Chandroitin sulfate hmoov, Molecular Cov Qauv M13h2No15s, CAS 9007-28-7. Hmoov dawb, soluble hauv dej thiab qee cov kuab tshuaj organic (xws li dimethyl sulfoxide, ethanol). Vim yog linear polysaccharide qauv, nws ua kom sib txawv sib txawv ntawm cov solubility hauv dej thiab cuam tshuam los ntawm qhov chaw xws li kub, thiab ph. Nws yog lub ntuj polymer nrog cov khoom anionic muaj zog, uas yog tsim los ntawm guilding guanylate thiab galactoguanylate unsaccharate unsuction txuas. Qhov kev taw qhia ntawm nws cov kev ntsuas Monosaccharide thiab txoj haujlwm thiab cov neeg sulfate pab txiav txim siab lub cev muaj nuj nqi thiab daim ntawv thov chandroitin sulfate. Cov qib ntawm sulfation thiab kev sib txawv ntawm Chondroitin sulfate cuam tshuam rau nws lub peev xwm los khi rau lwm yam molecules, uas yog tus yuam sij rau nws lub zog kev ua haujlwm. Nws yog lub ntuj sulfated polysaccharide dav nthuav qhia nyob rau hauv tib neeg pob txha, pob txha, ob lub qhov muag thiab lwm cov ntaub so ntswg.
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Tshuaj Cov Qauv |
C13h2no15s |
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Muaj pes tsawg leej |
463 |
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Molecular hnyav |
463 |
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m/z |
463 (100.0%), 464 (14.1%), 465 (4.5%), 465 (3.1%) |
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Kev Ntsuam Xyuas |
C, 33.70; H, 4.57; N, 3.02; O, 51.79; S, 6.92 |
Chondroitin sulfate yog polysaccharide molecule uas muaj nyob hauv cov tsiaj. Nws cov qauv molecular yog cov nyom heev thiab muaj ntau lub sijhawm sib txawv. Tshwj xeeb, Chandroitin sulfate molecule feem ntau yog muaj cov chav nyob xws li Meyer cov amino qab zib (GLCNS) thiab n} acetylucopsamine (Galnac).
Nyob rau hauv cov qauv molecular ntawm chondroitin sulfate, glca thiab glcan caj qaum, thiab glcns thiab glycan caj qaum nyob rau hauv ib qho tsis xwm yeem. Tsis tas li ntawd, Chandroitin Sulfate kuj muaj cov lej sib txawv thiab cov haujlwm sulfated, uas ua rau lub luag haujlwm tseem ceeb hauv kev ua haujlwm ntawm cov molecule. Tshwj xeeb, pawg sulfated tuaj yeem nce cov pab pawg hydrothilicity tuaj yeem ua kom lub taub lim, txo cov kev lim dej ntawm cov molecule thiab cuam tshuam nws kev sib cuam tshuam nrog lwm cov lwg me.
Hauv cov ntsiab lus, cov qauv molecular ntawm chondroitin sulfate yog qhov nyuaj heev, muaj ntau pawg thiab cov pab pawg sulfated. Qhov nyuaj ntawm nws cov qauv molecular txiav txim siab tias nws plays lub luag haujlwm tseem ceeb hauv kev ua haujlwm ntawm kev siv keeb kwm ntawm biology.
Chandroitin sulfate hmoovyog ib qho acidic mucopolysaccharide nthuav dav tam sim no hauv cov ntaub so ntswg sib txuas xws li pob txha mos, thiab lwm yam tseem ceeb ntawm lub cev muaj zog. Nws tsis tsuas yog ua lub luag haujlwm tseem ceeb hauv kev sib koom tes kev noj qab haus huv, tab sis kuj tau kho cov kev kho mob plawv, cov kev cai ntawm lub qhov muag, thiab kev tu tawv nqaij. Cov hauv qab no qhia tau cov ntsiab lus tseem ceeb tshaj plaws cov ntsiab lus tseem ceeb ntawm kev siv thiab cov tshuab ntawm Chondroitin sulfate los ntawm ntau qhov ntev xws li tshuaj, kev noj qab haus huv, thiab kev zoo nkauj.
Chondroitin sulfate yog ib qho tseem ceeb ntawm cov pob txha mos muaj txuj ci, thiab nws cov haujlwm tseem ceeb yog los tswj hwm cov qauv kev ncaj ncees thiab kev ua haujlwm ruaj khov ntawm pob txha mos. Daim ntaub ntawv tshwj xeeb suav nrog:
1. Kev noj haus thiab kev tiv thaiv ntawm pob txha mos tshuaj
Chondroitin sulfate txhawb nqa cov khoom ua kom synovial tso kua mis, nce pob txha taub hau thiab hnav thaum lub sij hawm sib koom tes. Meanwhile, raws li ib qho tseem ceeb ntawm pob txha mos latrix, nws tuaj yeem txhim kho pob txha mos me me thiab maj mam ncua cov txheej txheem ntawm pob txha mos thiab ncua cov txheej txheem ntawm pob txha mos tsis sib haum. Cov kev tshawb fawb soj ntsuam tau pom tias ntev- tsis muaj peev xwm txo qhov mob ntawm cov neeg mob Osteoarthritis, thiab txhim kho kev sib koom tes.
2. Txhawb pob txha mos kho pob txha mos thiab tsim dua tshiab
Chondroitin sulfate tuaj yeem txhawb cov prolrocyte proliferation thiab txawv, nrawm txheej txheej txheem kho ntawm pob txha pob tawb.
Nws tswj cov extracellular matrix metabolism, txhawb nqa collagen thiab proteoglycan synthesis, thiab muab cov kev tsim muaj roj ntsha scaffolds rau cov pob txha mos. Nyob rau hauv thaum ntxov kev cuam tshuam ntawm osteoarthitis, kev sib xyaw ua ke ntawm chondroitin sulfate thiab glucosamine tuaj yeem ua rau muaj kev txhim kho qeeb ntawm kev nce pob txha mos tuab.
3. Anti mob plab thiab kev mob siab
Chondroitin sulfate undovial mob synovial {{} nws txoj kev mob teeb meem transduction transductivity thiab txo qhov rhiab ntawm cov hlab ntsha ntawm cov hlab ntsha. Cov kev sim kho mob tau qhia tias Chondroitin sulfate muaj cov kev sib txawv zoo sib xws rau kev mob modostothritis, tab sis tseem ceeb txo qhov tshwm sim ntawm kev mob plab zom mov.
4. Kev ua si raug kho
Athletes and people who engage in long-term high-intensity exercise often face the problem of joint cartilage wear and tear. Chondroitin sulfate tuaj yeem nrawm cartilage kho dua tom qab raug mob kis las thiab luv luv lub sijhawm kho kom rov zoo dua los ntawm kev txhawb nqa lub pob txha mos los ntawm kev sib tw sib xyaw ua ke. Nws tau suav nrog hauv txoj haujlwm tiv thaiv kev sib koom ua ke rau cov neeg ncaws pob hauv kev ua si ntawm kev ua si kev ua si kev ua si.
Kev tiv thaiv plawv plawv kev tiv thaiv
Chandroitin Sulfate ua yeeb yam ntau cov kev tiv thaiv hauv Kev Noj Qab Haus Huv Kev Noj Qab Haus Huv:
1. Kev cai ntawm cov ntshav lipid thiab kev tiv thaiv ntawm atherosclerosis
Chondroitin sulfate txo cov roj (cholesteroles Nyob rau tib lub sijhawm, nws tuaj yeem txhawb nqa bile acid excretion thiab nrawm roj cholesabolism thiab hloov dua siab tshiab. Cov kev tshawb fawb soj ntsuam tau lees tias muaj 1200mg chandroitin sulfate tuaj yeem txo cov roj (LDL}}
2. Antithromicmotic
Chondroitin sulfate tuaj yeem ua rau muaj kev sib cais, txo cov ntshav viscosity, thiab tiv thaiv kom tsis txhob xaws cov pa. Nws cov tshuab kev nqis tes cuam tshuam nrog kev thaiv cov platelet adp receptors rau fibrinogen, txo cov khoom siv ntawm thromboxane A2. Nyob rau hauv high - Cov neeg muaj kab mob plawv, chondrotin sulfate tuaj yeem txo qhov kev rov ua dua tshiab thiab mob stroke.
3. Endothelial tiv thaiv cov ntshav
Chondroitin sulfate inhibits endothelial cell kev puas tsuaj los ntawm oxidized lipoprein (Ox LDL) los ntawm kev tshem tawm dawb radicals los ntawm kev tshem tawm cov vascular phab ntsa. Cov kev sim tsiaj qhia tias Chondrotitin sulfate tuaj yeem txhim kho cov vascularisity ntawm atherosclerosis qauv tsiaj thiab txo thaj ntawm cov quav hniav.
Kev Kho Mob ntawm Qhov Muag Cov Kab Mob thiab Kev Txij Nkawm ntawm Kev Kho Mob Qhov Muag
Chandroitin sulfate hmoovMuaj cov ntawv thov tshwj xeeb tus nqi hauv thaj teb Ophthalmology:
1. Cej thuam raug kho
Chondroitin sulfate qhov muag poob yog cov kev kho mob rau kev raug mob superficy xws li armasions. Nws ua kom lub qhov txhab ua kom zoo dua los ntawm kev txhawb nqa kev tsiv teb tsaws chaw thiab muaj peev xwm ntawm cov kab mob epithelial hlwb. Cov ntaub ntawv kuaj mob qhia tau tias kev siv 0.1% CHondroitin sulfate qhov muag poob tuaj yeem ua kom lub sijhawm kho kom zoo los ntawm 30% -50%.
2. Kev kho mob rau lub qhov muag qhuav
Chondroitin sulfate, raws li lub ntuj moisturizing muaj tseeb, tuaj yeem tsim zaj duab xis tiv thaiv ntawm pob zeb sab nrauv, txo lub kua muag evaporation. Cov tshuaj sib xyaw ua ke poob siv ua ke nrog cov txiaj ntsig hyaluronic tuaj yeem txhim kho cov tsos mob ntawm cov neeg mob muag thiab txhim kho cov kua muag stability stability.
3. Kev Tiv Thaiv Cataract
Chondroitin sulfate qeeb cov hnub nyoog ntawm {{}}}}}} related related related ox relatedid oxid stress stress in hauv lens epithelial cells. Kev tshawb nrhiav kabmob sib kis tau pom tias qhov tshwm sim ntawm cov pej xeem hauv cov pej xeem uas tau muab ntxiv nrog Chondroitin sulfate tau ntev yog 25% qis dua uas nyob hauv pawg tswj.
Kev cai ntawm cov hlab ntsha thiab neuroprotection
Chondroitin sulfate ua lub luag haujlwm tseem ceeb hauv kev tswj hwm neurological ua haujlwm:
1. Neural Kev Kho Mob
Chondroitin sulfate tuaj yeem txhawb kev ua yeeb yam zoo nkauj thiab kuv obelin tsim, kho kom nrawm rau txoj kev kho mob loj. Kev sim tsiaj tau qhia tias Chondroitin sulfate kev kho mob tuaj yeem ua kom lub sijhawm rov qab los ntawm kev siv hluav taws xob nrog 40%.
2. Txo cov neuralgia
Chondroitin sulfate muaj ib tug tseem ceeb muab kev cuam tshuam rau kev mob siab xws li trigemet neuralgia los ntawm kev tswj hwm cov neurotransmitter tso thiab txo cov kev tsis txaus siab.
Cov kev tshawb fawb soj ntsuam tau pom tias kev sib xyaw ua ke ntawm chondroitin sulfate thiab gabapentin tuaj yeem txo qhov mob ntawm cov neeg mob neuropathic los ntawm ntau dua 50%.
3. Kev Nkag Siab Ua Haujlwm
Chondroitin sulfate muaj cov kev tiv thaiv muaj peev xwm thiab kho mob ntawm cov kab mob tso tseg xws li Alzheimer tus kab mob los ntawm kev tso nyiaj ntawm {} amylonal apoptosis. Tsiaj Qauv Qauv tau lees paub tias Chandroitin Sulfate tuaj yeem txhim kho qhov kev tsis txaus siab muaj peev xwm nrog kev puas hlwb.
Daim tawv nqaij anti -}} kev laus thiab kev zoo nkauj daim ntawv thov
Chondroitin sulfate ua rau muaj nuj nqis tshwj xeeb hauv kev kho tawv nqaij: 1. Anti wrinkle thiab tawv elasticity li
Chandroitin sulfate hmoov, raws li ib qho tseem ceeb ntawm cov extracellular matrix, tuaj yeem txhawb cov fibrix kom synthesize collagen thiab elastin, txhim kho daim tawv nqaij txhawb nqa qauv. Cov kev kuaj mob tau pom tau qhia tias tom qab siv cov tawv nqaij tawv nqaij uas muaj 2% chondroitin sulfate rau lub qhov muag ntawm cov kev kawm poob qis ntawm 25%.
2. Yws thiab kev kho lub Barrier
Chondroitin sulfate muaj super nqus tau muaj peev xwm thiab tuaj yeem tsim cov yeeb yaj kiab moisturizing ntawm cov tawv nqaij kom tiv thaiv kom tsis txhob muaj dej.
Cov tshuaj kho tau siv ua ke nrog ceramide tuaj yeem txhim kho cov tawv nqaij tawv nqaij thiab txo tus nqi ntawm kev hloov dej los.
3.Plotaging kev tiv thaiv
Chondroitin sulfate inhibits mattalproteinase (MMP) hais tawm thiab txo cov depagen degagen los ntawm kev tshem UV ua rau dawb radicals. Nyob rau hauv cov kev sim vito tau pom tias Chondroitin sulfate pretreatment tuaj yeem txo UV puas ntawm fibroblasts los ntawm 60%.
Lwm Cov Kev Siv Kho Mob
1.Txhua yam puas tsuaj
Chondroitin sulfate tuaj yeem txhim kho sab hauv pob ntseg pob ntseg pob ntseg thiab muaj kev tawm tsam ntawm amotoxicity los ntawm aminoglycosity tshuaj tua kab mob xws li Streptomycin. Cov kev tshawb fawb soj ntsuam tau pom tias Chondroitin sulfate kev kho mob tuaj yeem ua kom cov rooj sib hais rov qab ntawm cov neeg siv yeeb yaj kiab uas tsis hnov lus los ntawm 30%.
2. Kev Kho Mob Txom Nyem rau Chronic Kab Mob Mob
Chondroitin Sulfate muaj cov nyhuv raum tiv thaiv rau cov ntshav qab zib nephritis thiab mob tus neeg tawm tsam los ntawm kev tso nyiaj ntawm cov khoom seem ntawm cov khoom sib xyaw. Cov kev sim tsiaj tau qhia tias Chondroitin sulfate kev kho mob tuaj yeem txo cov churinary protein excretion los ntawm 40% nyob rau hauv lub raum tus kab zauv nas.
3. Noadjuvant Kev Kho Mob
Chondroitin sulfate muaj kev cuam tshuam los ntawm kev loj hlob ntawm ntau cov qog nqaij hlav los ntawm inhibiting cov qog los ntawm inhibitisesis, thaiv cov zaub mov noj. Hauv cov kev sim vitro pom tias ChondroTin sulfate tuaj yeem txo lub peev xwm ntawm tus mob cancer mis.
Chandroitin sulfate hmoovyog ib tug nyuaj polysaccharide nrog ntau cov kev ua haujlwm ntawm lub cev thiab cov khoom siv pharapacological. Vim nws qhov nyuaj biosynthesis thiab cov kev tsis muaj peev xwm, cov hau kev rau synthesizing chondroitin sulfate yog qhov tseem ceeb tshaj plaws.
Tam sim no, chaondroitin sulfate feem ntau yog muab tau los ntawm cov nqaij tsiaj, xws li shark pob txha mos thiab bovine Nasal pob txha mos. Chondroitin sulfate tuaj yeem muab rho tawm los ntawm cov tsiaj cov ntaub so ntswg los ntawm hydrolysis thiab ion pauv. Txawm hais tias txoj kev no yooj yim thiab ua tau, muaj cov teeb meem xws li kev tiv thaiv kab mob thiab cov khoom siv tsawg. Nyob rau tib lub sijhawm, tsiaj - Cov khoom xyaw tuaj yeem ua rau ua xua lossis lwm yam teeb meem kev nyab xeeb, yog li lawv yuav tsum mus ua kev lim hiam thiab kev txhim kho.
Tshuaj lom hluav taws xob hluavtaws yog ib txoj kev ntawm synthesizing chandroitin sulfate ywj siab ntawm cov khoom ntuj. Qhov kom zoo dua yog tias nws tuaj yeem yog customized los synthesize trisulfide bonds thiab polysaccharide chains ntawm ntau qhov ntev, thiab cov ntim sib txawv yog tswj tau. Txawm li cas los xij, kev txwv ntawm cov tshuaj saftthesis yog tias nws cov txheej txheem yog qhov nyuaj thiab cov nqi tshuaj yog qhov siab. Cov tshuaj tiv thaiv kev tshuaj lom neeg muaj xws li synthesis, semi-}}} tag nrho cov hluavtaws, thiab cov synthesis tag nrho.
Enzymatic synthesis yog txoj kev lom neeg los ua ke chandroitin sulfate los ntawm kev cuam tshuam ntawm cov enzymes. Nws yog nrov vim tias nws tuaj yeem ua rau hauv qab mob me thiab yog heev. Txoj kev no yog feem ntau yog raws ob cov enzymes: LactosylTransferase thiab Chondroitin SulfuryLuryLuaj. Lub qub siv lactose raws li cov khoom siv raw thiab hloov nws mus rau hauv Chondroitin cov saw hlau; Tom kawg yog lub luag haujlwm rau kev ntxiv cov pab pawg sulfate rau cov polysaccharide. Txawm li cas los xij, cov hau kev tam sim no tseem pom teeb meem xws li tus nqi siab thiab huv kev huv ntawm enzyme.
Organic synthesis raws li cov synthesis yog ib txoj kev tshiab tau tsim nyob hauv kev ua suab synthesis. The main idea is to construct the polysaccharide chain structure of Chondroitin sulfate using organic synthesis techniques and skills, and then carry out sulfation reaction and other steps. Qhov zoo dua ntawm txoj kev no yog qhov ntev thiab sulfation℃ntawm synthesized polysaccharide tuaj yeem tswj hwm tau, thiab nws kuj muaj cov yam ntxwv ntawm ntau ntau lawm thiab tus nqi qis. Txawm li cas los xij, cov qauv no ntsib kev tsim kho ntawm polysaccharide chains, thiab kuj tseem muaj teeb meem xws li kev npaj siab dawb.
Hauv ntej, muaj ntau txoj hauv kev los ua ke chondroitin sulfate, txhua tus nrog cov txiaj ntsig thiab qhov tsis zoo. Rau cov ntawv thov tshwj xeeb, nws yog qhov tsim nyog kom hnyav qhov zoo thiab qhov tsis zoo raws li qhov xwm txheej thiab xaiv cov qauv hluavtaws feem ntau.
Cim npe nrov: Chondroitin Sulfate Hmoov AS 9007-28-7, Cov Neeg Muag Khoom, Chaw Tsim Tshuaj, Hoobkas, Muag Khoom Ntaus, Yuav Khoom, Rau Cov Muag Khoom