Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam txhab paub ntau tshaj plaws thiab cov chaw muag khoom ntawm -nicotinamide adenine dinucleotide cas 53-84-9 hauv Suav teb. Txais tos rau cov lag luam wholesale tej khoom zoo -nicotinamide adenine dinucleotide cas 53-84-9 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
-Nicotinamide adenine dinucleotide, tseem hu ua -NAD, yog ib qho tseem ceeb coenzyme koom nrog hauv ntau cov tshuaj tiv thaiv cellular metabolic. Nrog rau cov mis mos molecular C21H27N7O14P2 thiab lub cev hnyav ntawm kwv yees li 663.43 g / mol, nws ua lub luag haujlwm tseem ceeb hauv kev tsim hluav taws xob thiab cov txheej txheem ntawm tes.
Cov coenzyme no feem ntau tshwm sim hauv ob hom: oxidized (NAD +) thiab txo qis (NADH lossis NADH + H +). Hauv nws lub xeev oxidized, NAD + ua haujlwm ua tus txais hluav taws xob, thaum nyob hauv nws lub xeev txo qis, NADH ua haujlwm raws li tus neeg pub khoom siv hluav taws xob. Qhov kev hloov pauv no yog qhov tseem ceeb rau ntau txoj hauv kev metabolic, suav nrog glycolysis, -oxidation, thiab tricarboxylic acid (TCA) lub voj voog, txhawb kev hloov pauv ntawm hydrogen ions thiab txhawb kev sib txuas ntawm ATP, lub zog txiaj ntawm cov hlwb.
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| Tshuaj Formula | C21H28N7O14P2- |
| Exact Mass | 664.12 |
| Molecular Luj | 664.44 |
| m/z | 664.12 (100.0%), 665.12 (22.7%), 666.12 (2.9%), 665.11 (2.6%), 666.12 (2.5%) |
| Elemental Analysis | C, 37.96; H, 4.25; N, 14.76; O, 33.71; P, 9.32 |
-NAD yog soluble hauv dej heev tab sis insoluble hauv organic solvents xws li acetone. Nws yog ruaj khov nyob rau hauv qhuav tej yam kev mob thiab nruab nrab los yog me ntsis acidic kev daws teeb meem, tab sis nws yuav ua rau degradation nyob rau hauv alkaline ib puag ncig thiab thaum cua sov. Nws qhov nqus tau siab tshaj ntawm 259 nm (ε17800) thiab 230 nm (ε8000) ntawm pH 7.5, muab lub hauv paus rau nws qhov kev tshuaj xyuas ntau.
Tsis tas li ntawd, -NAD yog qhov tseem ceeb hauv kev tswj hwm cellular noj qab haus huv thiab kev ua haujlwm. Raws li ib tug cofactor rau dehydrogenase enzymes, nws txhawb ntau yam biochemical tshuaj, pab nyob rau hauv lub oxidation ntawm cawv, xws li ethanol.
Kev tshawb fawb tau pom tias kev tswj hwm qib txaus ntawm -NAD lossis nws cov precursors xws li nicotinamide mononucleotide (NMN) tuaj yeem ua rau qeeb cellular aging, txhim kho mitochondrial muaj nuj nqi, thiab txhim kho metabolic kev noj qab haus huv.
Hauv cov ntsiab lus, -NADH yog ib qho tseem ceeb coenzyme hauv cellular metabolism, pab txhawb kev tsim hluav taws xob thiab txhawb ntau yam txheej txheem biochemical uas tseem ceeb rau kev tswj hwm cellular noj qab haus huv thiab ua haujlwm.
-Nicotinamide adenine dinucleotideyog koom nrog ntau yam kev ua ub no xws li cellular metabolism, lub zog synthesis, thiab kho DNA cellular, thiab plays lub luag haujlwm tseem ceeb hauv lub cev tiv thaiv kab mob. Nyob rau hauv kev noj qab nyob zoo, qhov concentration ntawm nicotinamide adenine dinucleotide nyob rau hauv tib neeg lub cev yog ruaj khov, tswj lub cev ua haujlwm ntawm ntau lub hlwb. Cov concentration ntawm nicotinamide adenine dinucleotide hauv lub cev txiav txim siab txog cov txheej txheem thiab qhov loj ntawm cell aging, thiab kev txo qis hauv cov concentration yuav ua rau cov txheej txheem ntawm cell aging.Studies tau pom tias NAD + muaj kev tiv thaiv rau lub raum infarction los ntawm ischemic phais thiab tuaj yeem txo cov ntshav urea nitrogen thiab creatinine ntau ntau; NAD + muaj kev tiv thaiv ntawm lub raum tubular puas los ntawm kev phais ischemic.
NAD + tuaj yeem tiv thaiv lub raum puas los ntawm lub raum ischemia, thiab NAD + muaj txiaj ntsig tseem ceeb hauv kev npaj cov tshuaj tiv thaiv thiab kho lub raum ischemia. Tsis tas li ntawd, nicotinamide adenine dinucleotide muaj qee yam kev siv hauv kev npaj cov tshuaj rau kev kho mob ntawm qhov mob. NAD + koom nrog hauv kev tswj hwm kev qhia ntawm formalin thiab ua tiav Freund's adjuvant (CFA) los ntawm NAD+-dependent deacetylases SIRT1 thiab SIRT2. Induced inflammatory mob, thaum SIRT1 thiab SIRT2 koom rau hauv inhibitory nyhuv ntawm NAD + ntawm inflammatory mob los ntawm txawv mechanisms, yog li ua tiav cov nyhuv analgesic ntawm inflammatory mob.
Electron Carrier: -NADH ua haujlwm raws li cov khoom siv hluav taws xob hauv cov txheej txheem metabolic, tshwj xeeb hauv glycolysis, -oxidation, thiab citric acid voj voog (Krebs voj voog). Nws pub cov electrons thaum lub sij hawm oxidative phosphorylation, txhawb kev tsim cov ATP, lub zog txiaj ntawm cov hlwb.
Mitochondrial Function: -NADH yog qhov tseem ceeb rau kev tswj hwm mitochondrial kev ua haujlwm thiab kev tsim hluav taws xob. Nws feem ntau hu ua "mitochondrial vitamin" vim nws lub luag haujlwm hauv ATP synthesis los ntawm oxidative phosphorylation.
2. Cellular Signaling thiab DNA Kho
ADP-Ribosylation: -NAD+ (daim ntawv oxidized ntawm -NADH) ua lub substrate rau ADP-ribosyltransferases, uas muaj feem xyuam rau ntau yam cellular txheej txheem xws li teeb liab transduction thiab DNA kho.
Poly(ADP-Ribose) Polymerase (PARP) Kev Ua Haujlwm: -NAD+ yog siv los ntawm PARP enzymes los ua ke poly(ADP-} ribose), ib tug polymer uas ua lub luag haujlwm hauv DNA kho thiab cov lus teb ntawm cellular stress.
Enzyme Activity Assay: -NADH feem ntau yog siv rau hauv kev ntsuam xyuas biochemical los ntsuas qhov kev ua ntawm dehydrogenase enzymes. Qhov sib txawv ntawm qhov nqus ntawm 340 nm ntawm NAD + thiab NADH tuaj yeem siv los saib xyuas kev nce qib ntawm dehydrogenase- cov tshuaj tiv thaiv catalyzed.
Cov khoom siv kuaj mob: -NADH yog ib qho khoom siv hauv ntau yam khoom siv tshuaj ntsuam xyuas siv rau kev kuaj xyuas xws li lactate dehydrogenase (LDH), glutamic-pyruvic transaminase (ALT), glutamic-oxaloacetic transaminase (AST), thiab lwm yam. Cov khoom siv no vam khom rau cov dehydrogenase- cov tshuaj tiv thaiv catalyzed uas koom nrog -NADH.
4. Kev siv tshuaj thiab kev kho mob
Muaj peev xwm tiv thaiv -Txoj kev laus: Kev tshawb fawb qhia tias -NAD+ precursors yuav muaj kev tiv thaiv kev laus - los ntawm kev txhawb nqa NAD + qib hauv cov hlwb, uas tuaj yeem txhim kho cov metabolism hauv lub zog thiab txo cov kev ntxhov siab oxidative.
Cov Kab Mob Neurological: -NAD+-dependent enzymes koom nrog hauv kev tswj hwm cov kab mob neurodegenerative xws li Alzheimer's thiab Parkinson's. Cov tswv yim txhawm rau nce -NAD+ qib tab tom tshawb nrhiav raws li txoj hauv kev kho tau zoo.
Cancer Biology: -NAD+ thiab nws cov enzymes cuam tshuam ua lub luag haujlwm tseem ceeb hauv kev mob qog noj ntshav thiab kev loj hlob. Kev nkag siab txog cov luag haujlwm no tuaj yeem ua rau cov tswv yim kho tshiab rau kev kho mob qog noj ntshav.
Biotechnology: -NADH yog siv rau hauv cov txheej txheem biotechnological xws li fermentation thiab bioconversions, uas nws ua haujlwm ua cofactor rau ntau yam enzymes koom nrog hauv kev tsim cov tshuaj thiab roj.
Kev lag luam zaub mov thiab dej haus: -NADH tej zaum yuav muaj peev xwm siv tau hauv kev lag luam zaub mov thiab dej haus, tshwj xeeb hauv kev txhim kho cov khoom noj muaj txiaj ntsig thiab txee lub neej ntawm cov khoom los ntawm nws cov antioxidant thiab lub zog- txhawb zog.
txheej txheem synthesis
Cell cuam tshuam
Soak cov poov xab hauv hydrochloric acid aqueous tov rau 0.5-2.5h, ua qhov kub ntawm qhov sib txawv ntawm cov phab ntsa tawg, lim nrog ceramic membrane, thiab tau txais cov kua ntshiab A los ntawm kev siv cov lim.
Nco ntsoov
Ultrafiltration ntawm ntshiab kua A tau nyob rau hauv S1, nanofiltration ntawm ultrafiltrate kom tau concentrated tov B, thiab pH hloov ntawm concentrated tov B rau 2-2.5 nrog hydrochloric acid aqueous tov kom tau concentrated tov C.
Elution
Dhau cov tshuaj concentrated C tau nyob rau hauv S2 txog D152 resin kem, elute nrog ammonia dej, sau eluate D, thiab siv hydrochloric acid Chemic Tom qab kho cov pH ntawm lub eluent D rau 7-8 nrog albook aqueous tov, dhau los ntawm 717 resin kem, elute nrog poov tshuaj chloride aqueous tov, thiab sau cov tshuaj Eluent.
Kev sib cais
nanofiltration cov kev daws teeb meem E tau txais hauv S3 kom tau txais cov ntsiab lus F; kho cov pH ntawm cov tshuaj concentrated F rau 1-3 nrog nitric acid aqueous tov, ntxiv acetone rau nag lossis daus, thiab centrifuge kom tau cov khoom G.
Kev huv huv
yaj cov khoom G tau txais hauv S4 hauv dej, dhau los ntawm kev npaj chromatography, desalt, cais, sib sau cov tshuaj sib cais, mloog zoo, thiab khov -kom qhuav kom tau nicotinamide adenine dinucleotide.
-Nicotinamide adenine dinucleotide, feem ntau hu ua -NAD lossis NADH, nthuav tawm cov haujlwm lom neeg tseem ceeb hauv ntau cov txheej txheem biochemical. Nov yog cov ntsiab lus ntawm nws cov bioactivities tseem ceeb:
Ua ntej, -NADH ua haujlwm tseem ceeb hauv cofactor hauv ntau cov tshuaj tiv thaiv redox. Nws ua haujlwm raws li tus neeg pub khoom siv hluav taws xob thiab kev lees txais, ua kom yooj yim rau kev hloov ntawm electrons hauv txoj hauv kev metabolic. Lub luag haujlwm no tseem ceeb heev hauv cov txheej txheem tsim hluav taws xob xws li glycolysis, -oxidation, thiab tricarboxylic acid (TCA) cycle. Thaum cov txheej txheem no, -NADH pub cov khoom siv hluav taws xob, uas yog siv los tsim ATP, lub zog txiaj ntawm cov hlwb.
Qhov thib ob, -NADH ua haujlwm pub dawb ntawm ADP-ribose units hauv ADP-ribosylation cov tshuaj tiv thaiv. Cov tshuaj tiv thaiv no tseem ceeb hauv ntau cov txheej txheem ntawm tes, suav nrog kev kho DNA thiab kev tswj hwm ntawm cov protein ua haujlwm. Los ntawm pub ADP-ribose units, -NADH pab hloov cov proteins thiab lwm yam biomolecules, yog li cuam tshuam rau lawv cov dej num thiab kev ua haujlwm.
Tsis tas li ntawd, -NADH kuj yog ib qho ua ntej ntawm cyclic ADP-ribose, ib qho kev qhia molecule koom nrog hauv calcium signaling thiab kev tswj hwm ntawm insulin secretion. Nws lub luag haujlwm hauv calcium signaling yog qhov tseem ceeb tshwj xeeb rau kev tswj hwm cellular homeostasis thiab tswj ntau yam txheej txheem physiological.
Ntxiv rau, -NADH ua lub luag haujlwm hauv kev sib txuas thiab kho DNA. Nws txhawb kev ua haujlwm ntawm cov enzymes koom nrog hauv DNA replication thiab kho, ua kom muaj kev ruaj ntseg thiab kev ncaj ncees ntawm cov khoom siv caj ces.
Tsis tas li ntawd, -NADH tau cuam tshuam rau kev laus thiab kev ua neej ntev. Cov kev tshawb fawb tau pom tias kev tswj hwm qib txaus ntawm -NADH tuaj yeem ncua kev laus thiab txhawb kev noj qab haus huv ntawm tes. Qhov no yog vim nws lub luag haujlwm hauv kev tsim hluav taws xob thiab kev saib xyuas ntawm cellular homeostasis.
Hauv cov ntsiab lus, -NADH nthuav tawm ntau yam kev ua ub no, ua lub luag haujlwm tseem ceeb hauv cov metabolism hauv lub zog, ADP- cov tshuaj tiv thaiv ribosylation, calcium signaling, kho DNA, thiab cov txheej txheem kev laus. Nws qhov tseem ceeb hauv kev tswj hwm cellular noj qab haus huv thiab kev ua haujlwm underscores nws qhov tseem ceeb hauv cov kab mob lom.
Cov tswv yim rau Boost-NADQib
Kev noj zaub mov noj
Nicotinamide Riboside (NR) thiab Nicotinamide Mononucleotide (NMN): Precursors uas bypass tus nqi- txwv cov kauj ruam hauv -NAD synthesis, nce qib -NAD qib hauv cov nas thiab tib neeg.
Tryptophan-Cov Khoom Noj Khoom Haus: Qaib ntxhw, qe, thiab cheese muab tryptophan rau de novo -NAD synthesis.
Kev yoo mov tsis tu ncua thiab txwv calorie: Cov kev noj zaub mov no qhib sirtuins, nce -NAD turnover.
Kev tawm dag zog thiab lub cev ua haujlwm
Aerobic ce txhim kho mitochondrial biogenesis thiab -NAD synthesis ntawm AMPK thiab PGC-1 ua kom, txhim kho kev noj qab haus huv metabolic.
Pharmacological txoj kev
NAMPT Activators:
Cov tshuaj xws li P7C3 txhim kho NAMPT kev ua haujlwm, txhawb nqa -NAD khaws cia.
PARP Inhibitors:
Cov tshuaj zoo li olaparib txo -NAD noj los ntawm inhibiting PARP overactivation.
CD38 inhibitors:
Cov neeg ua haujlwm sim xws li 78c thaiv CD38, khaws cia - qib NAD.
Ntxiv nrog -NADPrecursors
NR thiab NMN Supplements:
Kev sim tshuaj ntsuam xyuas pom tau tias NR (300-1000 mg / hnub) nce -NAD txog li 60% hauv tib neeg.
Resveratrol:
Ib qho polyphenol uas ua rau SIRT1, txhawb kev ncaj qha - kev siv NAD.
I. Initial Discovery (1906)
Xyoo 1906, British kws tshawb fawb Harden thiab Young tau tshawb fawb txog cawv fermentation hauv poov xab. Lawv pom tias cov cua sov-sterilized poov xab extract drastic fermentation ceev ceev thiab hu ua lub tshav kub- ruaj khov active ingredient cozymase, lub primitive daim ntawv ntawm -NAD.
II. Tus Txheej Txheem Elucidation (1920–1936)
Xyoo 1929, Euler-Chelpin tau ntxuav cov khoom sib xyaw thiab txheeb xyuas nws cov qauv dinucleotide. Ob tus kws tshawb fawb tau sib koom ua ke muab khoom plig Nobel hauv Chemistry rau lawv cov kev tshawb fawb txog fermentation. Xyoo 1936, Warburg tau qhia meej txog cov haujlwm tseem ceeb ntawm lub cev ntawm -NAD, txheeb xyuas cov nicotinamide moiety raws li qhov chaw tseem ceeb rau redox hydrogen hloov, thiab tau lees paub tias -kev sib haum xeeb sib haum rau nws daim ntawv lom neeg.
III. Precursor Identification thiab Synthetic Perfection (1938–1950)
Hauv xyoo 1938, Elvehjem tau lees paub tias nicotinic acid thiab nicotinamide (vitamin B3) ua haujlwm ua cov txheej txheem endogenous biosynthetic precursors rau -NAD. Tom qab xyoo 1940, Kornberg maj mam nthuav tawm cov txheej txheem enzymatic tseem ceeb tswj hwm nws cov biosynthesis. Tag nrho cov tshuaj synthesis ntawm -NAD tau ua tiav xyoo 1950, ua tiav tag nrho cov molecular molecular molecules.
FAQ
Puas yog NAD + zoo li Ozempic?
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Tsis yog, NAD + tsis zoo li Ozempic. Lawv yog cov sib txawv kiag li uas ua haujlwm ntawm cov kab mob sib txawv. Thaum ob qho tib si nrov hauv kev noj qab haus huv, lawv ua haujlwm sib txawv kiag li.
Puas yog nicotinamide adenine dinucleotide zoo rau koj?
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Nicotinamide adenine dinucleotide (NAD +) yog ib qho tseem ceeb coenzyme pom nyob rau hauv tag nrho cov nyob hlwb, tseem ceeb rau lub zog metabolism, kho DNA, thiab cellular noj qab haus huv. Txawm hais tias nws yog ib qho tseem ceeb rau koj lub cev, noj nws ua ib qho ntxiv rau kev txhawb nqa kev noj qab haus huv tseem tab tom tshawb fawb, txawm tias nws tau cog lus rau kev laus noj qab haus huv.
Cov zaub mov twg siab hauv NAD?
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Koj tsis tuaj yeem nqus Nicotinamide Adenine Dinucleotide (NAD +) ncaj qha los ntawm koj cov khoom noj. Hloov chaw, koj lub cev tsim thiab rov ua dua NAD + siv cov khoom noj khoom haus. Txhawm rau txhawb koj qib, tsom mus rau cov khoom noj nplua nujNiacin (Vitamin B3), Tryptophan, thiab direct precursors nyiamNicotinamide Riboside (NR)los yogNMN.
Cim npe nrov: -nicotinamide adenine dinucleotide cas 53-84-9, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom