Sineptina CAS 1392-21-8

1. Antibacterial mechanism thiab spectrum - tso lub hauv paus tshuaj rau ntau yam kev siv
Cov tshuaj tua kab mob zoo heev zoo ib yam li erythromycin, thiab nws cov txheej txheem tseem ceeb ntawm kev ua haujlwm yog inhibit cov kab mob protein synthesis. Cov tshuaj khi rau 50S subunit ntawm kab mob ribosomes, inhibiting kev ua ntawm peptidyl transferase thiab thaiv qhov txuas ntxiv ntawm cov protein peptide chains, yog li inhibiting kab mob loj hlob thiab kev loj hlob. Cov txheej txheem no ua rau nws muaj kev cuam tshuam loj heev rau ntau yam kab mob pathogenic microorganisms thiab belongs rau cov tshuaj tua kab mob.

1.1 Muaj zog inhibitory nyhuv ntawm Gram zoo kab mob

Nws nthuav tawm tshwj xeeb tshaj yog cov tshuaj tua kab mob tiv thaiv kab mob Gram zoo, suav nrog:

Staphylococcus: Tshwj xeeb tshaj yog zoo tiv thaiv penicillin resistant thiab erythromycin resistant Staphylococcus aureus (Staphylococcus aureus), uas yog ib qho ntawm cov tseem ceeb tshaj plaws nta ntawm cov khoom no.

Streptococcus pyogenes, Streptococcus pyogenes, thiab Streptococcus pneumoniae yog tag nrho cov rhiab heev rau erythromycin thiab yog cov kev xaiv tseem ceeb rau kev kho cov kab mob streptococcal.

Tetanus bacillus, diphtheria bacillus, anthrax bacillus: kuj nyob rau hauv lawv cov kab mob tua kab mob, lawv muaj cov txiaj ntsig kho mob ntawm cov kab mob tshwm sim los ntawm cov kab mob tshwj xeeb no.

1.2. Tseem ceeb inhibitory nyhuv ntawm Gram negative bacteria
Txawm hais tias nws cov haujlwm tiv thaiv Gram tsis zoo yog tsis muaj zog li tiv thaiv kab mob Gram zoo, nws tseem muaj qhov cuam tshuam loj heev, feem ntau suav nrog:
Neisseria gonorrhoeae: Nws muaj cov nyhuv tua pov tseg ntawm Neisseria gonorrhoeae thiab yog ib qho tshuaj zoo rau kev kho kab mob gonorrhea thiab tsis yog gonococcal urethritis.

Bordetella pertussis: Nws muaj qhov cuam tshuam tseem ceeb ntawm Bordetella pertussis thiab yog ib qho ntawm cov tshuaj tseem ceeb rau kev kho tus kab mob pertussis.
Qee cov kab mob Gram tsis zoo xws li Haemophilus influenzae kuj tseem nyob hauv nws cov kab mob tua kab mob.

1.3. Kev dav dav ntawm cov kab mob tshwj xeeb
Ib qho txiaj ntsig tseem ceeb yog tias nws muaj txiaj ntsig sib npaug tiv thaiv ntau yam kab mob atypical:
Mycoplasma: Nws muaj cov nyhuv inhibitory zoo ntawm Mycoplasma thiab haum rau cov kab mob xws li Mycoplasma pneumonia.

Leptospira: Nws muaj cov nyhuv inhibitory ntawm Leptospira thiab tuaj yeem siv rau kev kho mob leptospirosis.
Rickettsia: Nws muaj cov nyhuv inhibitory ntawm Rickettsia thiab tuaj yeem pab kho tus kab mob Rickettsia.
Chlamydia trachomatis: Nws muaj cov nyhuv tua ntawm Chlamydia trachomatis thiab tuaj yeem siv rau kev kho mob trachoma thiab chlamydia kab mob.
Treponema pallidum: Nws muaj cov nyhuv inhibitory ntawm Treponema pallidum thiab tuaj yeem siv los ua kev kho mob rau tus mob syphilis.
Piv txwv li, nws cov kab mob dav dav ua rau nws muaj txiaj ntsig zoo hauv kev kho mob ntawm ntau yam kab mob.

2. Kev siv tshuaj kho mob tseem ceeb rau tib neeg - ntau yam tshuaj tiv thaiv kab mob
2.1. Kab mob ua pa
Nov yog daim ntawv thov kev kho mob tseem ceeb tshaj plaws. Tshwj xeeb, nws suav nrog:
Cov kab mob ua pa sab saud: xws li kab mob kis mus rau kab mob khaub thuas, pharyngitis, laryngitis, thiab lwm yam.
Pneumonia: suav nrog kab mob ntsws thiab mycoplasma pneumonia. Vim nws zoo heev inhibitory nyhuv ntawm mycoplasma thiab siab concentration nyob rau hauv lub ntsws cov ntaub so ntswg,sineptinatshwj xeeb tshaj yog haum rau kev kho mob ntawm mycoplasma pneumonia.

Bronchitis: Mob ntsws thiab mob ntev, tshwj xeeb tshaj yog kis kab mob ntsws los ntawm cov kab mob rhiab heev.

Tonsillitis, pharyngitis, scarlet fever, diphtheria: tonsillitis, scarlet fever, thiab diphtheria los ntawm tus kab mob streptococcal tuaj yeem kho tau zoo nrog erythromycin, tshwj xeeb tshaj yog rau cov neeg mob ua xua rau penicillin.
Pertussis: Nws cov nyhuv inhibitory ntawm Bordetella pertussis ua rau nws yog ib qho ntawm cov tshuaj classic rau kev kho tus kab mob pertussis.
Otitis media: Cov kab mob hauv nruab nrab pob ntseg tshwm sim los ntawm cov kab mob rhiab heev kuj nyob hauv nws cov lus qhia.

2.2. Kab mob ntawm daim tawv nqaij thiab cov nqaij mos

Nws muaj zog inhibitory nyhuv ntawm cov kab mob ntawm daim tawv nqaij xws li Staphylococcus thiab Streptococcus, thiab yog li ntawd dav siv rau:
Cov kab mob ntawm daim tawv nqaij tshwm sim los ntawm Staphylococcus aureus, xws li boils, abscesses, folliculitis, pyoderma, thiab lwm yam.
Cov kab mob ntawm daim tawv nqaij thiab cov nqaij mos uas tshwm sim los ntawm streptococci.

Pob txuv (pimples): Nws muaj qee yam inhibitory nyhuv ntawm Propionibacterium acnes thiab tuaj yeem siv los ua kev kho mob rau pob txuv.
Kev tiv thaiv thiab kho cov kab mob thib ob tom qab hlawv thiab raug mob.
Kev tiv thaiv thiab kho cov kab mob tom qab phais.

2.3. Cov kab mob hauv cov zis thiab cov kab mob hauv lub cev
Gonorrhea: Nws muaj cov nyhuv tua kab mob ntawm Neisseria gonorrhoeae thiab yog ib qho tshuaj zoo rau kev kho mob gonorrhea.
Tsis yog gonococcal urethritis: urethritis tshwm sim los ntawm cov kab mob atypical xws li mycoplasma thiab chlamydia, cov tshuaj no kuj siv tau.
Gonorrheic urethritis: kuj nyob rau hauv nws txoj kev kho mob.

2.4. Kev kis kab mob biliary
Tom qab nqus dej hauv lub cev, cov tshuaj tuaj yeem nthuav dav mus rau ntau yam ntaub so ntswg, tshwj xeeb tshaj yog nyob rau hauv siab concentrations hauv daim siab thiab gallbladder system. Cov yam ntxwv ntawm cov tshuaj pharmacokinetic no ua rau nws tsim nyog rau kev kho cov kab mob biliary, xws li cholecystitis thiab cholangitis.

2.5. Kev kho mob tshwj xeeb
Raws li cov ntaub ntawv kho mob tau tso cai, nws kuj tuaj yeem siv rau kev kho mob tshwj xeeb hauv qab no:
Anti tuberculosis: raws li cov tshuaj tua kab mob thaum ub, nws tuaj yeem txhim kho cov tsos mob ntawm tuberculosis thiab pab tua Mycobacterium tuberculosis.
Anti pestis: Tom qab kab mob pestis, nws tuaj yeem tswj tau qhov kev loj hlob ntawm tus kab mob los ntawm kev ua raws li tus kws kho mob cov lus qhia.
Anti trachoma: Nws muaj kev tua cov kab mob Chlamydia trachomatis.
Anti syphilis: tuaj yeem tua Treponema pallidum thiab txhim kho cov tsos mob xws li cov pob liab liab hauv zos los ntawm syphilis.
Sepsis: Nws kuj muaj qee yam kev kho tus nqi rau sepsis los ntawm cov kab mob rhiab heev.

2.6. Raws li lwm cov tshuaj rau erythromycin
Ib qho ntawm cov haujlwm tseem ceeb tshaj plaws hauv kev kho mob yog los ua kev hloov pauv rau erythromycin. Thaum cov neeg mob ntsib cov xwm txheej hauv qab no, erythromycin yog ib qho kev xaiv zoo tshaj plaws:
Qhov xwm txheej uas erythromycin yog rhiab heev tab sis xav tau lwm txoj kev kho mob;
Thaum cov neeg mob tsis tuaj yeem zam qhov tsis zoo tshwm sim ntawm erythromycin;
Thaum tus kab mob no tshwm sim los tiv thaiv erythromycin (nco ntsoov tias muaj cov kab mob sib kis nrog erythromycin);
Cov neeg mob uas tsis haum rau penicillin tab sis yuav tsum tau kho cov kab mob Gram zoo.

3. Veterinary thiab tsiaj txhu daim ntawv thov - ib qho tseem ceeb teb uas yuav tsis raug ignored
Tsis tsuas yog nws ua lub luag haujlwm tseem ceeb hauv tib neeg cov tshuaj, tab sis nws tseem tuav txoj haujlwm tseem ceeb hauv kev kho tsiaj thiab tsiaj txhu.
1. Kev kho cov kab mob ua pa hauv cov tsiaj nyeg thiab nqaij qaib
Nws muaj zog tiv thaiv kab mob tiv thaiv kab mob Gram zoo thiab mycoplasma, thiab tseem muaj txiaj ntsig tiv thaiv qee cov kab mob Gram tsis zoo, leptospira, rickettsia, thiab chlamydia. Yog li ntawd, nyob rau hauv veterinary clinical xyaum, nws yog tsuas yog siv rau:
Porcine pneumonia thiab kab mob dysentery: Beirimycin muaj qhov cuam tshuam tseem ceeb ntawm ob qho tib si porcine pneumonia thiab kab mob dysentery.

Cov kab mob ua pa ntev (CRD) hauv qaib: Nws muaj kev kho mob zoo rau cov kab mob ua pa ntev hauv qaib.

2. Pub additives - txhawb kev loj hlob
Hauv kev yug tsiaj, kuj tseem muaj kev siv tshwj xeeb - raws li kev pub mis ntxiv, koob tshuaj me me tuaj yeem txhawb nqa tsiaj loj hlob thiab txhim kho tus nqi hloov pauv. Txoj kev npaj siv tshwj xeeb yog raws li hauv qab no:
Raws li cov tswv cuab classic ntawm cov tshuaj tua kab mob macrolides,sineptinaplays lub luag hauj lwm irreplaceable nyob rau hauv kev kho mob tshuaj tiv thaiv kab mob vim nws broad antibacterial spectrum.

Kev siv tshuaj tiv thaiv kab mob -Resistant Staphylococcus aureus, siab concentration nyob rau hauv lub siab thiab gallbladder system, thiab tsawg toxicity. Los ntawm kab mob ua pa sab saud, mob ntsws, tonsillitis mus rau ntawm daim tawv nqaij thiab cov nqaij mos, los ntawm kab mob gonorrhea, nongonococcal urethritis mus rau kab mob biliary, los ntawm hnoos hawb pob mus rau chlamydia trachomatis kab mob, thiab txawm tuberculosis, pestis thiab lwm yam kab mob tshwj xeeb, nws muaj peev xwm muab kev kho mob zoo. Nyob rau tib lub sijhawm, nws tseem ua lub luag haujlwm tseem ceeb hauv thaj chaw kho tsiaj thiab tsiaj txhu, vim nws tuaj yeem kho cov kab mob ua pa hauv cov tsiaj nyeg thiab nqaij qaib, thiab txhawb kev loj hlob raws li cov khoom noj ntxiv.