Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov khoom lag luam tshaj plaws thiab cov khoom lag luam ntawm cov khoom ntiag tug 130-86-9 nyob hauv Suav teb. Txais tos rau kev lag luam wholesale tej ntshav siab zoo protopine CAS 130-86-9 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Kev tiv thaivyog ib qho isoquinoline alkaloid uas tau faib tawm hauv ntau cov papaveraceae, berberaceae, thiab menispermaceae tsev neeg. Nws yog ib qho tseem ceeb ntawm cov tshuaj suav cov tshuaj austrophine, uas muaj qhov ua kom muaj kev sib piv thiab sedative. Nws cov qauv molecular yog qhov tshwj xeeb, muaj ob qho cim ntawm phenyylmethylisoquinibine thiab protocatechuic acid. Qhov no heterocyclic ua haujlwm ua rau nws cuam tshuam nrog ntau neurotransmitter receptors thiab ion raws. Cov kev tshawb fawb ntawm lub cev kws tshuaj tau pom muaj ntau yam {{4 4}} gi ant target target {{{- muaj kev ntxhov siab; Nyob rau tib lub sijhawm, nws tuaj yeem sib tw heev txwv ion} {}}} hom opioid receptors, exererting tsis- txig analgesic cuam tshuam; Hauv cov hlab plawv, cov khoom sib xyaw no tuaj yeem ua rau muaj calcium influcation, thiab muaj kev cuam tshuam nrog kev ua si ntawm vascular du cov leeg. Cov kev tshawb fawb tsis ntev los no tau pom tias nws tuaj yeem tsis muaj qog cond enpoptosis, qhia anti {{cov qog. Vim nws qhov ncauj qis dua, cov kws tshawb nrhiav tau txhim kho derivatives ntawm protopine los ntawm kev hloov kho txheej txheem. Qhov molecule ntuj no, nrog nws cov cim ntau - Qhov tseem ceeb thiab kev quav yeeb yam tseem ceeb rau kev txhim kho cov tshuaj rau kev tsis sib haum xeeb thiab kev mob hlwb.
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Tshuaj Cov Qauv |
C20h19No5 |
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Muaj pes tsawg leej |
353.13 |
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Molecular hnyav |
353.37 |
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m/z |
353.13 (100.0%), 354.13 (21.6%), 355.13 (2.2%), 355.13 (1.0%) |
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Kev Ntsuam Xyuas |
C, 67.98; H, 5.42; N, 3.96; O, 22.64 |
Kev tiv thaivyog ib qho alkaloid muab rho tawm los ntawm cov nroj tsuag poppy, uas muaj ntau cov hluav taws xob cuam tshuam thiab cov kev thov kev cia siab.
Analgesic nyhuv
Thawj Opioid alkaloids muaj qhov tseem ceeb analgesic cuam tshuam, feem ntau los ntawm kev ua yeeb yam ntawm nruab nrab ntawm kev sib kis, ua kom muaj kev sib kis mob ntawm kev mob teeb meem thiab kev ua kom muaj kev cuam tshuam opositors thiab kev tsim cov teebmeem analgesic. Cov xeeb ceem no ua rau opioids ua si lub luag haujlwm tseem ceeb hauv kev kho mob.
(1) Kev kho mob mob ntev:
Thawj opioid alkaloids tuaj yeem siv los kho ntau yam mob caj dab ntev yog ntev}}}}} Ua kom zoo txhim kho lub neej ntawm cov neeg mob.
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(2) Kev tswj hwm mob hnyav:
Hauv kev tswj hwm ntawm kev mob mob hnyav xws li phais mob analesia thiab mob cancer, opioids kuj tau pom cov txiaj ntsig zoo. Los ntawm kev txo cov kis mob ntawm cov cim taw qhia, opioids tuaj yeem txo tus neeg mob mob kom hnov mob.
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(3) Daim Qauv Opioid Alkaloids
Nws tseem muaj cov anti tseem ceeb - txoj kev cuam tshuam nrog, uas tuaj yeem cuam tshuam nrog kev tsim khoom thiab tso tawm cov tshuaj tiv thaiv mob siab, yog li txo cov tshuaj tivthaiv. Cov xeeb ceem no ua rau opioids ua si lub luag haujlwm tseem ceeb hauv kev kho mob ntawm cov kab mob.
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(4) mob tshuaj tiv thaiv kab mob tiv thaiv kab mob:
Proto opioid alkaloids tuaj yeem siv los kho cov kab mob ntau, enhomiting cov tshuaj tivthaiv cov tshuaj tivthaiv cov tsos mob thiab lwm yam.
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(5) Kev Txhim Kho Tshuaj thiab Daim Ntawv Thov:
Raws li cov anti {- paps cov khoom ntawm opioids, cov kws tshawb nrhiav tau tsim ntau yam- kev siv tshuaj. Cov tshuaj no tau qhia tau zoo rau kev kho mob, muab cov neeg mob nrog cov kev kho mob tshiab.
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Antioxidant nyhuv
Oxidative kev nyuaj siab yog ib qho txheej txheem pathoticsiological hauv ntau cov kab mob uas muaj mob thiab kev rov kho dua tshiab, uas tuaj yeem ua rau muaj kev puas tsuaj ntawm tes thiab cov ntaub so ntswg. Proto opioid alkaloids muaj antioxidant cov khoom, tuaj yeem ua Scremenge dawb radicals, thiab tiv thaiv cov hlwb los ntawm oxidative kev puas tsuaj.
(1) antioxidant kev kho:
Hauv kev kho mob kho mob, tshuaj tiv thaiv kab mob antioxidant pab txo qis kev puas tsuaj theem nrab, txhawb nqa cov kev kho mob ntawm tes thiab ua kom rov zoo. Cov nyhuv antioxidant ntawm cov tshuaj tiv thaiv ua rau nws yog cov tshuaj tseem ceeb rau kev kho mob antioxidant.
(2) Kev Kho Mob ntawm Nurodegenerative Kab Mob:
Cov nyhuv antioxidant ntawm opioids kuj tseem yuav kho cov kab mob nurodegenerative xws li Parkinson tus kab mob. Los ntawm kev tshem tawm dawb radicals, opioids tuaj yeem tiv thaiv cov leeg hlwb los ntawm oxidative kev puas tsuaj, yog li ncua kev nce qib ntawm cov kab mob.
Kev tiv thaiv kab mob tsis muaj zog
Lub cev tsis muaj zog ua lub luag haujlwm tseem ceeb hauv tib neeg lub cev, thiab kev tiv thaiv kab mob txawv txawv tuaj yeem ua rau muaj ntau yam kab mob. Proto opioid alkaloids muaj immunomodulatory kev cuam tshuam, uas tuaj yeem tswj txoj haujlwm thiab kev ua tsis muaj zog ntawm lub cev tiv thaiv kab mob.
(1) Kev kho mob ntawm cov kab mob muaj kabmob tiv thaiv:
Proto opioid alkaloids tuaj yeem siv kho cov kab mob pib tawm, thiab cov haujlwm ntawm cov kab mob thiab kev tswj hwm tuaj yeem tswj tus kab mob thiab txhawb kev mob rov qab.
(2) Mob qog nqaij daim tawv:
Proto opioid alkaloids kuj muaj cov ntawv thov yuav muaj txiaj ntsig nyob rau hauv qog nqaij daim ntaub. Kev tshawb fawb tau pom tias opioids tuaj yeem inhibit txoj kev loj hlob thiab metastasis ntawm cov qog ntshav, thaum txhim kho cov txiaj ntsig} Cov kab mob ntawm lub cev. Qhov no muab cov tswv yim tshiab thiab cov hau kev rau cov qog nqaij daim tawv nqaij.
Kev Ua Haujlwm Cardiovascular System Muaj nuj nqi
Thawj Opioid alkaloids kuj muaj qee qhov cuam tshuam ntawm cov hlab plawv, uas tuaj yeem txo cov ntshav tawm tsam, thiab txhim kho microcirculation.
(1) Kev Kho Mob Kab Mob Kab Mob:
Thawj opioid alkaloids tuaj yeem siv los kho cov kab mob plawv kev noj ntshav xws li mob miteonary muaj cov tsos mob ntawm cov kab mob plawv.
(2) Txoj haujlwm ntawm kev txhawb cov ntshav ncig thiab tshem cov ntshav (STARIS
Hauv cov tshuaj yeeb tshuaj yeeb tshuaj ib txwm muaj,kev tiv thaivMuaj lub luag haujlwm ntawm kev txhawb cov ntshav ncig thiab tshem cov ntshav ntshav. Los ntawm kev txhim kho cov ntshav ncig, cov tshuaj opioids tuaj yeem pab txo cov tsos mob xws li qhov mob thiab o los ntawm cov ntshav ntshav.
Neurological muaj nuj nqi
Proto opioid alkaloids kuj muaj ntau yam ntawm cov paj hlwb, suav nrog kev ua kom loog, anticonvulsants, thiab lwm yam.
(1) Kev kho mob ntawm neurological?
Tseem thawj opioid alkaloids tuaj yeem siv los kho cov kev mob neurological xws li insomology, etioids tuaj yeem daws cov tsos mob ntawm cov neeg neurological.
(2) Cov nyhuv neuroprotective:
Cov kev tshawb fawb pom tau tias opioids kuj muaj cov teebmeem neuroprotefotive, uas tuaj yeem cuam tshuam cov neuronal apoptosis, txhawb nqa Nuronal Ciaj sia thiab kev tsim dua tshiab. Qhov no muab cov kev kho tshiab rau kev kho cov kab mob neurodegenerative.
Proto opioid alkaloids, kuj tseem hu ua prutropine, tshuaj pleev ib ce, hawb pob, hnoos qeev, tshuaj tua kab mob, thiab cov tshuaj tiv thaiv kab mob antibacterial. Lawv tuaj yeem siv los kho cov kab mob xws li rethalt, anti malaria, thiab anti thrombosis. Lawv kuj siv tau ua tus sawv cev ua haujlwm, thiab cov leeg nqaij cov leeg, thiab muaj cov ntawv thov kev kho mob zoo. Cov Opiate qub yog lub crystal monoclinic (ephanol chloroform). Melting taw tes 208 degree. DUAB hauv 15 qhov chaw chloroform, 900 Qhov Ethanol, 1000 ntu Etete, me me soluble hauv ethyl accelate, bolroleum ether, yuav luag insoluble hauv dej. Nws muaj analgesic, antispasmodic, hnoos suppressionant, antipicelot cuam tshuam, microvaschidal kev sib tw ntawm pentobarbital solient ntawm pentobarbitalidal thiab antipicidal kev cuam tshuam thiab anti- cov qog. Yuav siv tau los kho cov kab mob retinal thiab anti thombicial teebmeem.
Rho tawm ntawm protoopine los ntawm jujube xya
CN201310165386.7 Muab ib txoj hauv kev rau rho tawm cov nyom ntawm Jujube Xya, uas yog cov nqi qis, thiab ua siab zoo, thiab ua siab zoo- puritykev tiv thaivCov. Tam sim no tsim muaj los ntawm kev daws teeb meem hauv qab no: ib txoj kev rau kev rho tawm cov nyom ntawm Jujube Xya, muaj cov kauj ruam hauv qab no:
Siv tag nrho cov alkaloid extract ntawm fructus ziziphi thiab thauj nws mus rau ib qho alkaline silica gel kem. Siv cov chloroform methanol system yog cov eluent thiab ua gradient elient elient elient ntawm lub ntim piv ntawm (200: 1) rau (1). Tshawb pom lub effluent thiab sib txuas cov leb feem nrog cov ntim piv ntawm (30: 1) rau (10: 1). Evaporate cov kuab tshuaj kom tau txais cov ntu theem theem nrab;
Nqa cov kab xwm theem ob thiab thauj nws mus rau ib qho alkaline silica gel kem. Siv cov chloroform methanol system yog cov eluent thiab ua gradient elient elient elaws ntawm ib qho piv ntawm (50: 1) rau (10: 1) kom paub txog effluent. Muab cov leb feem sib xyaw nrog tib qhov chaw loj thiab yaj cov kuab tshuaj kom tau txais cov kab ntawv hauv kab lus theem nrab;
Qhov thib ob nplooj ntawv dhau ib feem yog cov qauv ntawm Dextran Gel kem, Chloroform - Methanol system yog siv raws li cov neeg eluent, thiab cov lus piv yog 1: 1 rau kev lees paub sib luag. Cov effluent tau kuaj pom. Tom qab distillates nrog tib lub chaw tseem ceeb tau sib xyaw ua ke, cov kuab tshuaj yog evaporated kom tau txais daim ntawv thib peb ib feem;
Tom qab rov qab ntxuav cov kab thib peb nrog Methanol, thawj cov khoom siv OPOUd tau txais.
Piv nrog cov thev naus laus zis uas twb muaj lawm, qhov muaj tswv yim tam sim no muaj cov txiaj ntsig zoo hauv qab no:
Tam sim no tsim muaj yog ib txoj hauv kev rau kev rho tawm protopioid alkaloid alkaloid alkaloids los ntawm Radix Calligonum rau cov tshuaj suav suav. Hauv txoj kev no, tag nrho cov alkaloids ntawm radix cheedigonum yog thawj kem, thiab thaum kawg rau kev sib luag los ntawm Dextran Gel kem kom tau protoopiod alkaloids. Cov txheej txheem ntawm cov tsim tam sim no yooj yim thiab yooj yim siv, nrog tus nqi qis, thiab lub purity, thiab lub purity ntawm lub storated thawj lub hauv paus pib tshaj 99%.
Purification ntawm protopeopine los ntawm cov dej sov
Ib txoj hauv kev rau kev huv kev ua kom huv ntawm cov tshuaj ntsuab lub caij ntuj sov, cov cim los ntawm cov kauj ruam hauv qab no:
1. Ephanol Extraction:
Zuaj cov ntaub ntawv nyoos los ntawm lub caij ntuj sov, ntxiv 85-95% ethanol rau refrectx extraction, extract 2-3 lub sij hawm, lim thiab sib txuas cov kua rho tawm;
2. Membrane sib cais:
Mloog cov extract hauv qab txo qis rau kev haus cawv ntawm 30-40% thiab ntxiv nws rau acetic acid. Ua ntej, lim nws los ntawm microfiltration membrane system, thiab tom qab ntawd ultrafiltration nws los ntawm ultrafiltration membrane system thiaj li sau cov permeate;
3. Sib xyaw Resin txhawb zog:
Qhov saum toj no -}} hais txog permeated thiab adsorbed los ntawm cov mastered resin kem, thiab cov muaju tau muab tso rau kom tau txais cov muaju crude;
4. Crystallization:
Dissalate cov crude muaju hauv ethanol ntawm RefleLux Saturation, lim lub muaju, tso cov muaju, lim thiab qhuav kom tau cov khoom.
Kev npaj ua qauv:
Nqa cov thawj opioid puag, ntxiv tshuaj siv tshuaj, thiab npaj cov ntsiav tshuaj lees paub, thiab cov tsiav tshuaj, thiab cov muag tshuaj mos, thiab cov tshuaj pleev muag cov tshuaj.
Coj cov khoom siv opiate, ntxiv cov khoom siv hluav taws xob ua kom zoo nkauj, kom cov ntsiab lus ntawm cov roj ntsha Lim membrane, sau thiab sterilize kom tau.
Nqa cov khoom siv raw ntawm protoopioid puag qaib los ntawm ultrasonic lossis lim dej kom qhuav, ntim cov pa roj hmab los yog siv lub taub hau me me, sib cais nws hauv penicillin fwj tsis muaj kab mob, thiab tom qab ntawd npogkev tiv thaiv.
Protopine, ib tug bioquat aiminoline alkaloid nrog kev nplua nuj keeb kwm hauv cov tshuaj ib txwm muaj, tau tawm los ntawm kev siv tshuaj kho mob nrog cov khoom siv hluav taws xob. Nws antioxidant, anti {{{{{ Txawm li cas los xij, cov kev sib tw xws li tsis zoo bioavailability thiab txwv siab {{3} Kev saib xyuas cov ntaub ntawv zoo yuav tsum tau hais kom paub txog nws lub peev xwm. Kev tshawb fawb yav tom ntej yuav tsum tsom rau kev siv lub tshuab hloov kho, tshawb xyuas kev kho mob, thiab ua cov pov thawj nyuaj los tsim pov thawj rau nws siv. Raws li lub nra thoob ntiaj teb ntawm tsis - Cov kab mob sib txuas lus nce, kev sib txuas lus zoo, Bridging qhov sib txawv ntawm kev txawj ntse ib txwm muaj thiab cov chaw muag tshuaj niaj hnub.
Cim npe nrov: Cov Nyiaj Pov Thawj 130-86-9, cov chaw muag khoom, chaw tsim khoom, chaw tsim khoom, lag luam, yuav khoom, nqe, loj, rau muag