Zaj tshaj tawm
Peb tsis muag cov tshuaj no, ntawm no tsuas yog rau xyuas cov ntaub ntawv yooj yim ntawm cov tshuaj lom neeg no.
Lub Peb Hlis 31 2025
Pregabalin Hmoov(Lyrica), tseem hu ua prostaglandin, feem ntau yog cov npe, cov npe khoom siv tshuaj (s) {{{{{}} methylcaproic acid. Raws li cov chaw tsim khoom tshaj lij ntawm cov khoom lag luam Pregabalin, peb tseem muab cov kev qhia tshwj xeeb ntawm Pregabalin Crystal ntawm peb txoj kev kawm paub, nws kuj cuam tshuam txog peb txoj kev nkag siab thiab paub txog cov khoom. Raws li cov tshuaj tiv thaiv tshuaj, nws yog tsuas yog siv los kho postherpetic neuralgia hauv chaw kho mob. Ib qho ntxiv, cov Pregabalin kuj tseem siv tau rau pw tsaug zog. Tom qab cov lus qhia saum toj no thiab cov ntsiab lus hauv qab no, yog tias koj xav paub tias yuav pabalin twg? Thov muab koj txoj kev cia siab rau cov kws tshaj lij. Peb yog cov chaw tsim khoom lag luam ntawm Pregabalin, nrog cov kws tshaj lij kev ua lag luam thiab cov neeg tshawb fawb uas tau ua haujlwm hauv chav kuaj ntau tshaj kaum xyoo. Vim peb cov kev pabcuam zoo thiab cov ntaub ntawv sib pauv lus, peb tau yeej txoj kev ntseeg siab ntawm ntau tus neeg yuav khoom. Lub chaw ua lag luam Pregabalin tau nce hauv ntau lub tebchaws, xws li Saudi Arabia, Tebchaws Asmeskas Arabaus, Australia, Canada thiab lwm yam. Thov tso koj cov ntaub ntawv. Peb zoo siab siv cov thev naus laus zis tshaj plaws los muab kev pabcuam ib-rau-ib-ntawm ib qho.
Additional information of chemical compound: Melting point {{0}} degree C, Specific rotation D23 + 10.52 degree (C=1.06 in water), Boiling point 274.0 ± 23.0 degree C (predicted), Density 0. 997}. 0.06 g / CM3 (kwv yees li cas), Inchikeysxypkufhzroozroog-zetcqymhsa-n
Pregalin yog qhov hluavtaws Gaba Analogue nrog cov molecular mis c8h17no2. Nws cov qauv tshuaj muaj feem cuam tshuam nrog Gaba (- aminobutyric acid yog ib tus tswv cuab ntawm cov pab pawg ua haujlwm thiab cov pab pawg ntawm cov neeg ua haujlwm, uas muaj ob tus tswv cuab ntawm cov khoom siv tsis zoo. Ntxiv rau, Pregarin Molecule kuj muaj a Cov pab pawg tsheb dawb dawb thiab pab pawg amino, ua rau nws zoo heev.
Cov qauv molecular yam ntxwv ntawm Pregabalin muab nws qee cov khoom siv lag luam tshwj xeeb. Firstly, cov qauv molecular ntawm Pregarin zoo ib yam li ntawm Gaba, cia nws los khi rau Gaba receptors thiab rub tawm nws cov teebmeem pharmacological. Qhov thib ob, amino methenyl thiab carboxyl pawg hauv Pregarin Molecules yog cov pab pawg polar, uas ua rau lawv muaj kuab tshuaj yeeb tshuaj thiab faib tshuaj. Tsis tas li ntawd, ob daim ntawv cog lus ob npaug thiab kev tsis zoo nyob rau hauv Pregarin Molecules muab lawv ib co kev ruaj ntseg ntawm kev tawm tsam thiab ua kom muaj kev ruaj ntseg ntawm lawv cov khoom siv hluav taws xob.
Lyrica cov qauv molecular tsom xam kuj qhia tias muaj lub chaw chiral hauv nws cov molecule. Qhov no txhais tau hais tias Lyrica muaj ob lub suab sib txawv, uas yog sab laug sab laug thiab sab xis-tes. Ntawm lawv, sab laug lub cev muaj kev ua tshuaj porthaological, thaum sab xis lub cev muaj yuav luag tsis muaj kev ua tshuaj. Yog li ntawd, chiral sib cais yuav tsum muaj nyob rau hauv cov txheej txheem ntau lawm ntawm Lyricra kom ntseeg tau tias cov khoom tau yog sab laug-tes.
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Pregabalin Hmoovyog ib -aminobutyric acid (Gaba) Analogue, zoo sib xws hauv cov qauv thiab kev nqis tes ua rau Gabapentin, nrog anti-epileptic, analgesic thiab anti-ntxhov siab ua haujlwm. Cov txheej txheem ntawm cov tshuaj tiv thaiv kev ua haujlwm ntawm Pregabalin tseem tsis meej. Hauv kev tshawb nrhiav kev kuaj, Pregabalin qhia Anticonvulsant kev ua hauv ntau cov tsiaj ntawv Epileptic; Cov kev ua si ntawm cov tsiaj tsiaj tau zoo ib yam li ntawd ntawm Gabapentin, tab sis Pregabalin tau {2}}}} sij hawm ua haujlwm zoo li gabapentin. Ib qho ntawm cov kev mob tshwm sim pregabalin yog peripheral edema thiab lub caij nyoog pr sij hawm.
Cov hauv qab no yog qhov yooj yim synthesis txoj kev rauPPregabalin Hmoov, Thov nco ntsoov tias qhov no tsis yog qhov tseeb ntawm txoj kev lag luam kev lag luam, tab sis es siv los ua piv txwv lub tswvyim.
Lub Hom Phiaj: Kom txo 3- aminopropanol ({{1} inopropanol) los ntawm hydrogenation.
Cov kev mob tshuaj tiv thaiv: nyob rau hauv muaj catalysts (xws li platinum, palladium, thiab lwm yam), hydrogen roj yog siv rau kev txo hydrogenation txo.
H2Nch2cn +2 h 2+ {catalalst → H2Nch2chOhoh
Lub Hom Phiaj: Los hloov 3- Aminopropanol mus rau hauv kev sib raug zoo hauv kev npaj rau kev sib txuas lus ntau ntxiv.
Cov tshuaj tiv thaiv: Cov tshuaj tiv thaiv ntawm cov tshuaj pleev pob zeb hauv acyl (propionic acid thiab roj cawv yog feem ntau nqa tawm hauv cov kab mob alkaline.
H2Nch2ch2ch2oh + (ch3co) 2O + catalyst → ch3cooch2ch2nh2chn2 {12}} ch3cooh
Lub Hom Phiaj: Los hloov cov Esters mus rau hauv cov tebchaw uas muaj cov qauv tseem ceeb ntawm nws. Vim yog cov qauv nyuaj ntawm Pregabalin, cov kauj ruam no yuav koom nrog ntau yam kev tawm tsam thiab kev tsim cov nruab nrab.
Cov kev mob tshwm sim: Cov kauj ruam no yuav xav tau cov catalysts, kub thiab siab, nrog rau cov kev tiv thaiv kev tiv thaiv kom ntseeg tau tias muaj cov pab pawg ua haujlwm tau tseeb.
Hypothetical cov kauj ruam theem: rau kev yooj yim, peb xav tias muaj kev ua haujlwm nruab nrab uas yog cov qauv ua ntej rau cov pab pawg ua haujlwm lossis muaj cov pab pawg sib txawv.
Ch3Cooch2ch2ch2ch2ch2ch2nh {4}}} catalaltys → Intermediat
Nruab Nrab + catalyst → pregabalin zoo li cov qauv
Lub Hom Phiaj: Hloov kho cov pab pawg ua haujlwm ntawm cov txheej txheem ua haujlwm ntawm Pregabalin kom tau txais cov qauv pregabalin kawg.
Cov kev mob tshwm sim: nyob ntawm cov pab pawg ua haujlwm xav tau, nws tuaj yeem suav nrog oxidation xws li oxidation, txo, halogenation, eliation, thiab lwm yam.
Pregabalin zoo li tus qauv + catalyst → C8h17No2
Lub Hom Phiaj: Hloov Pauv Pregabalin rau hauv nws cov ntawv hydrochloride kom nce nws cov dej solubility thiab ruaj khov.
Cov mob tshwm sim: ntxiv hydrochloric acid mus rau ib qho kev tsim nyog, xws li ethanol lossis isopropanol.
Pregabalin + HCL → C8H18N2O
Lub Hom Phiaj: Hauv cov txheej txheem synthesis tiag, feem ntau nws yog feem ntau tsim nyog los tsim cov qauv tseem ceeb ntawm cov txheej txheem tseem ceeb, uas muaj kev npaj thiab sib cais ntawm cov lej ntawm nruab nrab.
Cov kev mob tshwm sim: Cov kev tawm tsam no yuav xav tau cov lus catalysts, kub, thiab lub siab, thiab cov tshuaj tiv thaiv lub siab los ua kom cov tshuaj tiv thaiv.
Lub Hom Phiaj: Pregabalin muaj chiral carbon atom, yog li nws cov txheej txheem synthesis yuav tsum muaj cov lus qhia thiab sib cais ntawm cov chaw teev ntuj chiral.
Txoj Kev: Qhov no feem ntau yog ua tiav los ntawm kev siv chairal catalysts, chairal reagents, lossis chiral separators. Piv txwv li, ib qho enantiomer ntawm Pregabalin tuaj yeem npaj los ntawm Asymmetric synthesis lossis chiral sib cais.
Nco tseg: Chiral synthesis thiab sib cais yog cov txheej txheem sib txuas thiab cov txheej txheem sib txawv uas yuav tsum muaj kev tswj hwm cov kev xav tau thiab cov kauj ruam kev ua haujlwm.
Lub Hom Phiaj: Txhawm rau txhim kho cov txiaj ntsig, kev ua kom zoo nkauj, thiab ntau lawm tau ua kom zoo rau cov xwm txheej zoo nkauj thiab cov txheej txheem ua haujlwm.
Txoj kev: Qhov no suav nrog kev kuaj cov catalysts, kho cov tshuaj tiv thaiv kub xws li, txhim kho cov ntsiab lus ntws kuj tseem siv tau los txhim kho kev ua tau zoo.
XIM: Cov txheej txheem tsim nyog yuav tsum tau nkag siab txog qhov cuam tshuam xws li tus nqi xws li tus nqi, ib puag ncig ua phooj ywg, thiab cov khoom lag luam zoo.
Lub Hom Phiaj: Tom qab txiav txim siab cov txheej txheem hluavtaws tsim nyog thiab cov txheej txheem tsim nyog los ntsuas cov txheej txheem synthesis kom muaj nruj me ntsis tswj hwm.
Txoj Kev: Qhov no suav nrog cov txheej txheem tsim nyog, xaiv cov cuab yeej tsim tsim tsim tsim nyog, thiab tsim cov qauv kev tswj hwm zoo. Ib qho ntxiv, kev tsom xam dav thiab ntsuas cov khoom siv raw, cov khoom lag luam nruab nrab, thiab cov khoom siv zaum kawg yuav tsum ua kom muaj kev nyab xeeb thiab kev nyab xeeb ntawm cov khoom.
Txawm hais tias cov saftthesis saum toj no yog qhov yooj yim thiab hypothetical, nws muab lub tswv yim lub tswv yim kom nkag siab txog cov kauj ruam yooj yim thiab cov ntsiab cai ntawmPregabalin Hmoovsynthesis. Txoj kev tseeb hluav taws xob yuav suav nrog ntau qhov kev cuam tshuam ntau thiab cov kev tshwm sim nyuaj. Tsis tas li ntawd, rau cov kev tsim khoom loj-teev cov khoom lag luam, ntau cov hau kev nyuaj thiab cov hluavtaws hluavtaws muaj txiaj ntsig zoo tshaj plaws hauv kev lag luam.
Cov qauv molecular yam ntxwv ntawm Pregabalin muab nws qee cov khoom siv hluav taws xob tshwj xeeb thiab nws muaj ntau cov kev siv hauv kev kho mob.
1. Molecular qauv qauv
Lub npe tshuaj lom neeg ntawm nws yog (s) -3- (Aminomethyl) {}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}, tsuas yog 159.23 muaj ntau dua). Nws yog ib qho dawb kom tawm-dawb hmoov los yog dawb crystalline hmoov nrog lub melting point ntawm 194 mus rau 196 degree. Nyob rau hauv cov qauv molecular, nws yog tus cwj pwm ua ib qho kev ua yeeb yam ntawm gamma-aminobutyric acid (gaba), tab sis tsis khi ncaj qha rau Gabaa, Gabab, lossis Benzodiazepine recepors.
2. Pharmacological Cov Khoom Siv
High affinity rau 2- Δ Site:
Nws muaj kev sib txawv ntawm 2-} Δ δ δ δ δ site (ib tug kwv yees subunit ntawm voltage-gated calcium raws) nyob rau hauv nruab nrab lub paj hlwb. Qhov kev khi no yuav siv nws cov tshuaj pharcacologic los ntawm Modulating Calcium channel muaj nuj nqi thiab txo cov calcium-muaj kev tso tawm ntawm qee cov neeg neurotransmitters.
Analgesic thiab anticonvulsant cuam tshuam:
Cov txiaj ntsig los ntawm kev tshawb fawb hauv Transgenic Cov Tsiaj thiab Cov Qauv Txheej Txheem Tshaj Tawm (eg Nyob rau hauv cov kev tshawb fawb vitro kuj tseem yuav ua tau zoo hauv kev tswj hwm calcium chacium muaj nuj nqi, nrog rau kev txo qis dua hauv kev ntxim siab neurotransmitter tso.
Kev Nyab Xeeb thiab Zam Txim:
Nws tau pom muaj kev nyab xeeb nyab xeeb thiab thev tau muaj peev xwm ua haujlwm hauv chaw kuaj mob. Txawm li cas los xij, cov nyom tau zoo yog koob tshuaj-nyob thiab yuav ua rau cov nqi tsev kawm ntawv dua. Cov kev sib raug zoo xws li kiv taub hau, tsaug zog, qhov ncauj qhuav, Edema, tau txais lub zeem muag thiab qhov hnyav.
3. Cov khoom thov hauv kev kho mob teb
Postherpetic neuralgia:
Pregabalin tshuaj ntsiav yog cov tshuaj feem ntau rau kev kho ntawm postherpetic neuralgia. Nws txo qhov mob thiab txhim kho cov neeg mob lub neej zoo los ntawm kev tswj hwm kev tso tawm ntawm neurotransmitters.
Kev ncua kev kho mob ntawm epililsis:
Nws kuj yog siv los ua kev kho mob kom muaj kev qaug dab peg ib nrab. Los ntawm inhibiting 2-} Δ subunit ntawm voltage hlab ntsha, Pregabalin Recuces Neuronal excitability, yog li tswj hwm qaug dab peg.
Sciawsica:
Cov kev tshawb fawb soj ntsuam tau pom tias nws tau ua tau zoo dua li cov tshuaj antiepileptic tshuaj carbamazepine hauv kev kho kom muaj sciatica. Nws tuaj yeem txo cov kev tso tawm ntawm cov kev txaus siab neurotransmitters, mob siab rau neuropathic mob, thiab cov kev tsis zoo me, zoo siab.
Hauv cov ntsiab lus, nws muaj ntau yam ntawm kev thov kev cia siab hauv kev kho mob teb los ntawm nws cov cim roj ntsha cim thiab cov khoom siv pharacological. Txawm li cas los xij, nws txoj kev tsis zoo thiab dose cov kev ntseeg tau yuav tsum tau sau tseg thaum siv los xyuas kom tus neeg mob nyab xeeb.
Cim npe nrov: Pregabalin Hmoov Cas 148553-50-8, cov chaw muag khoom, chaw tsim khoom, Hoobkas, yuav, nqe, loj, rau muag