Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab cov chaw muag khoom ntawm GW0742 hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo GW0742 Kev Muag Khoom ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
GW0742, tseem hu ua GW610742, yog ib qho kev xaiv tau zoo ntawm cov hluavtaws pricthetic poliferator {{}} activ δ (ppp / Δ). Nws tus lej lej yog 317318-84-6, cov mis molecular yog c21h17f4no3s2, thiab cov molecular hnyav yog 471.49. Los ntawm cov tsos, cov khoom no feem ntau yog cov hmoov zoo los ntawm dawb mus rau lub teeb daj. Nyob rau hauv cov nqe lus ntawm solubility, nws muaj siab tshaj plaws solubility hauv dmo (dimethyl sulfoxide), xws li muaj ntau dua lossis sib npaug ntawm DMOs, tab sis yuav luag tsis muaj Insoluble hauv dej. Thaum khaws cia, feem ntau nws pom zoo kom nws ntawm -20℃C. Cov daim foos hmoov tuaj yeem khaws cia rau 2 xyoos. Yog tias yaj nyob rau hauv cov kuab tshuaj thiab muab khaws cia ntawm -80 degree, lub sijhawm siv tau yog 2 xyoos. Yog tias khaws cia ntawm -20 degree, nws yuav tsum siv nyob rau hauv 1 lub hlis kom ntau li ntau tau.
Cov khoom no tau xub tsim los ntawm GlaxosmithKline thiab nws yog qhov analogue ntawm GW501516. Raws li ib tug xaiv poliferator {{1} {} {} {Qhov tob ntawm lub luag haujlwm hauv ntau cov txheej txheem ntawm lub zog xws li lub zog Cov metabolism, lipid metabolism, thiab cov teb tsis yog. Yog li no, kev txhim kho ntawm cov neeg laus kev sib tw ua rau tus neeg txais no muaj qhov tseem ceeb tshaj plaws thiab muaj peev xwm thov cov txiaj ntsig.
 |
 |
GW0742 Hmoov Coa
Cov Lus Qhia Yooj Yim
Cov hmoov no yog ib qho kev xaiv tau zoo rau cov khoom siv sib xyaw ua ke {}}}}}}}}}}}} Cov lej molecular yog 471.49. Cov compound no muaj cov qauv tshuaj tshwj xeeb. Nws lub npe lus Askiv puv nkaus yog 2- [4- Fluoro-4- Methyl-1-ws-pethylsulfanyl] -2-MethylphenSulfanyl] -2-Methylphenoxy] acetic acid.
Cov Khoom Siv Lub Cev
Cov tsos mob thiab cov xwm txheej: GW0742 feem ntau tshwm raws li cov hmoov zoo los ntawm dawb mus rau lub teeb daj.
Ntom ntom: kwv yees li 1.462g / cm³.
Boint Taw tes: ntawm 760 Mmhg, qhov cub npau npau yog kwv yees li 591.476 degree.
Flash taw tes: kwv yees li 311.514 degree.
Refacking index: kwv yees li ntawm 1.609.
Solubility: Nws muaj qhov kev txhawb siab zoo hauv dmo (dimethyl sulfoxide), feem ntau tshaj li 5 mg / ml, tab sis yuav luag tsis muaj insoluble hauv dej.
Tshuaj lom neeg sab nrauv thiab kev cia khoom
Nws yog tus tsis ruaj khov nyob rau hauv kev cia khoom cia. Txawm li cas los xij, nws ruaj khov yuav raug cuam tshuam los ntawm ib puag ncig cov khoom siv xws li kub, lub teeb thiab av noo.
Txhawm rau kom muaj kev ruaj ntseg thiab kev ua si ntawm cov hmoov no, nws raug nquahu kom muab nws tso rau hauv qhov chaw qis {}} kev kawm, deb ntawm lub teeb thiab noo noo. Lub sijhawm siv tau ntawm cov hmoov tuaj yeem ncav cuag mus txog 2 xyoo.Yog kom muab nws pom zoo kom khaws nws ntawm -80℃thiab siv nws tsis pub dhau 6 lub hlis. Yog tias khaws cia ntawm -20 degree, nws raug nquahu kom siv nws nyob hauv ib hlis kom ntau li ntau tau.
Tshuaj lom neeg thiab xaiv
PARp / Δ Agronist
Cov khoom no yog ib qho kev xaiv PARpar PARP / Δ AGONIST. Nws tuaj yeem khi tau tshwj xeeb rau lub PPP / Δ receptor / Δ receptor thiab ua rau kev hloov pauv hloov pauv ntawm nws, thiab tom qab ntawd nrhiav cov neeg sib txuas ua ke los ua cov ntawv sib txuam.
RabELLIALS
Nws xaiv rau PARP / δ yog ntau dua li uas rau PPP thiab PARP. Ntawm lawv, EC50 qhov tseem ceeb ntawm cov hmoov no rau tib neeg pparΔ ppparΔ ppparΔ, pparΔ, 1.1 μm, 1.1 μm, 1.1 μm, (thiab nws muaj qhov kev xaiv rau ppparΔ.
Tej Tshuaj Lom Zem
Txawm hais tias qhov tshwj xeeb tshuaj lom neeg cuam tshuam ntawm cov khoom lag luam sib txawv raws li cov kev sim, nws tuaj yeem koom nrog ntau yam kev hloov pauv, nws tuaj yeem koom nrog cov kev hloov pauv ntawm cov khoom siv. Txawm li cas los xij, nyob rau hauv ib txwm cia thiab siv tau cov xwm txheej, nws muaj cov tshuaj ruaj khov thiab tsis yog qhov tseem ceeb rau kev sib raug zoo.
GW0742(GW610742) yog ib tug xaiv siab Proxisome proliferator {{1} Δ (ppp / δ) angonist rotion thiab plays lub luag haujlwm tseem ceeb hauv ntau lub teeb meem thiab cov txheej txheem pathological. Cov hauv qab no yuav piav qhia meej nyob rau hauv kev nthuav dav ntawm cov khoom ntawm cov kev cai no hauv cov kab mob metabolic, anti {3} Kev Noj Qab Haus Huv thiab Lwm Yam Kev Noj Qab Haus Huv.
Cov Kev Tswj Cov Teeb Tswj Kev Kawm
Cov khoom lag luam no tseem ceeb ua kom muaj kev ntxhov siab los ntawm kev ua kom lub ppp / Δ receptor. Nws tuaj yeem nce tus naj npawb thiab ntom ntawm mitochondria hauv cov leeg nqaij. Raws li "lub zog Hoobkas" ntawm cov cell, mitochondria txhim kho cov kev ua tau zoo me, ua rau lub cev tau ua kom muaj zog ntau rau kev qoj ib ce thiab muab cov tshuaj tiv thaiv txaus rau cov leeg. Cov nyhuv no tsis tsuas txuas qhov nyiaj siab tshaj plaws ntawm Aerobic qoj ib ce tab sis kuj ua rau cov neeg ua haujlwm nkees, ua rau cov neeg ncaws pob kom tiv thaiv ntau dua kev cob qhia ntau dua. Tsis tas li ntawd, nws tseem tuaj yeem nrawm qhov txheej txheem rov qab los ntawm lub cev tom qab qoj ib ce. Los ntawm kev tswj hwm qhov kev nthuav qhia ntawm cov noob thiab tsim kev ua kom tsis muaj kev tawm dag zog thiab ua kom cov kis las kom rov ua kom zoo dua rau kev cob qhia kev cob qhia tom ntej.
Cov khoom no ua yeeb yam tshwj xeeb zoo hauv Lipid metabolism txoj cai. Nws tuaj yeem txhim kho cov oxidation ntawm fatty acids, nce ntom ntom ntawm mitochondia hauv cov hlwb, thiab pab kom lub cev siv cov roj ua lub zog zoo dua. Los ntawm kev hloov cov roj khaws cia hauv cov hlwb thiab cov roj hauv cov leeg ua rau roj, tshwj xeeb tshaj yog nyob rau thaj chaw muaj roj ntau dua li cov duav. Lub caij no, nws kuj tuaj yeem nce cov leeg nqaij loj. Los ntawm kev txhawb nqa qhov kev hais tawm ntawm anti -}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} Qhov xwm txheej no ntawm kev txo cov rog yam tsis muaj cov leeg nqaij ua rau nws muaj cov ntawv thov muaj nuj nqis rau hauv kev ua haujlwm thiab poob phaus.
Cov khoom no tseem tuaj yeem txhim kho cov insulin rhiab thiab yog qhov tseem ceeb rau kev tiv thaiv thiab kev kho mob metabolic xws li ntshav qab zib. Los ntawm kev ua kom lub PPP / Δ cov khoom no tuaj yeem tswj cov hom caj ces, txhawb kev piam thaj thiab ua kom muaj cov ntshav qab zib. Cov nyhuv no tsis tsuas pab txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau cov neeg mob ntshav qab zib, tab sis kuj tseem tuaj yeem ncua cov teeb meem thiab kev loj hlob ntawm cov kev nyuaj ntshav qab zib.
Anti - inflammatory ua haujlwm
Inhibit qhov kev qhia ntawm inflammatory cytokines
GW0742Muaj ib qho tseem ceeb anti -} inflammatory nyhuv thiab tuaj yeem inhibit qhov kev qhia ntawm ntau yam pro {}}} kub cannines. Nyob rau hauv lub lps - Kev siv cov khoom lag luam protein, cov khoom lag luam mer} { Lawv txoj kev txo qis pab kom txo qis qib ntawm cov qib ntawm cov tsos mob teb thiab txhim kho cov tsos mob ntawm cov kab mob tshwm sim.
Kev tswj hwm cov kev tawm tsam
Cov khoom no nthuav tawm {- incammatory cuam tshuam los ntawm kev tswj hwm kev tawm tsam cov phiajcim. Nws tuaj yeem thaiv qhov nce ntawm - 1 mrka thiab erce {phosphorylation, yog li txo qhov kev puas tsuaj rau cov ntaub so ntswg. Tsis tas li ntawd, nws tseem tuaj yeem tiv thaiv bleomycin -}}}}} kb p65}} erk hauv bleomycin-thuam nas. Cov teebmeem no qhia tau tias nws ua si lub luag haujlwm hauv ntau qhov sib txuas ntawm cov phiaj xwm kev ua yeeb yam, muab cov phiaj xwm molecular rau kev kho mob ntawm cov kab mob.
Daim ntawv thov yuav muaj kab mob ntau yam
Raws li nws anti {- Cov khoom lag luam no, cov khoom no tau pom muaj peev xwm thov kev kho mob ntau yam mob. Piv txwv li, hauv cov kab mob pib xws li cov kab mob autoimmune, cov kab mob ntsws, nws yuav txhim kho cov tsos mob ntawm cov kab mob ntawm cov kab mob thiab txo cov nqaij mos. Ib qho ntxiv, cov khoom no tseem siv tau ua ke nrog cov tshuaj tiv thaiv uas twb muaj lawm los txhim kho cov nyhuv kho, txo cov tshuaj thiab cov kev mob tshwm sim ntawm cov tshuaj.
Neuroprotrective Liaj Ua
Txo cov hlab ntsha hlwb puas
Cov khoom no muaj cov nyhuv tiv thaiv ntawm cov hlab ntsha thiab tuaj yeem txo qhov kev puas tsuaj thiab kev tuag ntawm cov hlab ntsha. Hauv Nurodegenerer cov kab mob, nws txo cov neuronal apoptosis thiab kev tswj hwm qhov kev hais tawm ntawm cov noob muaj sia nyob ntawm lub hlwb. Cov nyhuv no yuav pab ncua kev nce qib ntawm cov kab mob nurodegenerative cov kab mob thiab tiv thaiv kev ua haujlwm ntawm cov leeg ntshav.
Txhim kho cov kev ua haujlwm neurological
Ntxiv nrog rau kev txo cov hlab ntsha puas tsuaj, cov khoom no tuaj yeem txhim kho txoj kev ua haujlwm ntawm lub hlwb. Nws tuaj yeem txhawb txoj kev tsim thiab kho cov kev sib txuas ntawm cov cuab yeej sab nraud thiab txhim kho kev sib txuas thiab kev ua tau zoo ntawm neural tes hauj lwm. Nyob rau hauv cov qauv kev raug mob neural, cov khoom no tuaj yeem nrawm ntawm kev rov qab ua haujlwm thiab txhim kho kev txawj ntse thiab kev coj cwj pwm ntawm cov tsiaj. Cov haujlwm no qhia tau tias nws muaj peev xwm thov cov txiaj ntsig hauv kev neuroprotection thiab kho.
Sib Koom Tes Kev Ua Haujlwm Txhawb Txoj Haujlwm
Lub Pob Txha Taus Taus Quav Thiab Kho
Cov khoom no ua si lub luag haujlwm tseem ceeb hauv kev txhawb nqa kev noj qab haus huv. Nws tuaj yeem txhawb nqa lub chondrogenic sib txawv ntawm tib neeg synovial kua ntshav (hsv {} mscs), thiab nce ntxiv cov proliferation thiab txawv muaj peev xwm ntawm chaondocytes. Los ntawm kev ua kom lub PPP / Δ cov khoom tswj hwm cov khoom lag luam nthuav dav thiab kho cov synthesis thiab tso nyiaj ntawm pob txha mos thiab tso nyiaj ntawm pob txha mos. Cov txiaj ntsig no pab tiv thaiv kev sib koom ua ke, kho cov pob txha pob txha pob txha mos lwj thiab txhim kho kev sib koom tes sib luag.
Ua kom haum pob txha thiab mob
Ntxiv nrog rau kev txhawb nqa pob txha mos tsim thiab kho, cov khoom no tseem tuaj yeem txo cov o thiab mob. Nws tuaj yeem tiv thaiv qhov kev qhia ntawm pro -}}}}}}}} pakhiav mem tes ntawm pob qij txha thiab ua kom muaj kev nkag siab ntawm cov hlwb. Lub caij no, cov khoom lag luam no tseem tuaj yeem txhawb nqa kev tsim cov anti- penpammironment ntawm cov pob qij txha, thiab kev sib koom tes ua si thiab kev mob siab. Cov haujlwm no ua rau cov khoom lag luam no muaj cov ntawv thov muaj nuj nqis rau kev kho cov kab mob sib koom ua ke xws li osteoarthritis.
Lub peev xwm ntawm kev ua ke kho mob rau osteoarthritis
Cov kev tshawb fawb tau pom tias cov khoom no ua ke nrog HSC - mscs hauv kev kho mob osteoarthritis yuav muaj qhov cuam tshuam zoo dua. Hsv-mscs have multi-directional differentiation potential and immunomodulatory functions, and can promote cartilage repair and reduce inflammation. Cov khoom no tuaj yeem txhim kho lub peev xwm Chonderrogen sib txawv thiab anti - inflammatory nyhuv ntawm hsv {}} mscs. Kev sib xyaw ua ke ntawm ob yuav tsim cov nyhuv synergistic thiab txhim kho cov nyhuv kho. Qhov kev tshawb fawb no muab cov tswv yim tshiab thiab cov hau kev rau kev kho mob ntawm osteoarthritis.
Lwm cov peev xwm kho tau
Kev Tiv Thaiv Kev Tiv Thaiv Cardiovascular
Cov khoom no tseem pom cov peev xwm hauv kev tiv thaiv kab mob plawv. Nws tuaj yeem tswj cov metabolism thiab lub zog metabolism hauv lub zog, qis dua cov qib ntshav hnyuv, thiab txo qhov kev pheej hmoo ntawm atherosclerosis. Lub caij no, cov khoom lag luam no tseem tuaj yeem ua rau muaj kev nthuav dav thiab tsiv teb tsaws ntawm vascular leeg hlwb, thiab txo cov vascular vascular thiab kev puas tsuaj. Cov haujlwm no pab tiv thaiv kev noj qab haus huv ntawm cov hlab plawv thiab tiv thaiv qhov tshwm sim ntawm cov kab mob plawv.
Anti - cov nyhuv} cov nyhuv
Cov kev tshawb fawb tsis ntev los no tau pom tias cov khoom no yuav muaj qee yam anti {{}}} qog ntshav. Nws tuaj yeem tiv thaiv cov kev sib tw thiab kev ntxub ntxaug ntawm cov qog ntshav los ntawm kev tswj hwm lawv cov metabolism thiab cov phiajcim txoj hauv kev. Lub caij no, cov khoom lag luam no tseem tuaj yeem txhim kho kev tiv thaiv kab mob ntawm lub cev thiab txhawb nqa lub cev thiab kev tshem tawm cov qog ntshav. Txawm li cas los xij, tam sim no, muaj ob peb txoj kev tshawb fawb ntawm nws anti {4 4}} cov kev sim, thiab cov kev tshawb fawb xav tau los txheeb xyuas nws txoj kev ua tau zoo thiab kev nyab xeeb.
Lwm cov ntawv thov yuav
Ntxiv rau cov haujlwm saum toj no, cov khoom no kuj yuav muaj cov ntawv thov muaj nuj nqis hauv lwm thaj chaw. Piv txwv li, nyob rau hauv kev kho mob ntawm cov kab mob metabolic xws li cov mob metabolic, rog thiab ntshav qab zib,GW0742Yuav txhim kho cov tsos mob ntawm cov kab mob kab mob los ntawm kev tswj cov mepid metabolism thiab lub zog metabolism. Ib qho ntxiv, hauv cov liaj teb xws li cov kab mob neurological thiab cov kab mob tsis muaj zog, cov khoom lag luam no tseem tuaj yeem ua ua si qee lub luag haujlwm.
Cim npe nrov: GW0742, cov neeg muab khoom, chaw tsim khoom, chaw tsim khoom, lag luam wholesale, yuav, nqe, loj, loj, loj, rau muag