Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm albendazole hmoov cas 54965-21-8 hauv Suav teb. Zoo siab txais tos rau cov lag luam wholesale bulk zoo albendazole hmoov cas 54965-21-8 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Albendazole hmoovyog ib tug hluavtaws organic compound nrog cov tshuaj formula C12H15N3O2S, thiab nws belongs rau cov chav kawm ntawm broad -spectrum imidazole derivative antifungal thiab anthelmintic tshuaj. Thawj zaug pom los ntawm Lub Tsev Saib Xyuas Kev Noj Qab Haus Huv Tsiaj ntawm GlaxoSmithKline (GSK) hauv xyoo 1972, qhov sib xyaw no txij li tau txais kev lees paub dav dav thiab qhov tseem ceeb ntawm kev kho mob vim nws qhov ua tau zoo thiab kev nyab xeeb profile.
Qhov tseem ceeb, albendazole tau raug suav nrog hauv Lub Koom Haum Saib Xyuas Kev Noj Qab Haus Huv Ntiaj Teb (WHO) Tus Qauv Sau Cov Tshuaj Tseem Ceeb, qeb duas ntawm cov tshuaj tseem ceeb tshaj plaws kev noj qab haus huv thoob ntiaj teb rau nws lub luag haujlwm tsis tuaj yeem hloov pauv hauv kev tawm tsam cov kab mob parasitic. Raws li kev ua tau zoo, qis - lom, thiab dav - spectrum anthelmintic tus neeg saib xyuas, nws tau raug qhia hauv kev kho mob los ntawm ntau yam kab mob hauv plab, nrog rau cov kab mob roundworms, pinworms, tapeworms, whipworms, hookworms, thiab fecal nematodes, thiab lwm yam.
Cov txheej txheem ntawm kev ua ntawm albendazole yog qhov tseeb: tom qab tau nqus hauv lub cev, nws tau metabolized rau hauv cov metabolites nquag xws li sulfoxides thiab sulfones. Cov tshuaj nquag no ces ua rau lawv cov nyhuv anthelmintic los ntawm inhibiting parasite lub peev xwm nqus cov piam thaj, uas ua rau cov khw muag khoom glycogen depletion hauv cov cab hauv lub cev. Tsis tas li ntawd, lawv tuaj yeem cuam tshuam cov kab ke fumarate reductase hauv cov kab mob cab, yog li cuam tshuam kev tsim cov adenosine triphosphate (ATP)- lub zog tseem ceeb rau kev ua haujlwm ntawm tes. Thaum kawg, lub zog tsis txaus no tiv thaiv cov kab mob tsis muaj sia nyob, loj hlob, thiab rov tsim dua, ua tiav lub hom phiaj ntawm kev tshem tawm cov kab mob.
Nyob rau tib lub sijhawm, peb lub tuam txhab tsis yog tsuas yog muab cov hmoov ntshiab, tab sis kuj muaj cov ntsiav tshuaj thiab kev ncua. Yog tias xav tau, thov koj xav tiv tauj peb txhua lub sijhawm.
Peb Cov Khoom
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Albendazole COA
Albendazole hmoovyog ib qho dav -spectrum antiparasitic tshuaj siv los kho ntau yam kab mob parasitic. Nws tuaj yeem tshem tawm ntau yam kab mob sib kis, kab kab kab, kab nuv ntses, kab nuv ntses, kab mob ntsws, kab kab mob, thiab lwm yam uas nyob hauv tib neeg lub cev raws li cov neeg laus thiab cov larvae. Albendazole yog thoob ntiaj teb lees paub tias yog tshuaj muaj kev nyab xeeb thiab siv tau zoo, uas yog siv dav hauv kev kho mob ntau yam kab mob.
Ascariasis:
Ascariasis yog kab mob cab uas tshwm sim los ntawm cov kab mob cab kab mob hauv tib neeg lub cev, feem ntau tshwm sim los ntawm kev noj zaub mov lossis dej haus uas kis los ntawm cov qe cab cab. Ascariasis feem ntau tshwm sim hauv cov menyuam yaus thiab tuaj yeem ua rau cov tsos mob xws li mob plab, xeev siab, ntuav, tsis qab los noj mov, thiab noj tsis txaus. Rau ascariasis, Albendazole tuaj yeem tshem tawm cov kab mob kab mob thiab cov neeg laus, tiv thaiv thiab kho tus kab mob zoo.
Tus kab mob Whipworm:
Trichuriasis yog cov kab mob cab uas tshwm sim los ntawm cov kab mob nplawm kab mob ntawm cov kab mob ntawm cov hnyuv thiab qhov quav. Cov neeg mob feem ntau muaj cov tsos mob xws li mob plab thiab raws plab. Tawm tsam tus kab mob parasitic no, Albendazole sai tshem tawm cov neeg laus thiab cov kab mob larvae thiab rov ua haujlwm ntawm plab hnyuv.
Pinworms:
Tus kab mob Pinworm yog kab mob cab uas tshwm sim los ntawm tib neeg tus kab mob pinworms nyob rau hauv txoj hnyuv, feem ntau yog vim noj los yog sib cuag nrog cov qe kab mob. Cov neeg mob pinworms yuav muaj cov tsos mob xws li raws plab, mob plab, thiab plab hnyuv. Rau pinworms, Albendazole tuaj yeem tshem tawm cov kab mob cab thiab cov neeg laus, thiab txo cov tsos mob sai.
Kab mob Hookworm:
Hookworm kab mob yog kab mob cab uas tshwm sim los ntawm cov kab mob hookworms nyob rau ntawm phab ntsa ntawm cov hnyuv thiab tuaj yeem ua rau tsis muaj zaub mov noj, ntshav ntshav, tsis muaj zog, thiab lwm yam tsos mob ntawm lub cev qaug zog. Albendazole tshem tawm cov neeg laus thiab cov larvae, tshem tawm cov kab mob, thiab txhim kho kev noj qab haus huv ntawm cov neeg mob.
Taeniasis:
Taeniasis yog kab mob cab uas tshwm sim los ntawm cov kab mob tapeworms uas nyob hauv tib neeg txoj hnyuv, feem ntau yog los ntawm kev noj cov nqaij npuas uas muaj kab mob los yog lwm yam khoom noj uas muaj kab mob. Cov neeg mob yuav muaj cov tsos mob xws li mob plab, xeev siab, ntuav, thiab ntshav liab. Rau cov kab mob tapeworms, Albendazole tuaj yeem tshem tawm cov kab mob tapeworm sai sai, tswj tus kab mob zoo.
Paragonimiasis:
Paragonimiasis yog kab mob parasitic tshwm sim los ntawm paragonimiasis parasitic nyob rau hauv tib neeg lub ntsws. Cov neeg mob feem ntau muaj cov tsos mob xws li hnoos, ua pa nyuaj, mob ntsws, thiab hnoos ntshav. Albendazole tuaj yeem tshem tawm cov neeg laus thiab cov larvae, txo cov tsos mob xws li mob ntsws thiab hnoos, thiab tswj tau tus kab mob zoo.
Hauv kev xaus, Albendazole yog ib qho kev nyab xeeb thiab siv tau dav -spectrum antiparasitic tshuaj, uas yog dav siv nyob rau hauv kev kho mob ntawm ntau yam kab mob parasitic. Cov kws kho mob yuav sau ntau npaum li cas thiab cov kev kawm ntawm Albendazole los kho cov kab mob cab raws li cov kab mob sib txawv thiab cov xwm txheej ntawm cov neeg mob..
Txoj kev hluavtaws ntawmalbendazole hmoovFeem ntau muab faib ua peb kauj ruam: cov tshuaj tiv thaiv nitration, txo cov tshuaj tiv thaiv thiab cov tshuaj tiv thaiv sulfuration.
Lub synthesis ntawm Albendazole pib nrog 4-chloro-5-methylthiophene-2-carboxylic acid (4-chloro-5-methylthiophene-2-carboxylic acid), uas yog tsim los ntawm sulfonation thiab methylation. Tom qab ntawd, nyob rau hauv alkaline tej yam kev mob, lub compound reacts nrog nitric acid kom tau cov coj nitrated khoom 5-nitro-4-chloro-2-[(methylsulfonyl)amino]benzoic acid (5-nitro-4-chloro-2-[ (methylsulfo)amino]benzoic acid).
Tom qab ntawd cov khoom siv nitrated yog tov nrog sodium nitrite thiab sodium hydroxide, thiab tom qab ntawd txo nrog hydrogen nyob rau hauv catalysis ntawm palladium kom tau cov compound 5-amino-4-chloro-2-[(methylsulfonyl)amino]benzoic acid (5-amino- 4-Chloro-2-[(methylsulfo)amino]benzoic acid).
Cov kauj ruam kawg yog cov tshuaj tiv thaiv sulfurization, uas qhia txog lub nplhaib phenylthiazole hauv 5-amino-4-chloro-2-[(methylsulfonyl)amino] benzoic acid. Ua ntej, hnov mob 5-amino-4-chloro-2-[(methylsulfonyl)amino] benzoic acid nrog phenylpropyleneimine los tsim ib qho nruab nrab ob daim ntawv cog lus. Tom qab ntawd siv sodium thioethoxide (NaSET) los ua kom txo qis vulcanization cov tshuaj tiv thaiv hauv cov kab cawv lossis cawv ether los tsim Albendazole (Albendazole)
Feem ntau, txoj kev hluavtaws ntawm Albendazole yog qhov nyuaj, tab sis nws tau paub txog cov ntsiab lus ntawm nitrogen, oxygen, thiab leej faj los ntawm cov qauv sib txawv, uas muaj qhov tseem ceeb ntawm kev nkag siab qhov tseem ceeb rau cov organic chemists.
Albendazole, ib qho dav -spectrum thiab muaj txiaj ntsig zoo tshuaj tiv thaiv kab mob, ua haujlwm tseem ceeb hauv ob qho tib si kws kho tsiaj thiab tib neeg cov tshuaj vim nws ntau yam kev siv thiab cov txiaj ntsig kho mob tseem ceeb. Raws li cov tshuaj nyiam rau kev kho ntau yam kab mob cab, albendazole tuaj yeem tsis tsuas yog tawm tsam ntau yam kab mob xws li kab mob sib kis, kab mob sib kis, kab mob npaws, kab mob hauv plab trichomonas, microsporidia, thiab lwm yam.
Ua ntej
Ib tug ntawm cov pharmacological mechanisms ntawmalbendazole hmoovyog los ntawm kev cuam tshuam nrog cytoskeleton system ntawm cov kab mob. Lub cytoskeleton yog cov qauv tseem ceeb rau kev tswj cov cell morphology, stability, thiab motility, thaum albendazole tuaj yeem xaiv khi rau microtubule proteins hauv cov kab mob cab. Qhov kev khi no muaj qhov tshwj xeeb thiab tuaj yeem tiv thaiv cov txheej txheem polymerization ib txwm ntawm microtubule proteins, ua rau muaj kev tsis sib haum xeeb thiab txawm tias kev puas tsuaj ntawm cov kab mob cab cell cytoskeleton. Thaum cov cytoskeleton cuam tshuam, cov kab mob yuav poob lawv daim ntawv qub thiab kev txav mus los, ua rau muaj kev hem thawj loj rau lawv txoj sia nyob thiab kev yug me nyuam. Tshwj xeeb, albendazole khi rau microtubule proteins, ua rau cov qauv microtubule hauv cov kab mob cab tsis ruaj khov thiab tsis tuaj yeem tswj hwm cell morphology thiab polarity ib txwm. Qhov kev cuam tshuam ntawm cov qauv no tsis tsuas yog cuam tshuam rau kev txav mus los thiab kev muaj peev xwm hauv cheeb tsam ntawm cov kab mob cab, tab sis kuj ua rau muaj kev cuam tshuam hauv lawv cov cell faib thiab kev tsim tawm, tswj cov naj npawb thiab kev ua haujlwm ntawm cov kab mob.
Thib ob
Albendazole kuj tseem siv cov tshuaj kho mob los ntawm kev cuam tshuam nrog cov txheej txheem metabolic ntawm cov kab mob cab. Kev ua haujlwm metabolic ntawm cov kab mob parasites yog lub hauv paus rau lawv txoj sia nyob thiab kev tsim tawm, thiab albendazole tuaj yeem cuam tshuam ncaj qha rau hauv txoj hauv kev metabolic ntawm cov kab mob. Ntawm ib sab, nws tuaj yeem cuam tshuam qhov nqus thiab siv cov piam thaj los ntawm cov kab mob cab, uas yog ib txoj hauv kev tseem ceeb rau cov kab mob kom tau txais lub zog. Los ntawm inhibiting kev thauj mus los thiab cov metabolism hauv qabzib, albendazole deprives parasites ntawm lub zog qhov chaw lawv xav tau los tswj lub cev kev ua ub no, ua rau muaj kev cuam tshuam metabolic kev ua ub no thiab tsis muaj peev xwm tswj tau txoj sia nyob.
Ntawm qhov tod tes, albendazole tuaj yeem cuam tshuam nrog ATP synthesis thiab kev siv cov kab mob cab. ATP yog lub ntsiab lus tseem ceeb ntawm lub zog cia hauv cov hlwb thiab tseem ceeb heev rau kev ciaj sia thiab kev tsim tawm ntawm cov kab mob. Albendazole inhibits cov synthesis ntawm ATP los ntawm cov kab mob los yog cuam tshuam cov qauv ntawm ATP, ua rau nws nyuaj rau cov kab mob kom zoo siv ATP los txhawb lawv lub cev kev ua ub no, yog li ua rau lawv muaj peev xwm ciaj sia taus ntxiv. Tsis tas li ntawd, albendazole tuaj yeem cuam tshuam cov txheej txheem synthesis ntawm cov kab mob parasite proteins thiab nucleic acids, uas yog cov khoom tseem ceeb rau cov kab mob loj hlob thiab kev loj hlob. Los ntawm kev cuam tshuam nrog cov synthesis ntawm cov biomolecules, albendazole tuaj yeem cuam tshuam kev loj hlob thiab kev loj hlob ntawm cov kab mob parasites, yog li ua tiav lub hom phiaj ntawm kev tswj cov kab mob parasitic.
Thib peb
Ntxiv nrog rau kev cuam tshuam nrog cov txheej txheem cytoskeleton thiab cov txheej txheem metabolic, albendazole tuaj yeem siv tshuaj kho los ntawm kev cuam tshuam cov qauv chromosome ntawm cov cab. Chromosomes yog cov nqa ntawm cov ntaub ntawv caj ces hauv cov hlwb, thiab lawv cov kev sib cais thiab kev faib tawm yog qhov tseem ceeb rau kev loj hlob ntawm tes thiab kev loj hlob. Thiab albendazole tuaj yeem cuam tshuam nrog kev sib cais ntawm chromosome thiab kev faib cov txheej txheem thaum cov kab mob parasite cell faib. Tshwj xeeb, nws tuaj yeem cuam tshuam cov qauv chromosome hauv cov kab mob cab los ntawm inhibiting tsim ntawm microtubules thiab spindles. Microtubules thiab spindles yog cov qauv tseem ceeb uas muaj lub luag haujlwm rau kev sib cais ntawm chromosome thiab kev faib tawm thaum lub sijhawm cell faib, thiab albendazole tuaj yeem cuam tshuam kev tsim thiab kev ua haujlwm ntawm cov qauv no. Thaum cov txheej txheem ntawm kev sib cais ntawm chromosome thiab kev faib tawm raug cuam tshuam, cov kab mob cab yuav tsis tuaj yeem faib thiab rov tsim dua ib txwm, ua rau lawv cov lej thiab kev ua haujlwm poob qis. Qhov kev cuam tshuam ntawm cov qauv chromosome no yog ib qho tseem ceeb ntawm albendazole hauv kev kho cov kab mob parasitic.
Plaub
Albendazole tseem muaj cov teebmeem immunomodulatory, uas tuaj yeem txo qhov kev mob tshwm sim los ntawm cov kab mob cab los ntawm kev tswj hwm tus tswv tsev lub cev tiv thaiv kab mob. Cov kab mob parasitic feem ntau ua rau muaj kev teb zoo los ntawm tus tswv tsev lub cev tiv thaiv kab mob, ua rau muaj kev mob ntxiv thiab kev puas tsuaj rau cov kab mob hauv nruab nrog cev. Abendazole hmoov tuaj yeem txo cov kev mob tshwm sim los ntawm inhibiting kev ua haujlwm ntau dhau ntawm lub cev tiv thaiv kab mob, yog li tiv thaiv cov kab mob hauv nruab nrog cev los ntawm kev puas tsuaj ntxiv.Qhov kev tiv thaiv kab mob no tsis tsuas yog pab txo cov tsos mob, tab sis kuj txhawb kev tshem tawm cov kab mob sai dua thiab ua kom cov txheej txheem rov qab los. Tshwj xeeb, albendazole tuaj yeem cuam tshuam kev tsim khoom thiab tso tawm ntawm qee yam kab mob hauv lub cev tiv thaiv kab mob, xws li interleukin thiab qog necrosis.
Cov kab mob inflammatory no ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv kab mob parasitic, tab sis lawv cov kev tsim tawm thiab tso tawm ntau dhau tuaj yeem ua rau muaj kev mob hnyav thiab kev puas tsuaj rau cov kab mob hauv nruab nrog cev. Los ntawm inhibiting zus tau tej cov thiab tso tawm ntawm cov inflammatory yam tseem ceeb, albendazole tuaj yeem txo cov qib thiab lub sijhawm ntawm cov tshuaj tiv thaiv kab mob, yog li tiv thaiv cov kab mob hauv nruab nrog cev los ntawm kev puas tsuaj ntxiv.
Albendazole, raws li qhov dav -spectrum thiab cov tshuaj tiv thaiv kab mob zoo heev, muaj txiaj ntsig zoo thiab cov txiaj ntsig kho mob hauv kev kho ntau yam kab mob parasitic. Nws ntau - lub hom phiaj kws tshuaj tuaj yeem cuam tshuam rau lub neej voj voog thiab cov txheej txheem metabolic ntawm cov kab mob cab, cuam tshuam lawv cov cytoskeleton thiab chromosome qauv, thiab txo cov kev mob tshwm sim thiab txhawb nqa cov kab mob tshem tawm los ntawm kev tiv thaiv kab mob. Txawm li cas los xij, tej zaum yuav muaj kev pheej hmoo thiab kev ceev faj yuav tsum tau coj mus rau hauv tus account thaum siv los ua kom muaj kev nyab xeeb thiab ua tau zoo ntawm kev kho mob. Nyob rau hauv lub neej yav tom ntej, nrog rau hauv - kev tshawb fawb tob ntawm lub pharmacological mechanism ntawmalbendazole hmoovthiab kev sib sau ua ke ntawm kev siv tshuaj kho mob, nws ntseeg tau tias cov tshuaj no yuav ua lub luag haujlwm tseem ceeb hauv kev kho cov kab mob parasitic.
Tus nqi- tsom xam cov txiaj ntsig hauv kev lag luam tsiaj txhu
Nqi peev
Tus nqi ntawm albendazole raw tshuaj yog li ntawm 150 txog 300 yuan ib kilogram. Loj - kev yuav khoom loj tuaj yeem txo nqi ntxiv. Noj 100,000-head npua teb ua piv txwv, yog tias 750 grams ntawm albendazole ntxiv rau txhua tuj pub, tus nqi yuav khoom txhua xyoo yog kwv yees li 81,000 yuan (ntawm tus nqi yuav ntawm 180 yuan ib kilogram).
Yog hais tias cov formulation yog optimized rau ib tug sustained - tso tawm npaj, txawm hais tias chav tsev nqi nce mus rau 1.2 yuan ib gram, qhov zaus ntawm kev siv yog txo los ntawm 60%, thiab tag nrho cov nqi yuav raug txo los ntawm 25%. Lub tshuab pub mis tsis siv neeg ua kom luv rau ib zaug - lub sijhawm noj tshuaj los ntawm 8 teev mus rau 2 teev, txuag 12,000 yuan hauv cov nqi zog txhua xyoo. Raws li kev kaw cia, qhov kev poob txhua xyoo ntawm cov khoom siv raw yog tsawg dua 0.3%, uas yog 72% qis dua li kev khaws cia.
Comprehensive economic rov qab
Noj ib tug npua ua liaj ua teb nrog ib xyoos ib zaug tso tawm ntawm 10,000 npua ua piv txwv, ua ntej deworming, kab mob cab ua rau ib xyoos twg poob ntawm 450,000 yuan. Tom qab deworming, qhov poob tau txo mus rau 120,000 yuan, thiab cov nyiaj tau los tau nce los ntawm 327,000 yuan ib xyoos twg. Cov txiaj ntsig muaj xws li:
Kev txhim kho kev tsim khoom:Qhov hnyav nce, ntau dua wool ntau lawm, ntau dua qe ntau lawm, thiab lwm yam, ncaj qha nce cov nyiaj tau los ntawm kev yug tsiaj txhu;
Kev txo nqi kho mob: Txo tus nqi ntawm kev kho tshuaj vim muaj kab mob cab;
Kev txo qis kev tuag:Txo cov tsiaj tuag los ntawm cov kab mob cab;
Kev txhim kho khoom zoo:Cov ntsiab lus ntawm cov kab mob hauv cov nqaij txo qis, thiab cov ntsiab lus ntawm cov qe kab mob parasite hauv cov mis nyuj txo qis, txhim kho cov nqi lag luam;
Ua cov nqi optimization:Txo cov nqi ntawm kev ua cov kauj ruam xws li ntxuav nqaij thiab mis kom tsis muaj menyuam.
Cov txiaj ntsig dej ntws:
Kab mob kab mob ua rau 8-15% txo qis hauv cov tsiaj nyeg txhua hnub, qhov tsis zoo ntawm kev hloov pauv hloov pauv los ntawm 5-10%, thiab txo qis 20-30% ntawm cov poj niam cov tsiaj txhu hauv cov xwm txheej hnyav, thiab nce ntawm 15% ntawm cov nyuj tuag. Albendazole inhibits polymerization ntawm microtubules ntawm cov kab mob los cuam tshuam nrog lawv cov metabolism hauv lub zog, thiab muaj txiaj ntsig zoo tua cov kab mob nematodes, tapeworms, thiab flukes. Cov ntaub ntawv sim qhia tau hais tias tom qab deworming, qhov hnyav txhua hnub ntawm cov nyuj nyuj nce ntxiv los ntawm 12.3%, thiab tus nqi hloov pauv hloov pauv tau nce los ntawm 8.7%. Rau npua, tus nqi deworming ntawm npua roundworm thiab posterior roundworm yog siab dua 98%, thiab qhov hnyav ntawm piglets nce 1.5-2.0 kilograms. Rau cov yaj, cov neeg laus cov kab mob ntawm cov ntshav nqus cov nematode thiab Ostertagia raug tshem tawm ntawm tus nqi ntau dua lossis sib npaug li 95%, thiab cov neeg laus cov kab mob siab ntawm daim siab fluke raug tshem tawm ntawm tus nqi ntawm 85% ntawm kev siv tshuaj ntau. Tsis tas li ntawd, cov tshuaj no tuaj yeem txhim kho tus tswv tsev lub cev tiv thaiv kab mob, ua kom cov ntshav IgG nce 20-30% thiab txo qhov kev pheej hmoo ntawm kev kis mob thib ob.
Cim npe nrov: Albendazole hmoov CAS 54965-21-8, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom