Leterobupivacaine hydrochloride, Molecular Cov Qauv Molecular C18h292929292, Cas 27262 {- 48- 2. Nws yog dawb lossis tawm {-}} Crystalline hmoov, tsw ntxhiab thiab ntsim me ntsis. Nws tsis yooj yim soluble hauv dej thiab ethanol, tab sis soluble hauv cov kuab tshuaj organic xws li chloroform. Lub solubility yog tsawg, lub solubility hauv dej yog 5mg / ml, thiab solubility hauv ethanol yog li 1mg / ml. Nws yog chiral molecule nrog ob enantiomers, l - thiab d-. Ntawm lawv, l- yog sab laug {{17} {{{18 {21}- lias molecule. Txij li tsuas yog tus l - enantiomer yog tshuaj uas muag tshuaj, nws feem ntau siv l- Enantiomer raws li cov khoom xyaw nquag. Nws yog ib qho tsis muaj zog alkaline nrog kev oneization tas li (PKA) ntawm txog 8.1. Raws li lub ntsiab cai ntawm sab laug-txoj cai symmetry, levo (sab laug) sawv cev nws txoj kev teeb tsa peb sab. Nws yog ib qho kev tshuaj loog hauv zos nrog lub tshuab sib xws ntawm kev nqis tes ua rau lidocaine thiab bupivacaine. Nws cov qauv tshuaj txiav txim siab nws cov yam ntxwv, uas yog qhov tseem ceeb hauv kev tshawb nrhiav chaw tshuaj noj, kev tsim tshuaj thiab lwm daim teb. Kab lus no yuav piav txog txhua yam khoom siv lub cev ntawm cov khoom.
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Levobiocaine hydrochloride yog ib qho kev ua yeeb yam zoo nkauj nrog tshuaj lom neeg ntawm 34,89, uas yuav sib txawv nyob ntawm seb muaj cov dej siv lead ua). Nws muaj cov ntawv thov kev kho mob ntau ntau, thiab cov hauv qab no yog cov lus qhia ntxaws ntxaws rau nws cov kev siv tshwj xeeb:
Epidural block tshuaj loog:
Nws yog ib qho uas siv tau siv rau kev phais mob epidgural. Nws block ntau tiam thiab kev sib kis ntawm cov hlab ntsha impulses, ua rau cov neeg mob ua rau muaj kev sib txuam nrog cov xwm txheej tsis txaus ntseeg nyob rau hauv cov kev mob tsis meej pem, yog li muaj kev cuam tshuam analgesic.
Thaum siv rau cov hlab ntsha thaiv lossis cov tshuaj loog rau cov neeg laus, qhov ntau tshaj plaws ntawm ib zaug yog 150MG. Hais txog kev tsim kho tshuaj-kev kho tshuaj epidural feem ntau siv cov tshuaj ntawm 0.5%, nrog rau 0.75%, nrog rau 0.75%, nrog rau 0.75%, uas tuaj yeem ua tiav los ua tiav kom tiav rau kev ua tiav cov nyhuv
Thaum 0.25% ~ 0.5%Leterobupivacaine hydrochlorideyog thov rau cheeb tsam thaiv, nws txoj kev ua tau zoo ib yam li ntawm Bupivacaine ntawm tib lub ntsiab lus; Thaum 0.375% ~ 0.75% epidural block yog ua, qhov pib thiab ntev ntawm kev hnov thiab lub zog thaiv tau zoo ib yam li ntawm bupivacaine.
Lumbar loog:
Txawm hais tias cov lus qhia tsis qhia meej meej txog lub xeev nws siv rau lumbar antesthesia, kev siv tshuaj loog rau lumbar, qev, thiab phais mob plab mog.
Neuroblock tshuaj loog:
Dav siv ntau hom kev ua yeeb yam ntawm cov hlab ntsha ensesthesia, thiab lwm yam tshuaj loog rau hauv thaj chaw uas yog cov leeg ua kom huv si.
Ua Haujlwm Analgesia:
Yuav siv tau rau kev txhaj tshuaj thaum yug menyuam, txo qis kev ua haujlwm ntawm lub cev muaj zog thiab tsis muaj kev cuam tshuam rau cov txheej txheem ntawm tus txheej txheem.
Postoperative Analgesia:
Qhov mob postoperative yog ib qho ntawm cov tsos mob tshwm sim hauv cov hlab ntsha phais, uas tuaj yeem siv rau kev ua kom muaj kev txhawb nqa kom ua rau tus neeg nyiam ua kom muaj kev nplij siab.
Tshuaj loog hauv lwm cov txheej txheem kho mob
Kev soj ntsuam thiab kev ua haujlwm entestesia:
Yuav siv tau rau kev ua kom loog ntau ntxiv, xws li endoscopy, me hotes thaiv kev ua kom cov neeg mob hauv nroog kom tiv thaiv cov neeg mob lub siab thaum kuaj mob lossis kev ua haujlwm.
Cov tshuaj loog pleev ib ce:
Txawm hais tias tsuas yog siv rau Infiltration Actionshesia thiab cov hlab ntaws thaiv cov tshuaj loog, nws kuj tuaj yeem siv rau kev ua kom loog nto hauv qee kis. Piv txwv li, hauv kev phais mob ophalecic, levoBupivacaine HCL tuaj yeem siv los ntawm cov tee qhov muag kom ntxias kom loog rau ntawm lub qhov muag. Txawm li cas los xij, ntau ntau cov tshuaj loog ib qho tib si yog obluoride gel, thiab lwm yam.
Anti inflammatory nyhuv:
Nws tuaj yeem cuam tshuam qhov kev tso tawm ntawm cov teeb meem ntawm cov yam ntxwv, yog li ua tiav anti - inflammatory teebmeem. Nws tuaj yeem siv los daws cov tshuaj tiv thaiv mob los ntawm kev phais mob Trauma, hlawv, thiab lwm yam. Txawm li cas los xij, txoj haujlwm no tsis yog nws lub ntsiab siv, thiab nws yuav tsum tau ua ke nrog cov kev cai tshwj xeeb thiab kws kho mob hauv cov ntawv thov kev kho mob.
Antiarrhythmic (siv nrog ceev faj):
In theory, levobupivacaine hcl may have a certain anti arrhythmic effect by affecting the electrophysiological activity of myocardial cells.
Txawm li cas los xij, vim nws lub plawv lom zem (txawm hais tias qis dua bupivacaine), nws tsis pom zoo rau kev siv tshuaj tua tshuaj tiv thaiv tshuaj. Hauv cov xwm txheej tshwj xeeb, xws li arrhythmia thaum lub loog hauv zos, cov kws kho mob yuav ua tib zoo ntsuas qhov mob ua ntej kev txiav txim siab seb puas siv nws.
Anti poob siab (tso tawm hauv cov ntsiab lus tshwj xeeb):
Tsis yog cov qauv tshuaj rau kev poob siab. Tab sis nyob rau hauv qee qhov xwm txheej tshwj xeeb, xws li thaum cov neeg mob poob siab xav tau phais tshuaj loog, cov kws kho mob yuav ua tib zoo sivLeterobupivacaine hydrochlorideRau kev ua kom loog nyob rau hauv kev saib xyuas ze ntawm tus neeg mob qhov xwm txheej tshwj xeeb thiab kev phais mob.
Nws yog cov tshuaj loog hauv zos uas tuaj yeem ua ke los ntawm ntau txoj hauv kev.
Qhov no yog ib qho ntawm cov kev siv hluavtaws feem ntau siv. Ua ntej, l - phenylacetic acid yog tau los ntawm cov pathycide acid, thiab tom qab ntawd txo nrog cov tshuaj tua kom txo cov poov tshuaj, hydrogen lossis tin hydride. Ntawm lub hauv paus no, HBR, HBL thiab lwmyam tau siv los ua cov alkaline hydrolysis ntawm cov neeg txo qis kom tau l {} iSobutylamine acetic acid. Thaum kawg, l - iSobutylamine acetic acid tau sib xyaw nrog cov kev cai lij choj thiab crystallized kom tau txais cov khoom lag luam.
Hauv hom no, 4 - Am1 {}}}}}}}}}}}}}}}}}}}} Tom qab ntawd, siv reagents xws li HCL los nqa tawm Amoosolysis cov tshuaj tiv thaiv nruab nrab, tsim L-Berpivacaine. Thaum kawg, nws yog crystallized los ntawm kev ntxiv hydrochloric acid.
Hauv hom no, nws yog thawj acylated nrog alkylphenols xws li 1 -6-dimethylphetethanol, thiab tom qab ntawd sterted nrog HCL thiab lwmyam kom tau txais cov khoom. Txawv cov neeg sawv cev sib txawv cuam tshuam rau cov khoom siv lub cev ntawm cov khoom lag luam, xws li solubility thiab tus nqi ntawm kev nqus thiab tso tawm.
Txoj kev no suav nrog cov kauj ruam hauv qab no:
(1) Ua ntej, tus coj 4 {{{4 4}}}}}}}}}} 2 ', 6'}} 2', 6'}} 2 ', 6'}} 2', 6'}} 2 ', 6'}} 2', 6'}} 2 ', 6'}} 2', 6'}} 2 ', 6'}}
(2) Tom qab ntawd, plaub Enantiomers tau sib cais thiab ua kom huv ntxiv los ntawm crystallization.
(3) Rau ob qho enantiomers, cov khoom lag luam, uas yog cov khoom lag luam, tuaj yeem tsim los ntawm kev txo qis, cov kev cuam tshuam thiab kev ua kom haum.
(4) Thaum kawg, cov khoom lag luam yog huv thiab sib cais kom tau txais siab- purity Leterobupivacaine HCL.
Hauv kev xaus, nws tuaj yeem npaj los ntawm tus naj npawb ntawm cov hluavtaws hluavtaws sib txawv. Ntawm lawv, feem ntau siv hluavtaws txoj kev yog los ntawm kev txo tus l-} cov tshuaj tiv thaiv cov qauv ntawm l- iSobutylamine. Tsis tas li ntawd, muaj ntau cov kev ua suab hluavtaws uas yuav tsum muaj cov haujlwm ua haujlwm ntau dua thiab Crystallization Purification cov txheej txheem.
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Tshuaj Cov Qauv |
C18H28N2O |
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Muaj pes tsawg leej |
288 |
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Molecular hnyav |
288 |
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m/z |
288 (100.0%), 289 (19.5%), 290 (1.8%) |
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Kev Ntsuam Xyuas |
C, 74.96; H, 9.79; N, 9.71; O, 5.55 |
Nws yog cov tshuaj loog hauv zos uas tau qhia thawj zaug rau hauv chaw kho mob thaum xyoo 1996. Nws tseem yog tshuaj tshuaj loog nrog kev nyab xeeb zoo, vim tias qhov no sib xyaw no tsuas siv nws sab laug {2} {{3} NRHIAV ISOMER yog lom.
Qhov pom ntawm cov khoom hnub rov qab mus rau xyoo 1990, thaum khw muag khoom tsim muaj tsawg (PPM) tau tshawb xyuas qhov chaw uas lawv pom muaj qhov sib sib sib sib sib sib sib sib sib sib sib sib sib sib sib sib sib tham tob tob tob tob. Lub tuam txhab pom tias qhov sib xyaw ua ke los ntawm cov roj sunflower tuaj yeem siv los ua cov khoom siv revobupivacaine hc - lias {}}} Cov neeg muaj kev tiv thaiv zoo li qub, los ntawm kev sib tw ntawm cov tshuaj lom neeg.
Thaum lub sijhawm, PPM tsis paub tias nws tau tsim cov tshuaj loog tshiab, yog li lawv tau thov nws hauv kev sim ntsuas kev ntsuas rau Guinea npua. Cov txiaj ntsig tau pom tias cov khoom lag luam, tau txo qis toxicity rau nas-} an localesiaia. Cov kev tshawb pom no qhia PPM los pib tshawb txog cov tib neeg tshiab hauv cov tib neeg txuas ntxiv ntsuas nws qhov kev nyab xeeb thiab kev ua tau zoo.
Hauv kev sim tshuaj xyuas thaum ntxov, nws pom tau zoo sib xws thiab kev ua kom zoo sib xws rau Bupivacaine, tab sis muaj kev nyab xeeb dua. Cov tshuaj muaj cov npav me me thiab tsis tshua muaj kev cuam tshuam rau lub tshuab ua pa thiab cov hlab hlwb tau siv dav hauv cov ntawv thov kev kho mob. Txij thaum ntawd los, nws tau raug lees paub tias yog kev nyab xeeb thiab ua tau zoo hauv cheeb tsam thiab tau dhau los ua kev ua kom loog hauv lub teb chaws lossis kev kho hniav, thiab phais cov yas.
Txawm hais tias nws tau siv dav dav siv kaw, cov ntsiab lus ntawm kev tshawb pom keeb kwm kev tshawb pom tseem tsis tau nkag siab. Tam sim no, kev tshawb fawb txog nws tsuas yog txwv rau nws daim ntawv thov tshuaj loog, thiab tsis muaj kev tshawb fawb ntxiv ntawm kev tshawb pom keeb kwm ntawmLeterobupivacaine hydrochloridetau ua tiav.
Cim npe nrov: LeteroBupCaine hydrochloride CAS 27262-48-2, Tus neeg xa khoom, chaw tsim khoom, chaw tsim khoom, lag luam, yuav, loj, loj, rau muag