Carisoprodol hmoov, tseem hu ua Kartil, myolysis, iMidaclampide, isoprophamide, isoproplamide, oocheptanediol, thiab lwm yam. Cov qauv molecular yog c12h24n2o4, nrog lub cev hnyav ntawm 260.330 thiab ib lub pov haum ntawm {6}}. Nws zoo li cov hmoov dawb lossis dawb crystalline hmoov. Cov hmoov no yog ruaj khov nyob rau hauv chav tsev kub thiab siab thiab tsis yooj yim decomposed. Nws qhov ceev yog txog 1.056 g / cm ³, uas txhais tau tias nws cov huab hwm coj yog lub teeb thiab yooj yim rau kev daws teeb meem. Hauv tib neeg lub cev, caliphamide hloov dua siab tshiab rau nws cov metabolite, methylprednisolone, los ntawm n-dealkylation los ntawm CYP2C19 enzyme. Tus nqi ntawm qhov caliphamide yog metabolized rau nws cov metabolized nquag yog cuam tshuam rau CYP2C19 enzyme polymorphism. Txoj cai no ua rau cov polymorphism no ua rau muaj kev sib txawv hauv cov metabolic tus nqi thiab bioavailability ntawm cov tib neeg. Txawm li cas los xij, nws yuav tsum raug sau tseg tias cov khoom no tsuas yog siv rau kev kuaj tshawb fawb thiab raug yuam kev txwv tsis pub siv rau lwm lub hom phiaj.
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Tshuaj Cov Qauv |
C12H24N2O4 |
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Muaj pes tsawg leej |
260.17 |
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Molecular hnyav |
260.17 |
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m/z |
260.17 (100.0%), 261.18 (13.0%) |
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Kev Ntsuam Xyuas |
C, 55.36; H, 9.29; N, 10.76; O, 24.58 |
Kev txhim kho thiab kev thov ntawm cov tshuaj antigens thiab lawv cov tshuaj tiv thaiv kev ua polyclon ib txwm ua lub luag haujlwm tseem ceeb hauv kev tshawb fawb thiab kev tshawb fawb. Kab lus no yuav delve rau hauv daim ntawv thov ntawm Kalbsa cov tshuaj tiv thaiv thiab kev soj ntsuam polyclon, txhawm rau soj ntsuam, thiab kev kho mob kom pom tseeb ntawm cov kev cia siab thiab muaj txiaj ntsig.
Carisoprodol hmoov, raws li cov compound nrog cov kev ua haujlwm tshwj xeeb, tau qhia cov muaj peev xwm tshwj xeeb hauv kev txhim kho cov tshuaj. Txawm li cas los xij, muaj ntau cov kev cov nyom hauv ncaj qha siv Calpidol rau kev tshawb fawb txhaj tshuaj lossis tshuaj ntsuam xyuas cov tshuaj tiv thaiv kab mob thiab tsis muaj zog. Yog li ntawd, kev npaj ntawm antiginal antigen ntawm Calpidol tau dhau los ua tus yuam sij los daws cov teeb meem no.
Kalbsa, raws li ib tug neeg tsim antigen ntawm calipudo, ho txhim kho nws txhaj tshuaj tiv thaiv kab mob thiab kev ruaj khov los ntawm kev hloov tshuaj lom thiab txuas nrog BSA. Cov txheej txheem tsim no antigen tsis tsuas yog khaws cov khoom siv roj ntsha (
Kev npaj ntawm Kalbsa muab cov cuab yeej tseem ceeb rau kev tsim tshuaj tiv thaiv tom qab, tshuaj ntsuam tshuaj yeeb tshuaj, thiab kuaj kab mob. Los ntawm kev txhaj tshuaj tiv thaiv kab mob thiab khaws cov ntshav dej, cov tshuaj tiv thaiv polyclonal tiv thaiv cov tshuaj tiv thaiv calipidor tuaj yeem tau txais, uas ua rau lub luag haujlwm tseem ceeb hauv cov ntawv thov txuas ntxiv.
Kev npaj ntawm anti kaleido clone tiv thaiv cov tshuaj tiv thaiv yog raws li kev txhawb nqa ntawm Kalebsa tsis muaj zog tiv thaiv kab mob. Los ntawm kev txhaj tshuaj tiv thaiv ntau zaus, lub cev tuaj yeem ua rau tsim cov tshuaj tiv thaiv tshwj xeeb tawm tsam calipidor. Cov tshuaj tiv thaiv no muaj nyob rau hauv ntau hom ntawv hauv dej hiav txwv, suav nrog immunoglibulins xws li IGG thiab IGM.
Txhawm rau kom tau txais cov kev coj dawb huv thiab muaj cov tshuaj pleev roj monoclonal tau tawm tsam caliplatin, cov txheej txheem ntawm cov txheej txheem ua kom huv si yuav tsum muaj. Firstly, cov tshuaj tiv thaiv tuaj yeem ua kom muaj kev ua kom huv los ntawm cov hau kev xws li ammonium sulfate nag lossis daus. Txawm li cas los xij, kev ua kom muaj kev huv ntawm cov tshuaj tiv thaiv tau los ntawm hom no txwv thiab yuav muaj lwm cov tshuaj tiv thaiv tsis yog. Yog li no, kev ua kom huv ntxiv siv afinity chromatography yog xav tau.
Affinity chromatography siv cov kev sib cuam tshuam tshwj xeeb ntawm antigys, ntes thiab ua kom cov tshuaj tiv thaiv kab ke nrog cov antigen. Hauv tsab xov xwm no, BSA Affinity kem thiab BGGG ARINAF COLIUS yog siv rau ob-kauj ruam purification. Firstly tshem tawm cov tshuaj tiv thaiv uas tsis khi tshwj xeeb rau BSA siv cov kab BSA Affinity; Tom qab ntawd, kev ua kom huv ntxiv tau nqa tawm siv cov kab hauv plab kom tau txais cov tshuaj tiv thaiv ntau thiab cov tshuaj tiv thaiv monoclonal tshwj xeeb tiv thaiv calipolido.
Cov tshuaj tiv thaiv huv tsis tsuas yog muaj kev coj dawb huv dua, tab sis kuj tseem ua kom muaj cov tshuaj tiv thaiv zoo thiab rhiab. Cov tshuaj tiv thaiv no tuaj yeem txheeb xyuas qhov tseeb thiab khi rau Calpidol hauv cov ntawv thov tom ntej, muab kev txhawb nqa zoo rau tshuaj ntsuam xyuas tshuaj, kuaj mob, thiab kuaj mob.
Hauv kev txhim kho cov tshuaj tsim tawm, caliphamide khoom siv antigens thiab lawv cov tshuaj tiv thaiv kev ua polyclonal muaj cov ntawv thov kev cia siab.
Firstly, lawv tuaj yeem ua cov cuab yeej los ntawm kev kuaj tshuaj yeeb tshuaj los ntsuas qhov sib txawv lossis inhibitory ua cov neeg sib tw ntawm lub calipidor. Los ntawm kev tsim cov tshuaj ntsuam xyuas cov tshuaj screen raws li Kalbsa, Mricbsa, muab kev txhawb zog rau kev loj hlob tshiab.
Thib ob, anti kaleidolon clone tshuaj tiv thaiv kuj tseem siv tau rau cov chaw tshawb xyuas pharcaconinate. Los ntsuas ntsuas cov kev sib khi ntawm cov tshuaj thiab cov tshuaj tiv thaiv, kev faib tshuaj hauv lub cev tuaj yeem nkag siab rau cov tshuaj tseem ceeb rau cov tshuaj.
Ib qho ntxiv, lub cev muaj zog tseem ceeb antigens thiab lawv cov tshuaj tiv thaiv kev ua polyclonal kuj tseem siv tau rau kev tshawb fawb immunogenicity ntawm cov tshuaj. Los ntawm kev tshuaj xyuas cov tshuaj tiv thaiv kev xav ntawm lub cev ntawm lub cev, tshuaj tiv thaiv kab mob huv, muab cov ntaub ntawv tseem ceeb rau kev tsim kho tshuaj thiab siv.
Hauv kev tiv thaiv kab mob,Carisoprodol hmoovAniginal antigens thiab lawv cov tshuaj tiv thaiv kev ua polyclonal kuj muaj cov ntawv thov thoob plaws.
Firstly, lawv tuaj yeem raug siv los ua cov khoom siv ntawm kev kuaj mob los tshawb xyuas qhov muaj ntawm lub sijhawm ntawm cov tshuaj tiv thaiv lossis cov tshuaj tiv thaiv ntsig txog cov neeg mob lub cev. Los ntawm kev tsim cov khoom siv kuaj mob raws li Kalbsa, nws yog qhov ua tau kom yooj yim rau cov theem ntawm Calipolido hauv cov neeg mob rau cov pov thawj ntawm cov kabmob.
Thib ob, anti kaleidolon monoclonal Antibodies kuj tseem siv tau rau tshuaj xyuas kab mob. Los ntawm kev soj ntsuam cov antibody qib hauv cov neeg mob lub cev nqaij, peb tuaj yeem nkag siab lawv cov lus teb rau kev kho thiab muab cov ntaub ntawv tseem ceeb rau kev kho cov phiaj xwm kho mob.
Tsis tas li ntawd, cov tshuaj tiv thaiv calipsido thiab lawv cov tshuaj tiv thaiv kev ua polyclonal kuj tseem siv tau rau kev kawm ntawm tus kab mob ntawm kab mob. Los ntawm kev kawm cov txheej txheem ntawm kev ua ntawm lub calipido nyob rau qhov tshwm sim thiab kev loj hlob ntawm cov kab mob, cov tswv yim thiab kev kho mob ntawm cov kab mob.
Hais txog kev soj ntsuam kev kho mob, Calipro agetial antigens thiab lawv cov tshuaj tiv thaiv kev ua polyclon kuj ua lub luag haujlwm tseem ceeb. Los ntawm kev saib xyuas theem ib txwm muaj los yog tshuaj tiv thaiv hauv cov neeg mob lub cev nqaij daim tawv, peb tuaj yeem nkag siab lawv cov lus teb rau kev kho thiab kho cov phiaj xwm kev kho mob kom ncav sijhawm.
Piv txwv li, hauv kev kho mob ntawm qee cov kab mob ntsig txog caliphamide, cov kev kho mob kho tuaj yeem ntsuas los ntawm kev kuaj pom ntawm cov neeg mob lub cev nqaij hlav. Yog tias theem ntawm lub calipidor hauv tus neeg mob lub hiav txwv tseem ceeb tau qis dua tom qab kev kho mob, nws qhia tau tias kev kho mob tau zoo; Ntawm qhov tsis sib xws, yog tias qib ntawm Calpidol tseem hloov pauv, nws yuav tsim nyog los kho txoj kev kho mob.
1. Kev tshawb fawb txog Calpidol txoj kev ua haujlwm roj ntsha, cov teebmeem hauv paus tshuaj thiab cov tshuab ntawm kev ua
Piv txwv li: Tshawb nrhiav lub luag haujlwm ntawm Calpidol hauv kev kho mob qog
Siv cov tshuaj tiv thaiv polyclonal npaj los ntawm Calip Multivers tsim antigen cov qib kev coj noj coj ua ntawm cov kab mob qog nqaij hlav tshuaj tiv thaiv kab mob Lub caij no, cov teebmeem ntawm calpidol ntawm cov qog nqaij hlav loj hlob thiab cov kev nthuav dav tau tshawb xyuas los ntawm kev tsim cov qauv qog nqaij hlav. Cov txiaj ntsig tau qhia tias Calpidol tuaj yeem ua rau muaj kev loj hlob ntawm cov qog nqaij thiab ua kom lawv lub hom phiaj. Cov kev kawm ntxiv qhia tias Calpidol yuav siv nws cov kev tswj hwm kev tawm tsam los ntawm kev tswj hwm cov phiajcim kev kawm tshwj xeeb) los ntawm cov kev siv tshuab. Qhov kev kawm no tsis yog muab cov lus tseem ceeb rau kev ua haujlwm rau kev ua haujlwm ntawm Calpidol, tab sis kuj muab cov hom phiaj tshiab rau cov qog kev kho.
2. Proeomics thiab Metabolomics Kev Kawm
Piv Txwv: Tshawb xyuas lub luag haujlwm ntawm Calipido nyob rau hauv cov ntshav qab zib ntawm ntshav qab zib mellitus
Siv cov tshuaj tiv thaiv kab mob polyclonic, cov kws tshawb nrhiav tshuaj tiv thaiv cov protein thiab cov tsiaj txhu uas muaj cov protein thiab cov tsiaj muaj protein thiab lwm yam. Cov txiaj ntsig tau qhia tias theem kev nthuav qhia ntawm tus qauv ntshav qab zib qauv tsiaj tau nce thiab nrog cov kev hloov pauv tsis zoo hauv cov metabolites. Kev soj ntsuam ntxiv qhia tias Calipido tuaj yeem koom nrog cov ntshav qab zib los ntawm kev cuam tshuam insulin kev tawm tsam, cov metabolism thiab lwm yam txheej txheem. Txoj kev kawm no muaj kev txiav txim siab thiab cov hau kev tshiab los qhia txog cov ntshav qab zib.
3. Cell Biology thiab Kev Tshawb Xyuas Kev Tshawb Fawb Biology
Piv Txwv: Tshawb nrhiav cov tshuab kev ua ntawm calipside hauv neurodegenerative kab mob
Raws li cov tshuaj tiv thaiv polyclonal npaj los ntawm calmovery teagen, cov kws tshawb nrhiav tau tsim cov kab xov tooj ntawm tes thiab siv cov xov tooj ntawm tes thiab kev tshawb fawb biology. Los ntawm kev ntws cytometry, immunofluorescence thiab lwm yam kev sib xyaw, cov kev cuam tshuam ntawm cov txheej txheem ntawm cov txheej txheem, txawv thiab apoptosis ntawm neural cell tau pom. Lub caij no, lub luag haujlwm ntawm calief hauv cov kab mob ntawm neurodegenerative cov noob thiab cov kev cai lij choj ntawm gene knockdown, kev cuam tshuam RNA thiab lwm yam kev sib xyaw. Cov txiaj ntsig tau pom tias calipside tuaj yeem tiv thaiv cov hlab ntsha hlwb los ntawm oxidative kev puas tsuaj thiab kho cov kev tsim kho neuronal thiab kho. Txoj kev kawm no muaj cov tshuaj muaj peev xwm tshiab rau kev kho mob ntawm neurodegenerative cov kab mob.
Hauv cov ntsiab lus, Calip Multives cov tshuaj antigen thiab cov tshuaj tua kab kev polyclon muaj ntau yam hauv cov tswv yim hauv paus, tab sis kuj tseem muab cov tswv yim thiab cov hau kev tshiab rau kev kho mob.
Calip neeg tsim antificial antigen thiab nws cov tshuaj tiv thaiv kev ua kom muaj kev cia siab ntawm cov kev npaj tshuaj thiab kev kuaj mob, kev soj ntsuam kev kuaj mob, thiab tshawb fawb txog kab mob pib. Nrog kev txhim kho txuas ntxiv thiab kev txhim kho ntawm cov thev naus laus zis, cov ntawv thov no yuav ua ntau dua thiab hauv qhov tob. Los txog, peb tuaj yeem tos ntsoov yuav ua kom tau kev nce qib ntxiv rau cov hauv qab no: Ua ntej txhim kho thiab txhim kho cov tshuaj tiv thaiv ntawm lub cev, txhim kho cov immunogenicity thiab ruaj khov ntawm cov antigen; Qhov thib ob yog los tsim cov kev paub zoo thiab rhiab thiab reagent cov khoom siv los txhim kho qhov raug thiab kev ntseeg tau ntawm kev kuaj mob; Qhov thib peb yog txhawm rau tshawb nrhiav hauv cov tshuab ntawm kev ua ntawm caliphamide hauv cov kab mob, muab cov tswv yim thiab kev tiv thaiv kab mob tshiab; Plaub yog kom nthuav tawm cov ntawv thov ntawm cov tshuaj antigens thiab lawv cov tshuaj polyclonal hauv lwm thaj teb, xws li kev nyab xeeb rau kev nyab xeeb thiab kev nyab xeeb ib puag ncig thiab ib puag ncig kev nyab xeeb.
Hauv cov ntsiab lus xaus, daim ntawv thov kev cia siab ntawmCarisoprodol hmoovThiab nws cov tshuaj tiv thaiv kev ua polyclonal yog qhov dav, uas yuav ua rau muaj kev hloov tshiab dua thiab tawg ua kev tshawb fawb biomedical thiab kev tshawb fawb. Peb cia siab tias yuav tshawb nrhiav tsis tu ncua thiab tshawb pom nws cov ntawv thov tshiab tus nqi thiab peev xwm hauv kev tshawb fawb yav tom ntej.
Cim npe nrov: Carisoprodol hmoov cas {{{{{}}, cov chaw muag khoom, chaw tsim khoom, Hoobkas, yuav, nqe, loj, rau muag