Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov neeg muag khoom ntawm naproxen sodium hmoov pre 26159-34-2 hauv Suav. Txais tos rau kev lag luam wholesale loj zoo napboxen sodium hmoov pre 26159-34-2 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Naproxen sodium hmoov, dawb lossis tawm dawb crystalline hmoov; Ntxhiab; Me ntsis hygroscopic. Cov khoom lag luam yooj yim soluble hauv dej, me ntsis soluble hauv ethanol, soluble me ntsis hauv acetone, thiab yuav luag tsis muaj insoluble hauv chloroform lossis toluene. Nws yog lipophilic, tsis acidic, nyob rau hauv lub rooj zaum naproxen prodrug. Ib zaug nqus tau, nws yuav yog hydrolyzed rau hauv pharmacologically nquag natroxen. Cov khoom kho mob tsis yog steroidal anti {{}} kev siv yeeb tshuaj. Nws yog qhov tsim nyog rau kev hloov kho txhua yam mob me rau mob me ntsis, xws li mob hniav ntxiv thiab lwm yam kev ua haujlwm, thawj zaug ua haujlwm DysmenorHea thiab mob taub hau. Nws tseem siv tau txog kev mob ntsws rheumatoid, asteoarritis, ankylosing spondylitis, mob caj dab thiab mob bursonitis, mob qog nqaij hlav thiab mob qog nqaij hlav. Nws tuaj yeem daws qhov mob, o thiab txwv kev ua phem ntawm kev mob caj dab. Cov khoom ntawm lub chaw kuaj mob no yog cov tshuaj kawm rau kev tshawb fawb xwb.
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Tshuaj Cov Qauv |
C14h13Nono3 |
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Muaj pes tsawg leej |
252 |
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Molecular hnyav |
252 |
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m/z |
252 (100.0%), 253 (15.1%), 254 (1.1%) |
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Kev Ntsuam Xyuas |
C, 66.66; H, 5.19; NA, 9.11; O, 19.03 |
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CaSipusheng tau ua thawj synthesized los ntawm Harrison li al. Thaum xyoo 1980s, thaum SYNTEX, Tebchaws Asmeskas, Monopolized nws. Lub tuam txhab tsim tawm txhua xyoo ntawm SYNTEX Kws Tshuaj nyob hauv Tebchaws Asmeskas yog 800 tons. Nws tau thawj fatented thiab muab tso rau hauv kev lag luam khoom lag luam. Xyoo 1992, nws tau tshaj li US $ 1Billion, ua lwm cov tshuaj antipyretic thiab analgesic uas hla lub ntsej muag fated nyob rau xyoo 1993
Cov tshuaj kho mob yog qhov tsis muaj zog los anti -} mob yeeb tshuaj. Nws yog qhov tsim nyog rau kev hloov kho txhua yam mob me rau mob me ntsis, xws li mob hniav ntxiv thiab lwm yam kev ua haujlwm, thawj zaug ua haujlwm DysmenorHea thiab mob taub hau. Nws tseem siv tau txog kev mob ntsws rheumatoid, asteoarritis, ankylosing spondylitis, mob caj dab thiab mob bursonitis, mob qog nqaij hlav thiab mob qog nqaij hlav. Nws tuaj yeem daws qhov mob, o thiab txwv kev ua phem ntawm kev mob caj dab. Piv nrog cov tshuaj aspirin thiab indomethacin, cov txiaj ntsig ntawm cov tsos mob nyem zoo ib yam, tab sis qhov muaj kev cuam tshuam ntawm txoj kev tsis zoo thiab cov leeg tsis muaj txiaj ntsig yog qhov tsawg.
Cov tshuaj kho mob yog qhov tsis muaj zog los anti -} mob yeeb tshuaj. Nws yog qhov tsim nyog rau kev hloov kho txhua yam mob me rau mob me ntsis, xws li mob hniav ntxiv thiab lwm yam kev ua haujlwm, thawj zaug ua haujlwm DysmenorHea thiab mob taub hau. Nws tseem siv tau txog kev mob ntsws rheumatoid, asteoarritis, ankylosing spondylitis, mob caj dab thiab mob bursonitis, mob qog nqaij hlav thiab mob qog nqaij hlav. Nws tuaj yeem daws qhov mob, o thiab txwv kev ua phem ntawm kev mob caj dab. Piv nrog cov tshuaj aspirin thiab indomethacin, cov txiaj ntsig ntawm cov tsos mob nyem zoo ib yam, tab sis qhov muaj kev cuam tshuam ntawm txoj kev tsis zoo thiab cov leeg tsis muaj txiaj ntsig yog qhov tsawg.
Naproxen sodium hmoov, raws li tsis yog steroidal anti - ibermatory los ntawm incibermatory antthesis, thiab yog siv nyob rau hauv kev kho mob ntawm ntau yam mob thiab mob kab mob. Nws cov kev siv npog ntau daim teb xws li mob caj dab rau cov tshuaj lom neeg, mob postativeative, tus thawj coj DysmenorHea, thiab kev tswj hwm ua npaws.
1. Kab mob ntsig txog kev mob caj dab
Rheumatoid mob caj dab (RA) thiab osteoarthritis (OA): Naproxen Sodium mob, thiab txhav thaum sawv ntxov, thiab txhim kho kev sib koom ua ke. Ib ob npaug - Qhov muag tsis pom kev hais tias nws qhov ua tau zoo hauv kev kho RA tau txog 94%, thiab ntev} Lub sijhawm siv tuaj yeem ncua cov qauv kev ua ke. Nws cov anti - Cov nyhuv muaj zog tshaj li ntawm 11 lub sij hawm muaj zog tshaj li qhov sib npaug thiab antipyretic cov teebmeem yog 7 zaug muaj zog dua li cov tshuaj aspirin. Nws muaj cov txiaj ntsig xaiv tau muaj zog rau COX-2, yog li nws cov kev nyuaj siab uas muaj hluav taws xob tsis zoo me me.
Ankylosing spondylitis (xws li): los ntawm inhibiting cov nqaj qaum thiab txhav qis dua, thiab txhim kho lub neej zoo ntawm cov neeg mob.
Cov mob caj dab (JIA): Haum rau cov menyuam yaus muaj mob voos mob, cov nqi yuav tsum tau hloov kho raws li lub cev hnyav (feem ntau 10-15mg / kg ib hnub, muab faib ua 2 qhov ncauj noj).
Kev sib koom ua mob caj dab: Ua kom sov, cua sov thiab mob, tab sis ua ke nrog colchicine lossis glucocorticoids los tswj tus kab mob.
2. Mos nqaij nqaij o
Tendinitis thiab bursitis: Los ntawm inhibiting qhov kev tso tawm ntawm cov kab mob hauv zos, thiab feem ntau siv rau hauv kev puas tsuaj rau lub xub pwg thiab lub luj tshib ntau.
Kab mob tshaj tawm - Kev Mob Siab Tshaj: xws li kev sib cav, tuaj yeem siv rau lub sijhawm luv luv thiab txhawb kev ua haujlwm rov qab.
3. Kev Tswj Xyuas Qhov Mob
Kev mob postperative: Ua ib feem ntawm malimodal analgesia regimen, nws tuaj yeem txo cov tshuaj opioid tshuaj thiab txo qis kev pheej hmoo ntawm kev nyuaj siab.
Prysmenorrhea: Los ntawm inhibiting synthesis ntawm prostaglandins nyob rau hauv lub endometrium nyob rau hauv lub endometrium, tus coj khaub ncaws yuav tau txais txiaj ntsig zoo ntawm 70% -80%.
Mob taub hau thiab mob hniav: nws muaj cov nyhuv nrawm nrawm rau migraine, nruj mob taub hau, thiab mob hniav, tab sis organic lesions yuav tsum tau txiav txim.
4. Kev tswj hwm kub
Qhov sib kis lossis tsis sib kis tau kub taub hau: ua rau hypothalamic thermoregulatory Center, thiab txhawb nqa rov qab cov neeg mob lub cev kub lub cev kom zoo li qub. Nws yog qhov haum rau Fever Story muaj los ntawm cov khaub thuas, mob ntsws, thiab yuav tsum muaj kev kho mob etiological.
1. Inhibition ntawm Prostaglandin synthesis
Naproxen sodium txo cov khoom siv sib kho xws li prostaglandin E2 (PEG-1 thiab kev mob siab rau kev mob siab rau kev mob siab Nws muaj lub zog xaiv tau Aveibory nyhuv rau COX-2, yog li lub plab hnyuv tau txais kev cuam tshuam tseem ceeb heev.
2. Thaiv cov kev tso tawm ntawm cov mob kho mob
Los ntawm inhibiting arachidonic acid metabolism thiab ua kom cov ntshav dawb rau hauv cov ntshav dawb tuaj yeem tiv thaiv, yog li txo cov ntaub so ntswg.
3. Kev cuam tshuam ntawm Chaw Tswj Kub Kub
Ua yeeb yam ntawm hypothaamic thermorulatory Center, txhawb kev kho mob kub dispuption, tab sis nrhiav kev kho mob kub tshaj 39℃lossis yog tus kub taub hau.
Muaj peb txoj kev hluavtaws raunaproxen sodium hmoov, uas muaj raws li hauv qab no:
1. Cov txheej txheem hluavtaws nrog 6-metoxy-2-acetylnthhalene li cov khoom siv raw.
Cov Synthesis txoj kev ntawm naproxen sodium los ntawm 6-metoxy-2-acetylnthalene feem ntau yog cov tshuaj lom neeg cov khoom nyoos rau hauv cov khoom lag luam.
Firstly,
6-metoxy-2-acetylnthhalene yog siv los ua cov khoom pib hloov pauv thiab cov pab pawg sib txuas lus (xws li carbonyl ntxiv) nyob rau hauv muaj ntawm catalyst. Cov kauj ruam no ua kom paub lossis kho cov pab pawg tseem ceeb hauv cov qauv molecular, tso lub hauv paus rau cov kev tawm tsam tom ntej.
Tom qab,
Los ntawm cov txheej txheem ntawm cov tshuaj tiv thaiv xws li oxidation, txo qis, Eterification, thiab lwm yam khoom siv tau hloov mus rau hauv nruab nrab ntawm naproxen. Cov tshuaj tiv thaiv no yuav tsum tau nruj me ntsis tswj kom ntseeg tau tias muaj txiaj ntsig zoo thiab qis- Cov khoom lag luam. Thaum lub sij hawm tus txheej txheem no, tshuaj lom neeg tshuaj lom neeg xws li Cyanides, cov kua qaub, cov kuab tshuaj uas tsim nyog yuav raug siv los txhawb cov tshuaj tiv thaiv.
Thaum kawg,
Raws li cov xwm txheej tsim nyog, cov theem nrab tau hloov mus rau naproxen thiab txuas ntxiv ua ke nrog sodium ions los ntawm ntsev tsim cov tshuaj tiv thaiv kom ua naproxen sodium. Cov kauj ruam no feem ntau cuam tshuam txog PH kev daws teeb meem ntawm kev daws teeb meem, ntsuas kub, thiab ua tau crystallization txheej txheem kom tau siab thiab ruaj khov naptoxen sodium cov khoom.
2. Cov txheej txheem hluavtaws siv 6-mexy-2-propionyl teas raws li cov khoom siv raw.
Cov txheej txheem hluavtaws rau kev tsim cov sodoxen sokium los ntawm 6-methoxy-2-protolthalfene (Nco ntsoov "
Firstly,
Nws yuav tsum tau qhia meej tias 6-methoxy-2-propionylnaphthalene yog qhov tseem ceeb hauv synthesis ntawm naproxen.
Nyob rau hauv cov txheej txheem hluavtaws, 6-metoxy-2-propionylnaphthalene tej zaum yuav muaj kev cuam tshuam nrog cov txheej txheem sib txawv los qhia lossis hloov cov pab pawg ua haujlwm hauv cov qauv ntawm naproxen. Cov kauj ruam no tuaj yeem koom nrog kev siv cov catalysts, xws li lewis acids, los pab txhawb cov tshuaj tiv thaiv.
Tom qab,
Los ntawm cov txheej txheem ntawm cov tshuaj tiv thaiv xws li oxidation, txo qis, ESterification, thiab lwm yam, theem nrab yog hloov dua siab tshiab rau hauv naproxen. Cov tshuaj tiv thaiv no yuav tsum tau nruj me ntsis tswj kom ntseeg tau tias muaj txiaj ntsig zoo thiab qis- Cov khoom lag luam. Thaum lub sijhawm no, ntau yam tshuaj lom neeg tshuaj lom neeg thiab cov kuab tshuaj yuav raug siv los ua kom zoo tshaj plaws cov tshuaj tiv thaiv.
Thaum kawg,
Naproxen yog ke nrog sodium ions los ua kom cov sodium napropen sodium. Cov kauj ruam no feem ntau cuam tshuam txog PH kev daws teeb meem ntawm kev daws teeb meem, ntsuas kub, thiab ua tau crystallization txheej txheem kom tau siab thiab ruaj khov naptoxen sodium cov khoom.
3. Cov txheej txheem hluavtaws nrog 2-methoxynthhalene raws li cov khoom siv raw
Synthesis txoj kev ntawmnaproxen sodium hmoovLos ntawm 2-methoxynthhalene feem ntau yuav cuam tshuam nrog ntau cov tshuaj hloov pauv, pom kom maj mam tsim cov qauv ntawm naproxen thiab thaum kawg qhia cov ntsev sodium.
Firstly,
2-methoxynthhalene Raws li cov khoom pib uas yuav tsum tau muaj cov tshuaj tiv thaiv kab mob, xws li cov pab pawg acreel (xws li acetyl lossis propionyl) los ua tus coj Ketone Qib Callmediate. Cov kauj ruam no yog cov kauj ruam tseem ceeb hauv kev tsim cov yuam sij carbonyyl moiety hauv Naproxen Molecules.
Tom qab,
Lub Ketone Intermediate yuav tsum tau mus dhau ib series ntawm kev hloov pauv ua ke, suav nrog kev ua tau zoo, kho cov qauv molecular thiab qhia lwm cov pab pawg tsim nyog. Cov tshuaj tiv thaiv no yuav tsum tau ua kom meej kom ntseeg tau tias qhov kev coj dawb huv thiab tawm los ntawm cov khoom.
Tom ntej no,
Nyob rau hauv theem mus txog cov khoom lag luam naproxen, cov kev tawm tsam ntxiv yog feem ntau nqa tawm los qhia cov roj carboxylic acid pab pawg rau hauv molecule, sib sau ua ntej ntawm naproxen. Kauj ruam no yog ib qho ntawm cov kauj ruam tseem ceeb hauv synthesizing naproxen, raws li nws txiav txim siab tus qauv thiab cov khoom ntawm cov khoom kawg.
Thaum kawg,
Naprox tau ua ke nrog sodium ions npaj sokroxen sodium los ntawm ntsev ua cov tshuaj tiv thaiv. Kauj ruam no feem ntau yog cuam tshuam txog cov tshuaj kho, ntsuas kub, thiab ua tau crystallization txheej txheem kom tau siab thiab zoo ruaj khov naptoxen sodium cov khoom.
4. Asymmetric synthesis
Asymmetric synthesis feem ntau pib txij pib cov ntaub ntawv nrog chiral cov chaw, xws li chiral Cleidals, lossis chiral catalysts. Nyob rau hauv synthesis ntawm naproxen sodium, chairal reagents xws li (2R, 3}} detethyl tartrate tej zaum yuav raug xaiv ua cov khoom siv lossis cov neeg tshuaj tiv thaiv. Cov kauj ruam tseem ceeb suav nrog kev sib tw asymmetric, asymmetric hydrocyanide, itymmetric catallyanide, thiab lwm yam nrog cov kev teeb tsa tshwj xeeb hauv cov mob me. Hom qauv no yog ib txoj kev muaj txiaj ntsig thiab ncaj qha rau kev npaj saib xyuas cov sodium dawb huv si. Asymmetric synthesis muaj qhov zoo ntawm txoj kev luv, tus nqi qis, thiab yog ib qho tseem ceeb txhais tau tias kev npaj cov tshuaj ntshiab.
Txheej txheem cej luam ntawm cov kev xwm txheej
Asymmetric Indusion:
Firstly, dhau los ntawm Asymmetric Induction kev tawm tsam lossis hydrogenric cyanide lossis hydrogen cyanide cov kev sib cav, cov khoom pib hloov pauv mus rau hauv cov chaw nruab nrab uas muaj chairal chaw.
Hloov dua siab tshiab ntawm kev ntseeg siab:
Tom qab, cov kev hloov pauv ntawm kev hloov pauv tau yog ua rau cov nruab nrab, xws li cov hydrolysis, xws li kev sib tw, thiab lwm yam, los tsim cov qauv ntawm naproxen. Cov kev tawm tsam no yuav tsum tau nqa tawm hauv cov kev tswj hwm nruj me ntsis kom ntseeg tau tias cov chaw khaws cia thiab cov khoom siv dawb huv ntawm cov khoom lag luam.
Ntsev nta:
Thaum kawg, cov tau txais preatroxen prefursor yog ke nrog sodium ions npaj sodium los ntawm ntsev tsim cov tshuaj tiv thaiv. Cov kauj ruam no feem ntau yog cuam tshuam txog PH kev daws teeb meem ntawm kev daws teeb meem, kev tswj qhov kub thiab muaj peev xwm ua tau crystallization txheej txheem.
Qhov sib npaug ntawm kev sib npaug ntawmnaproxen sodium hmoov is 1:1.1. After oral administration, they are easily and completely absorbed from the gastrointestinal tract, but the absorption rate of sodium salt is faster. It takes 1 hour to reach the peak concentration of blood drug, and it takes 2 hours for free acid. Gastric contents can prolong its absorption time, but do not affect its absorption rate. The binding rate of plasma protein was high (>99.5%). Nws tuaj yeem faib rau hauv tag nrho lub cev, ncav cuag cov kev xav tau zoo hauv cov kua huv si, thiab nkag mus rau hauv cov menyuam hauv lub nroog Placenta. Nws yog metabolized los ntawm daim siab thiab tawm los ntawm lub raum. Feem ntau ntawm kev ua yeeb yam yog metabolites, nrog me me ntawm cov qauv. Kwv yees li 3% yog excreted los ntawm cov quav thiab 1% yog zais cia los ntawm mis nyuj. Ntshav T1 / 2 yog 13 teev. Nws kuj tseem tuaj yeem muab tshuaj ntsuam, tab sis kev nqus yog qeeb dua li qhov ncauj.
Cim npe nrov: Naproxen sodium hmoov pre 26159-34-2, cov neeg muag khoom, chaw tsim khoom, chaw tsim khoom, lag luam, yuav, nqe, loj, rau muag