Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm oxytetracycline hmoov hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo oxytetracycline hmoov rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Oxytetracycline hmoovyog lub teeb daj mus rau daj xim av crystalline hmoov nrog polymorphic siv lead ua qauv. Cov mis mos molecular C22H24N2O9 CAS 79-57-2. Cov kev tshawb fawb tau pom tias oxytetracycline muaj nyob rau hauv ntau hom siv lead ua (xws li alpha thiab beta), thiab muaj qhov sib txawv ntawm solubility, dissolution npaum li cas, thiab bioavailability ntawm ntau hom siv lead ua. Piv txwv li, alpha daim ntawv muaj me ntsis solubility nyob rau hauv dej ntau dua li cov beta daim ntawv, tab sis lawv stability nyob rau hauv acidic tej yam kev mob zoo sib xws. Lub crystalline morphology (xws li koob zoo li los yog flake zoo li) cuam tshuam nws fluidity thiab compressibility. Hauv kev tsim cov formulations, nws yog ib qho tsim nyog los txhim kho cov txheej txheem crystallization (xws li kev xaiv cov kuab tshuaj thiab kev tswj qhov kub thiab txias) kom tau txais cov ntaub ntawv siv lead ua uas tsim nyog, txhawm rau xyuas kom meej tias cov ntsiav tshuaj hardness thiab dissolution raws li cov qauv.
Peb Cov Khoom
Oxytetracycline +. COA
Kev degradation yuav tshwm sim ntawm qhov kub thiab txias, ua cov khoom degradation nrog nephrotoxicity. Feem ntau siv los kho ntau yam kab mob sib kis los ntawm cov kab mob rhiab heev, xws li kab mob ua pa xws li mob ntsws thiab mob ntsws, kab mob hauv lub cev xws li cystitis thiab pyelonephritis, kab mob hauv plab xws li kab mob plab thiab amoebic enteritis, daim tawv nqaij thiab cov nqaij mos kab mob xws li cellulitis thiab abscesses, thiab kab mob ntawm lub qhov muag.
Solubility thiab pH dependence
Lub solubility ntawm oxytetracycline qhia tau hais tias ib qho tseem ceeb pH dependence, thiab nws solubility nkhaus raws li "U" - zoo li tus faib:
Acid tej yam kev mob (pH<3):
Kev solubility nce ntxiv, nce mus txog 10-20 mg / mL (xws li solubility ntawm 15 mg / mL hauv 0.1N HCl).
Cov xwm txheej nruab nrab (pH 6-8):
Tsis tshua muaj solubility (<0.5 mg/mL), prone to precipitation.
Alkaline conditions (pH>9):
Lub solubility nce me ntsis, tab sis cov tshuaj nquag ua rau cov tshuaj tiv thaiv hydrolysis, uas ua rau kev tsim cov 4-isomer tsis zoo.
Clinical tseem ceeb:
Formulation tsim:
Cov tshuaj hauv qhov ncauj yuav tsum raug zam los ntawm kev siv ua ke nrog cov tshuaj tiv thaiv kab mob kom tsis txhob muaj qhov nqus nqus vim qhov nce hauv plab pH.
Txhaj tshuaj compatibility:
Thaum infusion, ib txoj kev cais yuav tsum tsis txhob sib xyaw nrog cov calcium thiab magnesium ions los tiv thaiv kev tsim cov chelates.
Localized tshuaj:
Cov tshuaj pleev qhov muag (3% concentration) yuav tsum tau hloov mus rau pH 4.5-5.5 kom sib npaug tshuaj solubility thiab qhov muag khaus.
Acid puag bisexuality thiab ntsev tsim
Oxytetracycline hmoovcov molecules muaj phenolic hydroxyl pawg (pKa ₁=3.27) thiab enol hydroxyl pawg (pKa ₂=7.32), pom cov kua qaub- puag amphiphilic cwj pwm
Ib puag ncig acidic: Reacts nrog alkali los tsim sodium ntsev (xws li sodium oxytetracycline), nrog solubility nce mus txog 100 mg / mL, haum rau kev txhaj tshuaj.
Alkaline ib puag ncig: reacts nrog acid los tsim hydrochloride ntsev (xws li oxytetracycline hydrochloride), nrog rau solubility ntawm 50 mg / mL, feem ntau yog siv rau hauv qhov ncauj npaj.
Stability sib txawv:
Sodium oxytetracycline: ruaj khov hauv cov tshuaj alkaline, tab sis yooj yim decomposed thaum raug lub teeb, thiab yuav tsum tau muab cia kom deb ntawm lub teeb.
Oxytetracycline hydrochloride: ruaj khov hauv cov kua qaub, tab sis tuaj yeem ua rau cov kua qaub ua kua tom qab ntev - lub sijhawm cia, thiab qhov ntsuas kub yuav tsum tau tswj hwm (2-8℃). Tsiaj premix: siv oxytetracycline calcium ntsev kom txo tau qhov nqus ntawm cov tshuaj hauv plab hnyuv, txo cov ntaub so ntswg ntev, thiab ua kom ntev.
Oxytetracycline yog ib qho dav -spectrum tetracycline tshuaj tua kab mob, uas yog tsim los ntawm microbial fermentation. Cov txheej txheem tshuaj synthesis tsis tshua siv hauv kev lag luam vim lawv cov nqi siab thiab cov kauj ruam nyuaj. Cov hauv qab no tau piav qhia meej txog txoj hauv kev sib txuas thiab cov thev naus laus zis tseem ceeb ntawm oxytetracycline los ntawm plaub qhov loj: microbial fermentation, tshuaj synthesis, semi synthesis, thiab niaj hnub biotechnology optimization.
Microbial fermentation txoj kev: txoj hauv kev tseem ceeb ntawm kev tsim khoom
Microbial fermentation yog cov thev naus laus zis tseem ceeb rau kev tsim khoom ntawm oxytetracycline, thiab nws cov tub ntxhais yog siv lub peev xwm metabolic ntawm Streptomyces rimosus los yog Streptomyces aureofaciens kom ua tiav cov synthesis zoo los ntawm optimizing fermentation tej yam kev mob.
Kev tshuaj ntsuam xyuas cov txiaj ntsig siab: Streptomyces strains raug cais tawm ntawm cov av thiab raug cuam tshuam los ntawm kev siv hluav taws xob ultraviolet, tshuaj mutagens (xws li nitrosoguanidine), lossis cov txheej txheem kho noob (xws li CRISPR-Cas9) los tshuaj xyuas qhov siab -yielding . tetracycline. Piv txwv li, tom qab mutagenesis, zus tau tej covoxytetracycline hmoovhauv Streptomyces sp. M528 nce 30%.
Culture preservation technology: Txais yuav inclined low-txoj kev khaws cia kub (4℃lub tub yees khaws cia rau 3 lub hlis), xuab zeb tube preservation method (qhuav xuab zeb tov thiab sterilized, preservation lub sij hawm ntawm 1-}10 xyoo), lub tshuab nqus tsev freeze-drying txoj kev (ceev freezing hauv qab no -15℃5 xyoos), lub sij hawm preservation 5 xyoo. stability ntawm kab lis kev cai kev ua.
Kev xaiv cov pa roj carbon monoxide: Cov hmoov txhuv nplej siab thiab dextrin yog cov hauv paus ntsiab lus, thaum cov piam thaj ua rau cov metabolism hauv inhibition thiab yuav tsum tau ntxiv rau ntawm tus nqi tswj (feem ntau.<5%). For example, in a certain process, the amount of starch used in a fermentation tank reaches 546kg/10m ³, accounting for over 90% of the total carbon source.
Nitrogen qhov kev tswj hwm: Organic nitrogen qhov chaw xws li kua txiv hmab txiv ntoo ncuav mog qab zib hmoov thiab pob kws phoov yog siv ua ke nrog inorganic nitrogen qhov chaw xws li ammonium sulfate los txhawb cov kab mob loj hlob thiab tshuaj tua kab mob synthesis. Ntxiv 1.74kg/500L ammonium sulfate rau peb -theem fermentation tank, thiab tswj cov nitrogen qhov concentration ntawm 0.03% -0.05%.
Mineral ntsev ntxiv: Calcium carbonate (1.39kg / 500L) kho pH, sodium chloride (1.74kg / 500L) tswj osmotic siab, thiab potassium dihydrogen sulfate (10.49g / 500L) muab phosphorus qhov chaw.
Kev siv cov defoamer: ua npuas dej ntau yog tsim thaum lub sij hawm fermentation, thiab cov roj zaub (xws li roj taum pauv 1L / 500L) los yog ua npuas ncauj yeeb ncuab (polyether defoamer) yuav tsum tau ntxiv los tswj qhov siab ntawm npuas.
Kev tswj kub segmented: Peb -theem fermentation tank txais kev tswj kub hauv theem ntawm 30-31 degree: los ntawm 0-50 teev, 31℃txhawb cov kab mob loj hlob, los ntawm 51-150 teev, 30℃optimizes metabolic pathways, thiab los ntawm 151 teev mus rau 151 teev cov khoom kub .
PH dynamic hloov: Thaum lub sij hawm thawj theem ntawm fermentation, pH yog tswj ntawm 6.3-6.5 thiab tswj los ntawm kev ntxiv ammonia dej; Tom qab 100 teev, pH poob mus rau 6.2-6.3, txhawb cov synthesis ntawm oxytetracycline; Nres ammonia txhaj tshuaj 8 teev ua ntej tso lub kaus poom kom tsis txhob degradation ntawm cov khoom.
Dissolved oxygen thiab nplawm: Lub tubular cua kub exchanger thiab nplawm hniav (ceev 100-150rpm) yog siv los ua kom cov pa yaj, nrog rau qhov cua ntawm 0.5-1.0vvm (cua ntim ib cubic meter ntawm fermentation broth ib feeb) kom paub meej aerobic xav tau.
Pub cov tswv yim: Ntxiv cov hmoov txhuv nplej siab fermentation raws li cov nqi qab zib seem (4g / L residual qab zib tswj ua ntej 100 teev) kom tsis txhob muaj kab mob autolysis los ntawm cov pa roj carbon depletion; Ib txhij ntxiv cov khoom siv nitrogen xws li ammonium sulfate kom tswj cov metabolism hauv kev sib npaug.
Raws li dav -spectrum tetracycline tshuaj tua kab mob,Oxytetracycline hmoovmuaj cov kev kho mob dav dav thiab kev ua liaj ua teb, nrog rau nws cov kev siv tseem ceeb muab faib ua tib neeg kev kho mob thiab kev kho tsiaj & kev siv ua liaj ua teb raws li. Nyob rau hauv tib neeg cov tshuaj, nws yog dav siv los kho ntau yam kab mob sib kis los ntawm cov kab mob uas raug mob thiab cov kab mob atypical. Nws muaj txiaj ntsig zoo tiv thaiv kab mob ua pa nrog rau cov kab mob ntsws, mob ntsws bronchitis thiab mob hnyav heev ntawm cov kab mob bronchitis; rau kev kis kab mob hauv plab xws li kab mob dysentery, kab mob cholera thiab salmonella.
Thiab rau cov kab mob urinary nrog rau daim tawv nqaij thiab cov nqaij mos kab mob tshwm sim los ntawm cov kab mob pathogenic. Tsis tas li ntawd, nws ua hauj lwm raws li ib tug classic kho tus neeg sawv cev rau cov kab mob rickettsial xws li typhus, thiab kis tau los ntawm chlamydia thiab mycoplasma, xws li lymphogranuloma venereum.
Hauv cov kws kho tsiaj thiab kev ua liaj ua teb, Oxytetracycline yog ib qho tshuaj tua kab mob feem ntau siv. Nws yog siv los kho cov kab mob hauv cov tsiaj nyeg thiab nqaij qaib xws li nyuj, npua, qaib thiab lwm yam tsiaj yug tsiaj.
Feem ntau yog tsom rau cov kab mob hauv plab hnyuv thiab ua pa, mastitis, metritis thiab lwm yam kab mob hauv zos lossis kab mob hauv lub cev. Dhau li kev kho mob rau cov tsiaj muaj mob, nws nquag siv los ua cov khoom noj ntxiv ntawm cov koob tshuaj tsawg hauv loj- kev ua liaj ua teb loj: ntawm ib sab, nws tuaj yeem tiv thaiv kab mob kab mob hauv cov tsiaj txhu thiab cov nqaij qaib, txo cov kab mob ntawm cov tsiaj txhu thiab cov nqaij qaib. Ntawm qhov tod tes, nws inhibits plab hnyuv muaj teeb meem, txhim kho kev zom zaub mov thiab nqus tau zoo, thiab ntxiv dag zog rau kev loj hlob thiab pub siv tus nqi ntawm cov tsiaj nyeg thiab nqaij qaib, ua si ob lub luag haujlwm ntawm kev tiv thaiv kab mob thiab kev loj hlob.
Cov txheej txheem tshuaj synthesis: ib txoj hauv kev rau kev tshawb fawb hauv chav kuaj
Cov txheej txheem tshuaj synthesis tsim cov qauv molecular ntawmoxytetracycline hmoovlos ntawm ntau yam kev cuam tshuam cov organic, tab sis vim yog cov kauj ruam nyuaj thiab tus nqi siab, nws tsuas yog siv rau kev tshawb fawb hauv chav kuaj lossis kev hloov kho cov qauv.
Lub nplhaib nthuav tawm cov tshuaj tiv thaiv: Sulfopenicillin dhau C-C daim ntawv cog lus cleavage thiab recombination tom qab kho nrog phosphoric acid, tsim 12 lub nplhaib ntawm oxytetracycline core.
Kev taw qhia txog kev ua haujlwm hauv pab pawg: Qhia cov pab pawg ua haujlwm xws li dimethylamino (C4 txoj haujlwm) thiab hydroxyl (C5, C6 txoj haujlwm) los ntawm acylation, oxidation, thiab lwm yam kev cuam tshuam. Piv txwv li, pawg C6 hydroxyl tau qhia los ntawm kev xaiv oxidation cov tshuaj tiv thaiv, thiab cov tshuaj tiv thaiv yuav tsum tau tswj kom tsis txhob muaj oxidation ntau dhau.
Differential Isomer Control: Under acidic conditions (pH 2-6), the C4 dimethylamino group is prone to undergo differential isomerization, resulting in the formation of 4-differential oxytetracycline without antibacterial activity. It is necessary to suppress isomerization by controlling pH (>6) los yog ntxiv stabilizers (xws li citric acid).
Semi hluavtaws txoj kev: optimization txoj kev rau kev hloov kho cov qauv
Cov txheej txheem semi hluavtaws siv cov khoom siv ntuj tsim oxytetracycline raws li cov khoom siv raw thiab txhim kho nws cov khoom siv hluav taws xob los yog cov tshuaj tua kab mob los ntawm kev hloov kho tshuaj. Tus neeg sawv cev raug cai yog cov synthesis ntawm deoxytetracycline (doxycycline).
C6 deoxygenation hloov kho:
Nyob rau hauv acidic tej yam kev mob (xws li 50% sulfuric acid, rhuab ntawm 50 degree), oxytetracycline undergoes lub cev qhuav dej ntawm nws C6 hydroxyl pawg los tsim deoxytetracycline.
Qhov sib txawv isomer inhibition:
C5 hydroxyl pawg ntawm tetracycline tsim ib qho intramolecular hydrogen daim ntawv cog lus nrog C4 dimethylamino pawg, uas stabilizes alpha configuration thiab txo isomerization.
Optimization of Modern Biotechnology: Frontier Exploration of Synthetic Biology
Nrog rau txoj kev loj hlob ntawm hluavtaws biology, gene editing thiab metabolic engineering tau siv los txhim kho txoj kev biosynthetic ntawm oxytetracycline.
Cloning thiab nthuav qhia ntawm Gene Clusters:Clone lub oxytetracycline biosynthesis noob pawg (kwv yees li 30kb) los ntawm Streptomyces fissilis, qhia nws mus rau hauv Escherichia coli los yog poov xab, thiab tsim ib tug heterologous qhia system.
Cov txheej txheem metabolic:Los ntawm kev rhuav tshem txoj kev sib tw cov noob (xws li cov noob encoding theem nrab metabolites) lossis overexpressing cov enzyme tseem ceeb (xws li polyketide synthase noob), kev tsim covoxytetracycline hmoovtuaj yeem nce ntxiv.
Intelligent fermentation txheej txheem: Los ntawm kev sib txuas kev saib xyuas hauv online (xws li pH, yaj oxygen, thiab cov piam thaj seem) nrog cov kev tswj xyuas cov lus qhia, cov kev ntsuas fermentation tuaj yeem hloov kho tiag tiag - sijhawm.
Siv rau mob bronchitis
Mechanism of Action Against Respiratory Infections: Oxytetracycline exerts nws antibacterial nyhuv los ntawm inhibiting kab mob protein synthesis. Nws nkag mus rau hauv lub ntsws mucosal hlwb thiab cov ntaub so ntswg alveolar zoo, khi rau cov kab mob ribosomal subunit, thaiv qhov txuas ntxiv ntawm peptide chains, thiab yog li inhibits kev loj hlob thiab kev loj hlob ntawm cov kab mob pathogenic hauv cov kab mob hauv qab ua pa, tshem tawm cov kab mob hauv zos thiab txo cov kab mob pathological.
Core Clinical Indications: Nws yog qhia tshwj xeeb rau cov kab mob hauv qab ua pa uas tshwm sim los ntawm cov kab mob saum toj no, nrog rau cov kab mob ua rau mob ntsws, mob bronchitis, mob ua rau mob ntsws ntev. Cov xwm txheej no feem ntau nrog cov tsos mob xws li hnoos, expectoration, mob hauv siab thiab kub taub hau, thiab Oxytetracycline tuaj yeem tsom rau cov kab mob los txo cov kev mob tshwm sim.
Cim npe nrov: Oxytetracycline hmoov, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom