D Chiro Inositol hmoov(DCI Powder) yog ib txwm tshwm sim isomer ntawm inositol thiab belongs rau vitamin B complex. Nws ua lub luag haujlwm tseem ceeb hauv kev tswj hwm cov cim qhia ntawm insulin thiab kev sib npaug ntawm metabolic. Raws li cov dej dawb, dej- cov hmoov soluble, nws feem ntau yog siv rau hauv cov khoom noj khoom haus thiab feem ntau yog tsom rau cov kab mob metabolic xws li insulin tsis kam, polycystic zes qe menyuam syndrome (PCOS), thiab hom 2 mob ntshav qab zib.
DCI yog ib qho ntawm cov stereoisomers ntawm inositol. Hauv lub cev, nws ua raws li tus xa xov thib ob ntawm cov tshuaj insulin, pab txhim kho qhov kev nkag siab ntawm cov hlwb rau insulin thiab txhawb nqa cov piam thaj, yog li txo cov ntshav qab zib. Cov kev tshawb fawb tau pom tias qib D-chiro-inositol hauv cov neeg mob PCOS feem ntau qis. Ntxiv DCI tuaj yeem txhim kho hormonal tsis txaus, txhawb ovulation, thiab txo cov tsos mob hyperandrogenic (xws li pob txuv thiab hirsutism). Tsis tas li ntawd, nws tuaj yeem pab txhawb lipid metabolism thiab txo qhov kev pheej hmoo ntawm cov kab mob plawv.
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D Chiro Inositol Hmoov COA
D Chiro Inositolpowderyog ib qho kev sib xyaw nrog ntau yam kev ua ub no thiab tau pom cov ntawv thov dav dav hauv cov tshuaj, tshuaj pab kho mob, thiab khoom noj khoom haus. Cov hauv qab no yog nws cov haujlwm tseem ceeb thiab cov txheej txheem tshwj xeeb ntawm kev ua:
Kev Kho Mob Metabolic Disease: Txhim Kho Insulin Resistance thiab Glycemic Regulation
D-chiro-inositol (DCI) yog tus xa xov thib ob tseem ceeb hauv kev xa cov tshuaj insulin, ua lub luag haujlwm tseem ceeb hauv kev tswj cov piam thaj hauv ib txwm. Los ntawm kev ua kom lub dephosphorylation ntawm glycogen synthase thiab pyruvate dehydrogenase -ob enzymes tseem ceeb koom nrog hauv cov piam thaj metabolism- nws txhawb nqa ob qho tib si tsis yog - oxidative thiab oxidative metabolism ntawm qabzib, yog li txo qis insulin tsis kam, ib qho tseem ceeb ntawm cov kab mob metabolic.
Nws mechanism ntawm kev txiav txim muaj xws li:
Simulating cov nyhuv ntawm insulin: DCI tuaj yeem hloov qee qhov kev ua haujlwm ntawm insulin hauv lub cev, txhim kho lub cev kev noj qab haus huv thiab kev siv cov piam thaj los ntawm kev ua kom muaj feem cuam tshuam rau txoj hauv kev, thiab thaum kawg txo qis cov ntshav qab zib ntau ntxiv nrog rau cov tshuaj insulin ntau dhau, txo lub nra ntawm cov qog nqaij hlav.
Kev tswj hwm cov tshuaj hormones: Hauv cov neeg mob polycystic zes qe menyuam syndrome (PCOS), ib qho mob sib txuas nrog cov tshuaj insulin tsis kam, DCI tuaj yeem txo cov ntshav cov piam thaj hauv cov ntshav, uas pab txhim kho ovulation muaj nuj nqi thiab kho cov poj niam cev xeeb tub feem ntau pom hauv cov neeg mob PCOS.
Kev pab tshawb fawb soj ntsuam:
Ntawm qhov koob tshuaj ntawm 50 mg / kg, DCI tuaj yeem txhim kho cov ntshav qabzib siab hauv cov nas uas tau noj cov zaub mov muaj roj ntau - cov tsiaj, cov qauv tsiaj ntawm insulin tsis kam, thaum tseem txo qis daim siab lipid tsub zuj zuj, uas muaj txiaj ntsig zoo rau kev tiv thaiv lub siab rog cuam tshuam nrog cov kab mob metabolic.
Ntawm qhov koob tshuaj ntawm 150 mg / kg, nws tuaj yeem txo qhov kev puas tsuaj rau daim siab thiab fibrosis hauv cov nas nrog cov kua tsib stasis qauv. Qhov kev tiv thaiv no yog ua tiav los ntawm kev txhim kho cov kua tsib kua qaub thiab txo cov oxidative kev nyuaj siab hauv daim siab hlwb, yog li txo cov mob siab thiab fibrosis.
Cov Poj Niam Kev Tswj Xyuas Kev Noj Qab Haus Huv: PCOS thiab Fertility Support
Vim nws cov khoom tshwj xeeb ntawm kev txhim kho insulin tsis kam thiab tswj hwm cov tshuaj hormones sib npaug, DCI tau dhau los ua ib qho tseem ceeb thiab muaj txiaj ntsig zoo hauv kev kho mob ntxiv rau PCOS hauv xyoo tas los no:
Rov qab ua haujlwm ntawm ovulation: DCI tswj cov teeb liab kis ntawm follicle-stimulating hormone (FSH) hauv hypothalamic-pituitary- zes qe menyuam, txhawb kev loj hlob thiab loj hlob ntawm zes qe menyuam follicles, inducing ovulation tsis tu ncua, thiab yog li ua rau cov neeg mob infertile PCOS.
Kev txhim kho ntawm kev coj khaub ncaws tsis zoo: Kev sim tshuaj ntsuam xyuas nrog rau cov neeg mob PCOS tau pom tias kev noj DCI txuas ntxiv tuaj yeem txhim kho qhov kev coj khaub ncaws tsis tu ncua, txo qhov tshwm sim ntawm amenorrhea lossis kev coj khaub ncaws tsis tu ncua, thiab pab kho cov kab mob endocrine ib txwm.
Product Development Case:
Korean Aimekeong Health siv siab - zoo Mediterranean hiav txwv taum extract raws li raw khoom los tsim ib tug siab -purity DCI khoom, nrog ib tug purity ntawm ntau tshaj 95% thiab zoo stability. Cov khoom no muaj ntau yam thiab tuaj yeem siv rau ntau hom kev siv tshuaj xws li cov dej qab zib, ntsiav tshuaj thiab tshuaj ntsiav kom tau raws li cov neeg siv khoom sib txawv.
Kev tiv thaiv -tumor adjuvant therapy: Inhibiting cancer cell loj hlob
D Chiro Inositol hmoovua pov thawj los tiv thaiv- qog muaj peev xwm los ntawm kev tswj cov cellular metabolism thiab qhia txoj hauv kev:
inhibition qog nqaij hlav cancer mis: Ntawm qhov ntau ntawm 1-40 mM, DCI tuaj yeem cuam tshuam kev loj hlob ntawm cov qog nqaij hlav cancer mis MDA-MB-231 thiab txo cov qog nqaij hlav.
Kev kawm tshuab: DCI tuaj yeem cuam tshuam qhov kev loj hlob thiab kev tsiv teb tsaws ntawm cov qog hlwb los ntawm kev cuam tshuam nrog PKCε-PI3K/AKT txoj hauv kev.
Kev kuaj xyuas tsiaj txhu: Hauv cov qauv qog xenograft, koob tshuaj 500-1000 mg / kg tuaj yeem cuam tshuam cov qog loj hlob thiab ua kom muaj sia nyob ntev.
Kev tiv thaiv daim siab: txo qis cholestasis thiab fibrosis
DCI tiv thaiv daim siab noj qab haus huv los ntawm kev txhim kho cov kua tsib acid metabolism thiab antioxidant kev nyuaj siab:
Biliary stasis alleviation: DCI tuaj yeem txhim kho cov kua tsib kua qaub, txo cov oxidative kev nyuaj siab, txo cov ntshav ALT thiab AST, thiab txo cov kua tsib hyperplasia thiab daim siab parenchymal necrosis.
Los tiv thaiv -fibrotic effect: Hauv daim siab ua qauv cirrhosis, DCI inhibits kev ua kom cov kab mob siab stellate, txo collagen deposition, thiab qeeb cov txheej txheem fibrotic.
Kev Siv Tshuaj: Kev tswj qhov ncauj ntawm 150 mg / kg ib hnub ib zaug rau 2 lub lis piam tuaj yeem txhim kho daim siab pathological ntsuas.
Antioxidation thiab Anti-mob: ncua kev laus thiab kev tswj kab mob ntev
DCI siv tshuaj tua kab mob antioxidant thiab tiv thaiv - cov teebmeem inflammatory los ntawm kev tshem tawm cov dawb radicals thiab tswj cov kab mob inflammatory:
Dawb radical scavenging:DCI nthuav tawm cov kev ua haujlwm antioxidant siab tiv thaiv superoxide anion, hydrogen peroxide, thiab hydroxyl radicals, tiv thaiv cov hlwb los ntawm kev puas tsuaj oxidative.
Inflammatory factor tswj:DCI tuaj yeem txo qhov kev qhia ntawm pro- cov kab mob inflammatory (xws li NF-κB, TNF- ), alleviating chronic inflammatory responses.
Muaj peev xwm siv tau:Hauv atherosclerosis, hyperuricemia, thiab cov kab mob neurodegenerative, cov tshuaj tiv thaiv antioxidant thiab tiv thaiv - cov teebmeem ntawm DCI tuaj yeem ncua kev kis kab mob.
Kev ua lag luam thiab kev tsim khoom lag luam Trends
Health supplement field:Raws li kev noj haus ntxiv, DCI feem ntau ua ke nrog Myo-inositol (MYO) hauv qhov piv ntawm 40: 1 txhawm rau txhim kho metabolic syndrome thiab PCOS.
Khoom noj khoom haus muaj nuj nqi:Vim nws zoo solubility thiab saj qab zib me ntsis, DCI tuaj yeem ntxiv rau cov dej haus, lub zog tuav, thiab lwm yam khoom los txhim kho tus nqi noj qab haus huv.
Pharmaceutical intermediates:High-purity DCI (Ntau dua lossis sib npaug li 98%) tuaj yeem siv los tsim cov tshuaj tshiab rau kev kho mob ntshav qab zib, PCOS, thiab mob qog noj ntshav.
Txheej txheem optimization:Natural extraction method (xws li carob thiab kudzu root) thiab enzyme catalytic technology tau dhau los ua qhov tseem ceeb, txhim kho cov txiaj ntsig thiab purity, thiab txo cov nqi.
Kev tshawb nrhiav thiab tshawb fawb keeb kwm ntawm D-Chiro-Inositol (D- enantiomeric inositol, luv luv li DCI) yog ib tshooj tseem ceeb hauv kev tshawb nrhiav cov haujlwm ntawm tsev neeg inositol los ntawm kev tshawb fawb hauv zej zog. Nws qhov kev tshawb pom tuaj yeem taug qab mus rau nruab nrab-19th caug xyoo, tab sis qhov kev sib tw tseem ceeb uas qhia txog nws txoj haujlwm lom neeg tau tshwm sim nyob rau hauv ib nrab ntawm lub xyoo pua 20th. Nov yog cov ncauj lus ntxaws ntxaws ntawm DCI los ntawm nws qhov kev tshawb pom rau nws cov kev tshawb fawb ua haujlwm:
Qhov Kev Tshawb Nrhiav Thaum Ntxov ntawm Inositol: Tsim Lub Foundation (1850-1950)
Thawj qhov kev rho tawm ntawm inositol
Xyoo 1850, tus kws kho mob German Johann Joseph Scherer tau cais cov cawv polyhydroxy los ntawm cov leeg nqaij thiab hu ua "Inositol". Qhov kev tshawb pom no tau tsim lub hauv paus rau kev tshawb fawb tom ntej, tab sis cov qauv tshwj xeeb thiab kev ua haujlwm ntawm inositol tsis meej nyob rau lub sijhawm ntawd.
Kev tshawb pom ntawm inositol isomers
Xyoo 1887, tus kws tshawb fawb Maquenne tau tshawb pom tias inositol tsis yog ib qho sib xyaw ua ke tab sis muaj nyob hauv ntau lub isomers. Los ntawm xyoo 1964, Eisenberg thiab Bolden tau lees paub ntxiv tias cov ntaub so ntswg xws li cov qog thiab cov qog nqaij hlav muaj cov ntaub ntawv dawb ntawm Myo-inositol (cov leeg nqaij inositol), thiab qhov concentration ntawm inositol hauv cov phev yog peb npaug ntawm cov ntshav. Qhov kev tshawb pom no qhia txog lub luag haujlwm ntawm inositol hauv kev ua me nyuam.
Thawj qhov kev rho tawm ntawm DCI
Xyoo 1951, tus kws tshawb fawb Peter SL Stent cais DCI los ntawm cov noob ntoo carob. Qhov kev nthuav dav no tau nthuav tawm qhov tshwj xeeb ntawm DCI uas yog ib tus tswv cuab ntawm tsev neeg inositol, tab sis nws txoj haujlwm physiological tseem yuav tau tshawb nrhiav.
Qhia Txog Kev Ua Txhaum Cai ntawm DCI: Los Ntawm Cov Qauv rau Mechanism (1970-1990)
Lub luag haujlwm tseem ceeb ntawm kev hloov pauv ntawm insulin
Xyoo 1979, Dr. Larner, tus thawj coj ntawm Pharmaceutical College ntawm Virginia University, nrhiav pom tias DCI yog ib qho tseem ceeb ntawm cov tshuaj insulin thib ob. Qhov kev tshawb pom no tau nthuav tawm lub luag haujlwm tseem ceeb ntawm DCI hauv kev hloov pauv cov tshuaj insulin: DCI ua kom lub dephosphorylation ntawm glycogen synthase thiab pyruvate dehydrogenase, txhawb kev tsis muaj oxidative thiab oxidative metabolism ntawm qabzib, yog li txo qis insulin tsis kam.
Kev koom tes ntawm DCI nrog metabolic syndrome
Hauv xyoo 1990, nws tau lees paub tias theem ntawm DCI hauv tib neeg lub cev muaj feem cuam tshuam nrog kev noj qab haus huv hauv metabolic. Piv txwv li, cov neeg mob uas muaj ntshav qab zib hom 2 muaj qhov tsis tshua muaj DCI hauv lawv cov ntshav thiab cov zis ntau dua, qhia tias cov kab mob metabolic ua rau poob ntawm DCI, yog li ua rau cov tshuaj insulin ntau dua. Qhov kev tshawb pom no tau muab lub hauv paus theoretical rau DCI ua lub hom phiaj kho mob rau cov kab mob metabolic.
Kev Ua Tau Zoo hauv Kev Siv Tshuaj Kho Mob ntawm DCI: Los Ntawm Chav Ua Haujlwm mus rau Chaw Kho Mob (1999-2010)
Ib qho tseem ceeb hauv kev kho PCOS
Xyoo 1999, Dr. Larner pab neeg nrhiav tau qhov ntawdD Chiro Inositol hmoovtuaj yeem txhim kho txoj haujlwm ntawm ovulation thiab qhov sib npaug ntawm cov tshuaj hormones ntawm cov neeg mob polycystic zes qe menyuam syndrome (PCOS). PCOS cov neeg mob feem ntau muaj cov tshuaj insulin tsis kam thiab ntau dhau ntawm androgen, thiab DCI, los ntawm kev tswj hwm cov qib tshuaj hormones (xws li txo cov piam thaj androgen) thiab kho lub voj voog ntawm ovulation, dhau los ua cov tshuaj muaj peev xwm rau kev kho mob PCOS. Qhov kev tshawb pom no txhawb kev tshawb fawb txog kev siv DCI hauv cov tshuaj tua kab mob.
Kev txheeb xyuas cov txheej txheem ntawm kev tswj ntshav qab zib
Thaum ntxov xyoo 2000s, kev sim tsiaj tau lees paub tias DCI tuaj yeem txhim kho cov piam thaj hauv cov nas ntawm kev noj zaub mov muaj roj ntau thiab txo cov lipid hauv siab. Cov kev tshawb fawb ntxiv tau pom tias DCI tswj cov lipid metabolism los ntawm PKCε-PI3K/AKT txoj hauv kev, muab cov tswv yim tshiab rau kev kho mob ntshav qab zib hom 2.
Tshawb nrhiav cov tshuaj tiv thaiv antioxidant thiab tiv thaiv - ua haujlwm inflammatory
Nyob ib ncig ntawm 2010, cov kws tshawb fawb pom tias DCI muaj zog antioxidant kev tiv thaiv superoxide anion, hydrogen peroxide, thiab hydroxyl radicals, thiab tuaj yeem cuam tshuam qhov kev qhia ntawm pro- cov kab mob inflammatory (xws li NF-κB, TNF- ). Qhov kev tshawb pom no nthuav dav daim ntawv thov muaj peev xwm ntawm DCI hauv kev mob ntev thiab kev laus - kab mob ntsig txog.
Kev tshawb fawb niaj hnub thiab daim ntawv thov nthuav dav: Los ntawm Natural Extraction mus rau Industrial Transformation (Txij li xyoo 2010)
Optimization ntawm natural extraction technology
Cov kws tshawb fawb Suav tau siv cov buckwheat roasted ua cov khoom siv raw thiab ua haujlwm germination extraction thiab acid hydrolysis cov tswv yim kom nce DCI cov ntsiab lus los ntawm 20% mus rau 66%, thiab nce cov ntsiab lus monomer los ntawm kwv yees li 8 npaug. Cov argan extract tau dhau los ua qhov tseem ceeb ntawm DCI, thiab tau muab cais ua tus neeg sawv cev ntuj tsim los ntawm cov cai, tso cai rau kev tsim nyog ntxiv rau cov khoom noj xws li chocolate thiab dej haus.
Kev sib sib zog nqus ntawm kev tshawb fawb soj ntsuam
Kev kho PCOS: Kev sim tshuaj ntsuam xyuas tau pom tias cov neeg mob PCOS uas ntxiv 500-1000 mg ntawm DCI txhua hnub tuaj yeem txhim kho insulin tsis kam thiab ovulation muaj nuj nqi.
Kev pab tiv thaiv-cov qog nqaij hlav: DCI tuaj yeem cuam tshuam kev loj hlob ntawm cov qog nqaij hlav cancer ntawm lub mis (MDA-MB-231) ntawm qhov ntau ntawm 1 txog 40 mM, thiab txo cov qog nqaij hlav.
Kev tiv thaiv kab mob siab: Ib koob tshuaj 150 mg / kg ntawm DCI tuaj yeem txo qis kev puas tsuaj rau daim siab thiab fibrosis hauv nas nrog cov qauv ntawm cov kua tsib.
Industrialization thiab kev ua lag luam thov
DCI hmoov, raws li kev noj zaub mov ntxiv thiab cov tshuaj nruab nrab, tau siv dav hauv kev noj qab haus huv, khoom noj khoom haus, thiab kev tsim tshuaj. Piv txwv li, "Chirositol" compound supplement launched los ntawm US lub tuam txhab Swanson muaj 90 mg ntawm DCI thiab 3.6 mg ntawm manganese sulfate ib ntsiav tshuaj, thiab cov lus pom zoo noj yog ob zaug ib hnub twg, ib ntsiav tshuaj txhua zaus.
FAQ
1. Puas yog nws sib tw nrog kev thauj mus los hauv lub cev ntawm lwm tus isomer ntawm inositol (Myo-inositol)?
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Ob leeg tuaj yeem faib qee cov sodium-ion-dependent inositol transporters (SMIT). Qhov siab - koob ib zaug - pub D-enantiomeric inositol tuaj yeem cuam tshuam qhov kev noj qab haus huv ntawm Myo-inositol, cuam tshuam nrog tom kawg txoj cai ntawm oocyte zoo thiab cov thyroid ua haujlwm.
2. Dhau li ntawm txoj kev taw qhia cov tshuaj insulin, nws puas ua haujlwm los ntawm cov txheej txheem epigenetic?
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Cov kev tshawb fawb ua ntej qhia tau hais tias nws tuaj yeem ua raws li tus thawj coj ntawm phosphatidylinositol glycan, cuam tshuam rau kev sib txuas ntawm cov protein nyob hauv lub cev, yog li tswj cov haujlwm ntawm cov cell nto receptors cuam tshuam nrog insulin tsis kam. Qhov no suav nrog qhov tsis yog - theem qub ntawm kev cai teeb liab.
3. Dab tsi yog lub hauv paus ntawm biochemical rau qhov sib txawv ntawm kev kho mob rau cov neeg mob polycystic zes qe menyuam syndrome (PCOS) tshwm sim los ntawm kev sib txawv etiologies?
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Cov txiaj ntsig tuaj yeem yog nyob ntawm qhov tshwj xeeb phosphorylation ntawm insulin receptor substrate (IRS) hauv tus neeg mob thiab kev ua haujlwm hauv qab PI3K. Rau qee cov neeg mob uas muaj PCOS uas muaj polymorphisms hauv IRS cov noob caj noob ces lossis mob hnyav, kev txhim kho ntawm insulin rhiab heev yuav raug txwv.
4. Ntev npaum li cas - lub sij hawm thiab siab - koob tshuaj tuaj yeem cuam tshuam rau lub siab txoj hauv kev gluconeogenesis?
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Raws li cov tshuaj insulin rhiab heev, nws yog theoretically ua tau los txhim kho cov nyhuv inhibitory ntawm insulin ntawm hepatic gluconeogenesis. Rau cov tib neeg uas muaj lub siab ua haujlwm tsis zoo lossis muaj peev xwm tswj hwm cov piam thaj hauv cov ntshav, qhov kev pheej hmoo ntawm hypoglycemia yuav tsum tau saib xyuas.
Cim npe nrov: d chiro inositol hmoov, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom