Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm pramiracetam hmoov hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo pramiracetam hmoov rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Pramiracetam hmoov(tshuaj lub npe: N - [2- (diisopropylamino) ethyl] -2-oxo-1-pyrrolidine acetamide) yog ib qho khoom siv hluavtaws nootropic uas muaj nyob rau hauv pawg Racetam ntawm cov tshuaj. Cov tsos mob feem ntau yog dawb los yog tawm dawb crystalline hmoov, tsis muaj ntxhiab, iab hauv saj, yooj yim soluble hauv cov kuab tshuaj organic (xws li DMSO, ethanol), me ntsis soluble hauv dej, ruaj khov nyob rau hauv qhuav thiab txias txias, thiab yuav tsum tau muab cia kom deb ntawm lub teeb.
Nws tuaj yeem txhawb nqa cov choline los ntawm presynaptic neurons, yog li ua kom cov synthesis thiab tso tawm ntawm acetylcholine thiab txhim kho kev txawj ntse. Tej zaum yuav cuam tshuam rau kev ua haujlwm ntawm neurotransmitters xws li dopamine thiab serotonin, txhim kho kev xav thiab kev xav. Nws tuaj yeem ua rau cov ntshav ntws mus rau lub paj hlwb cortex thiab hippocampus, txhawb cov metabolism hauv qabzib, thiab txhim kho kev siv lub zog.
Nws kuj tseem tuaj yeem ua kom zoo dua receptor muaj nuj nqi thiab teeb liab hloov pauv los ntawm kev hloov pauv cov dej ntawm neural cell membranes. Nws yog siv los txhim kho kev nco, kev kawm muaj peev xwm, thiab kev saib xyuas, tshwj xeeb tshaj yog rau kev paub txog kev poob qis los ntawm kev laus, kev raug mob ntawm lub hlwb, lossis kev puas hlwb. Hauv kev sim tsiaj, nws tau pom tias muaj kev tiv thaiv ntawm lub hlwb ischemia, hypoxia, thiab lwm yam kev raug mob, uas tuaj yeem ua tiav los ntawm antioxidant thiab tiv thaiv - cov txheej txheem inflammatory. Tseem muaj kev tshawb fawb tshawb nrhiav nws lub peev xwm los ua kev kho mob ntxiv rau kev puas siab puas ntsws xws li kev nyuaj siab thiab kev ntxhov siab, tab sis cov pov thawj kho mob tseem tsis tau txaus. Nws yog ib qho cuab yeej siv tshuaj rau kev tshawb fawb neuroscience, siv los tshawb txog cov txheej txheem molecular ntawm kev kawm thiab kev nco.
Nyob rau tib lub sijhawm, peb lub tuam txhab tsis yog tsuas yog muab cov hmoov ntshiab, tab sis kuj muaj cov ntsiav tshuaj thiab tshuaj txhaj. Yog tias xav tau, thov koj xav tiv tauj peb txhua lub sijhawm.
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Cov ntaub ntawv ntxiv ntawm chemical compound:
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Khoom npe |
Pramiracetam Ntxiv |
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Yam khoom |
Hmoov |
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Khoom Purity |
100g / 1kg / thiab lwm yam. |
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Daim ntawv khoom |
Organic synthesis |
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Pramiracetam COA
Pramiracetam hmoovyog ib qho kev txawj ntse hluavtaws txhim kho cov tshuaj uas muaj nyob hauv tsev neeg tshuaj Racetam. Txij li thaum nws txoj kev loj hlob nyob rau xyoo 1970, nws tau txais kev saib xyuas dav dav rau nws txoj kev txhim kho hauv kev txawj ntse. Cov hauv qab no yog cov lus piav qhia ntxaws txog nws lub hom phiaj:
Txhim kho kev txawj ntse
Pramiracetam tau qhia cov teebmeem tseem ceeb hauv kev txhim kho kev nco thiab kev kawm muaj peev xwm. Ntau qhov kev tshawb fawb tau pom tias cov neeg laus noj qab haus huv thiab cov tib neeg uas muaj kev paub tsis zoo tau txhim kho kev nco thiab kev kawm muaj peev xwm tom qab tau txais kev kho mob Pramiracetam. Piv txwv li, hauv kev sim tsiaj, Pramiracetam tau pom los txhim kho kev kawm spatial thiab nco lub peev xwm hauv nas. Hauv kev tshawb fawb tib neeg, nws kuj tau tshaj tawm tias Pramiracetam tuaj yeem txhim kho kev nco thiab kev saib xyuas hauv cov neeg laus.
Pramiracetam tsis yog tsuas yog pab txhawb rau kev tsim thiab kev sib sau ua ke ntawm luv- lub sijhawm nco, tab sis kuj tseem tuaj yeem muaj txiaj ntsig zoo rau kev khaws cia thiab khaws cia ntev - lub sijhawm nco. Qhov no yog qhov tseem ceeb tshwj xeeb rau cov tub ntxhais kawm thiab cov kws tshaj lij uas yuav tsum tau sau ntau cov ntaub ntawv rau lub sijhawm ntev. Los ntawm kev txhim kho kev mloog zoo thiab ua kom pom tseeb, Pramiracetam tuaj yeem pab tib neeg nqus thiab ua cov ntaub ntawv zoo dua, yog li txhim kho kev kawm tau zoo.
Qhov no yog qhov tseem ceeb tshwj xeeb rau cov tub ntxhais kawm thiab cov kws tshaj lij uas yuav tsum tau sau ntau cov ntaub ntawv rau lub sijhawm ntev. Los ntawm kev txhim kho kev mloog thiab ua kom pom tseeb, Pramiracetam tuaj yeem pab tib neeg nqus thiab ua cov ntaub ntawv zoo dua, yog li txhim kho kev kawm tau zoo. Hauv lub neej niaj hnub no, kev cuam tshuam thiab tsis muaj kev xav yog teeb meem los ntawm ntau tus neeg.
Pramiracetam pab txhim kho ib tus neeg txoj kev mloog thiab kev saib xyuas qib los ntawm kev tswj hwm cov kab mob neurotransmitter thiab txhim kho cov ntshav cerebral. Qhov no yog qhov tseem ceeb tshwj xeeb rau cov dej num uas yuav tsum tau ua kom ntev ntev, xws li kev kawm lossis kev ua haujlwm. Pab txo qhov cuam tshuam ntawm kev cuam tshuam sab nraud ntawm kev saib xyuas, tso cai rau tib neeg tsom mus rau txoj haujlwm tam sim no. Los ntawm kev txhim kho kev ua kom pom tseeb, Pramiracetam tuaj yeem pab tib neeg ua tiav cov haujlwm tau zoo dua thiab txo qhov ua yuam kev.
Hauv lub neej niaj hnub no, kev cuam tshuam thiab tsis muaj kev tsom xam yog teeb meem los ntawm ntau tus neeg. Pramiracetam pab txhim kho ib tug neeg txoj kev mloog thiab concentration theem los ntawm kev tswj cov neurotransmitter system thiab txhim kho cerebral ntshav txaus. Qhov no yog qhov tseem ceeb tshwj xeeb rau cov dej num uas yuav tsum tau ua tib zoo saib xyuas, xws li kev kawm lossis kev ua haujlwm. Pramiracetam tuaj yeem pab txo qhov cuam tshuam ntawm kev cuam tshuam sab nraud ntawm kev saib xyuas, tso cai rau cov tib neeg tsom mus rau txoj haujlwm tam sim no. Los ntawm kev txhim kho kev ua kom pom tseeb, Pramiracetam tuaj yeem pab tib neeg ua tiav cov haujlwm tau zoo dua thiab txo cov nqi yuam kev.
Kev raug mob ntawm lub hlwb tuaj yeem ua rau muaj kev puas tsuaj rau cov qauv thiab kev ua haujlwm ntawm lub hlwb, ua rau lub hlwb tsis ua haujlwm. Pramiracetam pab kho kev puas siab puas ntsws ua haujlwm los ntawm kev txhawb nqa kev tso tawm ntawm cov neurotransmitters thiab cov ntaub ntawv xa mus ntawm cov neurons. Pramiracetam tau tshawb nrhiav los ua cov tshuaj muaj peev xwm kho tau hauv kev tshawb fawb txog cov kab mob neurodegenerative xws li Alzheimer's kab mob, Parkinson's kab mob, thiab lwm yam. Txawm hais tias tam sim no tsis muaj pov thawj txaus rau nws cov ntaub ntawv kho mob hauv cov kab mob no, kev sim tsiaj thiab kev sim tshuaj ntsuam xyuas ua ntej qhia tias nws yuav ua rau qeeb tus kab mob kev loj hlob thiab txhim kho kev paub txog kev ua haujlwm, los ntawm kev siv tshuaj tiv thaiv kab mob {3.
Pramiracetam hmoovkuj tseem yuav pab txhim kho lub hlwb adaptability thiab yooj. Qhov no txhais tau hais tias tib neeg muaj peev xwm kho lawv cov tswv yim kev txawj ntse thiab tus cwj pwm coj tus cwj pwm sai dua thaum ntsib ib puag ncig tshiab, kev ua haujlwm, lossis kev cov nyom. Pramiracetam tuaj yeem pab txhim kho ib tus neeg txoj kev paub yooj yim, ua rau lawv teb tau yooj yim dua rau kev paub txog kev paub thiab kev xav tau. Pramiracetam tuaj yeem pab tib neeg hloov kho thiab sib koom ua ke rau hauv ib puag ncig tshiab lossis xwm txheej sai dua, txo qis kev paub txog kev ntxhov siab los ntawm kev hloov pauv ib puag ncig.
neurotiv thaiv
Mechanism ntawm cov nyhuv neuroprotective
Pramiracetam tuaj yeem txhim kho qhov nce ntawm choline los ntawm presynaptic neurons, uas yog cov kauj ruam tseem ceeb hauv acetylcholine synthesis. Acetylcholine yog ib qho tseem ceeb neurotransmitter nyob rau hauv lub hlwb, ze ze rau kev txawj ntse zog xws li kev kawm, nco, thiab mloog. Los ntawm kev ua kom cov synthesis thiab tso tawm ntawm acetylcholine, Pramiracetam tsis tsuas yog txhim kho kev txawj ntse, tab sis kuj tseem tuaj yeem ua rau muaj kev tiv thaiv neuroprotective los ntawm kev tswj hwm qhov sib npaug ntawm cov neurotransmitter system. Ntxiv rau acetylcholine, Pramiracetam kuj tseem tuaj yeem cuam tshuam rau lwm cov kab mob neurotransmitter xws li dopamine thiab serotonin.
Cov neurotransmitters no ua lub luag haujlwm tseem ceeb hauv kev tswj cov kev xav, kev txhawb siab, kev paub txog kev ua haujlwm, thiab kev tiv thaiv neuroprotection. Los ntawm kev tswj hwm cov haujlwm ntawm cov neurotransmitters no, Pramiracetam tuaj yeem pab txo qis kev puas hlwb, txhawb kev kho paj hlwb thiab rov tsim dua tshiab. Pramiracetam tuaj yeem ua rau cov ntshav khiav hauv lub hlwb cortex thiab hippocampus, uas yog qhov tseem ceeb ntawm lub hlwb lub luag haujlwm rau kev kawm thiab kev nco. Nyob rau tib lub sijhawm, nws tuaj yeem txhawb nqa cov piam thaj metabolism, txhim kho kev siv hluav taws xob, yog li pab txhim kho kev txawj ntse ntawm lub hlwb thiab siv cov teebmeem neuroprotective. Kev nce hauv cerebral ntshav txaus thiab txhim kho cov metabolism hauv pab txhawb cov neurons nrog cov pa oxygen txaus thiab cov as-ham, txo cov kev puas tsuaj rau cov neurons los ntawm ischemia thiab hypoxia.
Mechanism ntawm cov nyhuv neuroprotective
Oxidative stress thiab inflammatory teb yog yam tseem ceeb uas ua rau kev puas hlwb neuronal thiab kab mob neurodegenerative. Pramiracetam yuav txo tau lub hlwb puas tsuaj los ntawm oxidative kev nyuaj siab thiab inflammatory teb los ntawm antioxidant thiab anti- inflammatory mechanisms. Piv txwv li, nws yuav tiv thaiv neurons los ntawm oxidative kev nyuaj siab thiab inflammatory teb tawm tsam los ntawm clearing dawb radicals, inhibiting tso tawm inflammatory mediators, thiab lwm yam kev. Neuronal apoptosis yog ib qho tshwm sim tshwm sim hauv cov kab mob neurodegenerative thiab mob hlwb. Pramiracetam tuaj yeem txo qis kev tuag neuronal los ntawm inhibiting neuronal apoptosis txoj hauv kev, xws li tswj kev qhia ntawm Bcl-2 tsev neeg cov proteins thiab inhibiting caspase enzyme kev ua. Qhov no pab tswj tus naj npawb thiab kev ua haujlwm ntawm cov neurons, yog li ua rau cov teebmeem neuroprotective.
Ntau qhov kev sim tsiaj tau pom tias Pramiracetam tuaj yeem txhim kho kev paub tsis meej thiab kev puas tsuaj ntawm cov paj hlwb los ntawm kev raug mob hlwb. Piv txwv li, nyob rau hauv tus qauv nas ntawm kev raug mob lub hlwb, Pramiracetam tau pom los txhim kho kev kawm spatial thiab nco lub peev xwm, thiab txo kev puas tsuaj rau hippocampal neurons. Cov txiaj ntsig no qhia tau tias Pramiracetam muaj peev xwm siv tau tus nqi hauv kev tiv thaiv neuroprotection thiab kev paub txog kev rov qab los tom qab raug mob lub hlwb. Pramiracetam kuj nthuav tawm cov teebmeem neuroprotective hauv tsiaj qauv ntawm cov kab mob neurodegenerative xws li Alzheimer's kab mob, Parkinson's kab mob, thiab lwm yam. Piv txwv li, nyob rau hauv ib tug nas qauv ntawm Alzheimer's kab mob, Pramiracetam tau pom los txhim kho kev nco tsis zoo thiab alleviate amyloid deposition thiab neuronal puas nyob rau hauv lub hlwb. Cov kev tshawb pom no muab cov pov thawj sim rau kev siv Pramiracetam hauv kev kho cov kab mob neurodegenerative.
Piv txwv li, nyob rau hauv tus qauv nas ntawm nruab nrab cerebral artery occlusion, Pramiracetam tuaj yeem txhim kho cerebral ntshav txaus, alleviate neuronal apoptosis, thiab txhawb kev rov qab los ntawm neurological function.Taumatic hlwb raug mob yog ib qho ua rau muaj kev puas tsuaj rau neuronal thiab kev paub tsis meej.Pramiracetam hmoovmuaj peev xwm siv tus nqi hauv kev tiv thaiv neuroprotection thiab kev paub txog kev rov qab los tom qab raug mob hlwb. Kev sim tshuaj ntsuam xyuas yav tom ntej tuaj yeem ntsuas qhov ua tau zoo thiab kev nyab xeeb ntawm Pramiracetam hauv cov neeg mob uas raug mob lub hlwb, muab lub hauv paus rau nws daim ntawv thov kev kho mob thoob plaws. Cov kab mob neurodegenerative yog ib hom kab mob uas tshwm sim los ntawm kev loj hlob ntawm neuronal kev tuag thiab kev txawj ntse poob.
Txawm hais tias tam sim no muaj pov thawj tsis txaus ntawm kev siv tshuaj Pramiracetam hauv cov kab mob neurodegenerative, kev sim tsiaj thiab kev sim tshuaj ntsuam xyuas ua ntej qhia tias nws yuav ua rau qeeb tus kab mob thiab txhim kho kev txawj ntse los ntawm cov txheej txheem xws li antioxidant, tiv thaiv -inflammatory, thiab neuroprotective teebmeem. Cov kev tshawb fawb yav tom ntej tuaj yeem tshawb nrhiav qhov zoo tshaj plaws ntau npaum, lub sijhawm, thiab kev sib xyaw ua ke ntawm Pramiracetam hauv kev kho cov kab mob neurodegenerative.
Cov lus nug nquag
Dab tsi receptor ua nws "tawm tsam" hauv lub hlwb? Vim li cas thiaj hu ua 'dab'?
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It is indeed a 'ghost' because it does not directly attack any classical receptors. Research has confirmed that it has no affinity for dopaminergic, serotonergic, GABAergic, adrenergic, muscarinic, adenosine (IC50>10 μ M), or even benzodiazepine receptors (IC50>1 μM). Nws cov txheej txheem ntawm kev ua haujlwm tseem yog qhov tsis paub, thiab nws ntseeg tau tias tsis muaj kev cuam tshuam los ntawm kev txhim kho neurotransmission los ntawm kev tswj cov ion raws (xws li kev txhim kho calcium thiab sodium influx) lossis cuam tshuam rau cov neurotransmitter metabolism.
Puas yog kev txhim kho ntawm kev nco raug kho kom sib npaug? Qhov twg zoo dua, ntev -lub sij hawm los yog luv- lub sij hawm nco?
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Tsis yog, nws nyiam ntev - lub sij hawm nco (reference memory). Hauv kev sim nas yim caj npab, Praxitan tau txhim kho tus tsiaj txoj kev kawm muaj peev xwm rau cov qauv ruaj khov (uas txhais caj npab ib txwm muaj zaub mov), uas yog siv lub cim xeeb; Tab sis nws tsis muaj qhov cuam tshuam loj rau kev ua haujlwm nco uas yuav tsum tau hloov kho hauv lub sijhawm tiag tiag - (uas txhais caj npab nyuam qhuav nyob ntawd). Qhov no qhia tias nws tuaj yeem ua haujlwm feem ntau hauv kev sib sau thiab khaws cia ntawm lub cim xeeb, tsis yog kev ua haujlwm ib ntus.
Puas yog nws cov ntshav cov tshuaj concentration ncov tuaj sai sai? Vim li cas thiaj muaj qhov sib txawv loj ntawm tib neeg?
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Lub sijhawm siab tshaj plaws tom qab kev tswj hwm qhov ncauj yog li 2-3 teev. Tab sis nws muaj cov yam ntxwv tseem ceeb: qhov tseem ceeb ntawm tus kheej sib txawv. Ib txoj kev tshawb fawb pharmacokinetic tau pom tias nws ib nrab-lub neej txawv ntawm 2 teev mus rau 8 teev ntawm cov kev kawm sib txawv, thiab tus neeg sib txawv ntawm cov ntshav plasma concentration thiab thaj chaw nyob rau hauv cov tshuaj lub sij hawm nkhaus kuj tseem ceeb. Qhov no qhia tau hais tias cov neeg sib txawv muaj peev xwm sib txawv metabolic rau nws.
Dab tsi yog qhov kev sib raug zoo ntawm nws thiab scopolamine? Nws puas tuaj yeem detoxify?
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Nws tuaj yeem thim rov qab cholinergic thauj teeb meem tshwm sim los ntawm scopolamine, tab sis tsis ncaj qha detoxify. Scopolamine tuaj yeem cuam tshuam kev thauj mus los ntawm choline los ntawm cov ntshav- lub paj hlwb teeb meem, thaum kev tswj hwm txuas ntxiv ntawm Praxitan (100 mg / kg / d) rau 14 hnub tuaj yeem tiv thaiv qhov teeb meem no thiab ua rau cov ntshav hauv hlwb nce ntxiv. Qhov no qhia tau hais tias nws tuaj yeem tiv thaiv cov kab mob cholinergic los ntawm kev tswj hwm kev ua haujlwm ntawm cerebral vascular endothelial hlwb.
Puas muaj txiaj ntsig rau Alzheimer's disease? Vim li cas qhov kev sim kho mob "qhib siab thiab qis mus"?
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Nws yog qhov ua tsis tau zoo thiab muaj "dose-cov lus teb tsis zoo". Kev sim tsiaj tau pom tias nws muaj qhov hloov pauv U- koob tshuaj zoo li - teb nkhaus (txawm tias qis dhau lossis siab dhau qhov koob tshuaj tsis zoo). Hauv kev tsim kom muaj txiaj ntsig ntawm 10 tus neeg mob Alzheimer's disease, txawm hais tias 8 tus neeg tau pom qhov "zoo tshaj plaws" nyob rau hauv lub sijhawm tshawb xyuas koob tshuaj, tsuas yog 2 kis tau zoo dua nyob rau theem tom ntej rov siv tau, thiab PET scans tsis muaj kev hloov pauv hauv lub hlwb metabolism. Qhov kev txiav txim siab yog tias koob tshuaj txog 4000mg / hnub tsis zoo li yuav ua rau muaj kev txhim kho cov tsos mob.
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