Ntshiab oxymetazoline CAS 1491-59-4

Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab cov khoom siv oxymetazoline li 1491-59-4 hauv Suav. Txais tos rau kev lag luam wholesale loj zoo ntshiab ntshiab oxymetazoline CAS 1491-59-4 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Ntshiab oxymetazoline, CAS 1491 {{{{{{}} 59-4, molecular formula c16h24n2o yog benzene compound uas zoo nkaus li tsis muaj kob lossis muaj lub qab zib. Nyob ntawm chav tsev kub, soluble hauv dej, dej cawv, thiab qee cov kuab tshuaj organic. Nws yog ib qho tseem ceeb organic tshuaj nrog ntau cov ntawv thov. Hydroxymetazoline yog alpha agonist nrog zoo peripheral vasoconsctive zoo cuam tshuam. Nws tsim kev txwv ntawm kev ua kom cov hlab ntshav ua kom cov hlab ntsha ntawm kev ua kom zoo ntawm vascular alpha-1 receptors, yog li txo kev ua txhaum thiab edema tshwm sim los ntawm kev ua paug. Hydroxymetazoline yuav siv sij hawm sai sai, feem ntau nyob rau hauv ob peb feeb, thiab kav ntev li ob peb teev, zoo relieving ntswg. Ib qho ntxiv, nws muaj cov nyhuv antihistamine, uas tuaj yeem inhibit tawm ntawm cov kab mob uas tsis muaj zog, thiab caj pas rau cov tshuaj haxosa, nthuav qhia cov tshuaj tua kab mob zoo.

Ntshiab oxymetazoline, raws li ib tug sawv cev siv tshuaj ntawm alpha adrenor econists catcular cultionors nyob rau hauv cov dej sib tw ua ke ntawm cov dej ntawm OtolaryGology thiab ophthalmology. Nws qhov tseem ceeb siv revolves nyob ib ncig ntawm lub pathological ntawm lub Nasal mucosa thiab ob lub qhov muag kom sai sai thiab pab kho mob.

Tus tub ntxhais txoj haujlwm ntawm kev siv tshuaj vasal

 

1. Mob rhinitis thiab txias ntsig cov ntswg congestion
Hydroxymetazoline yog cov tshuaj pleev ib ce uas nyiam tshaj plaws rau kev mob rhinitis (txias). Los ntawm kev txwv cov hlab ntshav ntawm lub ntswg ntswg ntawm lub ntswg mucosa, qhov ntswg turvased o tuaj yeem txo nyob rau hauv 5-10 feeb xws li qhov ntswg tsis zoo thiab los ntswg tuaj yeem ua tau. Cov chaw kuaj mob qhia tau hais tias tom qab siv ib zaug ntawm 0.05% qhov cua muaj peev xwm nce ntxiv los ntawm 60% -80%, kav ntev rau 8-12 teev. Rau cov neeg mob pediatric hnub nyoog 6 thiab siab dua, nws raug nquahu kom thov kev noj qab haus huv ib hnub ob zaug kom ua kom zoo tsis txhob muaj kev phiv los.

 

2. Ua ke kho rau kev ua xua
Hauv kev kho mob rhohomitis tsis haum, hydroxymetazoline ua haujlwm los ntawm ob lub tshuab sib txawv: Firstly, nws ncaj qha ntawv cog lus cov hlab ntsha kom txo qis tshuaj quav taus kom txo qis tshuaj quav av kom txo qis tshuaj quav taus los txo qis tshuaj tiv thaiv kab mob kom txo qis. Qhov thib ob, nws inhibits qhov tso tawm ntawm cov neeg sib kho mob xws li keeb kwm, txo cov tsos mob xws li txham thiab qhov khaus nawb. Lub triple kho ntawm "hydroxymetazoline + antihistamines + cov tshuaj steroids + nasal siv nyob rau hauv chaw kuaj mob, uas txhim kho kev tswj hwm tus nqi. Piv txwv li, rau cov neeg mob uas muaj kev sib xyaw raws caij nyoog muaj kev sib deev thaum sawv ntxov, thiab siv cov tshuaj lom neeg kom tsis txhob muaj kev ua xua ntawm cov tshuaj tsw qab.

 

3. Kev kho mob tshwj xeeb ntawm cov tshuaj rhinitis
Hypertrohic rhinitis: Lub sij hawm ntev mucosal hypertrophed ua rau muaj kev pheej hmoo noj, thiab kev ceev faj yuav tsum tau ua rau muaj kev pheej hmoo ntawm cov tshuaj - ua rau rhinitis.
Vasomotor Rhinitis: Rau cov neeg nkag siab qhov kub thiab cov av noo hloov, hydroxymetazoline tuaj yeem thaiv cov vasduaj cov tshuaj tiv thaiv, thiab nws raug nquahu kom siv nws raws li xav tau.
Cev xeeb tub ua rau muaj kab mob cev xeeb tub: Cov poj niam cev xeeb tub yog nquag mus rau cov kev sib tw tsis zoo vim kev hloov pauv cov qib kev hloov pauv ntawm qib. Hydroxymetazoline muaj kev nyab xeeb ntau dua profile rau luv- kev siv ntshav, tab sis nruj kev soj ntsuam cov ntshav siab yog qhov tsim nyog.

 

4. Txawj Ntse Kho rau Kev Kho Mob Rhinosinusitis
Mob Sinusitis cov neeg yuav mob feem ntau muaj cov kua dej tsis zoo vim yog o ntawm lub txhaum mucosa. Hydroxymetazoline tuaj yeem daws cov hlab ntshav ib ncig ntawm lub rooj zaum qhib, txhim kho qhov cua thiab kua paug. Kev tshawb fawb tau pom tias siv hydroxymetazoline peb hnub ua ntej kev phais mob tuaj yeem tiv thaiv kev phais mob los ntawm 30%}} 40%, thiab postoperative sib xyaw ua ke ntawm Sinus Adhesions. Rau cov neeg mob nrog kev sib xyaw ua ke Nasal polyps, luv luv siv ntawm hydroxymetazoline tuaj yeem txo cov polyps thiab tsim cov mob rau kev phais cov kev phais.

Kev nthuav dav thiab txheej txheem ntawm cov ntawv thov ophthalmic

 

1. Cov tsos mob ntawm kev ua xua ntawm kev ua xua
Hydroxymetazoline qhov muag poob (0.025% -0.05%%, cov tsos mob xws li hauv 15 feeb los ntawm cov hlab ntshav rau cov hlab ntshav. Nws tau txais txiaj ntsig zoo nyob rau hauv nws cov nyiaj rov qab dua cov tshuaj antihistamines, tshwj xeeb tshaj yog haum rau kev tawm tsam kev tawm tsam. Cov chaw kuaj mob suav nrog 2-3 zaug nyob rau ib hnub, nrog ib hnub kev kho tsis tshaj 7 hnub, kom tsis txhob ua rau ua rau rov qab tsis sib haum.

2. Kev pab cuam uas yuav tsum ua rau cov neeg tsis mob kis tau
Hydroxymetazoline tuaj yeem txhim kho cov tsos ntawm kev haus luam yeeb tshwm sim los ntawm cov pa luam yeeb, lub ntsej muag nrov, tab sis kis tau ua rau raug txiav txim.

 

Piv txwv li, ua ntej siv hydroxymetazoline hauv cov neeg mob SAC kev ua luam dej tom qab ua luam dej yuav tsum tau ua ua ntej los tiv thaiv cov tshuaj tiv thaiv kab mob.

3. Npaj tseg rau kev phais mob ophthalmic
Ua ntej cataract, caj pas thiab lwm yam kev phais mob, hydroxymetazoline qhov muag tuaj yeem daws cov qe ntshav ib puag ncig tus tub ntxhais kawm, txo qhov kev pheej hmoo ntawm kev pheej hmoo los ntshav. Kev tshawb fawb tau pom tias siv 0.05% Ntshav 30 feeb ua ntej kev phais mob tuaj yeem txo cov kev sib txuas lus los ntawm 50% thiab txhim kho kev phais phais ntawm 30%.

Tus kwv tij tus nqi hauv kev phais thiab tshuaj ntsuam xyuas

 

1. Kev tswj hwm ntawm Nasal endoscopic phais
Daim Ntawv Thov Hauv Zos ntawm Hydroxymgine Paj Ntse tuaj yeem txiav cov tshuaj qab ntswg roj mucosa, tso cai rau kev phais kom tiav. Piv txwv li, nyob rau hauv kev kho ntawm Nasal Septum Trainiation kev phais, tso cov ntaub paj rwb hauv 0.05% daws hauv qab ntawm 80mL thiab lub sijhawm phais 20CL thiab luv.

2. Kev ua kom zoo ntawm CT / MRI kuaj cov kev pab
Rau cov neeg mob nrog sinusitis, kev siv ntawm hydroxymetazoline ua ntej kev kuaj mob, txo cov nqaij mos saum toj no, thiab txhim kho kev tshawb pom tus nqi ntawm cov txhab.

 

Nws raug nquahu kom txhaj 2 tshuaj tsuag mus rau hauv cov kab ke tsis sib xws 30 feeb ua ntej kev soj ntsuam, uas tuaj yeem nce cov maxillary sinus translucency los ntawm 40%.

3. Kev ntsuam xyuas ntawm adenoid hypertrophy hauv cov menyuam yaus
Ua ntej noj nasopharyngeal tom qab sab nraud, kev siv ntawm hydroxymetazoline tuaj yeem txo qhov ntim ntawm adenoids thiab ntau ntsuas lawv qib ntawm txoj haujlwm. Kev tshawb fawb tau pom tias Adenoid Nasopyngeal piv (A / N tus nqi) txo los ntawm qhov nruab nrab ntawm 0.15 tom qab cov tshuaj sib txawv ntawm kev sib txawv ntawm lub cev thiab cov kev sib tw.

Cov ntawv thov kev kho mob hauv cov xwm txheej tshwj xeeb

 

1. Kev tiv thaiv ntawm kev txhaum kev txhaum
Thaum lub sij hawm high - ya davhlau, kev hloov pauv hauv txee rau hauv txee kom yooj yim ua rau tsis muaj kev txhaum ntawm lub cav mucosa. Siv hydroxymetazoline 30 feeb ua ntej lub plab ua haujlwm tuaj yeem tiv thaiv kev txhaum kev mob, tshwj xeeb tshaj yog cov ya dav hlau nquag. Nws raug nquahu kom tsuag ib lub nozzle ib sab ntawm qhov ntswg kab noj hniav thiab rov ua txhua 6 teev thaum lub davhlau.

2. Kev tswj hwm xwm ceev ntawm qhov ntswg
Lub zos compression ntawm hydroxymgine paj rwb ntaub qhwv tau sai sai los ntawm kev tawm tsam cov ntshav ib puag ncig ntawm kev hemostasis tuaj yeem ncav cuag 90%.

 

Txhawm rau los ntshav hauv cheeb tsam LI, nws raug nquahu kom siv 4CM × 1cm cov ntaub qhwv dawb huv si hauv 0.05% daws, uas tuaj yeem siv tau rau 5 feeb kom siv tau.

3. Detoxification Ntawm Yeeb Tshuaj Ntau
Txom Nyem qhov ncauj ntawm hydroxymetazoline (xws li Nasal poob rau cov menyuam yaus) tej zaum yuav ua rau mob hypotension thiab bradycardia. Cov kev kho yuav tsum tau txhaj tshuaj phenolamine tam sim ntawd (Alpha receptor antagonist), nrog thawj zaug ntawm 0.1-0.5mg / kg, thiab txoj kev lis ntshav ntaus raws li ntshav siab.

Muaj ob txoj hauv kev rau kev npaj ntawmNtshiab oxymetazoline.

1. Los ntawm acid catalysis ntawm fructose

Fructose yog rhuab thiab ua kom pom nyob rau hauv acidic tej yam kev mob rau hydrolyze rau carbyze rau carboxydehyde cov tshuaj tiv thaiv kom tau oxymetazoline. Fructose (fructose) yog ib tug monosaccharide uas tuaj yeem yog cov carbyzed rau carboxydes thaum rhuab tsis muaj oxymetazoline. Cov hauv qab no yog cov txheej txheem siv tshuaj lom neeg thiab cov txheej txheem hluavtaws rau cov kua qaub- catalalzed cov tshuaj tiv thaiv ntawm fructose los tsim oxymetazoline.

Hydrolysis tiv thaiv ntawm fructose:

C6h12O6 (Fructose) + h2o (dej) → c6h12o6 (carboxyaldehyde)

Lub cev qhuav dej ua rau cov tshuaj tiv thaiv kom haum:

[2C6H12O6 \\ ntawv {(C6h12O6)} \\ endarrowc12h24o12} + h2o]

Cov txheej txheem hluavtaws:

Ua ntej, fructose tau ua rau muaj cua sov nrog cov huab cua acidic thiab hydrolysis tshwm sim los tsim carboxyaldehyde.

Tom qab ntawd, ob lub lwg ntawm carboxyaldehyde yauv lub cev qhuav dej ua rau cov oxymetazoline. Hauv cov txheej txheem no, cov pawg hydroxyl thiab methyl thiab methyl pawg nyob rau hauv Carboxyaldehyde molecule sib txuas los ua cov oxymetazoline nplhaib qauv qauv.

Cov khoom kawg yog oxymetazoline, uas muaj ib tsib - cov pa ntiv nplhaib thiab cov pab pawg hydroxyl.

Cov kua qaub - catalyzed thiab lub cev qhuav dej- Cov qauv hluav taws xob uas muaj cov qauv ntawm cov qauv hauv nruab nrog cev thiab cov khoom siv tshwj xeeb tuaj yeem ua ke. Hauv chav kuaj, tswj cov yam zoo xws li cov tshuaj tiv thaiv kev kub ntxhov, cov tshuaj tiv thaiv kub thiab sijhawm yog ib qho tseem ceeb rau ob qho txiaj ntsig thiab xaiv cov khoom.

2. Oxidation hauv cov kuab tshuaj

OxymetAzoline tau txais los ntawm kev hu rau kev daws teeb meem nrog oxygen nrog cov kev xaiv oxidation.

Tshuaj Exidation Qhov tshwj xeeb rau cov oxidation ntawm fructose hauv cov kuab tshuaj kom tsim oxymetazoline yog raws li nram no:

C6h12O6 (fructose) + o2 (oxygen) → C12h24o12 (c16h24n2o) + h2o

Cov txheej txheem hluavtaws:

Ib qho kev daws teeb meem tau coj fructose tau coj mus rau hauv kev sib cuag nrog oxygen, uas tau qhia ua tus neeg saib xyuas oxidizing. Nyob rau hauv cov xwm txheej ntawm kev xaiv oxidation, fructose undergoes ib oxidation cov tshuaj tiv thaiv los tsim hydroxymetazoline. Xaiv oxidation feem ntau yuav tsum muaj cov catalysts tshwj xeeb lossis cov tshuaj tiv thaiv los ua kom ntseeg tau tias muaj txiaj ntsig zoo.

Cov txheej txheem kev tawm tsam yuav tau nrog cov dej ntau lawm, yog li cov khoom yuav tsum tau ua kom muaj cov kev tiv thaiv kom tsim nyog thiab cov tshuaj tiv thaiv kom tau txaisntshiab oxymetazoline.

Cov kev tshuaj tiv thaiv no yuav tsum tau nqa tawm raws li kev sim tsim nyog, suav nrog cov kev sim tsim nyog, cov tshuaj tiv thaiv oxidation ntawm fructose rau hydroxymetazoline.

Cim npe nrov: Dawb Oxymetazoline Cas 1491-59-4, cov neeg muag khoom, chaw tsim khoom, Hoobkas, lag luam Wholesale, yuav, nqe, loj, loj, rau muag