Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm methotrexate hmoov cas 59-05-2 nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo methotrexate hmoov cas 59-05-2 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Methotrexate hmoovyog ib qho tshuaj muaj zog uas feem ntau siv los tswj ntau yam mob autoimmune thiab qee hom mob qog noj ntshav. Nyob rau hauv cov chav kawm ntawm cov tshuaj hu ua antimetabolites, nws cuam tshuam DNA synthesis thiab cell proliferation, yog li exerting nws kho cov teebmeem.Nyob rau hauv autoimmune kab mob xws li rheumatoid mob caj dab, psoriasis, thiab tej yam vasculitis, nws yuav pab txo o thiab qeeb cov kab mob kev loj hlob los ntawm modulating lub cev tsis muaj zog teb. Kev tswj qhov ncauj lossis los ntawm kev txhaj tshuaj, nyob ntawm txoj kev kho mob, nws tuaj yeem txhim kho cov tsos mob thiab txhim kho lub neej zoo rau cov neeg mob.
Rau kev kho mob qog noj ntshav, tshwj xeeb yog qee hom kab mob leukemia, lymphoma, thiab mob qog noj ntshav ntawm lub mis, nws ua tus kws khomob, tsom mus rau faib cov qog nqaij hlav sai sai. Txawm li cas los xij, nws siv nyob rau hauv oncology feem ntau yuav tsum tau ceev faj noj thiab saib xyuas vim nws muaj peev xwm rau toxicity thiab phiv.
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Tshuaj Formula |
C16H15ClO6 |
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Exact Mass |
338.06 |
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Molecular Luj |
338.74 |
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m/z |
338.06 (100.0%), 340.05 (32.0%), 339.06 (17.3%), 341.06 (5.5%), 340.06 (1.4%), 340.06 (1.2%) |
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Elemental Analysis |
C, 56,73; H, 4,46; 10,47, 10; 28.34 Nws |
Daim ntawv thov Antimetabolite
Inhibition ntawm Dihydrofolate Reductase (DHFR)
Methotrexate hmoovua raws li antimetabolite los ntawm inhibiting enzyme dihydrofolate reductase (DHFR). Cov enzyme no tseem ceeb heev hauv kev hloov pauv ntawm dihydrofolate (DHF) mus rau tetrahydrofolate (THF), ib qho tseem ceeb cofactor hauv kev sib txuas ntawm purines, thymidylate, thiab qee cov amino acids.
Los ntawm inhibiting DHFR, methotrexate tiv thaiv kev tsim ntawm THF, yog li cuam tshuam cov synthesis ntawm DNA, RNA, thiab cov proteins tseem ceeb rau kev loj hlob ntawm tes thiab kev faib tawm.
Tiv thaiv DNA Synthesis
Raws li qhov tshwm sim ntawm inhibiting THF ntau lawm, methotrexate cuam tshuam rau ib qho -carbon hloov cov tshuaj tiv thaiv tsim nyog rau kev sib txuas ntawm nucleotides, thaum kawg inhibiting DNA synthesis. Cov nyhuv no tshwj xeeb tshaj yog thaum lub sij hawm S theem ntawm lub voj voog ntawm tes, thaum DNA replication tshwm sim.
Antitumor Activity
Dav siv los ua tus neeg sawv cev antineoplastic hauv kev kho mob ntawm ntau yam qog noj ntshav, suav nrog mob qog nqaij hlav qog nqaij hlav cancer mis, mob qog noj ntshav mis, mob qog nqaij hlav taub hau thiab caj dab, thiab lwm yam. Nws lub peev xwm los inhibit DNA synthesis ua rau kev ntes cov qog nqaij hlav qog noj ntshav thiab kev loj hlob.
Daim ntawv thov Antifolate
Folate Antagonism
Ua haujlwm raws li cov tshuaj tiv thaiv folate los ntawm kev tiv thaiv kev ua ntawm folic acid (vitamin B9). Folic acid yog qhov tseem ceeb rau kev sib txuas thiab metabolism ntawm nucleotides thiab amino acids, ua rau nws yog ib qho tseem ceeb ntawm kev loj hlob ntawm tes thiab kev faib tawm.
Los ntawm thaiv kev hloov pauv ntawm folic acid rau nws daim ntawv nquag, THF, methotrexate cuam tshuam lub voj voog folate thiab cuam tshuam cov synthesis ntawm nucleic acids thiab proteins.
Kev kho mob autoimmune
Ntxiv nrog rau nws cov haujlwm antitumor, nws kuj tseem siv los ua cov tshuaj tiv thaiv kab mob hauv kev kho mob autoimmune xws li mob caj dab rheumatoid.
Los ntawm inhibiting kev loj hlob ntawm lub cev tiv thaiv kab mob, methotrexate pab txo qhov mob thiab txo cov tsos mob cuam tshuam nrog cov kab mob no.
Kev Kho Mob Ua Ke
Feem ntau siv ua ke nrog lwm cov tshuaj los txhim kho nws cov teebmeem kev kho mob. Piv txwv li, hauv kev kho mob qog noj ntshav, methotrexate tuaj yeem ua ke nrog lwm cov kws khomob khomob txhawm rau tsom mus rau ntau txoj hauv kev koom nrog hauv kev loj hlob ntawm cov qog nqaij hlav cancer thiab kev ciaj sia.
hauv Kev Kho Mob Cancer
Methotrexate feem ntau ua haujlwm los ntawm inhibiting dihydrofolate reductase, ib qho enzyme tseem ceeb rau kev hloov dihydrofolate rau tetrahydrofolate (THF). THF yog ib qho tseem ceeb cofactor nyob rau hauv lub synthesis ntawm nucleotides, uas yog tsim blocks ntawm DNA thiab RNA. Los ntawm thaiv qhov kev hloov pauv no, methotrexate cuam tshuam kev tsim cov nucleotides, yog li inhibiting DNA synthesis thiab thaum kawg inhibiting qog nqaij hlav qog noj ntshav thiab kev loj hlob.
Mob Lymphoblastic Leukemia (TXHUA)
Methotrexate yog ib qho tseem ceeb hauv kev kho mob TAG NRHO, feem ntau siv ua ke nrog lwm cov tshuaj kws khomob xws li vincristine thiab prednisone. Qhov kev sib xyaw ua ke no, hu ua Vincristine-Adriamycin-Dexamethasone (VAD) kev tswj hwm, tau pom tias muaj txiaj ntsig zoo hauv txhua tus neeg mob.
Nws kuj yog siv rau hauv kev kho mob ntawm ntau yam qog nqaij hlav, nrog rau mob qog noj ntshav ntawm lub mis, mob ntsws cancer, mob qog nqaij hlav taub hau thiab caj dab, thiab mob qog noj ntshav. Cov koob tshuaj thiab kev tswj hwm lub sijhawm sib txawv nyob ntawm seb hom mob qog noj ntshav thiab theem twg.
Choriocarcinoma thiab Gestational Trophoblastic Disease
Methotrexate hmoovNws muaj txiaj ntsig zoo hauv kev kho mob choriocarcinoma thiab lwm yam kab mob gestational trophoblastic, uas tsis tshua muaj tab sis mob qog noj ntshav uas tshwm sim los ntawm cov ntaub so ntswg placental.
Nws yog siv rau hauv kev kho mob ntawm Hodgkin's thiab tsis yog -Hodgkin's lymphomas, feem ntau ua ke nrog lwm cov tshuaj xws li doxorubicin, bleomycin, vinblastine, thiab dacarbazine (ABVD regimen).
Hauv qee kis, kev kho mob siab - koob tshuaj methotrexate nrog leucovorin cawm (HD-MTX/CFR) yog muab rau cov neeg mob uas muaj cov qog nqaij hlav refractory lossis relapsed. Txoj hauv kev no suav nrog kev siv tshuaj ntau ntawm methotrexate ua raws li leucovorin txhawm rau txo cov tshuaj lom thiab txhim kho cov tshuaj ua tau zoo.
kab mob autoimmune
Rheumatoid mob caj dab (RA)
Kev siv thawj zaug: MTX yog lub hauv paus kev kho mob rau RA, tshwj xeeb tshaj yog nyob rau nruab nrab mus rau mob hnyav. Nws pab txo qhov mob, qeeb kab mob, thiab txhim kho kev ua haujlwm.
Mechanism: Los ntawm inhibiting T thiab B cell kev ua si thiab txo cov neeg tiv thaiv kab mob, MTX siv nws los tiv thaiv - mob thiab tiv thaiv kab mob.
Daim ntawv thov: MTX kuj tseem siv tau los kho cov menyuam yaus idiopathic mob caj dab, mob caj dab psoriatic, Felty's syndrome, thiab daim tawv nqaij vasculitis cuam tshuam nrog RA.
Kev ua tau zoo: Nws txoj kev ua tau zoo tau ua tau zoo- tau tsim nyob rau hauv cov xwm txheej no, feem ntau ua rau cov neeg mob tau txais txiaj ntsig zoo dua.
Cov kab mob autoimmune
Systemic Lupus Erythematosus (SLE)
Methotrexate (MTX) hmoov yog ib qho tseem ceeb ntawm kev kho tus neeg sawv cev rau kev tswj xyuas kev kho mob ntawm Systemic Lupus Erythematosus (SLE), ua lub luag haujlwm pabcuam tsis tuaj yeem hloov pauv hauv cov qauv kev kho mob SLE. Rau feem ntau me me -rau- cov neeg mob SLE nruab nrab, cov qauv kev kho mob ib txwm muaj xws li glucocorticoids thiab hydroxychloroquine tuaj yeem tswj cov tsos mob yooj yim, tab sis muaj coob tus neeg mob raug mob los ntawm cov pob liab liab, mob caj dab rov qab, mob me me thiab lwm yam kev mob tshwm sim uas tsis tuaj yeem daws tau tag nrho} cov tshuaj ua ntej {{3}.
Tsis tas li ntawd, qee cov neeg mob intolerance rau siab - koob tshuaj glucocorticoids lossis ntsib kev pheej hmoo ntawm tus kab mob rov tshwm sim thaum lub sij hawm cov tshuaj hormone tapering. Nyob rau hauv cov xwm txheej no, qhov qis - mus rau - koob tshuaj methotrexate tuaj yeem muab ntxiv ua ke ua ke. Nws ua kom muaj zog tiv thaiv - mob thiab tiv thaiv kab mob los ntawm inhibiting folate metabolism thiab txo qhov kev loj hlob ntawm cov kab mob hauv lub cev tsis zoo, txhim kho kev mob pob qij txha, cov kab mob ntawm daim tawv nqaij thiab cov kab mob ntev ntev hauv cov neeg mob SLE, thaum pab txo qis cov tshuaj ntau ntxiv ntawm glucocorticoids 6} cov tshuaj tiv thaiv kab mob xws li txo qis hauv cov tshuaj tiv thaiv kab mob. osteoporosis thiab hyperglycemia. Nws yog qhov tsim nyog tshwj xeeb rau cov neeg mob SLE uas muaj qhov tshwm sim ntawm articular thiab cutaneous tshaj plaws uas teb tsis zoo rau ib txwm siv - tshuaj kho.
Qhov Systemic Sclerosis (SSc)
Systemic Sclerosis (SSc) yog ib hom kab mob autoimmune refractory uas tshwm sim los ntawm diffuse daim tawv nqaij fibrosis, vascular lesions thiab ntau -organ interstitial puas, nrog rau kev kho mob tsis tshua muaj kev xaiv thiab tsis zoo ntev - lub sij hawm prognosis. Ntau qhov kev tshawb fawb soj ntsuam thiab cov txheej txheem kho mob tau lees paub tias Methotrexate muaj txiaj ntsig tseem ceeb hauv kev kho mob SSc thiab tuaj yeem ua rau txo qis tag nrho kev loj hlob ntawm tus kab mob.
Rau thaum ntxov -theem diffuse cutaneous systemic sclerosis cov neeg mob uas muaj cov tawv nqaij tawv tawv, o thiab induration, MTX tuaj yeem cuam tshuam qhov txawv txav ntawm fibroblasts thiab ntau deposition ntawm extracellular matrix, li no alleviating daim tawv nqaij fibrosis thiab txhim kho daim tawv nqaij hardness thiab kev sib koom tes.Meanwhile, nws muaj peev xwm inflammatory dab nyob rau hauv cov hlab ntsha. lub cev, thiab ncua kev loj hlob ntawm microvascular lesions thiab interstitial lesions ntawm sab hauv nruab nrog cev. Rau cov neeg mob uas muaj SSc thaum ntxov uas tsis muaj lub cev tsis ua haujlwm hnyav, tus qauv MTX monotherapy lossis ua ke nrog qis - koob tshuaj glucocorticoids tuaj yeem txhim kho cov tsos mob zoo, txhim kho cov kab mob, thiab txo qhov kev pheej hmoo ntawm kev loj hlob sai ntawm daim tawv nqaij thiab lub cev fibrosis.
Inflammatory Myopathies
Inflammatory myopathies, sawv cev los ntawm dermatomyositis thiab polymyositis, yog ib pab pawg ntawm cov kab mob autoimmune inflammatory kab mob tsom rau cov leeg pob txha, kev kho mob tshwm sim raws li cov leeg nqaij tsis muaj zog, mob nqaij, thiab nrog rau cov tsos mob ntawm daim tawv nqaij (hauv dermatomyositis) thiab elevated nqaij. Glucocorticoids yog thawj - cov tshuaj kho kab mob, tab sis feem ntau ntawm cov neeg mob tsim cov kab mob refractory nrog cov tshuaj hormone monotherapy tsis zoo, lossis raug kev txom nyem los ntawm cov kab mob rov tshwm sim thaum lub sij hawm txo cov tshuaj hormones, thiab qee cov neeg mob hnyav tsis tuaj yeem ua tiav cov kab mob tshem tawm txawm tias muaj siab - koob tshuaj glucocorticoids.
Methotrexate hmoovyog ib qho classic thiab nyiam cov tshuaj tiv thaiv kab mob rau xws li refractory thiab mob hnyav myopathies. Nws muaj peev xwm tshwj xeeb inhibit lub cev tiv thaiv kab mob -kev kho mob inflammatory infiltration ntawm cov leeg nqaij, txo cov nqaij fiber ntau necrosis thiab inflammatory exudation, zoo txo cov ntshav creatine kinase, txhim kho cov leeg nqaij thiab txo cov tsos mob ntawm myalgia. Tsis tas li ntawd, MTX tuaj yeem txo cov koob tshuaj ntawm glucocorticoids, txo qhov tshwm sim ntawm qhov ntev - cov teeb meem tshuaj hormones, thiab txhim kho lub sij hawm ntev - kev kho mob zoo thiab lub neej zoo ntawm cov neeg mob uas muaj mob hnyav lossis rov muaj mob myopathies.
Cov kab mob autoimmune ntawm daim tawv nqaij
Psoriasis
Methotrexate yog ib qho ntawm cov classic tshaj plaws, muaj kev nyab xeeb thiab zoo - tau tsim cov tshuaj kho mob rau cov mob hnyav rau psoriasis, thiab tau suav nrog cov txheej txheem kho mob psoriasis hauv tsev thiab txawv teb chaws tau ntev. Nws yog dav siv rau ntau yam kev kho mob subtypes ntawm kev loj hlob thiab refractory psoriasis, nrog rau cov quav hniav -type psoriasis, mob guttate psoriasis, thiab hnyav erythrodermic psoriasis thiab pustular psoriasis.
Rau cov mob psoriasis mob me, cov tshuaj pleev xim thiab cov duab kho mob yog cov kev kho mob tseem ceeb, thaum nruab nrab thiab hnyav psoriasis nrog thaj tsam loj, pom tseeb inflammatory infiltration thiab rov tshwm sim yuav tsum muaj kev tiv thaiv kab mob tiv thaiv kab mob.MTX inhibits qhov kev loj hlob ntau dhau ntawm epidermal keratinocytes thiab thaiv qhov txawv txav ntawm cov tawv nqaij tiv thaiv kab mob, txo cov tawv nqaij sai sai. scaling thiab infiltration o. Ntev -lub sij hawm tus qauv qis- koob tshuaj MTX kev kho mob tuaj yeem tswj cov kab mob rov qab zoo, txo qhov kev tiv thaiv kab mob, thiab txhim kho cov neeg mob cov tawv nqaij thiab cov tsos mob zoo. Nrog cov nyhuv curative tseeb thiab tswj tsis tau cov kev phiv tshwm sim, nws tseem yog ib qho tseem ceeb cov tshuaj siv rau kev kho mob ntawm cov mob nruab nrab mus rau mob psoriasis.
Cov kab mob autoimmune bullous
Cov kab mob autoimmune bullous uas sawv cev los ntawm pemphigus vulgaris thiab bullous pemphigoid yog ib pab pawg ntawm cov kab mob autoimmune ntawm daim tawv nqaij mob hnyav tshwm sim los ntawm autoantibodies tsom rau ntawm daim tawv nqaij thiab cov mucosal hauv qab daus daim nyias nyias, kev kho mob uas tshwm sim los ntawm hlwv tsim, yaig thiab exudation ntawm daim tawv nqaij thiab mucous daim nyias nyias, uas muaj feem xyuam rau cov neeg mob lub neej txhua hnub. Glucocorticoids yog thawj - kab tshuaj rau kev tswj cov kab mob hnyav, tab sis ntev - lub sij hawm siab - kev siv tshuaj hormones yog nrog los ntawm ntau yam kev tsis zoo ntawm lub cev, thiab qee cov neeg mob muaj cov kab mob tsis ruaj khov tom qab txo cov tshuaj hormones.
Methotrexate feem ntau yog siv los ua kev kho mob tseem ceeb ua ke nrog corticosteroids rau cov kab mob zoo li no. Nws pab tiv thaiv cov kab mob autoimmune tsis zoo, txo qhov tsim cov kab mob autoantibodies, ua kom cov tawv nqaij thiab mucosal erosions thiab hlwv, thiab stabilizing cov kab mob. Qhov tseem ceeb tshaj, kev sib xyaw ua ke nrog MTX tuaj yeem txo qhov xav tau ntau npaum li cas thiab cov txheej txheem ntawm glucocorticoids, zam cov tshuaj hormone dependence thiab cov tshuaj hormones hnyav- cuam tshuam txog cov teeb meem, thiab tshwj xeeb tshaj yog tsim rau cov neeg laus, cov neeg mob uas muaj cov tshuaj hormone intolerance thiab rov tshwm sim autoimmune bullous cov neeg mob.
Vascular Inflammatory Disease
Vasculitis
Vasculitis yog ib pawg ntawm cov kab mob sib txawv ntawm cov kab mob hauv nruab nrab ntawm vascular phab ntsa inflammatory puas thiab necrosis, nrog rau cov hlab ntsha ntawm txawv calibers thoob plaws hauv lub cev, thiab tuaj yeem ua rau muaj kev puas tsuaj rau ntau lub cev thiab lub cev. Methotrexate yog ib hom tshuaj tiv thaiv kab mob sib kis tau dav siv hauv kev kho mob ntawm ntau yam kab mob vasculitides, suav nrog Wegener's granulomatosis (granulomatosis nrog polyangiitis), mob loj heev ntawm tes, Takayasu's arteritis thiab lwm hom vasculitis.
Nws tuaj yeem siv rau kev mob me me - mus rau - mob vasculitis nruab nrab raws li kev kho mob monotherapy, los yog kev saib xyuas ua ke rau kev kho mob vasculitis mob hnyav tom qab tshem tawm los ntawm siab - cov tshuaj hormones thiab tshuaj tiv thaiv kab mob.
Mechanism
Tus nqi kho mob tseem ceeb ntawm MTX hauv cov kab mob vascular inflammatory stems los ntawm nws ob qho kev cuam tshuam ntawm kev tiv thaiv zoo -mob thiab tsom inhibition ntawm lub cev tiv thaiv kab mob- kho mob vascular puas tsuaj.
Ntawm ib sab tes, MTX inhibits cov synthesis ntawm inflammatory cytokines xws li qog necrosis yam thiab interleukin, thaiv lub cascade amplification ntawm vascular inflammatory teb, txo inflammatory cell infiltration mus rau hauv vascular phab ntsa, thiab relieves vascular phab ntsa edema, exudation thiab inflammatory necrosis.Ntawm qhov tod tes, nws regulates lub cev tsis muaj zog. autoimmune-kev kho mob vascular tiv thaiv kab mob, tiv thaiv vascular stenosis, occlusion thiab aneurysm tsim los ntawm ntev - lub sij hawm vascular o, zoo tswj cov kab mob kev ua ub no, qeeb vascular lesion kev loj hlob, txo tus nqi rov qab ntawm vasculitis, thiab txo qhov kev pheej hmoo ntawm lub cev ischemic rape ntau yam kev nyab xeeb thiab kev nyab xeeb, kev ruaj ntseg ntev 3. kab mob vasculitis.
Methotrexate hmoov(MTX) yog ib qho tshuaj tiv thaiv kab mob metabolic uas tau dhau los ua cov tshuaj tseem ceeb rau kev kho mob qog noj ntshav, kab mob autoimmune (xws li mob caj dab), thiab qee yam kab mob ntawm daim tawv nqaij (xws li psoriasis) txij li thaum nws tshawb pom hauv 1940s. Nws qhov kev tshawb pom thiab kev loj hlob sawv cev rau cov ntsiab lus tseem ceeb hauv cov tshuaj chemistry niaj hnub thiab kws tshuaj, tsis yog tsuas yog txhawb kev tshawb fawb ntawm cov tshuaj tiv thaiv - qog nqaij hlav, tab sis kuj qhib txoj hauv kev tshiab rau kev kho immunomodulatory.
Kev tshawb pom ntawm methotrexate yog ze ze rau txoj kev tshawb fawb ntawm folic acid. Folic acid yog B- cov vitamin complex (vitamin B9), thawj zaug tshawb pom los ntawm tus kws tshawb fawb Askiv Lucy Wills hauv xyoo 1931, uas tau pom tias cov poov xab extract tuaj yeem tiv thaiv gestational megaloblastic anemia.
Xyoo 1941, Asmeskas cov kws tshawb fawb Herschel K. Mitchell thiab lwm tus tau cais cov folic acid los ntawm nplooj spinach thiab txiav txim siab nws cov qauv tshuaj. Folic acid hloov mus rau hauv tetrahydrofolate (THF) hauv tib neeg lub cev, uas koom nrog DNA synthesis, amino acid metabolism, thiab cell proliferation. Vim muaj kev loj hlob sai ntawm cov qog nqaij hlav cancer thiab lawv txoj kev vam khom ntawm folate metabolism, cov kws tshawb fawb tau pib kawm yuav ua li cas cuam tshuam nrog folate metabolism hauv inhibit qog hlav.
Hauv xyoo 1940, cov kws tshawb fawb tau tshawb pom tias qee cov tshuaj folate analogues tuaj yeem cuam tshuam cov metabolism hauv folate, yog li tiv thaiv kab mob qog noj ntshav.
Xyoo 1947, tus kws tshuaj Asmeskas kws tshuaj Sidney Farber thiab nws pab neeg tau tshawb pom tias aminopterin (4-aminofolate) tuaj yeem txo cov tsos mob leukemia ib ntus thaum kawm cov kab mob leukemia hauv cov menyuam yaus hauv Tsev Kawm Ntawv Kho Mob Harvard. Qhov no yog thawj cov tshuaj nyob rau hauv keeb kwm uas tau ua tiav siv rau kev kho mob qog noj ntshav, cim qhov pib ntawm lub sijhawm ntawm kev siv tshuaj khomob.
Aminopterin muaj zog toxicity thiab ua rau tus neeg mob tsis zoo. Txhawm rau tshawb nrhiav cov txiaj ntsig zoo dua, tus kws tshuaj Asmeskas Yellapragada Subbarow thiab nws pab pawg tau hloov kho cov aminopterin hauv Lederle Laboratories thiab thaum kawg ua ke Methotrexate (MTX), tseem hu ua 4-amino-10-methylfolate, hauv xyoo 1948. Muab piv nrog cov tshuaj tiv thaiv kab mob, tab sis muaj cov tshuaj tiv thaiv kab mob tsawg dua, tab sis cov tshuaj tiv thaiv kab mob. tseem ceeb heev.
Hauv xyoo 1950, cov kws tshawb fawb tau piav qhia ntxiv txog kev ua haujlwm ntawm methotrexate. Nws cuam tshuam nrog purine thiab thymidine xav tau rau DNA synthesis los ntawm inhibiting dihydrofolate reductase (DHFR) thiab tiv thaiv qhov txo qis ntawm dihydrofolate (DHF) rau tetrahydrofolate (THF). Vim muaj kev loj hlob sai ntawm cov qog nqaij hlav cancer thiab kev thov siab rau folate, methotrexate tuaj yeem xaiv inhibit qog loj hlob.
Xyoo 1953, Roy Hertz thiab Min Chiu Li los ntawm National Cancer Institute (NCI) tau tshaj tawm thawj zaug tias methotrexate tau ua tiav zoo kho choriocarcinoma, thawj cov qog nqaij hlav hauv tib neeg keeb kwm kom kho tau los ntawm kev siv tshuaj khomob. Qhov kev tawg no tau ua rau methotrexate yog ib qho tshuaj tseem ceeb rau kev kho mob qog noj ntshav.
Nyob rau xyoo 1960, cov kws tshawb fawb tau tshawb pom tias methotrexate tsis tsuas yog muaj kev tiv thaiv - qog nqaij hlav, tab sis kuj tuaj yeem cuam tshuam kev ua kom lub cev tsis muaj zog.
Xyoo 1964, tus kws kho mob Asmeskas Edmund Dubois thawj zaug sim kho psoriasis nrog qis - koob tshuaj methotrexate thiab ua tiav cov txiaj ntsig tseem ceeb. Tom qab ntawd, nyob rau xyoo 1980, methotrexate tau siv dav rau kev kho mob rheumatoid mob caj dab (RA), dhau los ua tus qauv kub rau "kab mob hloov kho cov tshuaj tiv thaiv kab mob (DMARDs)".
FAQ
Puas yog methotrexate muaj nyob hauv daim ntawv ua kua?
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Methotrexate tsuas yog muaj nyob rau hauv cov tshuaj. Nws los ua cov ntsiav tshuaj,ib lub kua uas koj nqos, thiab ua ntej -cov cwj mem los yog cov koob txhaj tshuaj uas koj txhaj rau hauv koj daim tawv nqaij. Koj tus kws kho mob tshwj xeeb yuav pom zoo txhaj tshuaj yog tias cov ntsiav tshuaj lossis cov kua dej tsis ua haujlwm rau koj.
Dab tsi yog methotrexate siv rau?
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Cov tshuaj no yog dab tsi? METHOTREXATE (METH oh TREX noj)kho cov mob autoimmune, xws li mob caj dab thiab psoriasis. Nws ua haujlwm los ntawm kev txo qis qhov mob, uas tuaj yeem txo qhov mob thiab tiv thaiv ntev - raug mob rau pob qij txha thiab tawv nqaij. Nws kuj tseem siv tau los kho qee yam mob qog noj ntshav.
Cim npe nrov: Methotrexate hmoov CAS 59-05-2, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom