Paracetamol hmoov CAS 103-90-2

Paracetamol hmoov(tseem hu ua paracetamol thiab acetaminophen) yog cov hmoov dawb crystalline tsis muaj ntxhiab tsw thiab iab saj. Nws yog soluble hauv ethanol, acetone, dej kub, ether, chloroform, insoluble hauv dej, roj av ether, thiab benzene. Nws yog cov tshuaj uas tsis yog tshuaj steroidal anti-inflammatory, nrog rau cov organic synthetic intermediate, hydrogen peroxide stabilizer, thiab tshuaj yees duab. Cov mis mos molecular C8H9NO2, CAS 103-90-2, molecular hnyav 151.16 g/mol. Nws muaj cov nyhuv antipyretic thiab analgesic. Nws yog ib qho khoom ntawm chav tsev kub. Nws muaj zoo solubility hauv dej. Txhua gram ntawm dej tuaj yeem yaj kwv yees li 1.25g ntawm 2-acetaminophen (ntawm 20 degree C). Raws li txoj cai, nws muaj lub nplhaib benzene thiab acylamine pawg. Lub chav siab yog qis thiab maj mam nce nrog qhov kub thiab txias. Nws tus nqi pH kuj nyob ze rau nruab nrab, xws li ntawm 6.3 txog 6.5 hauv cov kua dej aqueous. Nws yog ib qho chaw ruaj khov uas tuaj yeem khaws cia rau lub sijhawm ntev raws li cov xwm txheej khaws cia. Tab sis thov ceev faj kom tsis txhob ya raws thiab raug rau lub teeb muaj zog.

Paracetamol hmoovTus neeg muag khoom los ntawm: BLOOM TECH

Lus Cim: BLOOM TECH (Txij li xyoo 2008), ACHIEVE CHEM-TECH yog lub chaw pabcuam ntawm peb.

Paracetamol, tseem hu ua Paracetamol lossis paracetamol, yog ib qho tshuaj uas siv ntau hauv khw muag khoom nrog cov tshuaj tua kab mob thiab tshuaj tua kab mob.

1. Kev siv tshuaj tua kab mob: Paracetamol siv tshuaj tua kab mob los ntawm inhibiting qhov mob kis mus rau hauv nruab nrab paj hlwb. Nws txo qhov tsim ntawm Prostaglandin thiab indirectly inhibits kev tso tawm ntawm inflammatory mediators los ntawm inhibiting cov kev ua ntawm alanase nyob rau hauv tus txha caj qaum dorsal horn.

2. Antipyretic nyhuv: Paracetamol exerts antipyretic nyhuv los ntawm influencing lub chaw Thermoregulation. Nyob rau hauv lub chaw Thermoregulation, nws yuav txo tau cov synthesis ntawm Prostaglandin nyob rau hauv lub hypothalamus los ntawm inhibiting cov kev ua ntawm cyclooxygenase, yog li ua rau cov nyhuv ntawm txo lub cev kub.

3. Anti-inflammatory effect: Piv nrog cov tshuaj uas tsis yog steroidal anti-inflammatory tshuaj (NSAIDs), Paracetamol muaj zog tiv thaiv inflammatory nyhuv. Nws cov nyhuv anti-inflammatory yog tsuas yog ua tiav los ntawm kev txo cov khoom tsim cov kab mob inflammatory, tsis yog cuam tshuam ncaj qha rau inflammatory enzymes.

4. Tshuaj metabolism: Paracetamol yog metabolized nyob rau hauv daim siab, feem ntau yog los ntawm Glucuronic acid thiab sulfation nyob rau hauv daim siab hlwb. Ib qho me me ntawm Paracetamol tuaj yeem ua rau metabolized los ntawm Cytochrome P450 series enzymes los tsim hepatotoxic metabolites. Nyob rau hauv ib txwm muaj xwm txheej, metabolites yog ua los ntawm detoxification mechanisms thiab tawm los ntawm lub cev.

5. Tsis muaj cov nyhuv antiplatelet tseem ceeb: Piv rau NSAIDs, Paracetamol tsis muaj qhov cuam tshuam loj rau platelet aggregation.

Tag nrho cov chemical laboratory synthesis txoj kev rauParacetamol hmoov:

1. Synthesis method siv 4-Nitrophenol ua raw khoom:

Kauj Ruam 1: 4-Nitrophenol reacts nrog Sodium acetate los tsim cov amide sib xws.

Reaction formula: C₆H₄ (NO₂) OH + CH₃COV → C₆H₄(NO₂) NHC (O) CH₃

Kauj Ruam 2: Amide reacts nrog Sodium bisulfite los tsim 2-aminophenol los ntawm Redox.

Reaction formula: C₆H₄(NO₂) NHC (O) CH₃+NWS₃ → C₆H₄(NH₂) OH

Kauj Ruam 3: 2-aminophenol reacts nrog acetic anhydride los tsim Acetyl pawg compound, uas yog acetaminophen.

Reaction formula: C₆H₄(NH₂) OH+(CH₃CO)₂O → C₈H₉TSIS MUAJ₂

2. Synthesis method siv p-aminophenol ua raw khoom:

Kauj Ruam 1: Cov tshuaj tiv thaiv ntawm p-aminophenol nrog acetic anhydride tsim nws cov khoom acetylation.

Reaction formula: C₆H₃(OH) (NH₂)+(CH₃CO)₂O → C₈H₉TSIS MUAJ₂

Kauj Ruam 2: Cov khoom lag luam acetylation reacts nrog Sodium nitrate los tsim Electrophilic hloov pauv kom tau txais p-nitro-p-acetylaminobenzene.

Reaction formula:C₈H₉TSIS MUAJ₂+NWS₃ → C₈H₈N₂O₄+ CH₃COOH

Kauj Ruam 3: Acetaminophen tau txais los ntawm cua sov qhov txo cov tshuaj tiv thaiv p-nitroacetaminobenzene.

Reaction formula: C₈H₈N₂O₄+3H₂ → C₈H₉TSIS MUAJ₂+2H₂O

3. Synthesis method siv p-aminophenol ua raw khoom:

Kauj Ruam 1: p-aminophenol reacts nrog acetic anhydride los tsim cov khoom acetylation.

Reaction formula:C₆H₄ (NO₂) OH+(CH₃CO)₂O → C₈H₉TSIS MUAJ₂

Kauj Ruam 2: Cov khoom acetylation hnov ​​​​mob nrog hydrogen peroxide nyob rau hauv alkaline tej yam kev mob los tsim N - (4-hydroxyphenyl) acetaldehyde amine.

Reaction formula:C₈H₉TSIS MUAJ₂+H₂O₂ → C₈H₉TSIS MUAJ₂+H₂O

Kauj Ruam 3: N-({2}}hydroxyphenyl) acetaldehyde amine thiab aminophenol tau txais cov tshuaj tiv thaiv Condensation los tsim acetaminophen.

Reaction formula:C₈H₉TSIS MUAJ₂+C₆H₃(OH) (NH₂) → C₈H₉TSIS MUAJ₂

4. Txoj kev tsim cov tshuaj paracetamol yog raws li nram no:

(1) Zinc tau siv los txo p-nitrophenol hauv glacial acetic acid, thiab p-acetylaminophenol tau txais los ntawm acetylation;

(2) Cov hydrazone tsim los ntawm p-hydroxyacetophenone tau muab tso rau hauv sulfuric acid acid tov, thiab sodium nitrite tau ntxiv los hloov mus rau p-acetylaminophenol;

(3) Acetylation ntawm aminophenol. Nyob rau hauv biopharmaceutics, raws li ib tug non-steroidal compound, nws muaj peev xwm inhibit lub synthesis thiab tso tawm ntawm prostaglandins, yog li nws yuav alleviate ntau hom mob.

Paracetamol hmoov, tseem hu ua acetaminophen hmoov, tuaj yeem cuam tshuam nrog lwm yam tshuaj. Cov hauv qab no yog cov lus piav qhia ntxaws ntawm cov kev sib cuam tshuam no:

1.Kev cuam tshuam nrog lub siab enzyme inducers

• Mechanism ntawm kev txiav txim: Kev haus cawv ntev ntev lossis kev siv txuas ntxiv ntawm lwm lub siab enzyme inducers (xws li barbiturates lossis lwm yam tshuaj antispasmodics) tuaj yeem ua rau muaj kev pheej hmoo ntawm daim siab toxicity. Qhov no yog vim lub siab enzyme inducers tuaj yeem txhim kho cov haujlwm ntawm cov enzymes hauv daim siab, yog li ua kom cov tshuaj metabolism thiab tshem tawm, tab sis kuj tseem tuaj yeem ua rau cov tshuaj lom metabolites.

• Ceeb toom: Thaum siv, tsis txhob siv lub siab enzyme inducers ib txhij los yog siv ceev faj raws li kev qhia ntawm tus kws kho mob.

2.Kev sib tham nrog cov tshuaj anticoagulant

• Mechanism of action: Thaum ua ke nrog cov tshuaj tiv thaiv coagulants xws li warfarin, nws tuaj yeem txhim kho cov nyhuv anticoagulant. Qhov no yog vim tias nws tuaj yeem cuam tshuam rau kev ua haujlwm ntawm coagulation ntsig txog cov enzymes hauv daim siab, yog li ua kom lub sijhawm ua kom ntev.
• Ceeb Toom: Thaum siv nws, yog tias cov tshuaj anticoagulant yuav tsum tau siv tib lub sijhawm, cov tshuaj anticoagulant yuav tsum tau hloov kho raws li tus kws kho mob cov lus qhia kom tsis txhob muaj kev phiv xws li los ntshav.

3.Kev sib tham nrog lwm cov tshuaj uas tsis yog steroidal los tiv thaiv kev mob

• Mechanism of action: Kev siv lub sij hawm ntev nrog cov tshuaj aspirin lossis lwm yam tshuaj uas tsis yog tshuaj tiv thaiv kab mob (xws li ibuprofen) tuaj yeem ua rau muaj kev pheej hmoo ntawm nephrotoxicity. Qhov no yog vim tias cov tshuaj no tuaj yeem cuam tshuam rau cov metabolism thiab kev ua haujlwm ntawm lub raum, yog li ua kom lub nra ntawm lub raum.
• Ceebtoom: Thaum siv nws, tsis txhob siv lwm yam tshuaj uas tsis yog tshuaj steroidal anti-inflammatory tib lub sijhawm, lossis siv nrog ceev faj raws li tus kws kho mob qhia. Nyob rau tib lub sijhawm, kev kuaj xyuas lub raum ua haujlwm tsis tu ncua yuav tsum tau ua kom ntseeg tau tias cov tshuaj muaj kev nyab xeeb.

4.Kev sib tham nrog cov tshuaj tiv thaiv kab mob

• Mechanism of action: Thaum siv ua ke nrog cov tshuaj tiv thaiv kab mob xws li zidovudine, nws tuaj yeem ua rau muaj tshuaj lom. Qhov no yog vim hais tias cov tshuaj no tuaj yeem cuam tshuam rau ib leeg hauv lub cev, ua rau muaj kev txawv txav hauv cov tshuaj metabolism thiab kev tso tawm.
• Ceeb Toom: Thaum siv r, tsis txhob siv cov tshuaj tiv thaiv kab mob tib lub sijhawm lossis siv ceev faj raws li kev qhia ntawm tus kws kho mob. Nyob rau tib lub sijhawm, cov neeg mob cov tsos mob thiab cov tsos mob yuav tsum tau saib xyuas kom zoo, thiab yog tias muaj kev cuam tshuam tsis zoo, lawv yuav tsum nrhiav kev kho mob sai.

5.Lwm kev ceev faj

• Thaum siv nws, yuav tsum tau saib xyuas kom tsis txhob siv ib txhij nrog lwm cov tshuaj uas yuav ua rau muaj kev cuam tshuam tshuaj.
• Yog tias lwm yam tshuaj yuav tsum tau siv ib txhij, lawv yuav tsum tau ua raws li tus kws kho mob cov lus qhia thiab qhia txog txhua yam tshuaj uas tau siv, suav nrog cov tshuaj noj, tshuaj tom khw, tshuaj noj, thiab lwm yam.
• Yog tias muaj kev tsis xis nyob lossis xav tias muaj kev phiv tshwm sim thaum siv, cov tshuaj yuav tsum tau nres tam sim ntawd thiab nrhiav kev kho mob.

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