DMHA hmoovyog tau los ntawm amination thiab catalytic hydrogenation. Peb lub tuam txhab yog DMHA khoom. Ntxiv rau DMHA, peb kuj tsim DMAA. Thiab khaws cia rau hauv ib qho chaw txias, qhuav thiab zoo ventilated warehouse. Khaws kom deb ntawm qhov hluav taws kub thiab qhov chaw kub. Tiv thaiv los ntawm tshav ntuj ncaj qha. Ntim cov ntsaws ruaj ruaj. Nws yuav tsum tau muab cais los ntawm cov kua qaub thiab cov tshuaj uas siv tau kom tsis txhob sib xyaw cia. Qhov chaw cia khoom yuav tsum tau nruab nrog cov ntaub ntawv tsim nyog kom muaj cov xau.
DMHA, tshuaj hu ua 1,5-dimethylhexylamine, yog cov kua dej uas muaj qhov kub qis dua thiab siab dua melting point uas tsim cov muaju dawb ntawm qhov kub thiab txias. Qhov ceev 0.78-0.79 g / cm³. Qhov no yog cov kua sib zog nrog qhov qis dua li dej, yog li nws maj mam nce los ntawm qhov chaw thaum ntxiv rau dej. Qhov no yog cov kua dej uas muaj qhov kub kub qis dua thiab cov ntsiab lus melting ntau dua, uas yog cov kua hauv chav sov, tab sis tsim cov muaju dawb ntawm qhov kub thiab txias. Nws yog ib qho organic compound nrog cov yam ntxwv ntawm alkyl amine, thiab nws cov tshuaj formula yog C8H19N. Nws cov qauv molecular muaj xws li yim carbon ncaj saw, nyob rau hauv uas ob carbon atoms txuas nrog ib pawg amino thiab ob pawg methyl. Nws yog cov kua uas muaj ntxhiab tsw ntxhiab, lipophilicity, tsawg ntom, tsis tshua muaj boiling point, nruab nrab flash point, melting point, thiab viscosity, thiab tsawg nto nro. Cov yam ntxwv no ua rau 1,5-dimethylhexylamine dav siv hauv kev lag luam tshuaj thiab ntau daim ntawv thov.
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CF |
C8H19N |
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EM |
129 |
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MW |
129 |
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m/z |
129 (100.0%), 130 (8.7%) |
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EA |
C, 74.34; H, 14.82; N, 10.84 |
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Nrog rau kev siv tshuab ua kom paub tab ntawm DMHA bulk hmoov, muaj ntau thiab ntau DMHA cov tshuaj uas tsim tau DMHA ntau dua rau kev muag khoom. Tab sis nws yuav tsum tau muab sau tseg tias txhua qhov chaw tsim khoom cov khoom muaj cov purities sib txawv vim txawv technologies, thiab yuav dmha hmoov yuav tsum tau ua tib zoo saib xyuas.
Fatty acid txo txoj kev:
Txoj kev no siv cov roj fatty acids ua cov khoom siv raw, tsim cov cawv sib xws los ntawm kev txo qis, thiab tom qab ntawd ua rau lub cev qhuav dej thiab cov tshuaj tiv thaiv catalytic hydrogenation thaum kawg tau txais 1,5-dimethylhexylamine. Cov tshuaj tiv thaiv raw cov ntaub ntawv feem ntau suav nrog fatty acids, ethanol, acetic acid, catalysts, thiab lwm yam. Cov txheej txheem cov tshuaj tiv thaiv yog raws li nram no: ua ntej, cov fatty acid yog reacted nrog ethanol kom tau txais cov fatty acid ethyl ester; Tom qab ntawd, acetic acid thiab catalyst yog siv rau lub cev qhuav dej cov tshuaj tiv thaiv kom tau txais cov roj fatty acid aldehydes; Thaum kawg, nws tau hloov mus rau 1,5-dimethylhexylamine los ntawm hydrogenation lossis oxidation ntawm stannous cyclohexane. Cov qauv no muaj lub sijhawm ntev, tab sis kev ua haujlwm yooj yim, cov ntaub ntawv raw tau yooj yim, thiab nws yog qhov tsim nyog rau cov khoom loj loj nrog cov txiaj ntsig siab.
Fatty amino acid txo txoj kev:
Txoj kev no siv fatty amino acids li raw cov ntaub ntawv, los ntawm kev txo thiab alkylation cov tshuaj tiv thaiv, thaum kawg tau 1,5-dimethylhexylamine. Cov tshuaj tiv thaiv raw cov ntaub ntawv feem ntau suav nrog fatty amino acids, sodium borohydride, methyl sodium iodide, thiab lwm yam. Cov txheej txheem cov tshuaj tiv thaiv yog raws li nram no: ua ntej, cov fatty amino acids reacted nrog sodium borohydride kom tau txais cov khoom txo qis; Cov khoom yog ces reacted nrog methylsodium iodide mus rau undergo alkylation cov tshuaj tiv thaiv, ua rau tus coj 1,5-dimethylhexylamine. Txoj kev no siv ntau yam khoom siv raw, cov tshuaj tiv thaiv me me, thiab muaj kev cuam tshuam me ntsis rau ib puag ncig, tab sis cov txiaj ntsig qis.
1,5-dimethylhexylamine (CAS naj npawb 543-82-8) yog ib yam tshuaj uas muaj cov yam ntxwv physicochemical thiab muaj peev xwm ua tshuaj. Nyob rau hauv xyoo tas los no, qhov sib xyaw no tau nyiam ntau yam hauv kev ua kis las khoom noj khoom haus, thiab ntseeg tau tias muaj peev xwm los txhim kho kev ua si, txhawb kev rog oxidation, thiab txhim kho kev txawj ntse. Txawm li cas los xij, nws txoj kev siv kuj tseem muaj kev pheej hmoo rau kev noj qab haus huv thiab kev tsis sib haum xeeb.
Mechanism ntawm kev ua
Cov kev cai ntawm Neurotransmitter:
Los ntawm inhibiting qhov kev ua ntawm monoamine oxidase (MAO), qhov concentration ntawm catecholamines (xws li dopamine thiab norepinephrine) hauv synaptic cleft yog nce. Qhov nce ntawm cov neurotransmitters no cuam tshuam nrog kev zoo siab, nce kev ceeb toom, thiab txhim kho kev ua kis las.
5-hydroxytryptamine tso tawm:
Nws tau raug pov thawj los ua kom tso tawm serotonin hauv platelets.DMHA hmoovyog ib tug dav faib neurotransmitter koom tes nyob rau hauv ntau yam physiological functions xws li kev xav, qab los noj mov, thiab mob xaav. Txawm li cas los xij, lub luag haujlwm tshwj xeeb ntawm kev cuam tshuam ntawm serotonin tso tawm hauv kev ua haujlwm ntawm lub cev tseem tsis tau meej.
receptor agonistic nyhuv:
Muaj ib feem agonist cuam tshuam rau receptors, tshwj xeeb tshaj yog 3 receptors . 3 receptors yog heev nthuav nyob rau hauv adipocytes, thiab stimulation ntawm cov receptors activates lipolysis, tso fatty acids. Cov fatty acids no tuaj yeem ua lub zog substrate, muab roj rau kev tawm dag zog.
Acid rhiab heev ion channel (ASIC) thaiv:
Los ntawm thaiv ASIC, qhov concentration ntawm H + hauv synaptic cleft tuaj yeem hloov pauv. ASIC yog ib qho tsis xaiv ion channel uas tau qhib thaum tus nqi pH qis dua 7. Los ntawm kev thaiv ASIC, qhov nkag ntawm H + ions mus rau hauv synaptic cleft tuaj yeem txo, ua rau txo qis hauv neuronal excitability.
Anti-inflammatory nyhuv:
Muaj cov tshuaj tiv thaiv -cov teebmeem inflammatory, tuaj yeem tiv thaiv kev tsim cov cytokines inflammatory thiab txo oxidative kev nyuaj siab. Cov teebmeem no tuaj yeem pab txo cov leeg mob thiab mob ua rau muaj kev tawm dag zog hnyav.
Kev tshaib plab:
Los ntawm kev tso tawm norepinephrine thiab dopamine kom txo tau kev tshaib kev nqhis, nws muaj kev noj qab haus huv suppressing nyhuv. Cov nyhuv no yuav pab tswj qhov hnyav thiab tswj kev ua kis las.
Qhov cuam tshuam rau kev ua kis las
Txhim khu kev ceeb toom thiab saib xyuas:
Los ntawm kev nce siab ntawm catecholamines hauv synaptic cleft, kev ceeb toom thiab kev saib xyuas tuaj yeem txhim kho, yog li txhim kho kev txiav txim siab- ua thiab teb lub peev xwm thaum lub sijhawm ua haujlwm. Kev tshawb fawb ntawm 18 qhov dej- cov txiv neej tau txais kev cob qhia pom tias tom qab noj nws, 400 meter sprint lub sij hawm luv luv los ntawm 1.5%.
Txhim khu cov leeg muaj zog:
Kev ua kom cov beta receptors tuaj yeem txhawb cov rog ua kom tawg, tso cov roj fatty acids ua lub zog substrates, thiab muab lub zog rau cov leeg nqaij. Tsis tas li ntawd, nws cov tshuaj tiv thaiv -cov nyhuv inflammatory tuaj yeem pab txo cov leeg mob, yog li ua kom cov leeg tsis muaj zog. Kev tshawb fawb ntawm 12 tus kws qhia lub zog tau pom tias tom qab noj nws, tus naj npawb ntawm lub rooj zaum xovxwm tau nce 10%.
Txhawb kom muaj roj oxidation:
Los ntawm activating beta adrenergic receptors, rog hlwb raug txhawb kom tso cov fatty acids, thiab los ntawm kev siv cov fatty acids ntau, cov roj oxidation yog txhawb los muab lub zog rau cov leeg. Ib txoj kev tshawb nrhiav pom tias cov txiv neej uas coj nws muaj 18% siab dua ntawm cov roj oxidation thaum 60 feeb ntawm kev caij tsheb kauj vab piv rau cov pab pawg placebo. Lwm txoj kev tshawb nrhiav pom tias cov poj niam uas coj nws muaj 10% ntau dua cov roj oxidation thaum lub sij hawm 30 feeb ntawm treadmill ce piv rau cov placebo pawg.
Cognitive function enhancement:
Muaj kev paub txog kev txawj ntse, xws li kev ceeb toom, kev mloog, thiab kev xav, uas tuaj yeem txhim kho kev txiav txim siab- ua kom muaj peev xwm ua tau thiab muaj peev xwm tshwm sim thaum tawm dag zog. Tsis tas li ntawd, nws cov tshuaj tiv thaiv kab mob - tuaj yeem pab txo cov kev mob tshwm sim hauv lub hlwb thiab txhim kho kev txawj ntse ntxiv.
Muaj peev xwm txaus ntshai
Cov teeb meem hauv plawv:
Tej zaum yuav ua rau mob plawv xws li arrhythmia, ntshav siab, thiab myocardial infarction. Cov kev pheej hmoo no tseem ceeb tshwj xeeb ntawm cov neeg ncaws pob vim lawv twb nyob hauv lub xeev siab ntawm cov hlab plawv thaum lub sijhawm ua haujlwm.
Kev ntxhov siab thiab insomnia:
Nws muaj cov nyhuv neural excitatory thiab tej zaum yuav ua rau neurological thiab puas siab puas ntsws cov tsos mob xws li ntxhov siab vim thiab insomnia. Cov tsos mob no yuav cuam tshuam rau cov neeg ncaws pob so thiab rov qab los, yog li cuam tshuam rau lawv qhov kev ua kis las.
Lwm yam kev phom sij rau kev noj qab haus huv:
Kev siv mus ntev yuav ua rau muaj teeb meem kev noj qab haus huv xws li lub siab puas, lub raum tsis ua haujlwm, thiab endocrine system tsis zoo. Tsis tas li ntawd, nws cov peev xwm carcinogenicity thiab mutagenicity tsis tau soj ntsuam tag nrho.
Lub hom phiaj ntawm DMHA ntshiab:
Hlau tu:
1,5-dimethylhexylamine kuj tseem siv tau rau kev ntxuav hlau thiab tiv thaiv corrosion. Kev sib xyaw nrog cov tshuaj alkaline xws li sodium carbonate lossis sodium bicarbonate tuaj yeem tshem tawm oxides thiab lwm yam kuab paug los ntawm cov hlau.
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Cov lus ceeb toom, Cov lus piav qhia Hazard h226-h302-h315-h319-h301-h314-h318, Kev ceev faj P301 + p310a-p303 + p361 + p353-p405-p2101a- p330-p305 + P351 + p338-p370 + p378, Dangerous goods sign xn, Hazard qeb code 10-22-36 / 37 / 38, Safety instruction 26-36 / 37 / 39-37 / 39-16, UN, Dangerous. WGK Lub Tebchaws Yelemees 3, RTECS No. mq4840000, F 10-34, TSCA Yes, HazardClass 3, PackingGroup III.
DMHA hmoovyog ib qho organic compound uas feem ntau yog siv los ua ib qho kev ua txhaum cai hauv kev tawm dag zog lub cev vim nws muaj zog irritant thiab stimulant los. Nws keeb kwm kev tshawb pom yog luv luv, yos rov qab mus rau 2009.
Xyoo 2009, cov khoom noj khoom haus hu ua "Jack3d" tau nrov hauv Asmeskas kev ua lag luam, thiab nws cov khoom xyaw tseem ceeb tau tshaj tawm tias "dawb ntawm cov khoom txwv tsis pub". Txawm li cas los xij, US Anti-Doping Agency (USADA) tau tshaj tawm kev tshawb nrhiav ntxiv tom qab ntau tus neeg ncaws pob tau kuaj pom zoo rau cov tshuaj txwv tsis pub. Tom qab kuaj thiab tshuaj xyuas, lawv pom tias cov tshuaj ntxiv muaj 1,5-dimethylhexylamine, ib qho tshuaj tiv thaiv tsis raug cai.
Txij thaum ntawd los, DMHA tau txais kev saib xyuas thoob plaws thiab tau suav nrog hauv lub koom haum tiv thaiv -doping cov npe ntawm cov tshuaj txwv tsis pub. Txawm hais tias cov tshuaj tseem siv nyob rau hauv qee lub tebchaws, nws suav tias yog kev pheej hmoo rau kev noj qab haus huv.
Mechanisms ntawm Action
DMHA cov teebmeem stimulant feem ntau yog vim nws lub peev xwm los cuam tshuam rau hauv nruab nrab paj hlwb (CNS). Nws ntseeg tau tias ua raws li norepinephrine-dopamine reuptake inhibitor (NDRI), txhais tau tias nws tiv thaiv kev rov qab los ntawm cov neurotransmitters rau hauv presynaptic neurons, yog li ua rau lawv cov concentrations hauv cov synaptic cleft. Qhov no ua rau kev txhim kho neuronal firing thiab ua kom cov kev taw qhia downstream uas cuam tshuam nrog nce kev ceeb toom, lub zog, thiab mus ob peb vas.
Norepinephrine, ib qho tseem ceeb neurotransmitter koom nrog "sib ntaus los yog ya" teb, txhim khu kev xav, kev xav, thiab kev txawj ntse. Dopamine, ntawm qhov tod tes, yog txuam nrog nqi zog, kev txhawb siab, thiab kev tswj lub cev muaj zog. Los ntawm kev ua kom muaj cov neurotransmitters no, DMHA tuaj yeem txhawb txoj kev xav ntawm kev zoo siab, ua kom pom tseeb, thiab kev txhawb siab, ua rau nws txaus siab rau kev siv hauv siab - kev siv zog los yog kev ua haujlwm uas yuav tsum tau siv zog siab.
Tsis tas li ntawd, DMHA tau raug qhia kom muaj qhov tsis muaj zog adrenergic receptor agonist ua haujlwm, tshwj xeeb tshaj yog ntawm 1 thiab 2 receptors. Qhov no tuaj yeem pab txhawb ntxiv rau nws qhov kev txhawb nqa los ntawm kev txhawb nqa vasoconstriction thiab nce ntshav siab, txawm hais tias qhov tseem ceeb ntawm qhov kev ua no tseem tsis meej.
DMHA hmoov sawv cev rau lub ntsiab lus nyuaj thiab tsis sib haum xeeb nyob rau hauv lub zog thiab kev lag luam ntxiv. Txawm hais tias nws cov khoom txhawb zog tuaj yeem muab cov txiaj ntsig zoo ntawm lub zog, ua kom pom tseeb, thiab kev ua kis las, cov no yuav tsum tau ntsuas qhov kev pheej hmoo ntawm cov kev mob tshwm sim thiab kev tswj xyuas tsis meej. Qhov tsis muaj kev pom zoo thoob ntiaj teb ntawm nws txoj cai tswj hwm ua rau qhov teeb meem nyuaj ntxiv, qhia txog qhov xav tau kom pom tseeb dua thiab kev kawm rau cov neeg siv khoom.
Raws li peb mus tom ntej, nws yog ib qho tseem ceeb rau cov koom haum tswj hwm, tuam ntxhab, thiab cov neeg siv khoom ua haujlwm ua ke kom muaj kev nyab xeeb thiab kev ua tau zoo ntawm cov khoom noj khoom haus. Los ntawm kev saib xyuas cov pov thawj tseem ceeb-raws li kev tshawb fawb, daim ntawv lo pob tshab, thiab lub luag haujlwm ua lag luam, peb tuaj yeem pab tiv thaiv kev noj qab haus huv thiab kev noj qab haus huv- yog cov tib neeg nrhiav kev txhim kho lawv lub cev thiab lub hlwb. Lub sijhawm no, cov tib neeg xav txog kev siv DMHA- muaj cov tshuaj ntxiv yuav tsum tau ceev faj thiab sab laj nrog cov kws kho mob kom paub txiav txim siab txog lawv txoj kev noj qab haus huv.
Cov lus nug nquag
Puas yog DMHA raug cai lossis tsis raug cai?
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FDA txiav txim siab DMHA yog ib yam khoom uas tsis ua raws li txoj cai txhais ntawm cov khoom noj khoom haus thiab yog cov khoom noj tsis zoo. Yog li ntawd, peb xav txog cov khoom noj uas muaj DMHA yuav tsum tau deev raws li Tsoom Fwv Teb Chaws Khoom Noj, Tshuaj, thiab Tshuaj pleev ib ce (FD&C Act).
Puas yog DMHA zoo rau koj?
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Hauv Tebchaws Meskas, FDA suav tias DMHA yog cov khoom tsis muaj kev nyab xeeb hauv cov khoom noj.
Puas yog DMAA nce dopamine?
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Hauv kev thauj mus los hauv tib neeg lub raum hlwb, DMAA inhibited dopamine uptake los ntawm tib neeg dopamine transporter hauv kev sib tw.
Lub npe tiag tiag rau DMHA yog dab tsi?
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Octodrine, tseem hu ua dimethylhexylamine (DMHA), yog lub hauv paus paj hlwb stimulant.
Cim npe nrov: dmha hmoov cas 543-82-8, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom