Paracetamol hmoov CAS 103-90-2

Paracetamol hmoov(tseem hu ua paracetamol thiab acetaminophen) yog cov hmoov dawb crystalline tsis muaj ntxhiab tsw thiab iab saj. Nws yog soluble hauv ethanol, acetone, dej kub, ether, chloroform, insoluble hauv dej, roj av ether, thiab benzene. Nws yog cov tshuaj uas tsis yog steroidal los tiv thaiv - cov tshuaj tiv thaiv kab mob, nrog rau cov khoom siv hluavtaws nruab nrab, hydrogen peroxide stabilizer, thiab cov tshuaj yees duab. Molecular formula C8H9NO2, CAS 103-90-2, molecular hnyav 151.16 g/mol. Nws muaj cov nyhuv antipyretic thiab analgesic. Nws yog ib qho khoom ntawm chav tsev kub. Nws muaj zoo solubility hauv dej. Txhua gram ntawm dej tuaj yeem yaj kwv yees li 1.25g ntawm 2-acetaminophen (ntawm 20℃C). Raws li txoj cai, nws muaj lub nplhaib benzene thiab acylamine pawg. Lub chav siab yog qis thiab maj mam nce nrog qhov kub thiab txias. Nws tus nqi pH yog ze rau nruab nrab, xws li ntawm 6.3 txog 6.5 hauv cov kua dej aqueous. Nws yog ib qho chaw ruaj khov uas tuaj yeem khaws cia rau lub sijhawm ntev raws li cov xwm txheej khaws cia. Tab sis thov ceev faj kom tsis txhob ya raws thiab raug rau lub teeb muaj zog.

Paracetamol hmoovTus neeg muag khoom los ntawm: BLOOM TECH

Lus Cim: BLOOM TECH (Txij li xyoo 2008), ACHIEVE CHEM-TECH yog lub chaw pabcuam ntawm peb.

Paracetamol hmoov, uas yog siv dav siv tshuaj tua kab mob thiab tshuaj tua kab mob, feem ntau yog siv los txo qhov mob, txo lub cev kub, thiab pab kho cov tsos mob ntsig txog.

Kev tswj cua sov

 

Indications: Ua kom lub cev kub los ntawm kev mob khaub thuas, mob khaub thuas, kub taub hau tom qab phais, thiab lwm yam.
Cov yam ntxwv ua haujlwm: Nws yuav siv tau sai sai (feem ntau nyob rau hauv 30 feeb) thiab tuaj yeem txo cov tsos mob xws li mob taub hau thiab mob nqaij mob ua npaws. Txawm hais tias cov nyhuv antipyretic yog me ntsis qis dua ibuprofen, nws muaj tsawg dua cov kab mob plab thiab tsim nyog rau cov menyuam yaus, cov neeg laus, thiab cov neeg mob uas muaj mob me me.
Cov ntaub ntawv kho mob: Cov neeg laus ib koob tshuaj ntawm 500-1000mg, rov ua dua txhua 4-6 teev, nrog rau tag nrho cov koob tshuaj tsis pub tshaj 4g hauv 24 teev; Cov menyuam yaus raug xam raws li lub cev hnyav ntawm 10-15mg / kg, nrog rau qhov siab tshaj plaws ib koob tshuaj tsis pub tshaj 600mg.

Mob nyem

 

Mob taub hau: nrog rau mob taub hau thiab mob migraine. Mob pob qij txha: xws li osteoarthritis thiab mob caj dab rheumatoid (yuav tsum tau ua ke nrog lwm cov tshuaj). Mob nqaij: tom qab qoj ib ce mob, fibromyalgia. Mob Hniav: mob pulpitis, periapical periodontitis, thiab lwm yam. Dysmenorrhea: feem ntau siv tshuaj rau thawj dysmenorrhea. Postoperative mob: feem ntau siv rau kev tswj mob me me mus rau nruab nrab tom qab mob, nws tuaj yeem siv ib leeg lossis ua ke nrog cov tshuaj opioid kom txo cov koob tshuaj tom kawg.
Cov yam ntxwv ua haujlwm: Nws muaj txiaj ntsig zoo rau qhov mob npub (xws li mob taub hau thiab mob pob qij txha) dua li qhov mob hnyav (xws li visceral colic), tsis muaj yees, thiab tsim nyog rau kev siv tsis tu ncua ntev - mob ntev.

Kev pab cuam ntawm cov tsos mob khaub thuas

 

Cov Lus Qhia: Cov khoom tseem ceeb ntawm cov tshuaj ua kom txias yog siv los txo cov tsos mob xws li kub taub hau, mob taub hau, mob leeg, qhov ntswg congestion, thiab los ntswg qhov ntswg los ntawm khaub thuas.
Cov yam ntxwv ua haujlwm: Txhim kho cov tsos mob los ntawm kev siv tshuaj tua kab mob thiab tshuaj tua kab mob, thaum ntxiv tshuaj tiv thaiv kab mob (xws li chlorpheniramine) lossis decongestants (xws li pseudoephedrine) rau qee qhov kev npaj ua kom muaj txiaj ntsig zoo.

Cov ntawv thov rau cov pej xeem tshwj xeeb

 

Cov menyuam yaus: Cov ntawv tshwj xeeb ntau npaum li cas (xws li granules thiab suspensions) muaj qhov saj zoo thiab kev nyab xeeb siab, thiab feem ntau siv cov tshuaj tua kab mob hauv cov menyuam yaus.
Cov neeg laus: Cov neeg uas tsis muaj lub siab thiab lub raum ua haujlwm yuav tsum tau kho qhov ntau npaum li cas thiab tsis txhob siv sijhawm ntev - siv ntau dhau.
Cov poj niam cev xeeb tub thiab lactating: Muaj cov pov thawj tsawg ntawm kev nyab xeeb thaum cev xeeb tub (tsawg dua lossis sib npaug li 12 lub lis piam), thiab qhov zoo thiab qhov tsis zoo yuav tsum tau ntsuas; Kev siv thaum lactation muaj qhov cuam tshuam tsawg heev rau cov menyuam mos, tab sis yuav tsum tsis txhob noj tshuaj ntau.

Tag nrho cov chemical laboratory synthesis txoj kev rauParacetamol hmoov:

1. Synthesis txoj kev siv 4-Nitrophenol ua raw khoom:

Kauj Ruam 1: 4-Nitrophenol reacts nrog Sodium acetate los tsim cov amide sib xws.

Reaction formula: C₆H₄ (NO₂) OH + CH₃COV → C₆H₄(NO₂) NHC (O) CH₃

Kauj Ruam 2: Amide reacts nrog Sodium bisulfite los tsim 2-aminophenol los ntawm Redox.

Reaction formula: C₆H₄(NO₂) NHC (O) CH₃+NWS₃ → C₆H₄(NH₂) OH

Kauj Ruam 3: 2-aminophenol reacts nrog acetic anhydride los tsim Acetyl pawg compound, uas yog acetaminophen.

Reaction formula: C₆H₄(NH₂) OH+(CH₃CO)₂O → C₈H₉TSIS MUAJ₂

2. Synthesis method siv p-aminophenol ua raw khoom:

Kauj Ruam 1: Cov tshuaj tiv thaiv ntawm p-aminophenol nrog acetic anhydride tsim nws cov khoom acetylation.

Reaction formula: C₆H₃(OH) (NH₂)+(CH₃CO)₂O → C₈H₉TSIS MUAJ₂

Kauj Ruam 2: Cov khoom lag luam acetylation reacts nrog Sodium nitrate los tsim Electrophilic hloov pauv kom tau p-nitro-p-acetylaminobenzene.

Reaction formula:C₈H₉TSIS MUAJ₂+NWS₃ → C₈H₈N₂O₄+ CH₃COOH

Kauj Ruam 3: Acetaminophen tau txais los ntawm cua sov qhov txo cov tshuaj tiv thaiv p-nitroacetaminobenzene.

Reaction formula: C₈H₈N₂O₄+3H₂ → C₈H₉TSIS MUAJ₂+2H₂O

3. Synthesis method siv p-aminophenol ua raw khoom:

Kauj Ruam 1: p-aminophenol reacts nrog Acetic anhydride los tsim cov khoom acetylation.

Reaction formula:C₆H₄ (NO₂) OH+(CH₃CO)₂O → C₈H₉TSIS MUAJ₂

Kauj Ruam 2: Cov khoom acetylation hnov ​​​​mob nrog hydrogen peroxide nyob rau hauv alkaline tej yam kev mob los tsim N - (4-hydroxyphenyl) acetaldehyde amine.

Reaction formula:C₈H₉TSIS MUAJ₂+H₂O₂ → C₈H₉TSIS MUAJ₂+H₂O

Kauj Ruam 3: N-(4-hydroxyphenyl) acetaldehyde amine thiab aminophenol tau txais cov tshuaj tiv thaiv Condensation los tsim acetaminophen.

Reaction formula:C₈H₉TSIS MUAJ₂+C₆H₃(OH) (NH₂) → C₈H₉TSIS MUAJ₂

4. Txoj kev tsim cov tshuaj paracetamol yog raws li nram no:

(1) Zinc tau siv los txo p-nitrophenol hauv glacial acetic acid, thiab p-acetylaminophenol tau txais los ntawm acetylation ;

(2) Cov hydrazone tsim los ntawm p-hydroxyacetophenone tau muab tso rau hauv sulfuric acid acid tov, thiab sodium nitrite tau ntxiv los hloov mus rau p-acetylaminophenol ;

(3) Acetylation ntawm aminophenol. Hauv biopharmaceutics, raws li tsis yog -steroidal compound, nws tuaj yeem cuam tshuam cov synthesis thiab tso tawm ntawm prostaglandins, yog li nws tuaj yeem txo ntau hom mob.

Paracetamol hmoov, tseem hu ua acetaminophen hmoov, tuaj yeem cuam tshuam nrog lwm yam tshuaj. Cov hauv qab no yog cov lus piav qhia ntxaws ntawm cov kev sib tshuam no:

1.Kev cuam tshuam nrog lub siab enzyme inducers

• Mechanism ntawm kev txiav txim: Kev haus cawv ntev ntev lossis kev siv txuas ntxiv ntawm lwm lub siab enzyme inducers (xws li barbiturates lossis lwm yam tshuaj antispasmodics) tuaj yeem ua rau muaj kev pheej hmoo ntawm daim siab toxicity. Qhov no yog vim lub siab enzyme inducers tuaj yeem txhim kho cov haujlwm ntawm cov enzymes hauv daim siab, yog li ua kom cov tshuaj metabolism thiab tshem tawm, tab sis kuj tseem tuaj yeem ua rau cov tshuaj lom metabolites.

• Ceeb toom: Thaum siv, tsis txhob siv lub siab enzyme inducers ib txhij los yog siv ceev faj raws li kev qhia ntawm tus kws kho mob.

2.Kev sib tham nrog cov tshuaj anticoagulant

• Mechanism of action: Thaum ua ke nrog cov tshuaj tiv thaiv coagulants xws li warfarin, nws tuaj yeem txhim kho cov nyhuv anticoagulant. Qhov no yog vim tias nws tuaj yeem cuam tshuam rau kev ua haujlwm ntawm coagulation ntsig txog cov enzymes hauv daim siab, yog li ua kom lub sijhawm ua kom ntev.
• Ceeb Toom: Thaum siv nws, yog tias cov tshuaj anticoagulant yuav tsum tau siv tib lub sijhawm, cov tshuaj anticoagulant yuav tsum tau hloov kho raws li kev qhia ntawm tus kws kho mob kom tsis txhob muaj kev phiv xws li los ntshav.

3.Interactions nrog lwm yam nonsteroidal tshuaj tiv thaiv -inflammatory

• Mechanism of action: Kev siv lub sij hawm ntev nrog cov tshuaj aspirin los yog lwm yam nonsteroidal anti-{0}}cov tshuaj inflammatory (xws li ibuprofen) yuav ua rau muaj kev pheej hmoo ntawm nephrotoxicity. Qhov no yog vim hais tias cov tshuaj no tuaj yeem cuam tshuam rau cov metabolism thiab kev ua haujlwm ntawm lub raum, yog li ua rau lub nra ntawm lub raum.
• Ceev faj: Thaum siv nws, tsis txhob siv lwm yam tshuaj uas tsis yog tshuaj steroidal los tiv thaiv - cov tshuaj tiv thaiv kab mob tib lub sijhawm, lossis siv ceev faj raws li tus kws kho mob cov lus qhia. Nyob rau tib lub sijhawm, kev kuaj xyuas lub raum ua haujlwm tsis tu ncua yuav tsum tau ua kom ntseeg tau tias cov tshuaj muaj kev nyab xeeb.

4.Kev sib tham nrog cov tshuaj tiv thaiv kab mob

• Mechanism ntawm kev txiav txim: Thaum siv ua ke nrog cov tshuaj tiv thaiv kab mob xws li zidovudine, nws tuaj yeem ua rau muaj tshuaj lom. Qhov no yog vim hais tias cov tshuaj no tuaj yeem cuam tshuam rau ib leeg hauv lub cev, ua rau muaj qhov txawv txav hauv cov tshuaj metabolism thiab tso tawm.
• Ceeb Toom: Thaum siv r, tsis txhob siv cov tshuaj tiv thaiv kab mob tib lub sijhawm lossis siv ceev faj raws li kev qhia ntawm tus kws kho mob. Nyob rau tib lub sijhawm, cov neeg mob cov tsos mob thiab cov tsos mob yuav tsum tau saib xyuas kom zoo, thiab yog tias muaj kev cuam tshuam tsis zoo, lawv yuav tsum nrhiav kev kho mob sai.

5.Lwm kev ceev faj

• Thaum siv nws, yuav tsum tau saib xyuas kom tsis txhob siv ib txhij nrog lwm cov tshuaj uas yuav ua rau muaj kev cuam tshuam tshuaj.
• Yog tias lwm yam tshuaj yuav tsum tau siv ib txhij, lawv yuav tsum tau ua raws li tus kws kho mob cov lus qhia thiab qhia txog txhua yam tshuaj uas tau siv, suav nrog cov tshuaj noj, tshaj -- tshuaj tiv thaiv, tshuaj kho mob, thiab lwm yam.
• Yog tias muaj kev tsis xis nyob lossis xav tias muaj kev phiv tshwm sim thaum siv, cov tshuaj yuav tsum tau nres tam sim ntawd thiab nrhiav kev kho mob.

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