Hydroxyecdysone, tseem hu ua molting hormone, yog ib yam khoom uas tau muab rho tawm los ntawm cov hauv paus hniav ntawm cov nroj tsuag xws li Cyanotis arachnoidea CB Clarke hauv tsev neeg Commelinaceae. Nws cov qauv tshuaj yog C27H44O7, qhov hnyav molecular yog 480.63406, thiab CAS nkag tus lej yog 5289-74-7. Nws tuaj yeem tshwm sim dawb, tawm dawb, lub teeb daj, lossis lub teeb xim av crystalline hmoov. Qhov sib txawv xim no feem ntau yog vim qhov sib txawv ntawm cov ntsiab lus impurity thiab cov txheej txheem ntau lawm. Cov khoom siv purity siab, xws li ecdysterone siv hauv cov tshuaj pleev ib ce, feem ntau yog cov ntshiab dawb crystalline hmoov lossis tsis muaj xim pob tshab siv lead ua nrog cov yam ntxwv zoo. Tsawg solubility hauv dej, manifested li me ntsis solubility. Txawm li cas los xij, nws cov solubility sib txawv hauv cov kuab tshuaj sib txawv. Tshwj xeeb, nws yog soluble hauv ethanol, qhia tias nws zoo hydrophilicity ntawm cawv; Me ntsis soluble hauv acetone, tab sis me ntsis soluble hauv ethyl acetate, chloroform, thiab dej kub; Nws yuav luag insoluble nyob rau hauv ether, qhia tias nws tsis zoo lipophilicity. Cov yam ntxwv solubility no yuav tsum tau xaiv cov kuab tshuaj uas tsim nyog thaum nws npaj thiab siv cov txheej txheem. Qhia qee cov yam ntxwv tshwj xeeb hauv kev sim tshuaj. Piv txwv li, thaum yaj nyob rau hauv sulfuric acid, nws yuav tshwm reddish xim av; Tom qab yaj hauv ethanol thiab ntxiv 1-2 tee ntawm ferric chloride test tov, xim ntsuab tsaus yuav tshwm. Cov tshuaj tiv thaiv no tuaj yeem siv rau kev txheeb xyuas thiab kuaj purity ntawm cov khoom.
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Tshuaj Formula |
C27H44O7 |
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Exact Mass |
480 |
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Molecular Luj |
481 |
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m/z |
480 (100.0%), 481 (29.2%), 482 (4.1%), 482 (1.4%) |
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Elemental Analysis |
C, 67.47; H, 9.23; O, 23.30 |
Hydroxyecdysone, raws li ib txwm tshwm sim steroid, belongs rau cov nroj tsuag sterols thiab yog dav nyob rau hauv ntau yam nroj tsuag thiab tsiaj, tshwj xeeb tshaj yog nyob rau hauv herbaceous nroj tsuag xws li cov nroj tsuag dej uas muaj qib siab. Nws cov qauv tshuaj tshwj xeeb endows ecdysteroids nrog ntau yam kev ua haujlwm lom neeg thiab ntau yam kev siv.
Kev kho mob teb
Hauv kev lag luam tshuaj, nws yog dav siv rau kev kho mob ntawm ntau yam kab mob thiab kev kho mob vim nws ntau yam kev ua ub no lom neeg.
Txhawb nqa protein synthesis thiab tshem tawm cov cholesterol:
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Nws tuaj yeem txhawb nqa cov synthesis ntawm tib neeg cov proteins, tshwj xeeb tshaj yog collagen, uas yog qhov tseem ceeb rau kev tswj xyuas kev noj qab haus huv ntawm cov ntaub so ntswg xws li tawv nqaij, pob txha, thiab cov leeg. Nyob rau tib lub sijhawm, nws tseem tuaj yeem pab tshem tawm cov cholesterol hauv lub cev, txo cov ntshav lipid, thiab pab tiv thaiv kab mob plawv.
Anti arrhythmia thiab anti qaug zog:
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Nws muaj qee yam kev tiv thaiv arrhythmia, tuaj yeem txhim kho lub plawv ua haujlwm, thiab txo qhov tshwm sim ntawm arrhythmia. Tsis tas li ntawd, nws tuaj yeem txhim kho lub cev tiv thaiv kev qaug zog, txhim kho endurance thiab rov ua kom nrawm.
Hypoglycemic thiab hypolipidemic:
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Cov khoom xyaw zoo hauv, xws li 20 hydroxyecdysterone, tau raug pov thawj los ntawm kev tshawb fawb soj ntsuam kom muaj cov nyhuv hypoglycemic ncaj qha, tshwj xeeb tshaj yog rau cov neeg mob ntshav qab zib hom II. Nyob rau tib lub sijhawm, nws tuaj yeem txo cov ntshav lipids thiab tiv thaiv atherosclerosis thiab lwm yam kab mob plawv.
Anti-inflammatory thiab analgesic:
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Nws muaj kev tiv thaiv -cov teebmeem inflammatory, tuaj yeem txo cov kev mob tshwm sim, thiab txo cov tsos mob xws li mob thiab o. Qhov no ua rau nws muaj txiaj ntsig zoo hauv kev kho mob inflammatory kab mob xws li mob caj dab thiab gout.
Anti mob qog noj ntshav:
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Nws kuj nthuav tawm qee yam tshuaj tiv thaiv- mob qog noj ntshav thiab tuaj yeem cuam tshuam kev loj hlob thiab kis ntawm cov qog hlwb. Txawm hais tias kev tshawb fawb hauv cheeb tsam no tseem tab tom ua, nws lub peev xwm hauv kev tiv thaiv thiab kho mob qog noj ntshav tau pom ua ntej.
Hauv kev ua kis las cov khoom noj qab haus huv, lawv tau nyiam ntau yam vim lawv lub peev xwm los txhawb cov leeg nqaij thiab rov zoo.
Txhawb cov leeg loj hlob:
Nws tuaj yeem ua kom muaj txiaj ntsig zoo ntawm cov amino acid sib sau ua ke rau hauv cov saw hlau protein, yog li txhawb kev txhais lus thiab kev tsiv teb tsaws ntawm cov nqaij leeg ntawm cov leeg nqaij protein. Qhov no ua rau cov neeg ncaws pob tuaj yeem rov qab tau lawv lub cev lub zog sai dua tom qab kev cob qhia, ua kom cov leeg muaj zog thiab kev ua siab ntev.
Txhim kho lub cev muaj zog:
Ntxiv nrog rau kev txhawb nqa cov leeg nqaij, nws tuaj yeem txhim kho daim siab ua haujlwm thiab cov txheej txheem metabolism hauv lub zog, ua rau lub cev hloov pauv sai sai rau ib puag ncig thiab kev ntxhov siab. Qhov no pab txhim kho lub cev tag nrho thiab kev sib tw ntawm cov neeg ncaws pob.
Nyob rau hauv lub tshav pob ntawm cov tshuaj pleev ib ce, nws yog txaus siab rau nws zoo heev kev tu tawv nqaij nyhuv.
Exfoliation thiab Whitening:
Nws tuaj yeem txhawb cov metabolism thiab ua kom cov stratum corneum tshem tawm cov laus stratum corneum, thiab ua rau daim tawv nqaij smoother thiab muag heev. Nyob rau tib lub sijhawm, nws tuaj yeem cuam tshuam kev tsim thiab tso tawm ntawm melanin, thiab muaj cov nyhuv ntawm whitening ntawm daim tawv nqaij.
Txhim kho daim tawv nqaij barrier:
Nws tuaj yeem txhim kho cov haujlwm thiab cov peev txheej metabolic ntawm daim tawv nqaij, txhawb kev kho thiab rov tsim kho ntawm daim tawv nqaij barrier. Qhov no yuav pab txhim kho daim tawv nqaij tiv thaiv thiab tiv thaiv kab mob, thiab txo qhov kev puas tsuaj ntawm ib puag ncig sab nraud rau ntawm daim tawv nqaij.
Anti aging:
Vim nws lub peev xwm los txhawb cov synthesis ntawm collagen thiab kev tsim kho thiab kho cov hlwb ntawm daim tawv nqaij, nws kuj muaj cov teebmeem tseem ceeb hauv kev tiv thaiv - laus. Siv cov tshuaj pleev ib ce uas muaj ecdysteroids tuaj yeem ncua cov txheej txheem kev laus ntawm daim tawv nqaij thiab tswj nws cov hluas.
Exfoliation thiab Whitening:
Nws tuaj yeem txhawb cov metabolism thiab ua kom cov stratum corneum tshem tawm cov laus stratum corneum, thiab ua rau daim tawv nqaij smoother thiab muag heev. Nyob rau tib lub sijhawm, nws tuaj yeem cuam tshuam kev tsim thiab tso tawm ntawm melanin, thiab muaj cov nyhuv ntawm whitening ntawm daim tawv nqaij.
Txhim kho daim tawv nqaij barrier:
Nws tuaj yeem txhim kho cov haujlwm thiab cov peev txheej metabolic ntawm daim tawv nqaij, txhawb kev kho thiab rov tsim kho ntawm daim tawv nqaij barrier. Qhov no yuav pab txhim kho daim tawv nqaij tiv thaiv thiab tiv thaiv kab mob, thiab txo qhov kev puas tsuaj ntawm ib puag ncig sab nraud rau ntawm daim tawv nqaij.
Anti aging:
Vim nws lub peev xwm los txhawb cov synthesis ntawm collagen thiab kev tsim kho thiab kho cov hlwb ntawm daim tawv nqaij, nws kuj muaj cov teebmeem tseem ceeb hauv kev tiv thaiv - laus. Siv cov tshuaj pleev ib ce uas muaj ecdysteroids tuaj yeem ncua cov txheej txheem kev laus ntawm daim tawv nqaij thiab tswj nws cov hluas.
Nyob rau hauv lub teb ntawm aquaculture, nws yog dav siv nyob rau hauv sericulture thiab aquaculture.
Sericulture:
Nws tuaj yeem ua rau lub hnub nyoog ntawm silkworms luv, ua rau lawv pawg zoo zoo, thiab txhawb kev tsim cov kab lo lo ntxhuav thiab cocoons. Qhov no tuaj yeem tsis tsuas yog nce cov qoob loo thiab qhov zoo ntawm cov kab lo lo ntxhuav, tab sis kuj txo cov nqi yug me nyuam thiab cov nqi sij hawm.
Aquaculture:
Cov zaub mov yog cov khoom tseem ceeb rau kev loj hlob, kev loj hlob, molting, thiab metamorphosis ntawm cov dej crustaceans xws li cws thiab crabs. Ntxiv qhov tsim nyog ntawm cov tshuaj no thaum lub sijhawm yug me nyuam tuaj yeem txhawb nqa qhov sib xws ntawm cws thiab roob ris molting thiab kev loj hlob thiab kev loj hlob, zoo zam qhov tshwm sim ntawm tus neeg tua neeg, thiab txhim kho cov ciaj sia taus thiab cov khoom specifications ntawm aquaculture.
Hauv kev ua liaj ua teb, nws yog siv los ua cov nroj tsuag kev loj hlob regulator thiab tshuaj tua kab ntxiv.
Txhawb kev cog qoob loo:
Nws tuaj yeem cuam tshuam txoj kev loj hlob thiab kev loj hlob ntawm cov nroj tsuag, txhawb cov qoob loo loj hlob, thiab nce yield. Nyob rau tib lub sijhawm, nws tseem tuaj yeem txhim kho cov qoob loo zoo thiab txhim kho lawv txoj kev ntxhov siab, xws li drought resistance, tiv thaiv kab tsuag thiab kab mob.
Pesticide adjuvants:
Muaj peev xwm cuam tshuam rau txoj kev loj hlob thiab kev loj hlob ntawm kab los tswj lossis tua kab tsuag ua liaj ua teb. Yog li ntawd, nws tau raug tsim los ua thib peb - tshuaj tua kab rau kev siv thiab kev tshawb fawb. Tsis tas li ntawd, nws kuj tseem siv tau los ua qhov siab -yield additive rau cov qoob loo los txhawb kev loj hlob thiab nce yield thaum lub sij hawm kev loj hlob.
Ntxiv nrog rau kev ua tus tswj kev loj hlob ntawm cov nroj tsuag hauv kev ua liaj ua teb, nws kuj muaj cov tshuaj tua kab mob tseem ceeb. Thaum lub sij hawm loj hlob thiab kev loj hlob ntawm kab, molting cov tshuaj hormones ua lub luag haujlwm tseem ceeb. Los ntawm kev tswj cov qib thiab cov txheej txheem ntawm cov tshuaj hormones molting, cov txheej txheem molting thiab metamorphosis ntawm kab tuaj yeem cuam tshuam, yog li ua tiav lub hom phiaj ntawm kev tswj cov kab tsuag. Cov koob tshuaj ntau ntawm ecdysteroids tuaj yeem cuam tshuam cov txheej txheem metabolic hauv cov kab, ua rau lawv molt lossis metamorphose ntxov ntxov rau cov neeg laus lossis cov neeg tsis zoo, thiab tseem ua rau lawv tuag. Txoj kev siv tshuaj tua kab no muaj cov yam ntxwv ntawm kev tiv thaiv ib puag ncig, tsis muaj tshuaj lom, thiab ua haujlwm siab, thiab yog ib qho ntawm cov lus qhia tseem ceeb rau kev tsim tshuaj tua kab yav tom ntej.
Nws kuj tau qhia qee qhov peev xwm hauv thaj tsam ntawm ecological thiab kev tiv thaiv ib puag ncig. Ua ntej, ua ib yam khoom tshwm sim, nws ua rau ib puag ncig muaj kuab paug tsawg thiab ua raws li cov hauv paus ntsiab lus ntawm kev ua liaj ua teb niaj hnub ecological thiab kev tsim kho kom ruaj khov. Qhov thib ob, nws ua lub luag haujlwm zoo hauv kev txhawb nqa kev loj hlob thiab photosynthesis ntawm cov nroj tsuag dej, pab txhim kho cov dej zoo thiab tswj kom muaj qhov sib npaug ntawm cov dej hauv dej. Los ntawm kev txhawb lub decomposition ntawm cov organic teeb meem thiab cov kev ncig ntawm cov as-ham, lub peev xwm ntawm tus kheej purification ntawm cov dej lub cev tuaj yeem txhim kho, thiab qhov tshwm sim ntawm eutrophication thiab kev ua qias tuaj hauv dej tuaj yeem txo.
Corticosteroids ua rau tib neeg lub cev los txhawb collagen synthesis, tiv thaiv arrhythmia, thiab alleviate nkees nkees; Txhawb nqa kev loj hlob ntawm tes, txhawb nqa kev faib tawm ntawm tes, thiab tshem tawm cov roj cholesterol hauv lub cev; Txo cov ntshav lipids thiab inhibit qhov nce ntawm cov ntshav qab zib; Physiological kev ua ub no xws li meridian activation, dehumidification thiab analgesia. Nws yog ib yam tshuaj tiv thaiv kab mob -tus neeg sawv cev. Txij li thaum nws cov lus qhia nyob rau hauv 1976, dewgrass molting hormone tau tsim rau hauv cov ntsiav tshuaj tsis tu ncua, txhaj tshuaj, thiab muab tshuaj txhuam. Nws yog siv nyob rau hauv pej xeem rau rheumatoid mob caj dab. Nws muaj cov nyhuv curative zoo hauv kev kho mob rheumatism thiab mob caj dab nrog cov tsos mob sib txawv. Nws cov khoom muaj txiaj ntsig 20 hydroxyecdysterone tau raug pov thawj los ntawm kev tshawb fawb soj ntsuam kom muaj cov nyhuv Hydroxyecdysone ncaj qha. Tag nrho cov txiaj ntsig zoo rau hom ntshav qab zib hom II yog 84%, tshwj xeeb tshaj yog rau cov neeg mob ntshav qab zib uas muaj "ntau dua peb thiab tsawg dua".
Nyob rau hauv cov nqe lus ntawm kev ua kis las noj qab haus huv cov khoom, ecdysteroids muaj ib tug tseem ceeb lub peev xwm los txhawb cov protein synthesis nyob rau hauv cov leeg nqaij cytoplasm los ntawm kev ua kom cov amino acids sib sau ua ke rau hauv cov protein chains, thiab lub peev xwm no muaj peev xwm taug qab rov qab mus rau kev txhais lus thiab kev tsiv teb tsaws ntawm cov protein. Corticosteroids tsis yog tsuas yog muaj txiaj ntsig zoo rau kev noj qab haus huv tab sis kuj muaj kev nyab xeeb. Lawv pab txhim kho cov hlwb puas los ntawm cortisol, normalize lub zog synthesis theem (ATP thiab creatine), thiab txhim kho daim siab ua haujlwm, ua kom cov kab mob hloov pauv sai sai rau ib puag ncig thiab kev ntxhov siab. Nws txoj kev nyab xeeb tau pom los ntawm ntau dua 50 qhov kev tshawb fawb kom tsis muaj kev phiv, tsis muaj kev cuam tshuam nrog cov tshuaj hormones, thiab qib toxicity tsawg heev. Thaum kuaj los ntawm ICN Biochemical Laboratory hauv xyoo 1998, cov ntaub ntawv tau pom tias txhawm rau txhawm rau ecdysteroids kom pom cov tshuaj toxicity, ib qho tshuaj ultra- siab ntawm 6400mg / kg yog qhov tsim nyog. Ntxiv mus, nyob rau hauv cov kev ntsuam xyuas endocrine uas muaj xws li kev ntsuam xyuas rau testosterone, cortisol, insulin, corticotropin, kev loj hlob hormone, thiab luteinizing hormone, tsis tau muaj lus ceeb toom txog tej teebmeem ntawm ecdysteroids ntawm mammalian hormonal system.
Kev tshawb pom ntawm Hydroxyecdysone tuaj yeem taug qab mus rau xyoo 1930s. Xyoo 1934, British biologist Vincent Wigglesworth thawj zaug pom tias kab molting muaj feem xyuam rau cov tshuaj hormones tsis paub. Hauv kaum xyoo tom ntej no, cov kws tshawb fawb maj mam nthuav tawm lub neej thiab cov yam ntxwv ntawm cov tshuaj hormone no los ntawm kev sim ntau yam. Xyoo 1954, tus kws tshawb fawb German Peter Karlson tau ua tiav cov khoom siv los ntawm silkworm pupae uas tuaj yeem ua rau kab molting, thiab hu ua "molting hormone". Qhov kev tshawb pom no yog ib qho tseem ceeb hauv kev kawm txog kab endocrinology. Xyoo 1965, Karlson tau koom tes nrog Butenandt kom cais tawm 25 milligrams ntawm cov tshuaj ntshiab molting los ntawm 500 kilograms ntawm silkworm pupae thawj zaug, thiab ua ntej txiav txim siab nws cov qauv tshuaj. Xyoo 1966, cov kws tshawb fawb Nyij Pooj Hoffmann thiab Koolman ntawm nws tus kheej tau cais lwm cov tshuaj nrog kev ua haujlwm molting los ntawm silkworm pupae, uas yog hydroxyecdysteroid. Qhov kev tshawb pom no ntxiv dag zog rau tib neeg txoj kev nkag siab ntawm kab molting cov tshuaj hormones. Tom qab ntawd, cov kws tshawb fawb tau txuas ntxiv cais hydroxyecdysteroids los ntawm ntau yam kab thiab nroj tsuag, thiab tau ua hauv - kev tshawb fawb tob txog lawv cov qauv tshuaj lom neeg thiab kev ua haujlwm lom neeg.
Hydroxyecdysone yog ib qho chaw zoo nkauj zoo nkauj nrog ntau yam kev ua haujlwm lom neeg thiab muaj peev xwm siv tau. Nws lub luag haujlwm hauv kev tswj hwm kev loj hlob, kev loj hlob, molting, thiab kev yug me nyuam hauv kab thiab crustaceans tau kawm zoo -, thiab nws muaj nyob rau hauv cov nroj tsuag raws li kev tiv thaiv mechanism qhia txog nws qhov tseem ceeb ntawm ecological. Hauv tib neeg, nws muaj peev xwm anabolic, antioxidant, tiv thaiv - inflammatory, thiab tiv thaiv - mob qog noj ntshav ua rau nws yog tus neeg sib tw txaus nyiam rau ntau yam kev kho mob thiab kev ua kis las - ntsig txog kev siv. Txawm li cas los xij, kev tshawb fawb ntxiv yog xav tau kom nkag siab tag nrho nws cov txheej txheem ntawm kev ua, kev ua tau zoo, thiab kev nyab xeeb hauv cov ntsiab lus sib txawv. Raws li kev tshawb fawb hauv zej zog txuas ntxiv tshawb nrhiav cov khoom ntawm hydroxyecdysone, nws tuaj yeem qhib txoj hauv kev tshiab rau kev txhim kho kev kho ntuj thiab kev ruaj ntseg thiab kev daws teeb meem ua liaj ua teb.
Hydroxyecdysone yog ib qho chaw zoo kawg nkaus nrog deb - mus txog qhov cuam tshuam thoob plaws hauv biology, tshuaj, thiab kev lag luam. Los ntawm kev tswj hwm kab kev txhim kho kom muaj peev xwm kho tau tib neeg cov kab mob, nws cov versatility underscores tus nqi ntawm kev kawm cov khoom ntuj. Txawm hais tias muaj teeb meem cuam tshuam txog bioavailability, kev tswj kom meej meej, thiab ntev -kev nyab xeeb nyob twj ywm, kev tshawb fawb tsis tu ncua cog lus tias yuav qhib cov ntawv thov tshiab. Los ntawm kev sib txuas ntawm qhov sib txawv ntawm entomology thiab tib neeg kev noj qab haus huv, hydroxyecdysone ua piv txwv lub zog ntawm kev tshawb fawb kev sib raug zoo los daws cov teeb meem thoob ntiaj teb. Raws li kev coj noj coj ua thiab cov tshuaj kho tus kheej tau txais txiaj ntsig zoo, cov qauv qub qub no tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev txhim kho yav tom ntej ntawm kev noj qab haus huv thiab kev ua liaj ua teb.
Cim npe nrov: Hydroxyecdysone CAS 5289-74-7, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom