Cyclophosphamide Monohydrate hmoov CAS 6055-19-2

Cyclophosphamide monohydrate hmoovCov mis mos molecular: C7H17Cl2N2O3P, molecular hnyav: txog 279.1 g/mol, CAS 6055-19-2. Muaj nyob rau hauv daim ntawv ntawm cov xim tsis muaj xim lossis dawb crystalline solids. Nws cov tsos yog feem ntau nyob rau hauv hmoov los yog crystalline daim ntawv. Nruab nrab solubility hauv dej. Ntawm chav tsev kub, kwv yees li 50-100 grams ntawm Cyclophosphamide monohydrate tuaj yeem yaj hauv 100 milliliters dej. Tsis tas li ntawd, nws tuaj yeem yaj hauv ethanol, ether, dichloromethane thiab lwm cov kuab tshuaj organic. Relatively ruaj khov nyob rau hauv qhuav, tsaus, thiab tsis kub kub tej yam kev mob. Txawm li cas los xij, nws yog rhiab heev rau lub teeb, cua sov, thiab noo noo, yog li nws yuav tsum tau muab cia rau hauv cov ntim ntim thiab tsis txhob raug lub teeb ntev los yog kub. Nws yog ib qho electrophilic compound uas tuaj yeem hydrolyzed rau 4-hydroxy Cyclophosphamide thiab Malondialdehyde. Nws yog ib qho tsis ruaj tsis khov uas yog metabolized nyob rau hauv lub cev thiab hloov mus rau hauv nws daim ntawv nquag, yog li ua haujlwm los tiv thaiv qog. Nws yog ib qho tseem ceeb Nitrogen mustard compound, feem ntau siv hauv kev kho mob qog noj ntshav.

Cov qauv molecular ntawm Cyclophosphamide monohydrate muaj cov hauv qab no tseem ceeb:

1. Cyclophosphamide pawg: Cyclophosphamide yog ib qho chaw uas muaj cov pab pawg cyclophosphamide, uas yog tsim los ntawm kev sib txuas ib lub nplhaib uas muaj phosphorus thiab nitrogen nrog ib pawg carbonyl (C=O). Cov pab pawg neeg Cyclophosphamide endows Cyclophosphamide nrog kev tiv thaiv qog thiab kev tiv thaiv kab mob.
2. Oxazole nplhaib: lub nplhaib ntawm Cyclophosphamide pawg hauv Cyclophosphamide kuj txuas nrog lub nplhaib oxazole. Lub nplhaib oxazole yog tsim los ntawm carbon, nitrogen thiab oxygen atoms, uas ua ke nrog pawg Cyclophosphamide tsim cov qauv tseem ceeb ntawm Cyclophosphamide.
3. Monohydrate: Cyclophosphamide monohydrate yog ib qho monohydrate, qhia tias nws khi rau cov dej molecule (H2O). Cov dej molecule no feem ntau cuam tshuam nrog cov pab pawg ua haujlwm hauv Cyclophosphamide molecule hauv daim ntawv ntawm hydrogen bonds.
Cov qauv molecular ntawm Cyclophosphamide monohydrate tuaj yeem txiav txim siab los ntawm ntau yam kev sim thiab tshuaj xyuas, xws li X-ray diffraction, nuclear magnetic resonance thiab loj spectrometry. Cov txheej txheem no tuaj yeem muab cov ntaub ntawv hais txog qhov txheeb ze ntawm atoms hauv cov molecules thiab kev sib txuas ntawm cov pab pawg ua haujlwm, yog li nthuav tawm cov qauv molecular ntawm Cyclophosphamide monohydrate.

Cyclophosphamide monohydrate (Cyclophosphamide monohydrate) yog cov tshuaj siv tshuaj siv dav hauv kev kho mob. Nws yog tsuas yog siv los tiv thaiv qog noj ntshav, tab sis kuj plays lub luag hauj lwm nyob rau hauv kev kho mob ntawm lwm yam kab mob.

1. Kev kho mob qog nqaij hlav:

Cyclophosphamide monohydrate yog ib yam tshuaj cytotoxic uas siv dav hauv kev kho mob qog noj ntshav. Nws cov txheej txheem ntawm kev ua haujlwm yog los thaiv kev loj hlob ntawm cov qog hlwb los ntawm inhibiting DNA synthesis thiab kho. Cyclophosphamide monohydrate tuaj yeem siv rau kev kho mob ntawm ntau hom qog nqaij hlav, nrog rau mob qog noj ntshav ntawm lub mis, lymphoma, mob qog noj ntshav zes qe menyuam, mob ntsws cancer, mob qog noj ntshav, thiab lwm yam.

2. Kev kho mob autoimmune:

Cyclophosphamide monohydrate kuj tseem siv los kho qee cov kab mob autoimmune, xws li Myasthenia gravis, rheumatoid mob caj dab, kab mob lupus erythematosus, thiab lwm yam. Nws ua tiav cov txiaj ntsig kho mob los ntawm inhibiting kev ua haujlwm ntawm lub cev tiv thaiv kab mob thiab txo cov tshuaj tiv thaiv autoimmune.

3. Kev kho mob sepsis:

Cyclophosphamide monohydrate tuaj yeem siv los kho cov kab mob hnyav thiab cov neeg mob sepsis. Nws pab tswj cov tshuaj tiv thaiv inflammatory thiab ua kom lub cev tiv thaiv kab mob los ntawm kev tswj lub cev tiv thaiv kab mob.

4. Kev tiv thaiv ntawm graft tiv thaiv tus kab mob:

Graft tiv thaiv tus kab mob (GVHD) yog ib qho teeb meem tshwm sim thaum lub sij hawm hematopoietic qia cell transplantation. Cyclophosphamide monohydrate yog siv los ua tshuaj tiv thaiv rau GVHD, uas tuaj yeem tiv thaiv kev tawm tsam ntawm cov kab mob hauv lub cev ntawm cov ntaub so ntswg.

5. Kev kho mob raum rau menyuam yaus:

Cyclophosphamide monohydrate tuaj yeem siv rau kev kho mob raum rau menyuam yaus, xws li Stevens Johnson syndrome thiab kab mob membranous raum. Nws txo qhov mob thiab kev puas tsuaj los ntawm kev tswj lub cev tiv thaiv kab mob, yog li txo cov kab mob raum.

6. Lwm yam kev siv:

Cyclophosphamide monohydrate kuj tau siv rau hauv kev kho mob ntawm qee yam kab mob. Piv txwv li, nws tuaj yeem siv los kho cov kab mob sclerosis, Ntau myeloma, psoriasis, Thrombocytopenic purpura, thiab lwm yam.

Hauv cov ntsiab lus, Cyclophosphamide monohydrate yog dav siv los ua cov tshuaj tiv thaiv qog thiab cov tshuaj immunomodulatory hauv kev kho mob ntawm ntau yam kab mob. Nws siv tshuaj kho los ntawm inhibiting DNA synthesis thiab kho, tswj kev ua haujlwm ntawm lub cev tsis muaj zog. Tab sis yog vim nws muaj zog pharmacological kev ua ub no, nws yog ib qho tsim nyog yuav tsum nkag siab tag nrho nws cov lus qhia thiab muaj peev xwm txaus ntshai ua ntej siv, thiab siv nws raws li kev qhia ntawm tus kws kho mob.

Lub synthesis ntawm Cyclophosphamide monohydrate feem ntau muaj peb kauj ruam tseem ceeb: kev taw qhia ntawm oxazole nplhaib, amidation cov tshuaj tiv thaiv, thiab cov tshuaj tiv thaiv hydration. Hauv qab no yog cov lus piav qhia ntawm cov kauj ruam tshwj xeeb:

Kauj Ruam 1: Taw qhia ntawm oxazole nplhaib

Nyob rau hauv lub xub ntiag ntawm oxazole Procaine (Proca ï n oxazole), oxazole nplhaib tau nkag mus rau hauv lub compound 2-chloroethyl Sulfonamide. Ua ntej, 2-chloroethyl Sulfonamide thiab oxazol Procaine raug SN2 Hloov cov tshuaj tiv thaiv los tsim N - (2-chloroethyl sulfonyl) - N '- (4-oxazolyl) hydrazine. Tom qab ntawd, tom qab deprotection cov tshuaj tiv thaiv, cov khoom tau txais tom qab kev taw qhia ntawm lub nplhaib oxazole.

Kauj Ruam 2: Amination cov tshuaj tiv thaiv

Hauv cov khoom tau txais hauv thawj kauj ruam, N - (2-chloroethylsulfinyl) - N '- (4-oxazolyl) oxamide yog tsim los ntawm amidation nrog Sulfinic acid derivatives. Cov tshuaj tiv thaiv no feem ntau siv di N-Methylformamide (DMF) ua cov kuab tshuaj, thiab Sulfinic acid derivatives thiab lub hauv paus catalysts, xws li triethylamine, ntxiv. Tom qab cov tshuaj tiv thaiv, cov khoom yog tau los ntawm extraction thiab crystallization purification.

Kauj Ruam 3: Cov tshuaj tiv thaiv dej

Cov khoom tom qab amidation reacts nrog dej los tsim Cyclophosphamide monohydrate. Nyob rau hauv cov tshuaj tiv thaiv no, cov khoom yog yaj nyob rau hauv dej thiab undergoes hydrolysis los tsim ib tug crystalline tshuaj nrog ib tug dej molecule.

Nws yuav tsum tau muab sau tseg tias cov reagents thiab tej yam kev mob siv nyob rau hauv lub synthesis txheej txheem ntawm Cyclophosphamide monohydrate yuav tsum tau nruj me ntsis tswj los xyuas kom meej lub purity thiab tawm los ntawm cov khoom. Tsis tas li ntawd, thaum lub sij hawm tsim cov txheej txheem, ntau crystallization thiab purification cov kauj ruam yuav tsum tau kom tau high-purity Cyclophosphamide monohydrate.

Txhawm rau ua kom tiav, kev sib txuas ntawm Cyclophosphamide monohydrate suav nrog kev qhia txog lub nplhaib oxazole, cov tshuaj tiv thaiv amidation, cov tshuaj tiv thaiv dej thiab lwm cov kauj ruam uas tau cog lus. Los ntawm cov kauj ruam no, cov tshuaj pib tuaj yeem hloov mus rau hauv cov khoom lag luam, ua rau Cyclophosphamide monohydrate. Txawm li cas los xij, vim qhov nyuaj ntawm txoj kev sib xyaw ua ke, cov txheej txheem ntawm synthesizing Cyclophosphamide monohydrate yuav tsum muaj kev tswj xyuas nruj ntawm cov tshuaj tiv thaiv thiab cov txheej txheem purification los xyuas kom meej qhov zoo thiab purity ntawm cov khoom.

1. Melting point:

Lub melting point ntawm Cyclophosphamide monohydrate yog kwv yees li 48-52 degrees Celsius. Qhov no txhais tau hais tias nyob rau hauv qhov ntsuas kub no, nws yuav hloov ntawm cov khoom mus rau cov kua.

2. Molecular Luj:

Qhov hnyav molecular ntawm Cyclophosphamide monohydrate yog kwv yees li 279.1 g / mol. Molecular hnyav yog hais txog tag nrho qhov loj ntawm atoms hauv ib lub molecule.

3. Ceev:

Qhov ceev ntawm Cyclophosphamide monohydrate yog kwv yees li 1.27 g / cm³. Tus nqi no sawv cev rau qhov loj ntawm ib chav tsev ntim.

4. Refractive index:

Lub refractive index ntawm Cyclophosphamide monohydrate yog 1.572. Lub refractive index yog ib qho kev ntsuas ntawm qhov degree uas lub teeb deviates thaum dhau los ntawm cov khoom siv interface.

5. pH tus nqi:

Tus nqi pH ntawm cov tshuaj Cyclophosphamide monohydrate feem ntau yog nyob rau hauv nruab nrab ntau yam (txog 7), tab sis nws nyob ntawm qhov concentration ntawm cov tshuaj thiab kev npaj.

6. Xwm:

Cyclophosphamide monohydrate yog ib qho electrophilic compound uas tuaj yeem hydrolyzed rau 4-hydroxy Cyclophosphamide thiab Malondialdehyde. Nws yog ib qho tsis ruaj tsis khov uas yog metabolized nyob rau hauv lub cev thiab hloov mus rau hauv nws daim ntawv nquag, yog li ua haujlwm los tiv thaiv qog.

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