Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov khoom lag luam thiab cov khoom lag luam ntawm cov hmoov matrine hmoov 519-02-8 nyob hauv Suav teb. Txais tos rau kev lag luam wholesale ntau cov hmoov zoo matrine hmoov cuab yeej 519-02-8 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Theem matrine hmoov, lub ntuj alkaloid tau rho tawm feem ntau los ntawm cov keeb kwm ntawm Sophora Flavescens nroj tshuag, tseem hu ua Suav Tshuaj, tuav cov peev txheej tseem ceeb hauv cov tshuaj niaj hnub. Qhov kev sib txuas no yog muaj ntau yam kev ua tshuaj ua haujlwm, suav nrog cov tshuaj porcasacological, suav nrog cov tshuaj porcasological, suav nrog cov tshuaj tiv thaiv, tshuaj tiv thaiv, thiab anticalsle cuam tshuam.
Hauv kev siv ib txwm siv, matrine tau siv rau ntau pua xyoo los kho kev mob siab, thiab cov kab mob plab zom mov, thiab cov lus teb tsis zoo rau kev hloov kho. Nws cov tshuaj tua kabmob ua rau nws siv cov tshuaj tiv thaiv ntau yam, muaj kev cuam tshuam lwm cov tshuaj tiv thaiv hauv cov tshuaj-}}}}}} {tus kab mob resistant.
Ntxiv mus, kev tshawb fawb tau ua kom pom tias cov khoom ua haujlwm antectumor los ntawm kev ua haujlwm ntawm cov kabmob tshuaj tiv thaiv kab mob), thiab tsim cov hlab ntshav tshiab (cov qog ntshav tshiab) hauv cov qog. Cov anticancer cov txiaj ntsig tau tshawb nrhiav hauv cov kev tshawb fawb ua ntej rau cov qog nqaij hlav xws li daim siab, mob ntsws, thiab mob qog noj mis.
Tsis tas li ntawd, Matrine cov khoom siv tshuaj tua kab mob muaj kev ua kom zoo nkauj nyob rau xyoo tas los no, nrog kev tshawb fawb txog kev tiv thaiv kab mob tus kab mob tus kab mob siab B thiab HIV. Nws lub peev xwm los cuam tshuam nrog cov kab mob kis rau tus neeg sib tw ua rau nws muaj peev xwm kho tus neeg sib tw hauv kev kho mob tawm tsam.
Hauv kev xaus, theem, nrog nws cov khoom siv muaj txiaj ntsig zoo, sawv cev rau kev txhim kho cov tshuaj uas muaj txiaj ntsig zoo los daws cov kabmob ntau, los ntawm kev kis mob qog nqaij hlav cancer. Kev Tshawb Fawb Ntxiv Ntxiv mus txog qhov tsis tau tag nrho cov peev txheej tag nrho, muab kev cia siab rau kev txhim kho kev xaiv kho yav tom ntej.
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Tshuaj Cov Qauv |
C15H24N2O |
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Muaj pes tsawg leej |
248.19 |
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Molecular hnyav |
248.37 |
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m/z |
248.19 (100.0%), 249.19 (16.2%), 250.20 (1.2%) |
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Kev Ntsuam Xyuas |
C, 72.54; H, 9.74; N, 11.28; O, 6.44 |
Cov dej qub thiab dej kub crude extract ntawm sophora alopecuroids tau siv nyob rau sab hnub poob rau 25 xyoos. Cov extract ntawm sophora flavescens alkaloids alkaloids, tau hais tias muaj 20% oxymatrine thiabTheem matrine hmoov, tau qhia rau lub chaw ua lag luam sab hnub poob los ntawm lub koom haum ntawm Materia tshuaj rau hauv daim ntawv ntawm oxymatrine ntsiav tshuaj nyob rau hauv lub npe oxymatrine. Nws tau tsim nyob rau xyoo 1998. Nws siv tsis muaj kev phiv. Hauv Suav teb, Sophora alkaloids feem ntau tau txhaj, tab sis cov qauv no tsis raug lees txais nyob rau sab hnub poob thiab raug saib xyuas. Tom qab cov thawj coj ntawm qhov ncauj, feem ntau ntawm cov oxymatrine hloov pauv mus rau hauv theem; Yog tias cov ntshav siab rau cov qib oxymatrine yog qhov yuav tsum tau ua, kev txhaj tshuaj yog qhov tsim nyog. Txawm li cas los xij, nws tsis paub meej tias kev ua tau zoo ntawm oxymatrine zoo dua li matrine hauv chaw kuaj mob. Suav cov kws tshawb nrhiav kuj siv cov ntsiav tshuaj ntawm sophora alkaloids, thiab cov txiaj ntsig zoo li yuav txhaj tshuaj. Sophora Flavescens kuj tseem tau kho kom zoo nkauj thiab coj raws li tshuaj suav tshuaj.
Sophora flavescens muaj ntau cov alkaloids, ntawm cov ntsiab lus zoo tshaj plaws yog qhov hnyav ntawm Sophora, cov nyiaj tau los muaj nyob hauv daim ntawv Oxymatrine). Kuj tseem muaj lwm cov alkaloids zoo sib xws, feem ntau yog Sophocarpine (c15h22o), nrog rau cov me nyuam yaus me me ntawm Sophoronol, sophoramine, sab nrauv anomatic, yog qhov sib txawv thiab lwm yam alkaloid Cheebtsam. (Saib Daim Duab 2). Cov khoom siv no tau pom thawj zaug los ntawm Sophora Flavescens ntawm 1958 thiab 1978.
Sophora Flavescens txhaj tau siv los kho 64 tus neeg mob uas muaj tus kab mob siab B thiab piv nrog Alpha Interferon. Tom qab 3 lub hlis ntawm kev kho nrog Sophora Flavescens txhaj tshuaj (600mg / hnub X 45 hnub Qee tus neeg mob tseem tau ntsib ntau qib varying ntawm shrinkage nyob rau hauv daim siab thiab mob plab (2.63% thiab 38.1%, feem nrog). Tsis tas li ntawd, nws muaj qee qhov kev nce siab ntawm cov ntshav peripheral leukopenia thiab thrombocytop. Cov kev ua haujlwm txhim kho ntawm daim siab muaj nuj nqi yog qhov zoo, thiab cov lus qhia txog Alanine AminoTranserase (SB) yog 81.6% thiab 69.9%, feem. Qhov kev hloov pauv tsis zoo ntawm HBEAG thiab HBV DNA yog 44.4% thiab 45.3%, feem.
Tom qab kev kho mob interfering, cov kev hloov pauv tsis zoo ntawm HBEAG thiab HBV DNA yog 46.0% thiab 48.0%, feem. Tsis muaj qhov sib txawv ntawm kev sib txawv thiab alpha interferon, qhia tau tias muaj qee qhov kev nyab xeeb ntawm kev kho mob me me, tsis muaj lwm tus kev nyab xeeb ntawm kev nyab xeeb ntawm kev txhaj tshuaj tiv thaiv me, tsis muaj lwm yam kev nyab xeeb ntawm kev nyab xeeb, tsis muaj lwm tus kev nyab xeeb ntawm kev nyab xeeb ntawm Sophora Flavescens txhaj tshuaj. Txoj kev kawm no tsuas yog tsom rau luv luv- kev tshawb fawb tau zoo, thiab xav tau kev tshawb fawb ntxiv los txiav txim siab nws ntev} kev ua tau zoo.
Kev tshawb fawb soj ntsuam hauv Suav teb tau tias muaj kev kho mob siab rau HBAG thiab HBV Intramititis B tau 44.4% thiab 50.0%, feem. Kev kho mob nrog Alt thiab Ast pom kev txhim kho tseem ceeb hauv daim siab muaj nuj nqi, nrog tag nrho cov txiaj ntsig tag nrho ntawm 70.0%. Cov txiaj ntsig tau pom tias Sophora Flavescens muaj anti hbv thiab enzyme txo qis. Ib txhij muaj kev nyab xeeb zoo thiab thev taus, uas tsis muaj tshuaj lom.
Lwm kis: Tsev pw hauv tsev kho mob kis tau tus kab mob kis tau: 42 Cov neeg mob uas muaj tus kab mob siab qaib B tau kho nrog Sophora Flavescens. Cov txiaj ntsig tau pom tias qhov kev rov qab ntawm xeev siab thiab kev qaug zog tom qab kev mob siab thiab mob plab yog 100%.
Qee cov neeg mob kuj tau pom cov qib varyage nyob rau hauv cov kev cuam tshuam loj thiab muaj qee yam ntxiv) 3% thiab 30%, ntshav paj dawb, thiab platelets. Tus nqi ib txwm muaj ntawm Alt, Ast, thiab SB los ntawm Sophora Flavescens yog 71.4%, 61.9%, thiab 100%, feem. Cov kev hloov pauv hloov pauv tsis zoo ntawm HBEAG thiab HBV DNA
Cov chaw kuaj mob sim nyob rau hauv Suav teb: 17 Cov neeg mob uas muaj tus mob HCV ntev tau raug kho nrog kev tsim qauv ntawm sab hauv ntawm 600mg ntawm sophora flavescens ib zaug ib hnub. Tom qab kev kho mob, Ntshav HBV DN qhov hloov tsis zoo hauv 8 tus neeg (47.1%. Ntawm 18 tus neeg mob hauv pab pawg tswj, 1 tus (5.6%) muaj kev hloov pauv tsis zoo ntawm serum HBV DNA. Muaj qhov sib txawv ntawm ob pawg. Lub cev ntaj ntsug ib txwm muaj nyob hauv Sophora Flavescens cov pab pawg kho mob siab dua li ntawm pawg tswj tau tshaj plaws ntawm 1st thiab 2 hlis tom qab kev kho mob. Cov txiaj ntsig tau pom tias Sophora Flavescens tau muaj kev cuam tshuam txog HCV ntawm Alphabant, thiab nws yog qhov kev hloov pauv txawv teb chaws
Kev tshawb fawb qhia tias cov tshuab kev ua ntawm Sophora Flavescens tiv thaiv HBV thiab HCV tuaj yeem yog:
(1) Oxymatrine ua rau muaj qee yam tshuaj (xws li cytokines zoo li interferon) tsis pub dhau ntawm kev ua tsis ncaj ntawm HBV thiab HCV noob noob;
(2) Tus qauv tshuaj ntawm oxymatrine zoo ib yam li ntawm kev ua kom huv, thiab nws muaj peev xwm cuam tshuam nrog HBV thiab HCV mechanisms hauv cov hlwb lossis hauv Vivo yuav tsum tau tshawb xyuas ntxiv.
Cov chaw kuaj mob sim nyob hauv Suav teb: Tus qauv mob fibrososis mob fibrososis tau tsim muaj nyob hauv cov nas siv carbon tetrachloride (CCL4), thiab Oxy tau siv rau kev tiv thaiv thiab kev kho mob. Cov theem ntawm serrum alanine aminotransferase (alt), ntaus} cov kua txiv qaub (his}), thiab patholog}), thiab patholog}), thiab patholog}), thiab patholog}), thiab patholog} Qhov kev nthuav dav ntawm cov ntaub so ntswg fibrous nyob rau hauv daim siab yog kev tshuaj xyuas siv lub computer tsom xam cov duab. Cov txiaj ntsig tau pom tias cov dej hiav txwv alt,}}}}}} Dose cov pab pawg kho mob, thiab cov tshuaj pleev roj rau cov pa oxy Kev ua si, inhibited collagen synthesis thiab anti lub siab ua siab mob fibrosis cuam tshuam.
Cov chaw kuaj mob sim nyob hauv Suav teb: Siv Ni3t3 fibroblasts raws li phiaj hlwb, mtt assay, Northern BLOTY HYBRIDISTONS, thiab Immunohistochemistry cov tswv yim tau thov. Txoj kev tshawb nrhiav pom tias thaum lub siab xav txog oxy yog ntau dua 62.5 ug / ml, qhov kev loj hlob ntawm fibrife inhibited hauv qhov koob tshuaj {}}. Lub hlwb inibited muaj cov colibited me me, feem ntau cytoplasm, feem ntau ntxaiv puab lossis puag ncig, nucleus me me, thiab ob peb lub hlwb nyob rau theem no. Oxy tuaj yeem ua tau zoo heev ntawm hom III prodollaglast {} hauv cov kev tshawb pom saum toj no tej zaum yog ib qho ntawm cov oxy inhibitions fibrosis.
Muaj cov lus qhia sib txawv ntawm kev cuam tshuam ntawm oxymatrine ntawm kev tiv thaiv kab mob. Feem ntau ntseeg tau tias muaj kev tiv thaiv kab mob Bidirectional uas tuaj yeem txhawb nqa Lymphoocyte ntawm cov kev sib zog thiab inhibit nws ntawm cov siab. Tab sis txhua yam, cov nyhuv tseem muaj zog tiv thaiv kev loj hlob.
Cov chaw sim khomob tau pom tias kev tshawb fawb tau pom tias oxymatrine muaj qhov ua rau mob oxymatation ntawm cov tshuaj oxymatation, qhia txog cov tshuaj oxymategia, qhia txog cov tshuaj oxymategation, qhia txog cov tshuaj oxymategial los tiv thaiv thiab kho cov qog metastas.
6. Theem matrine hmoovtau anti faultgic thiab anti - inflammatory
Tuaj yeem tswj kev tiv thaiv thiab nce cov qe ntshav dawb. Nyob rau hauv xyoo tas los, kev tshawb fawb tau pom tias oxy thiab matrine lev muaj {}}}}}}} Cov neeg sib txuas lus, thiab muaj cov txiaj ntsig ruaj khov ntawm cov tshuaj mem duab cell. Kuj tseem muaj cov ntawv qhia txog Oxy 100 Mg ·; KG-1 tuaj yeem nce cov ntsiab lus ntawm HOPATIC OFFICOMAL CYtoCrome P450 thiab ua kom zoo nkauj tshaj tawm Cyclate ntawm lub cell membrane, yog li nce cov nce qib chaw pw hav zoov. Oxy ntawm 100 mg / kg tau muaj zog choleretic nyhuv ntawm nas, uas yuav cuam tshuam nrog qhov nce hauv cov roj ntsha li hauv chav dej. Cov nyhuv ntawm oxy ntawm kev nthuav dav ntawm cov kab mob hlwb yog ze rau kev kho ntshav ntawm kev kho mob ntawm kev kho mob ntawm kev kho mob autoimitis thiab leukoplenia thiab thebopocytopenia.
Muaj Peev Xwm Kho
Mob kha xaw:
- Matrine tau pom pom anticancer cuam tshuam tawm tsam ntau hom mob qog noj ntshav (NSPATOCELLULARCE Canca (HEPC), thiab lub qog papillary Carcinoma (TPC).
- Nws txwv tsis pub muaj mob cancer ntawm tes, tsiv teb tsaws, thiab txhawb nqa kev ua haujlwm ntawm tes) los ntawm kev kho mob BCL-22-5P qhia hauv cov qog nqaij hlav.
- Kev tshawb nrhiav tsiaj tau qhia tias muaj los ntawm kev tswj hwm cov qog, kev cuam tshuam qog nqaij hlav thiab metastasis hauv xenograft cov qauv.
O thiab oxidative ntxhov siab:
- Matrine cov khoom ua haujlwm los tiv thaiv - mob thiab antioxidant thiab antioxidant thiab kev puas tsuaj los ntawm ntau yam stimuli.
- Hauv cov kev tshawb fawb dav tau qhia tiasTheem matrine hmoovinhibits qhov kev tsim cov khoom siv oxygen hom (ros) thiab proinflatory cytokines xws li} 1, IK-6, thiab TNF- hauv hlwb raug mob.
- Nws tseem thim Mitochondction ua tsis tiav hauv cov hlwb raug mob los ntawm kev ua kom lub Sirt3 / OPA1 txoj hauv kev.
Raug Mob Hlob Mobile (AKI):
- Tau pom muaj txiaj ntsig zoo hauv kev txo lub raum puas tsuaj thiab apoptosis hauv cisplatin, ib tus neeg saib xyuas tshuaj tiv thaiv.
- Kev tswj hwm ntawm matrine txo qhov mob, ua kom lub sirt3 axis, thiab khaws cia cov roj liab qab.
Kis Kab Mob:
- Thaum cov pov thawj coj ncaj qha rau kev siv cov kab mob kis rau qee yam, nws cov anti {{
- Cov kev tshawb fawb ntxiv yog xav tau kom nkag siab txog nws lub luag haujlwm hauv thaj chaw no.
Mob kab mob siab B (CHB):
- Matrine tau raug tshuaj xyuas rau nws cov kev muaj peev xwm hauv Chb cov neeg mob, qhov chaw uas nws yuav pab txhim kho kev ua haujlwm ntawm lub siab ua haujlwm thiab txo cov kab mob kis.
- Txawm li cas los xij, ntau cov kev tshawb fawb tau xav kom paub meej tias nws ua tau zoo thiab kev nyab xeeb hauv Chb kev kho mob.
Dawb ntshav ntawm cov ntshav cuam tshuam:
- Matrine tau siv los kho cov ntshav ntawm cov ntshav ntawm lub cev dawb, tshwj xeeb yog cov tshuaj kho mob los ntawm kev siv ntshav lossis hluav taws xob kom ua rau cov ntshav tsis suav nrog.
Theem matrine hmoov, tus bioctive alkaloid tau los ntawm cov hauv paus hniav ntawm sophora flavescens, muaj tsoos suav tshuaj ntsuab, khav poj niam muaj keeb kwm nplua nuj ntawm kev siv nyiaj txiag. Nws daim ntawv thov tuaj yeem raug taug qab mus rau lub sijhawm thaum ub hauv Suav tshuaj (TCM), uas nws tau tswm seeb rau nws lub peev xwm rau kev txo qis kev mob ilermiate.
Keeb kwm, Matrine tau ua haujlwm los kho cov mob xws li kub cev, thiab qee yam mob ntawm ove {}}} pa, thiab antipyretic cov khoom. Hauv TCM theories, nws ntseeg tau tias muaj kev sib haum xeeb lub cev Qi thiab cov ntshav txaus, txhawb kev noj qab haus huv tag nrho thiab zoo- ua.
Raws li kev tshawb fawb tau kev tshawb fawb tau zoo, muaj peev xwm ntawm lub chaw muag khoom muaj peev xwm ntawm kev sib txuam yog txuas ntxiv. Cov kev tshawb fawb niaj hnub tau paub tseeb tias nws txoj kev ua tau zoo hauv kev tiv thaiv kab mob siab, mob cancer, thiab cov kab mob ntawm lwm tus. Nws cov kev ua haujlwm antiviral thiab anticumt cov haujlwm tau txais kev saib xyuas tseem ceeb, tshwj xeeb hauv kev kho mob tau tshawb pom raws li cov neeg kho mob cancer.
Ntxiv mus, matrine lub neuroProtective, anti {- arrhythmic, thiab immunomodatory kev cuam tshuam tau nthuav dav nws cov kev kho kom dav. Niaj hnub no, nws tsis yog siv hauv cov qauv ib txwm tab sis tseem tso rau hauv kev npaj tshuaj niaj hnub no ntawm cov tshuaj kho mob thaum ub hauv cov tshuaj kawm niaj thaum ub.
Hauv kev xaus, theem nrab yog qhov ua tim khawv txog kev txawj ntse ntawm cov tshuaj suav ib txwm muaj peev xwm qhib tau cov txiaj ntsig tag nrho rau tib neeg.
Cim npe nrov: Matrine hmoov CAS 519-02-8, lwm tus neeg, chaw tsim khoom, Hoobkas, lag luam wholesale, yuav, nqe, loj, loj, rau muag