Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm marbofloxacin kua hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo marbofloxacin kua muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Marbofloxacin kuayog fluoroquinolone tshuaj tua kab mob tshuaj tua kab mob tshwj xeeb siv hauv kev kho tsiaj kho tsiaj. Los ntawm kev tiv thaiv kab mob DNA gyrase tau zoo, nws nthuav tawm dav -spectrum thiab muaj zog bactericidal kev ua haujlwm tawm tsam ntau yam Gram-tsis zoo thiab Gram- cov kab mob zoo. Nws yog tsuas yog siv rau kev kho cov kab mob kab mob hauv cov tsiaj xws li nyuj, npua, dev, thiab miv, thiab tuaj yeem tiv nrog cov kab mob xws li ua pa, kab mob hauv lub cev, thiab cov tawv nqaij thiab cov nqaij mos kab mob.Lub formulation ntawm cov kua no yog scientific tsim, feem ntau muaj dej solubility zoo, thiab yog yooj yim rau kev tswj ntawm cov dej haus los yog qhov ncauj noj cov neeg noj cov kev kho mob kom raug. kev ua raws cai thiab yooj yim.
Txawm li cas los xij, kom tsis txhob muaj cov tshuaj seem thiab qhov tshwm sim ntawm cov kab mob tsis zoo, nws yog ib qho tsim nyog yuav tsum ua raws li cov cai ntawm lub sijhawm tshem tawm thiab siv nws raws li cov kws kho tsiaj cov lus qhia kom muaj kev nyab xeeb ntawm cov khoom noj los ntawm cov tsiaj txhu thaum tiv thaiv kev noj qab haus huv rau pej xeem.
Peb cov khoom
Cov ntaub ntawv ntxiv ntawm chemical compound:
Marbofloxacin COA
Antibacterial mechanism
Marbofloxacin kuayog ib qho tsiaj tshwj xeeb fluoroquinolone bactericidal tshuaj uas muaj qhov zoo ntawm cov kab mob dav dav ntawm cov kab mob bactericidal, muaj zog bactericidal kev ua si, ob peb yam tsis zoo, thiab ntev ntev. Nws cov txheej txheem bactericidal yog qhov tshwj xeeb, feem ntau los ntawm inhibiting cov haujlwm ntawm cov kab mob topoisomerase.
Cov kab mob DNA gyrase, tseem hu ua hom II topoisomerase, yog ib qho tseem ceeb enzyme hauv cov kab mob DNA replication thiab transcription txheej txheem, nrog ob subunits A thiab B. Mabofloxacin tsuas yog ua nyob rau hauv lub subunit ntawm lub enzyme, inhibiting cov kev ua ntawm cov kab mob DNA gyrase los ntawm generating ib tug ternary complex ntawm DNA, topoisomerase thiab tshuaj. Cov nyhuv no cuam tshuam qhov kev rov ua dua qub thiab kev hloov pauv ntawm cov kab mob DNA, thaiv DNA synthesis, thiab tiv thaiv cov kab mob ntawm cov kab mob los ntawm kev faib thiab loj hlob ib txwm, thaum kawg ua rau cov kab mob tuag.
Hauv Gram tsis zoo cov kab mob, DNA gyrase yog lub hom phiaj tseem ceeb ntawm mapofloxacin. Piv txwv li, rau feem ntau Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, thiab lwm yam Escherichia coli, mapofloxacin tuaj yeem cuam tshuam cov kev ua ntawm lawv cov DNA gyrase, tiv thaiv kab mob DNA replication, thiab ua kom muaj zog bactericidal nyhuv. Mabofloxacin tuaj yeem ua tiav cov kab mob bactericidal tiv thaiv Pasteurella multocida los ntawm inhibiting nws DNA gyrase.
Ntxiv nrog rau hom II topoisomerase, mapofloxacin kuj tseem muaj cov nyhuv inhibitory ntawm hom IV topoisomerase hauv cov kab mob hlwb. Hom IV topoisomerase kuj tseem ua lub luag haujlwm tseem ceeb hauv cov kab mob DNA metabolism, thiab inhibition ntawm nws los ntawm mapofloxacin ntxiv cuam tshuam rau lub cev lub cev ntawm cov kab mob DNA, txhim kho nws cov kab mob bactericidal. Qhov no inhibitory nyhuv ntawm ntau lub topoisomerases ua rau cov kab mob bactericidal ntawm mapofloxacin ntau dua thiab zoo tiv thaiv kab mob.
3. Cov kab mob bactericidal thiab qhov sib txawv ntawm lwm cov tshuaj tua kab mob
Mabofloxacin muaj broad bactericidal spectrum thiab muaj txiaj ntsig zoo tawm tsam dav -spectrum Gram zoo kab mob (tshwj xeeb yog Staphylococcus), Gram tsis zoo cov kab mob (xws li Escherichia coli, Salmonella typhimurium, Campylobacter jejuni, Citrobacter freundii, Enterobacterley, Protectia clover. Mirabilis, Shigella spp., Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Pasteurella multocida, Klebsiella spp., Haemophilus spp., thiab lwm yam) thiab mycoplasma.
Piv nrog rau lwm cov tshuaj tua kab mob, cov kab mob bactericidal ntawm mapofloxacin yog qhov sib txawv, yog li qhov ua tau ntawm kev tiv thaiv kab mob me me, tshwj xeeb tshaj yog nrog cov tshuaj tua kab mob uas tsis yog fluoroquinolone. Piv txwv li, qee cov kab mob pathogenic uas tau tsim ib feem ntawm erythromycin, lincomycin, chloramphenicol, doxycycline, thiab sulfonamide tshuaj, xws li Staphylococcus aureus, tseem rhiab rau ciprofloxacin. Qhov no yog vim qhov tshwj xeeb bactericidal mechanism ntawm mapofloxacin tso cai rau nws kom ua tau zoo ntawm nws cov kab mob bactericidal yam tsis muaj kev cuam tshuam los ntawm cov tshuaj tiv thaiv ntawm cov tshuaj no.
4. Kev tshwm sim ntawm cov kab mob bactericidal
Mabofloxacin tuaj yeem tua cov kab mob sai sai los ntawm cov txheej txheem bactericidal saum toj no. Cov kab mob rhiab heev tuaj yeem ua rau tuag hauv 20-30 feeb tom qab kis tau. Hauv daim ntawv thov kev kho mob, nws tuaj yeem siv los kho ntau yam kab mob ntawm tus tsiaj los ntawm cov kab mob rhiab heev, xws li kab mob sib sib zog nqus thiab sab saum toj ntawm daim tawv nqaij, kab mob urinary kab mob hauv dev, kab mob ntawm daim tawv nqaij thiab cov nqaij mos hauv miv, mob ua pa sab sauv, mob plab thiab yaj mastitis, thiab porcine mastitis uteritis tsis muaj mis nyuj.
Main Clinical Veterinary Indications
Marbofloxacin kuayog thib peb - tiam fluoroquinolone broad -spectrum bactericidal kua formulation nkaus xwb rau veterinary siv. Featuring ib tug dav bactericidal spectrum, muaj zog bactericidal kev ua si, siab cov ntaub so ntswg nkag mus rau hauv cov tsiaj, nws yog dav siv los kho ntau yam kab mob nyob rau hauv dev thiab miv. Los ntawm inhibiting kab mob DNA gyrase thiab topoisomerase IV, tus neeg sawv cev thaiv cov kab mob nucleic acid replication thiab transcription kom ua tiav cov kab mob sai sai.
Nws pom tau tias muaj kev cuam tshuam zoo rau Gram- cov kab mob tsis zoo, xaiv Gram- cov kab mob zoo thiab cov kab mob mycoplasmas, ua rau nws yog ib qho tseem ceeb ntawm cov tshuaj tiv thaiv kab mob hauv me me - tsiaj txhu. Nws cov ntaub ntawv kho mob zoo sib xws rau cov kab mob uas muaj kab mob hauv cov dev thiab miv, npog cov kab mob ntawm cov kab mob ua pa, urinary, daim tawv nqaij thiab cov nqaij mos, cov kab mob hauv lub cev, thiab kev ua me nyuam.
Canine Bacterial Respiratory Tract Infections
Cov kab mob ua pa ua pa yog cov kab mob kis tau zoo heev hauv cov dev. Nws nyob rau ntawm thawj - kab kev kho mob rau cov kab mob ua pa ntawm cov kab mob ua pa, feem ntau yog tsom rau cov kab mob tracheobronchitis (kennel hnoos) thiab bronchopneumonia los ntawm cov kab mob xws li Pasteurella spp., Bordetella bronchiseptica, Escherichia coli thiab Staphylococcus.
Kennel hnoos, los yog canine kis kab mob tracheobronchitis, kis tau sai heev ntawm cov dev hluas thiab pab pawg -cov tsiaj hauv tsev. Cov dev uas muaj mob tshwm sim nrog paroxysmal hnoos qhuav, pharyngalgia thiab tracheal rales. Yog tias tsis muaj kev cuam tshuam raws sijhawm, kev kis tus kabmob thib ob tuaj yeem ua rau mob ntsws. Cov khoom no yog absorbed sai heev nyob rau hauv lub pa mucosa thiab ua tiav high concentrations nyob rau hauv tracheal, bronchial thiab pulmonary ntaub so ntswg, zoo tshem tawm cov kab mob thiab sai sai alleviating hnoos, inflammatory edema thiab txuam cov cim qhia.
Canine bronchopneumonia feem ntau tshwm sim los ntawm kev kis kab mob ua pa sab saud, kev ntxhov siab ib puag ncig thiab kev tiv thaiv tsis zoo. Cov tsos mob tshwm sim muaj xws li kev nyuaj siab, pyrexia, hnoos hnoos, dyspnoea thiab pulmonary crackles; Cov mob hnyav ua rau pulmonary congestion thiab consolidation. Cov ntaub ntawv kho mob paub meej tias muaj zog bactericidal kev ua haujlwm ntawm cov khoom tiv thaiv cov kab mob polymicrobial ntawm canine bronchopneumonia. Superior rau cov laus antibacterials nyob rau hauv cov ntaub so ntswg nkag mus, nws hla inflammatory pulmonary barriers kom tshem tawm cov kab mob nyob rau hauv lub ntsws mob sib sib zog nqus, markedly txo deterioration thiab relapse txoj kev pheej hmoo. Nws yog qhov tsim nyog rau cov kab mob bronchopneumonia thoob plaws txhua pawg hnub nyoog, tshwj xeeb tshaj yog cov kab mob refractory ua pa tsis zoo rau cov tshuaj tua kab mob.
Canine Bacterial Urinary Tract Kab Mob
Cov kab mob urinary feem ntau tshwm sim los ntawm cov kab mob nkag mus, nrog cystitis thiab pyelonephritis raws li qhov tshwm sim feem ntau. Cov kab mob tseem ceeb yog Gram-cov kab mob tsis zoo xws li E. coli, Proteus spp. thiab Klebsiella spp., tawm tsam qhov uas nws nthuav tawm tau zoo heev; yog li cov khoom no yog ib qho kev kho mob rau canine urinary tract infection.
Cov dev nrog cystitis qhia pollakiuria, stranguria, dysuria, turbid zis thiab haematuria, ua ke nrog mucosal congestion, yaig thiab purulent exudation.
Cov kab mob tsis tu ncua tuaj yeem nce mus rau ob lub raum thiab ua rau pyelonephritis, tshwm sim nrog kub taub hau, mob lumbar, kev nyuaj siab thiab anorexia, thiab muaj feem cuam tshuam rau lub raum tsis zoo nyob rau hauv cov mob hnyav.
Tom qab kev tswj hwm qhov ncauj lossis tshuaj pleev ib ce, nws raug tso tawm hauv lub raum thiab ua kom muaj zog hauv cov zis thiab cov ntaub so ntswg, ua kom muaj qhov siab zoo tshaj qhov tsawg kawg nkaus inhibitory concentrations rau lub hom phiaj ntawm qhov mob hauv lub zais zis thiab lub raum pelvic mucosa thiab tshem tawm cov kab mob tag nrho.
Cov tshuaj no yog me ntsis irritant rau urinary mucosa thiab tsis ua phem mucosal puas. Nws sai sai kho cov urinary o, kho micturition abnormality thiab blocks ascending kis thiab recurrence, txhawb tag nrho -kourse tswj ntawm mob thiab ntev canine kab mob nyob rau hauv lub cev.
Canine Bacterial Skin and soft-Tissue Infections
Cov tawv nqaij thiab mos-cov ntaub so ntswg kab mob yog ib qho kev nthuav tawm ntau tshaj plaws hauv cov chaw kho tsiaj me me, suav nrog pyoderma, qhov txhab mob, abscess thiab folliculitis, feem ntau tshwm sim los ntawm Staphylococcus aureus, Streptococcus spp.
Thiab Pasteurella spp. Nws ua haujlwm raws li kev kho tseem ceeb rau cov xwm txheej no vim nws qhov dav - spectrum kev ua ub no thiab hauv zos los tiv thaiv - inflammatory zog.
Canine pyoderma yog cais raws li qhov tob lossis tob. Pyoderma sab saum toj nthuav tawm nrog erythema, papules, pustules thiab scaling, whereas sib sib zog nqus pyoderma mus rau ulceration, exudation, crusting thiab subcutaneous o o, feem ntau nrog ib tug protracted, relapsing chav kawm.
Rau kev raug mob qhov txhab, kev phais tom qab phais- qhov chaw mob, subcutaneous abscess thiab kab mob folliculitis, kev tswj hwm hauv zos lossis cov txheej txheem ntawm cov khoom tsim tsa cov ntaub so ntswg zoo hauv daim tawv nqaij thiab subcutaneous compartments.
Nws sai sai suppresses cov kab mob loj hlob thiab daws cov tsos mob xws li o, suppuration, mob thiab exudation, ua kom lub qhov txhab zoo. Piv nrog rau lwm cov kua dej bactericidal, nws txhawb nqa cov kab mob bactericidal ntev dua thiab txo qis kev pheej hmoo rov qab los, npog cov kab mob thawj thiab theem nrab ntawm daim tawv nqaij thiab mos- cov kab mob hauv cov dev.
Lwm yam kab mob Canine kab mob
Tshaj li cov mob loj tshaj plaws saum toj no, nws tau qhia rau cov kab mob otitis media, kab mob hauv lub cev thiab prostatitis hauv dev.
Canine periodontal kab mob feem ntau ua raws qhov ncauj dysbiosis thiab kho hniav calculus, manifesting li gingival erythema, los ntshav, periodontal suppuration thiab halitosis. Cov tshuaj selectively tshem tawm cov kab mob pathogens thiab txo cov qhov ncauj o.
Canine kab mob prostatitis feem ntau cuam tshuam rau cov neeg laus txiv neej dev thiab feem ntau tshwm sim los ntawm kev kis kab mob los ntawm E. coli thiab staphylococci. Cov dev raug mob tsim dysuria, perineal o thiab kev nyuaj siab, thiab cov kab mob sepsis tuaj yeem tshwm sim yam tsis muaj kev kho mob. Systemic nws ua tiav cov ntsiab lus siab hauv cov ntaub so ntswg prostatic rau kev tswj cov kab mob prostatitis zoo thiab tiv thaiv cov teeb meem hauv lub cev los ntawm kev kis kab mob.
Marbofloxacin kuayog ib qho tsiaj tshwj xeeb fluoroquinolone tshuaj tua kab mob nrog lub dav spectrum thiab muaj zog bactericidal kev ua si, dav siv nyob rau hauv veterinary kho mob xyaum.
(I) Synthesis of the Core Scaffold
Cov synthesis pib nrog 2,4-difluoroaniline ua cov khoom pib. Ua ntej, electrophilic hloov nrog sulfuryl chloride qhia leej faj ntawm ib txoj hauj lwm uas tau hais tseg ntawm lub nplhaib benzene kom tau txais 2,4-difluorophenylthio nruab nrab.
Lub intermediate undergoes diazotisation nrog sodium nitrite thiab hydrochloric acid los tsim diazonium ntsev, ua raws li intramolecular cyclisation los tsim cov benzothiadiazine core thiab tsim 3-methyl-9-fluoro-7-oxobenzothiadiazine carboxylate precursor.
Qhov no cyclisation yog ib kauj ruam tseem ceeb: qhov kub thiab txias yuav tsum nruj tswj ntawm 0-5℃nyob rau hauv tsis muaj zog acidic tej yam kev mob kom txo tau cov sab tshwm sim, khaws cia scaffold kev ncaj ncees thiab pab kom functionalization tom ntej.
(II) Kev Ua Haujlwm Kev Ua Haujlwm thiab Hloov Cov Kev Sib Tham
Tom qab cov tub ntxhais sib dhos, ester pawg ntawm cov nruab nrab yog hydrolysed rau carboxylic acid, muab benzothiadiazine carboxylic acid intermediate. Cov tshuaj tiv thaiv nucleophilic hloov pauv qhia txog 4-methylpiperazine ntawm C10 txoj haujlwm ntawm scaffold.
Cov tshuaj tiv thaiv yog ua nyob rau hauv anhydrous ethanol nyob rau hauv cua sov thiab reflux, nrog ib tug alkaline catalyst rau modulate tus nqi, txhim kho conversion thiab txo los ntawm - khoom.
Tom qab lub tshuab nqus tsev distillation thiab recrystallisation, crude marbofloxacin tau txais. Kev ua kom huv ntxiv los ntawm cov kua qaub- kev kho mob hauv paus, ntxuav dej thiab qis- qhov kub thiab txias ua rau API nrog purity Ntau dua lossis sib npaug li 98.5%.
(III) Liquid Formulation Manufacturing
Cov kua yog tsim los ntawm siab -purity API nrog excipients nrog rau cov dej rau kev txhaj tshuaj, propylene glycol thiab buffer ntsev. Kev sib tov meej ua rau cov kua dej ruaj khov.
Cov ntsev tsis yog yaj hauv dej huv kom kho pH mus rau 5.5-7.0 rau kev ruaj ntseg tshuaj. Propylene glycol yog ntxiv los txhim kho API solubility, thiab nws yog qhia maj mam nyob rau hauv qis -kub stirring kom txog thaum tiav dissolution.
Tsim nyog preservatives thiab stabilizers yog incorporated nyob rau hauv tas mus li homogenisation. Cov kev daws teeb meem yog ob npaug - lim los ntawm 0.22 μm sterile membrane, ntim thiab kaw kom tsim cov khoom tiav.
Cov txheej txheem no txwv tsis pub cov tshuaj degradation, khaws cia cov kab mob ua kom zoo ib yam thiab ua tau raws li cov qauv kws kho tsiaj.
FAQ
Puas yog broad spectrum tshuaj tua kab mob?
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Tawm tswv yim: Marbofloxacin yog ib qho tshuaj fluoroquinolone tshuaj tua kab mob, nrog rau dav -spectrum kev ua haujlwm tawm tsam ob qho Gram-zoo thiab Gram- cov kab mob tsis zoo.
Puas muaj kev nyab xeeb rau tib neeg?
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Fluoroquinolones, suav nrog marbofloxacin, tuaj yeem ua rau muaj kev kub ntxhov rau hnub ci. Lub hnub ncaj los yog ntev ntev yuav tsum zam rau txhua yam tsiaj ntawm cov tshuaj no. Cov tshuaj no tsis yog tsim los siv rau tib neeg.
Puas yog Marbocyl yog tshuaj tua kab mob muaj zog?
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Marbofloxacin yog ib hom tshuaj tua kab mob uas muaj zog, yog li nws yuav tsum tsis txhob muab rau me me - thiab nruab nrab - cov dev yug me nyuam hnub nyoog qis dua 8 lub hlis, loj - cov dev yug me nyuam yaus hnub nyoog qis dua 12 lub hlis, lossis loj heev - yug me nyuam dev hnub nyoog qis dua 18 lub hlis. Nws tseem yuav tsum tau zam hauv cov miv uas muaj hnub nyoog qis dua ib xyoos.
Cov tshuaj dab tsi cuam tshuam nrog nws?
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Muab tsawg kawg 2 teev ua ntej lossis tom qab noj cov tshuaj uas muaj calcium, antacids, hlau, magnesium, lossis txhuas (xws li sucralfate, Tums®, Pepto-Bismol®, lossis tshuaj ntxiv hlau). Cov ntsiab lus ntawm cov tshuaj no txo qis kev nqus marbofloxacin.
Nws puas kho E. coli?
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coli thiab P. multocida, siv cov ntsuas kev ua tau zoo: Cmax / MIC thiab AUC0-24hr / MIC, qhia tias kev tswj hwm IM ntawm MBF ntawm koob tshuaj 2 mg kg-1 hnub-1 yog qhov tsim nyog los kho cov kab mob los ntawm E. coli. Txawm li cas los xij, ib koob tshuaj 5 mg kg-1 hnub-1 raug pom zoo los kho mob ntsws los ntawm P.
Cim npe nrov: marbofloxacin kua, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom