chaw tsim khoom, Hoobkas, lag luam wholesale, yuav, nqe, loj, rau muag