Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm rotenone tshuaj cas 83-79-4 nyob Suav teb. Txais tos rau cov lag luam wholesale bulk zoo rotenone tshuaj cas 83-79-4 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Rotenone TshuajNws yog ib qho tshuaj tua kab thiab tshuaj tua kab uas tshwm sim los ntawm cov hauv paus hniav thiab cov tawv ntoo ntawm qee cov nroj tsuag, feem ntau cov genus Derris thiab Lonchocarpus. Nws yog nyob rau hauv chav kawm ntawm cov tebchaw hu ua isoflavones thiab yog tus cwj pwm los ntawm nws cov ntses muaj zog - tshuaj lom thiab tshuaj tua kab. Raws li cov tshuaj tua kab mob lom, uas tau siv rau ntau pua xyoo hauv kev ua liaj ua teb thiab nuv ntses thoob ntiaj teb.
Chemically, nws ua raws li ib tug mitochondrial complex I inhibitor, cuam tshuam cov electron thauj saw nyob rau hauv lub hlwb ntawm lub hom phiaj kab mob, ua rau ATP depletion thiab tshwm sim ntawm cell tuag. Qhov kev ua haujlwm no ua rau nws muaj txiaj ntsig zoo tiv thaiv ntau yam kab thiab kab tsuag dej, suav nrog yoov tshaj cum, yoov, thiab qee cov nroj tsuag dej.
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| Tshuaj Formula | C23H22O6 |
| Exact Mass | 394.14 |
| Molecular Luj | 394.42 |
| m/z | 394.14 (100.0%), 395.14 (24.9%), 396.15 (2.7%), 396.15 (1.2%) |
| Elemental Analysis | C, 70.04; H, 5.62; O, 24.34 |
Txawm li cas los xij, nws txoj kev siv tau raug tshuaj xyuas vim nws qhov kev cuam tshuam ib puag ncig thiab muaj feem cuam tshuam txog kev noj qab haus huv. Nws muaj tshuaj lom heev rau lub neej hauv dej, thiab nws cov khoom seem tuaj yeem nyob hauv dej, cuam tshuam rau cov hom tsis yog hom phiaj. Hauv tib neeg, kev cuam tshuam rau rotenone tau txuas rau cov kab mob hauv lub paj hlwb thiab Parkinson's - cov tsos mob zoo li, tshwj xeeb tshaj yog nyob rau hauv cov neeg uas ua haujlwm tsis tu ncua tsis muaj kev tiv thaiv zoo.Txawm tias muaj kev txhawj xeeb no, nws tseem ua hauj lwm hauv kev ua liaj ua teb organic thiab kev tswj xyuas kab tsuag (IPM) cov kev pab cuam, qhov twg nws lub hauv paus chiv keeb thiab tshwj xeeb rau kev tiv thaiv kab tsuag muaj nuj nqis.
Cov kws tshawb fawb tseem tab tom tshawb nrhiav lwm txoj hauv kev thiab kev xa khoom kom txo qis nws ib puag ncig hneev taw thiab txhim kho nws qhov kev nyab xeeb. Zuag qhia tag nrho,rotenone tshuajtseem yog ib qho tseem ceeb uas tseem tsis tau muaj teeb meem nyob rau hauv lub arsenal ntawm kev tswj kab tsuag.Rotenone, tseem hu ua Barbasco, Dactinol, Paraderil, Rotenon, thiab Rotocide, yog ib tsob nroj - muab tshuaj tua kab muab rho tawm los ntawm cov nroj tsuag leguminous. Nws muaj cell toxicity thiab ua raws li ib qho inhibitor ntawm mitochondrial complex I electron thauj saw.
Kev siv Agricultural
Insecticide thiab Miticide
Feem ntau siv los ua tshuaj tua kab thiab tshuaj tua kab mob hauv kev ua liaj ua teb. Nws muaj cov tshuaj tua kab muaj zog rau ntau yam kab tsuag, suav nrog aphids, planthoppers, nplooj kab, thrips, melon yoov, nplooj miners, cabbage worms, thiab noctuid npauj. Nws hom kev ua cuam tshuam nrog inhibiting mitochondrial respiratory saw kab ntawm kab, ua rau ua pa nyuaj, qeeb zog, thiab tuag tes tuag taw, thaum kawg ua rau tuag.
Xaiv thiab Tsis yog -systemic
Xaiv nyob rau hauv nws qhov kev txiav txim thiab tsis yog -systemic, txhais tau tias nws tsis nkag mus rau hauv cov ntaub so ntswg mus rau thoob plaws hauv cov nroj tsuag. Qhov no ua rau nws muaj kev xaiv zoo rau kev tswj cov kab tsuag ntawm nplooj thiab txiv hmab txiv ntoo.
Photodegradable thiab Low Residue
Decomposed yooj yim thaum raug lub teeb, txo ib puag ncig muaj kuab paug. Cov yam ntxwv no ua rau nws tsim nyog siv rau hauv kev ua liaj ua teb organic lossis hauv cov xwm txheej uas xav tau cov tshuaj tua kab tsawg.
Kev tshawb fawb biochemical
Inhibition ntawm Mitochondrial Respiration
Lub peev xwm los inhibit mitochondrial complex kuv tau ua rau nws muaj txiaj ntsig zoo hauv kev tshawb fawb biochemical. Nws yog siv los kawm txog kev ua haujlwm thiab kev tswj hwm ntawm kev ua pa ntawm mitochondrial, nrog rau cov teebmeem ntawm kev ua pa ntawm cov hlab ntsha inhibitors ntawm cell metabolism thiab ciaj sia.
Qauv rau Cov Kab Mob Neurodegenerative
Rotenone tau siv los ntxias cov qauv ntawm cov kab mob neurodegenerative, xws li Parkinson's disease, hauv cov tsiaj. Los ntawm inhibiting mitochondrial ua pa, nws ua raws li qee yam ntawm cov txheej txheem pathological tau pom hauv cov kab mob no, muab lub platform rau kev kawm txog kab mob mechanisms thiab muaj peev xwm kho tau.
Txoj kev tsom xam
Kev soj ntsuam zoo yog ib txoj hauv kev uas siv cov tshuaj reagents los yog cov cuab yeej los txiav txim seb puas muaj qee yam khoom muaj nyob hauv cov khoom siv tshuaj raws li cov tshuaj tiv thaiv ntawm cov tshuaj sib txawv nrog cov reagents tshwj xeeb. Rau rotenone, nws cov khoom siv tshuaj tshwj xeeb tuaj yeem siv rau kev tshawb pom zoo. Piv txwv li, rotenone tuaj yeem raug cov tshuaj tiv thaiv xim lossis tsim tshwj xeeb precipitates nrog qee cov reagents nyob rau hauv cov xwm txheej tshwj xeeb, yog li lees tias nws muaj.
Kev ntsuam xyuas toxicological feem ntau yog ntsuas qhov mob toxicity, subacute toxicity, thiab ntev - toxicity ntawm cov khoom siv tshuaj. Los ntawm kev tswj hwm cov tshuaj sib txawv ntawm cov khoom siv tshuaj rau cov tsiaj sim thiab saib xyuas lawv lub cev thiab cov tshuaj tiv thaiv kab mob, kev nyab xeeb ntawm cov khoom siv tshuaj tuaj yeem txiav txim siab.Rau rotenone, kev kuaj tshuaj toxicological tuaj yeem ntsuas nws cov tshuaj lom rau cov tsiaj sim, suav nrog cov tsos mob lom (xws li xeev siab, ntuav, mob plab, raws plab, ntuav, thiab lwm yam). ob lub raum, nrog rau ua tau carcinogenic, teratogenic, thiab mutagenic teebmeem.
Cov kev ceev faj
Cov tshuaj toxicity ntawm rotenone yog ib qho tseem ceeb uas yuav tsum tau muab coj los txiav txim siab thaum siv cov tshuaj no. Nws yog tshuaj lom heev rau cov kab mob hauv dej xws li ntses, thiab tuaj yeem tsim kev puas tsuaj rau npua, silkworms, thiab txawm tib neeg thiab tsiaj txhu. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum tau ceev faj heev los tiv thaiv kev raug mob lom.
Lub sijhawm ntev - raug rau cov koob tshuaj me me ntawm rotenone tuaj yeem ua rau muaj teeb meem kev noj qab haus huv, suav nrog kev puas tsuaj rau lub paj hlwb. Qhov no yog vim nws lub peev xwm los cuam tshuam cov mitochondrial respiratory saw, uas yog qhov tseem ceeb rau cellular zog tsim thiab ciaj sia.
Ntxiv mus, nws cov photodegradability txhais tau hais tias nws muaj peev xwm decompose thaum raug lub teeb, txo nws cov hauj lwm zoo nyob rau lub sij hawm. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum tau khaws cia rau hauv qhov chaw txias, tsaus ntuj kom nws muaj zog thiab ua kom nws muaj kev nyab xeeb.
Hauv cov ntsiab lus, thaum rotenone muaj ntau yam kev siv, nws cov toxicity thiab photodegradability yuav tsum tau ua tib zoo tswj kom muaj kev nyab xeeb thiab siv tau zoo. Kev tuav kom zoo, khaws cia, thiab pov tseg yog qhov tseem ceeb kom txo qis kev pheej hmoo ntawm kev lom thiab ib puag ncig.
Qhov chaw & txoj kev rho tawm
Rotenone, muab tau los ntawm cov hauv paus hniav thiab rhizomes ntawm qee hom nroj tsuag uas feem ntau yog cov genus Derris thiab Lonchocarpus, yog ib qho tshuaj tua kab thiab piscicide uas muaj keeb kwm ntev ntawm kev siv. Nws yog tshwj xeeb tshaj yog muaj nyob rau hauv subtropical thiab tropical cheeb tsam ntawm Asia, Africa, thiab South America, qhov twg cov nroj tsuag no endemic. Nws cov khoom siv tshuaj tua kab tshwm sim los ntawm nws lub peev xwm los inhibit mitochondrial complex I, cuam tshuam kev ua pa ntawm tes thiab ua rau kev tuag ntawm cov kab mob.
Txoj kev rho tawm ntawm rotenone feem ntau muaj ob peb kauj ruam.
Thaum pib, cov khoom cog yog sau thiab huv si kom tshem tawm tej impurities.
Cov khoom ntxuav yog ces qhuav, feem ntau nyob rau hauv lub hnub los yog siv dag zog kom qhuav txoj kev, kom mloog zoo rau cov active khoom xyaw.
Thaum qhuav, cov nroj tsuag qhov chaw yog finely hmoov los ua kom qhov chaw saum npoo kom zoo extraction.
Kev rho tawm tuaj yeem ua tau los ntawm kev siv ntau cov kuab tshuaj, nrog rau methanol, ethanol, lossis acetone yog cov kev xaiv vim lawv cov txiaj ntsig hauv kev ua kom tiav.
Cov kuab tshuaj - cog sib tov yog agitated los yog nplawm rau ib lub sij hawm ntev los xyuas kom meej qhov siab tshaj plaws extraction, ua raws li pom los cais cov khoom seem ntawm cov extract.
Cov kauj ruam tom ntej no suav nrog evaporating cov kuab tshuaj kom mloog zoo rau nws, feem ntau los ntawm distillation lossis nqus evaporation.
Thaum kawg, purification cov txheej txheem xws li crystallization yuav ua hauj lwm los cais cov khoom ntshiab los ntawm cov concentrated extract. Cov txheej txheem zoo tib yam no ua kom cov khoom muaj peev xwm thiab cov ntawv ntshiab uas haum rau kev ua liaj ua teb thiab kev tshawb fawb.
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Cordycepin, ib qho nucleoside muab los ntawm Cordyceps militaris, tau pom tias muaj ntau yam tshuaj ua haujlwm, suav nrog tshuaj tua kab mob, tshuaj tua kab mob, thiab tshuaj tiv thaiv - cov teebmeem. Nws muaj peev xwm siv tau hauv cov tshuaj thiab kev kho mob yog qhov loj, ua rau nws muaj txiaj ntsig zoo.
Qhov discovery ntawdrotenone tshuajtuaj yeem txhim kho cordycepin synthesis thaum lub sij hawm submerged fermentation ntawm Cordyceps militaris sawv cev rau qhov tseem ceeb ntawm kev tsim cov khoom tseem ceeb no. Cov txheej txheem ib txwm siv ntawm cordycepin extraction los ntawm ntuj Cordyceps militaris feem ntau txwv los ntawm cov txiaj ntsig qis thiab cov nqi siab. Los ntawm kev siv nws los txhawb cordycepin synthesis, cov kws tshawb fawb tau pom tias muaj txiaj ntsig zoo thiab tus nqi - txoj hauv kev zoo los tsim cordycepin.Qhov tshiab lub tswv yim no tsis yog tsuas yog ua kom cov qoob loo ntawm cordycepin tab sis kuj muaj peev xwm txo tau qhov cuam tshuam ntawm ib puag ncig ntawm cordycepin ntau lawm.Submerged fermentation yog ib txoj hauv kev zoo dua qub rau kev tsim tawm thiab kev tsim tawm.
Los ntawm kev siv nws los txhim kho cordycepin synthesis thaum lub sij hawm submerged fermentation, cov kws tshawb fawb tuaj yeem tsim cordycepin nyob rau hauv ntau ntsuab thiab muaj txiaj ntsig zoo.Nyob rau hauv xaus, qhov kev tshawb pom ntawm lub luag hauj lwm ntawm kev txhawb cordycepin synthesis nyob rau hauv Cordyceps militaris thaum lub sij hawm submerged fermentation sawv cev rau ib tug tseem ceeb kev nce qib nyob rau hauv zus tau tej cov no muaj nuj nqis compound. Nws qhib cov lus qhia tshiab rau daim ntawv thov ntawm qhov no hauv kev tshawb fawb tshawb fawb thiab tuav cov lus cog tseg zoo rau kev cog qoob loo ntsuab thiab muaj txiaj ntsig zoo ntawm cordycepin, muaj peev xwm muab kev nplua nuj thiab ntau dua -cov khoom siv cordycepin zoo rau kev lag luam tshuaj thiab kev noj qab haus huv.
Cov txheej txheem tshuaj ntsuam xyuas ntawmRotenone Tshuaj(nqaij ntses tannin) feem ntau suav nrog kev tshuaj xyuas zoo, kev tshuaj xyuas ntau, kev tshuaj xyuas spectroscopic, kev tshuaj xyuas huab hwm coj spectrometry, thiab kuaj tshuaj toxicological. Cov hauv qab no yog cov ncauj lus kom ntxaws txog cov txheej txheem no:
Quantitative Analysis
Kev soj ntsuam ntau suav nrog ntsuas thiab txiav txim siab qhov feem pua ntawm txhua qhov khoom siv tshuaj lom neeg. Rau rotenone, ntau txoj hauv kev tsom xam muaj xws li tshuaj titration tsom xam thiab siab -kev ua tau zoo kua chromatography (HPLC), thiab lwm yam.
Cov txheej txheem tshuaj titration tsom xam: Kev ua haujlwm yooj yim, qhov ntsuas qhov xav tau tsis siab, thiab qhov tseeb txaus siab (qhov yuam kev tsis tshaj 0.2%). Txawm li cas los xij, nws yog ib qho tsim nyog los xyuas kom meej tias cov tshuaj tiv thaiv tau ua kom tiav raws li qhov sib npaug (feem ntau yuav tsum muaj ntau dua 99.9%), thiab cov tshuaj tiv thaiv tuaj yeem ua tiav sai, thiab cov khoom sib xyaw ua ke tsis cuam tshuam nrog cov tshuaj tiv thaiv tseem ceeb, lossis muaj cov txheej txheem tsim nyog los tshem tawm lawv cov kev cuam tshuam.
High -kev ua tau zoo kua chromatography (HPLC): Nws yog ib txoj kev tsom xam kom meej ntau dua. Nws siv qhov sib txawv ntawm qhov sib txawv ntawm qhov sib txawv ntawm cov khoom sib txawv ntawm cov theem nyob ruaj khov thiab theem mobile rau kev sib cais thiab kev tshawb nrhiav. Los ntawm HPLC, cov ntsiab lus ntawm rotenone tuaj yeem txiav txim siab raug, thiab lwm yam khoom tsis huv lossis degradation tuaj yeem kuaj pom ib txhij.
Kev tsom xam Spectral
Kev tsom xam spectral yog ib txoj hauv kev tseem ceeb heev rau kev kuaj xyuas cov khoom siv tshuaj zoo, suav nrog ultraviolet spectroscopy, infrared spectroscopy, Raman spectroscopy, thiab lwm yam. Cov kev tsom xam no kawm txog kev hloov pauv ntawm lub teeb nqus, emission, tawg, thiab lwm yam tshwm sim los ntawm kev cuam tshuam ntawm cov qauv thiab lub teeb, yog li txiav txim siab nws cov khoom thiab cov qauv.
Ultraviolet spectrum: Nws tuaj yeem siv los txheeb xyuas cov kab ke sib txuas hauv fisetin molecule, yog li lees tias nws muaj nyob thiab purity.
Infrared spectrum: Los ntawm kev txheeb xyuas cov qauv kev co ntawm cov tshuaj sib txuas hauv fisetin molecule, cov pab pawg ua haujlwm tshwj xeeb hauv cov qauv molecular tuaj yeem lees paub.
Raman spectrum: Zoo ib yam li infrared spectrum, tab sis nws pom cov kev hloov hauv lub teeb tawg los ntawm molecular vibrations. Nws yog qhov rhiab dua rau kev tshawb pom ntawm qee cov qauv tshwj xeeb.
Mass spectrometry tsom xam
Mass spectrometry tsom xam yog ib txoj kev tsom xam uas ntsuas qhov huab hwm coj - rau - nqi piv (m/z) ntawm ions. Nyob rau hauv cov huab hwm coj spectrum, lub ncov sib haum mus rau molecular ion yog lub ncov molecular ion, thiab nws cov huab hwm coj - rau - tus nqi piv yog tus txheeb ze molecular loj ntawm cov compound. Yog li ntawd, huab hwm coj spectrometry tuaj yeem ntsuas qhov hnyav molecular thiab infer tus qauv molecular ntawm cov compound. Rau fisetin, huab hwm coj spectrometry tsom xam tuaj yeem paub meej tias nws qhov hnyav molecular thiab infer qhov tshwj xeeb ntawm nws cov qauv molecular los ntawm kev tshuaj xyuas ntawm cov khoom tawg.
FAQ
Rotenone yog ib tug natural isoflavonoid compound muab rho tawm feem ntau los ntawm cov hauv paus hniav thiab stems ntawm leguminous nroj tsuag. Nws yog ib qho classic mitochondrial respiratory chain inhibitor, uas tuaj yeem thaiv cov txheej txheem thauj hluav taws xob hauv cov kab mob, cuam tshuam nrog lub zog metabolism, thiab yog li siv tshuaj tua kab, acaricidal thiab qee yam kev tshawb fawb tshuaj. Nws yog siv dav hauv kev tsim tshuaj tua kab, kev tshawb fawb biochemical thiab cov khoom siv raw rau cov tshuaj zoo.
Feem ntau yog siv los ua biopesticide thiab biochemical tshawb fawb reagent.
Rotenone muaj qee yam lom lom rau tib neeg thiab tsiaj txhu, thiab ntev -lub sij hawm los yog ntau dhau yuav ua rau muaj kev puas tsuaj rau cov paj hlwb thiab cov kab mob metabolic. Thaum lub sij hawm kev sim thiab kev lag luam tuav, kev sib cuag ntawm daim tawv nqaij ncaj qha, nqus tau cov plua plav thiab vapor, thiab kev sib tsoo yuav tsum raug zam kom nruj. Nws yuav tsum tau ua nyob rau hauv ib qho chaw zoo - qhov cua qhov chaw nrog cov hnab looj tes tiv thaiv thiab lub qhov ncauj qhov ntswg, thiab khaws cia kom deb ntawm cov oxidants, kub kub thiab hluav taws kub los xyuas kom meej tias kev siv nyab xeeb thiab ruaj khov.
Khaws kaw, qhuav, txias thiab deb ntawm lub teeb.
Cim npe nrov: rotenone chemical cas 83-79-4, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom