Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov neeg muag khoom hauv Florfenicol hmoov tshaj plaws 73231-34-2 hauv Suav. Txais tos rau kev lag luam wholesale? Zoo florfenol hmoov cas 73231-34-2 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Cov hmoov nplej hmoov flufenicolyog cov khoom siv hluavtaws monofluorinated derivative ntawm thiamethoxole. Cov qauv molecular yog c12h14Cl2f2f2s, uas yog dawb lossis greyish dawb crystalline hmoov. Me ntsis iab, tsw ntxhiab. Yooj yim soluble hauv dimethylformamide thiab soluble hauv methanol. Soluble me ntsis hauv dej thiab chloroform, me ntsis soluble hauv glacial acetic acid, thiab yooj yim soluble hauv methanol thiab ethanol. Nws yog lub suab hluavtaws monofluoro derivative ntawm thiamethoxole, thawj pib hauv Nyij Pooj rau xyoo 1993, Norway pom zoo rau kev kho mob ntawm salmon furuncle kab mob. Fabkis, Tebchaws Askiv, Austria, Mexico, nws kuj tseem pom zoo rau cov tsiaj txhu ua pa hauv xyoo 1995. Raws li dav {{14-} spectrum cov tshuaj tua kab mob, flufenicol tau siv dav nyob rau hauv cov chaw kho tsiaj teb txij li thaum xyoo 1980s, thiab tau pom zoo hauv Suav teb.
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Tshuaj Cov Qauv |
C12h14cl2FNO4 |
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Muaj pes tsawg leej |
357 |
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Molecular hnyav |
358 |
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m/z |
357 (100.0%), 359 (63.9%), 358 (13.0%), 361 (10.2%), 360 (8.3%), 359 (4.5%), 361 (2.9%), 362 (1.3%) |
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Kev Ntsuam Xyuas |
C, 40.24; H, 3.94; Cl, 19.79; F, 5.30; N, 3.91; Au, 17.87; S, 8.95 |
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Cov hmoov nplej hmoov flufenicol, raws li ib feem peb {{{-}} {{1} Vim nws cov tshuaj tua kab mob hauv ntiaj teb no thiab kev ua haujlwm ntawm cov tshuaj tua kab mob thiab kev qhia dav. Nws ua kom muaj zog nyob rau hauv cov kab mob pathogenic microorbanisms xws li gram cov kab mob zoo tshaj plaws 50s subunit, thaiv cov protein hluav taws xob, thaiv cov protein.
1. Kev kho mob ntawm tsiaj txhu thiab nqaij qaib kab mob
Tus Kab Mob Mob
Flufenicol muaj qhov tseem ceeb kho cov teebmeem ntawm cov kab mob ua pa thiab sib kis tau plasopneumonia tshwm sim los ntawm Actinobacillus thiab Pasteurella nyob rau hauv npua. Kev tshawb fawb tau pom tias kev txawj ntse intramuscular ntawm qhov koob tshuaj ntawm 20mg / kg tuaj yeem ua tiav tus nqi ntawm 80% rau kev ua pa nyuaj li 50% hauv Amoxicillin Group. Hauv cov kab mob ua pa ua pa ntawm cov nqaij qaib, nws tuaj yeem ua tau zoo pab cov tsos mob xws li hnoos thiab hawb pob thiab txo qis.
Mob plab hnyuv
Flufenicol tuaj yeem tswj hwm thiab los ntawm txhaj tshuaj kom tswj tau cov kab mob raws plab xws li Escherichia coli thiab Salmonella.
Piv txwv li, thaum kho cov piglet daj thiab dawb dysenty, nws kho tus mob deb tshaj li ntawm cov tshuaj ib txwm muaj; Hauv kev tiv thaiv thiab tswj tus kab mob qaib, kev sib xyaw ua ke tuaj yeem ua rau cov kev kho mob thiab txo qhov kev pheej hmoo ntawm tus mob thib ob.
Kev tiv thaiv cov kab mob thiab cov kab mob thib ob
Thaum cov kab mob sib kis tau thoob plaws lub cev thiab ua rau muaj cov tshuaj sepsis, xws li nkag mus rau cov kab mob Cerebriater (xws li nkag mus rau hauv cov nyuj xwb). Ib qho ntxiv, nws tuaj yeem tiv thaiv lwm cov kab mob thiab txo cov pejxeem cov pejxeem thaum lub sijhawm muaj kab mob kev ntxhov siab ntawm cov tsiaj.
2. Kev tiv thaiv thiab tswj cov tshuaj muaj tsiaj
Cov ntses ntses
Flufenicol muaj cov kev cuam tshuam tseem ceeb ntawm cov ntses liab tawv nqaij, Gill cov kab mob, tus kab mob enteris, thiab croton zoo li Sepsis. Piv txwv li, kev kho mob ntawm artificially induction porcine idcine actinobacillus monleuropneum los ntawm kev pub mis ntawm 50ppm muaj kho tus nqi 100%; When treating Pasteurella infection in yellow tailed fish, oral administration has a higher protective rate than other commonly used antibiotics.
Cov kab mob ntawm cov cw thiab roob ris
Nyob rau hauv teb rau cws thiab crab liab puab tus kab mob, cov kab mob nkag rau hauv cov kab mob protein uas muaj cov kab mob protein ntawm cov kab mob pathogenical thiab cov saw hlau ntawm kis tus kab mob. Kev tshawb fawb tau pom tias nws tuaj yeem txo qis lub nra ntawm cov kab mob pathogenic rhawv dej aquaculture, thiab txhim kho cov nqi muaj sia nyob.
3. Cov kev siv yeeb yaj kiab tshwj xeeb
Kev kho mob ntawm mastitis
Lub xyoob muaj kev sib koom tes ntawm cov kab ke Florfenicol hauv Lactating Nws tuaj yeem nkag mus rau hauv cov nqaij mos, inhibit cov kab mob pathogenic xws li Staphylococcus aureus, thiab txo qhov kev pheej hmoo ntawm cov tshuaj tiv thaiv kab mob.
Economic Tsiaj Noj Qab Haus Huv
Nyob rau hauv Nyij Pooj thiab Mexico, Florfelol tau pom zoo ua kev pub mis rau npua los tiv thaiv cov kab mob xws li RHURSORCHITISS RHINITECT. Hauv kev yug me nyuam ntawm cov tsiaj muaj nyiaj txiag xws li luav thiab hma liab, nws tuaj yeem hloov cov tshuaj siab uas muaj ntau yam thiab ua kom cov pluab.
1. Protein synthesis thaiv
Cov hmoov nplej hmoov flufenicolinhibits peptidyl hloov kev ua si los ntawm kev khi rau 50s subunial ntawm cov kab mob 70s ribosome, blocking peptide cov saw txuas ntxiv thiab yog li inhibing protein synthesis. Cov txheej txheem no zoo ib yam li Chloramphenicol, tab sis FlorylSicol hloov cov pab pawg methylhenicol nrog cov tshuaj tiv thaiv methylslfif
2. Antibacterial Extension
Gram cov kab mob zoo
Nws muaj cov txiaj ntsig muaj zog rau Staphyrococcus aureus, streptococcus, porcine erysipelas, thiab lwm yam haum rau cov tshuaj- tiv taus.
Gram cov kab mob tsis zoo
Nws muaj cov teeb meem tseem ceeb ntawm plab hnyuv thiab ua pa cov kab mob xws li Escherichia
atypical pathogen
Nws muaj qhov cuam tshuam ntawm MyClaslamma, Chlamydia, thiab lwm yam thiab feem ntau siv hauv kev kho mob ntawm cov kab mob ua pa ua pa ua pa.
3. Cov Khoom Siv Hluav Taws Xob
Flufenicol yog nrawm nrawm, nrog siab bioavailability (xws li 55.3% ib nrab- lub neej (6-8 teev), thiab ntev ntev lub sij hawm txij nkawm. Nws lipophilicity tso cai rau nws kom diffuse rau hauv hlwb thiab yog siv tau tawm tsam cov kab mob kascolenatular xws li myCoplasma.
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Melting point 153 Qib C, Kev Sib Hloov Tshwj Xeeb}}}} ±℃±℃degree℃((((((degree℃(((ORC36 coefficient (PKA) 10.73 ± 0.46 (kwv yees), ua tiav
Flufenicol yog cov tshuaj tua kab mob, uas muaj qhov dav - specitive peptidyl kev ua haujlwm, suav nrog cov kab mob peptidyl ntxiv, suav nrog cov kab mob zoo, tsis zoo thiab mypsopasma. Cov kab mob rhiab suav nrog cov nyuj Haemophilus ntawm cov nyuj thiab npua, mob khaub thuas, cov tshuaj tsw qab, chlamyloroccus aureus, cengydia, rickettsia, thiab lwm yam.
Peb yog lub Hoobkas ntawmCov hmoov nplej hmoov flufenicol.
Cov lus hais: Bloom Tech (Txij xyoo 2008), ua tiav chem - tech yog cov neeg pabcuam ntawm peb.
Cov compound [1 {- benzylaziridin-2-meth] phenyl ketone tau synthesized tshuaj lom neeg pib los ntawm Benzyl sulfide. Cov khoom tau txuas ntxiv ua ke los ntawm asymmetric hydrogenation txo kev siv lub chairal catalyst kom tau txais ntau yam tshuaj lom neeg los npaj cov tshuaj fluorofenicol.
Cov kauj ruam tshwj xeeb yog raws li hauv qab no:
Benzyl sulfide reacts nrog bromoacetate los tsim cov khoom lag luam Esterification. Tom qab ntawd, cov khoom esterification undergoes migration aromatic anity hloov cov kev xav tau raws li Alkylaziridin-2-YL] - methyhlthio) ketne.
C7H8S + Bromoacetate → Esterification Khoom
Esterification khoom + muaj zog puag → [1-Benzylaziridin-2-YL] [4- Methylthio) Phenyl] Ketone
RESE [1-BENZYLAZIRIDIN-2-YL] [METHYRHO) PENYYRCE) rau Asymmetic Hydrogenation Txo kom tau [1-(Methylthio.
[1-Benzylaziridin-2-YL] [4- Methylthio) PenylSt + H2 → [1- Methylthio) Penylie) Pthhanol
Tom qab ob peb cov tshuaj ntsig txog ob peb-benzylaziridin-2-YL] [4- Methylthio) Penylh) Methanol hloov dua siab tshiab rau fluorofenol. Cov kev tshaj lij tshwj xeeb yuav sib txawv nyob ntawm qhov xwm txheej tiag tiag, thiab cov hauv qab no yog qhov piv txwv:
(Piv txwv) [1-Benzylaziridin-2-YL] [Methylthio) Phenyranol + Cenpous fluoride → Intermediate 1
Intermediate 1+ Alkaline Cov Mob → Intermediate 2
Intermediate 2+} sulfoxide chloride → Intermediatia 3
Intermediate 3+ acidic tej yam mob → flufenicol
Siv chiral amine ntiv nplhaib kaw kom tau txais enantiomery amino Tom qab ob peb kauj ruam ntawm cov tshuaj tiv thaiv, cov khoom tiav ntawmCov hmoov nplej hmoov flufenicolyog tau. Cov kauj ruam tshwj xeeb yog raws li hauv qab no:
Kauj ruam 1: Ntiv nplhaib kaw
Refore reines amines (r {{0} ◆ amines los yog s ey ı {1} ◆ amincidine cyclic canclic ntawm amino ketones. Ob tug enantiomers tau tsim nyob rau hauv cov kauj ruam no.
R - Amine + + Acyl Chloride → Aziridine Ternary Ntiv nplhaib (ob qho enantiomers)
Kauj ruam 2: kev sib cais ntawm lub cev
Siv cov txheej txheem sib cais chiral (xws li chairal chromatography, chiral crystallization, thiab lwm yam) cais cov ternary zerone ntiv tes los ntawm lwm cov enantiomers.
Kauj Ruam 3: Ntiv Nplhaib Koj Ntiv Zaus Qhib Cov Khoom Siv
Rov qab ua R -} Kev Kho Mob Amino Ketone Azir Strooforel thiab yauv Hmoob Lub Nplhaib Qhib Cov Tshuaj Lom Zem Thaum Alkaline atoms.
R - Aminooketone's Ternary Ternary Ntiv nplhaib + C6H18F3N → fluorinated nplhaib qhib cov khoom
Kauj Ruam 4: Kev Tawm Tsam Tom Qab
Los ntawm cov tshuaj tiv thaiv uas tsim nyog, lub nplhaib fluorinated qhib cov khoom yog hloov mus rau hauv qhov kawg xav tauFluorofofenicol hmoovkhoom. Cov kev tawm tsam no yuav suav nrog kev cuam tshuam dab tsi, txo cov kev tawm tsam, thiab cov teeb meem tshwj xeeb yuav nyob ntawm cov txheej txheem tshwj xeeb.
Cim npe nrov: Florfenicol Hmoov CAS 73231-34-2, Cov neeg muab khoom, chaw tsim khoom, chaw tsim khoom, lag luam, yuav khoom, rau muag