Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab cov khoom lag luam ntawm Sildenafil Citrate Hmoov Li 171599-83-0 nyob hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo sildenafil citrate hmoov yog 171599 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Sildenafil citrate hmoov, tseem paub tias yog Sildenafil citrate, muaj cov molecular formrate c28h38n6o11s, qhov hnyav molecular hnyav ntawm 666.700, thiab CASE 171599-83-0. Nws yog dawb lossis yuav luag dawb crystalline hmoov nrog tsis tshua muaj siab purity. Qhov ceev yog kwv yees li 1.445g / cm / cm) ³), qhov tseeb no tus nqi yog qhov siab dua, qhia tau muaj zog sib txuam thiab teeb meem nruj. Cov cuab yeej no muaj qee yam cuam tshuam rau cov solubility thiab tso tshuaj tawm ntawm cov tshuaj. Hais txog kev nyab xeeb, nws tau faib ua cov khoom phom sij cim xi, uas txhais tau tias kev saib xyuas nws cov peev xwm tsis sib xws thiab corrosiveness thaum siv nws. Ib qho ntxiv, solubility hauv dej kuj yog cov khoom tseem ceeb uas txiav txim siab cov pa nqus thiab faib tshuaj hauv lub cev.
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Tshuaj Cov Qauv |
C28H38N6O11S |
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Muaj pes tsawg leej |
666 |
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Molecular hnyav |
667 |
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m/z |
666 (100.0%), 667 (30.3%), 668 (4.5%), 668 (2.7%), 668 (2.3%), 667 (2.2%), 668 (1.7%), 669 (1.4%) |
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Kev Ntsuam Xyuas |
C, 50.44; H, 5.75; N, 12.61; O, 26.40; S, 4.81 |
Sildenafil citrate (lub npe luam npe Viagra), raws li lub ntiaj teb thawj pom zoo posphodiester (ed) txij li lub cyclic ntawm guanosine monophosphate (CGMP), Txhawb kev so ntawm cov leeg nqaij hauv lub cornus cavernosum ntawm lub penis, nce cov ntshav hauv zos ua tiav thiab tswj txoj kev ua kom tau ua erections. Ntxiv rau ED kev kho, cov tshuaj no tseem tau qhia tau tias kev tiv thaiv tseem ceeb, thiab kev tiv thaiv kab mob plawv, thiab kev puas siab ntsws.
1. Kev kho mob organic ed
Rau cov organic ed tshwm sim los ntawm cov kab mob ntev, kub thiab atherosclerosis, sildenafil citrate los ntawm kev txhim kho cov ntshav ntawm cov nqaij noovous lub cev. Txoj kev tshawb no qhia tau tias ntawm Ed cov ntshav qab zib, 50 mg tuaj yeem ua 63% ntawm cov neeg mob ua tiav kev sib deev vam meej, uas yog siab dua 25% ntawm pab pawg sib deev. Nws qhov kev ua tau zoo tsis cuam tshuam los ntawm cov ntshav khiav ntshav zoo, tab sis saib xyuas kom tau txais kev pheej hmoo ntawm kev pheej hmoo ntawm kev pheej hmoo ntawm kev pheej hmoo thaum siv ua ke nrog tshuaj antihyperensive.
2. Kev cuam tshuam rau lub hlwb Ed
Rau ed cov neeg mob tshwm sim los ntawm kev xav txog lub siab xws li ntxhov siab thiab kev nyuaj siab, tuaj yeem ua rau tsis muaj peev xwm ntawm "ntxhov siab vim tias tsis muaj kev txhim kho lub dag zog sai sai.
Ib ob npaug - Cov neeg mob dig muag uas muaj kev cog qoob loo ntawm lub zog ntawm 50mg Kev txhim kho ob lub cev thiab kev txhim kho lub cev thiab lub hlwb ua rau nws tseem ceeb ntawm kev kho mob rau kev puas siab ntsws.
3. Kev tswj hwm zoo ntawm kev sib xyaw ed
Rau kev sib xyaw ed nrog ob yam organic thiab hlwb ntawm kev coj ua ke nrog kev cob qhia kev coj tus cwj pwm) tuaj yeem txhim kho kev ua tau kev sib deev. Cov ntaub ntawv kuaj mob qhia tau hais tias cov kev ua haujlwm thoob ntiaj teb ua haujlwm (iTief) Lub tswv yim cuam tshuam ntau ntau yog tsim nyog rau cov neeg mob uas muaj mob rau ED.
1. Kev kho mob rau kev mob ntsws rau kev kub ntxhov
Muaj koob tshuaj ntau tshaj plaws sildenafil citrate (20-80mg / hnub) tau pom zoo rau kev kho mob ntsws, thiab nws cov leeg ua haujlwm ntawm cov leeg ntshav hlab ntsha Kev tshawb fawb qhia tau hais tias tom qab 12 lub lis piam ntawm kev kho mob, cov neeg mob 'taug kev deb ntawm 226 me, thiab qhov tshwm sim ntawm cov tshuaj tiv thaiv kev ua yeeb yam.
2. Kev tiv thaiv ncaj qha ntawm cov hlab plawv
Tsawg KoobSildenafil citrate hmoov(25MG txhua lwm hnub) qhia cov txiaj ntsig ntawm kev txhim kho Endothelial muaj nuj nqi thiab inhibiting tsim kev tsim ntawm atherosclerotic ntawm cov kev sim tsiaj.
Kev kawm soj ntsuam ntawm cov neeg mob angina ruaj khov qhia tias ntev kev pheej hmoo ntawm Sildiovascular xwm txheej (hr} {{1} {{1} =0.72
3. Kev tiv thaiv daim ntawv thov ntawm kev mob siab
Hauv cov cheeb tsam saum toj kawg nkaus 5000 metres saum hiav txwv theem, sildenafil tuaj yeem tiv thaiv kev kub siab-} istitude ustitting pulmonary los ntawm kev txhim kho pulmonary ncig. Kev tshawb fawb ntawm cov roob siab muag uas tau qhia tias kev tawm tsam ntawm 50mg sildudactic txo qis ntawm siab siab ntawm 12%, tsis muaj kev pheej hmoo siab phem ntawm lub roob mob siab. Lub tshuab siv hluav taws xob yuav cuam tshuam nrog txo cov hlab ntshav siab thiab txhim kho oxygenation.
1. Kev sib deev kev sib daj sib deev tau kho rau cov neeg mob caj qaum raug mob
Rau cov neeg mob uas muaj kev mob siab tom qab txha caj qaum raug mob, sildenafil ua ke nrog kev co kom pom kev kho mob hnyav tuaj yeem txhim kho txoj kev vam meej ntawm erection. Kev sib hais tau nrog 45 tus neeg mob pom tias txoj kev vam meej ntawm cov erections yog 67% tom qab 6% kev ua tiav hauv pab pawg ib leeg. Lub tswv yim kev cuam tshuam ntau no muab cov tswv yim tshiab rau kev sib deev ntawm cov neeg mob tus txha caj qaum.
2. Kev Kho Mob Txuas Rau Kev Tiv Thaiv Kev Ua Haujlwm Kev Ua Haujlwm
Tom qab sildenatomy, sildenafil tuaj yeem txhawb kev tsim kho ntawm neurovascular bundles los ntawm kev cuam tshuam thaum ntxov (pib 2 lub lis piam tom qab phais).
Kev tshawb fawb tau pom tias cov neeg mob uas siv Sildenafil 6 lub hlis tom qab phais kom rov zoo li piv rau cov pab pawg tswj (5%), thiab nws tsis cuam tshuam rau cov leeg leeg tswj. Qhov no 'neurroprotecive' cov nyhuv ua rau nws tseem ceeb txhais tau tias ntawm kev tswj hwm kev sib deev ua haujlwm phais mob prostility.
3. Kev sib daj sib deev nrog tus khub koom nrog
Raws li kev taw qhia ntawm tus kws sib deev ntawm tus kws sib deev, Sildenafil tuaj yeem siv los ua cov cuab yeej siv rau cov neeg koom tes koom nrog kev kho ua ke. Los ntawm kev txhim kho txiv neej lub cev muaj zog ua haujlwm, txo kev sib deev sib deev hauv ob qho tib si, thiab txhawb kev coj tus cwj pwm sib luag. Kev tshawb fawb cuam tshuam nrog 80 tus khub qhia tau tias tom qab 6 lub hlis ntawm kev ua haujlwm sib txuas nrog kev kho mob, tus khub tau txais txiaj ntsig ntau ntxiv tau nce los ntawm 2.1 zaug hauv ib hlis.
Sildenafil citrate tau maj mam nthuav dav los ntawm ed kev kho mob rau ntau daim teb xws li kev tiv thaiv mob ntsws, thiab rov sib deev. Qhov kev sib txawv ntawm nws cov kev ua tau zoo stems los ntawm kev ua kom haum ntawm PDE5 enzyme kev tswj hwm kev tswj hwm thiab kev hloov kho tus kheej.
Sildenafil citrate hmoov(Kuj tseem hu ua Viagra) yog ib hom tshuaj uas muaj los kho qhov tsis zoo thiab erectile kawg. Nws cov tshuaj lom neeg lub npe yog Sildenafil thiab nws yog 5-phosphatase inhibitor. Cov synthesis ntawm no compound yog feem ntau cuam tshuam nrog ntau cov kauj ruam, suav nrog cov kauj ruam tseem ceeb hauv qab no:
1. Khoom cua ntawm glutaraldehyde: glutaraldehyde yog synthesized los ntawm hydrogenized los ntawm hydrogenized los ntawm hydrogenized los ntawm hydrogenation los ntawm hydrogenation ntawm m- nitrobenzaldehyde.
2. Khoom cua ntawm Glutinlimide: Glutaraldehyde thiab urea muaj kev tshwm sim nyob rau hauv acidic tej yam kev mob los ua glutinlimide.
3. Khoom cua ntawm glutinallylhydrazide: Reed glutarylimine nrog ammonia los ua glutinallhydrandrazide.
4. Khoom cua ntawm glutinlimine diacetate: reacting gutararylhydrazide nrog diacetate anhydride los tsim cov diacetinate.
5. Khoom cua ntawm Sildenafil: cov kauj ruam kawg yog los ua cov kab kos duab nrog EthylenediaMine (1,2-etylenediamine) nyob rau hauv ib puag ncig alkaline los ua sildenafil.
Cov kauj ruam no yog cov lus qhia luv luv ntawm cov txheej txheem sharthesis rau sildenafil, tab sis cov txheej txheem synthesis tseeb yuav sib txawv vim yog cov tuam txhab chaw tshuaj thiab cov chaw ua haujlwm. Nws yog tsim nyog sau cia tias synthesis ntawm cov tshuaj lom neeg yuav tsum ua kom nruj thiab paub txog cov kws tshaj lij hauv kev tswj hwm.
Sildenafil citrate, kuj tseem hu ua Sildenafil Citrate, yog ib qho tshuaj nrog kev cuam tshuam tseem ceeb hauv cov chaw muag tshuaj, tsuas yog siv los kho txiv neej erectile kawg (ed). Tom ntej no, peb yuav muab cov lus qhia ntxaws ntxaws rau sildenafil citrate ntawm kev pom ntawm cov khoom siv pharmacological.
Ua ntej
Los ntawm kev pom ntawm lub chaw tshuaj, sildenafil citrate yog ib tug xaiv manitoritor ntawm pyclic guhabphate (CGMP) Hom 5 phosphodiesterase (PDE5). Kev siv hluav taws xob ntawm cov neeg tuag ua haujlwm tau cuam tshuam nrog kev tso tawm ntawm nitric oxide (tsis muaj) hauv cov plaub mos lwj thaum lub cev txhuam cev. Tsis muaj kev qhib Guananlate Cyclase, ua rau muaj nce hauv CGMP qib, ua rau kev so ntawm cov leeg nqaij thiab cov ntshav txhaws. Sildenafil citrate xaiv pursively PDE5, txhim kho cov kab mob CGMP, thiab nce qoob loo rau cov neeg mob erectile mus rau kev sib deev.
Nyob rau hauv cov nqe lus ntawm pharapacoin Cov Lus Cog Tseg ntawm Pharmaconininetics,
Sildenafil citrate yog maj mam nqus tau tom qab cov thawj coj ntawm qhov ncauj, nrog ib qho txiaj ntsig me me ntawm 40%. Nws cov chaw muag tshuaj pharmiters yog ib qho sib xws rau cov koob tshuaj pom zoo ntau. Cov tshuaj feem ntau yog metabolized los ntawm daim siab (Cytochyme P450 Islozyme 3A4 txoj kev 3A4 txoj kev), tsim cov khoom siv metabolite zoo ib yam li sildenafil. Cytochrome P450 Isozyme 3A4 (CYP4503A4) xws li Sildenafil, tej zaum yuav ua rau muaj kev nce ntshav ntawm sildenafil. Kev tshem tawm ib nrab - lub neej ntawm sildenafil thiab nws cov metabolites yog li 4 teev. Thaum muab 25-100mg ntawm lub plab khoob, cov ntshav ntshav siab tshaj plaws (CMAX) ntawm 127-560G / ML tau mus txog hauv kwv yees li 1 teev. Nyob rau ntawm qhov siab tshaj plaws Plasma Converration ntawm tag nrho Sildenafil, CMAX ntawm Dawb Sildenafil yog 22Nng / ml.
Nyob rau hauv cov nqe lus ntawm lub sijhawm ntawm kev ua tau zoo
Cov kev sim tau pom tias kev ua tau zoo ntawm Sildenafil citrate tuaj yeem mus txog 4 teev, tab sis cov lus teb tsis muaj zog tshaj li ntawm 2 teev. Qhov no qhia tau hais tias tom qab noj cov ntawv sam thiaj, cov neeg mob txaus siab rau nws cov txiaj ntsig rau lub sijhawm ntev.
Ntxiv nrog rau nws cov kev cuam tshuam rau Cenpile erection ua haujlwm
Sildenafil citrate hmoovKuj tseem muaj qee yam khoom siv pharmacological hauv nws cov lus teb rau Myocardial raug mob. Vim tias qhov tsis muaj PDE5 hauv cov nqaij uas tsis muaj mob lossis qog noj mov, Nyob rau hauv ib txwm cov txiv neej ua haujlwm pab dawb, ib qho ntawm qhov ncauj ntawm 100mg ntawm sildenafil tsis ua rau hauv tsev kho mob electrocardiogram hloov. Tsis tas li ntawd, cov nyhuv ntawm sildenafil citrate rau ntawm cov ntshav siab kuj tsim nyog rau kev saib xyuas. Tom qab ib qho ntawm ib qho ntawm cov kab ntawm 100mg ntawm sildenafil, cov ntshav siab ntawm cov neeg mob txiv neej zoo, tab sis tsis muaj qhov sib txawv piv rau cov pab pawg hauv placebo 8 teev tom qab noj tshuaj. Qhov no qhia tau tias ntawm ib qho kev siv tshuaj tsim nyog, cov nyhuv ntawm sildenafil citrate ntawm cov ntshav siab yog ib ntus thiab zoo.
Qhov kev tshawb pom keeb kwm ntawm Sildenafil Citrate yog qhov kev tshawb fawb txog kev tshawb nrhiav thiab kev hloov pauv tshiab, uas tau coj kev hloov pauv ntawm tib neeg kev noj qab haus huv. Tom ntej no, peb yuav rov xyuas cov ncauj lus qhia ntawm cov txheej txheem pom ntawm sildenafil citrate.
Thaum ntxov xyoo 1980s, Pfizer pib tshawb fawb txog kev tshawb fawb tshuaj los kho cov kab mob plawv thiab cov kab mob cerebrovases. Lub sijhawm ntawd, cov kws tshawb fawb feem ntau ntseeg tias cov kab mob plawv thiab cov kab mob cerebrovases tau cuam tshuam nrog qee cov kab ke tseem ceeb hauv kev sib tw. Nyob rau hauv cov ntsiab lus no, Pfizer tau tsim tsa cov pab neeg hauv kev tshawb fawb txog kev tshuaj ntsuam thiab kawm ntau yam ua tau enzyme inhibitors.
Ntawm ntau cov lus qhia kev tshawb fawb, cov pab neeg soj ntsuam tau tsom rau ib qho enzyme hu ua phosphodiesterase 5 (PDE5). Cov enzyme no ua lub luag haujlwm ntawm kev tswj txoj kev sib dhos ntawm tib neeg lub cev thiab yog qhov tseem ceeb rau kev noj qab haus huv ntawm cov hlab plawv. Cov kws tshawb fawb tau pom tias muaj qhov ua haujlwm PDE5 tuaj yeem txhawb nqa vasodilation, txo cov tsos mob ntawm cov tsos mob ntawm cov kab mob plawv thiab cov kab mob cerebrovascular thiab cerebrovascular.
Txawm li cas los xij, nyob rau hauv thawj txheej txheem tshawb fawb, cov kws tshawb fawb tau tsis cuam tshuam ncaj qha PDE5 inhibitors nrog erectile kawg (ed). Qhov tseeb, lawv lub hom phiaj thawj zaug tau tsim cov tshuaj los kho angina thiab kub siab. Txawm li cas los xij, nyob rau hauv cov kev tshawb fawb soj ntsuam thaum ntxov, cov kws tshawb fawb tau poob nthav pom tias PDE5 Inhibitor kuj muaj kev cuam tshuam loj heev hauv kev kho ed.
Qhov kev tshawb pom no tau ua rau muaj kev txaus siab nrog cov kws tshawb fawb. Lawv pib delve mus rau hauv lub tshuab los ntawm cov tshuaj no cuam tshuam erectile muaj nuj nqi. Tom qab cov kev sim thiab kev tshawb nrhiav hauv kev soj ntsuam, yog li kev txhawb nqa cov pa roj ntsha tuaj yeem ua rau muaj kev txhim kho kom zoo dua qub hauv kev ua haujlwm erectile.
Hauv kev tshawb nrhiav cov txheej txheem ntawm Sildenafil citrate, cov kws tshawb fawb tsis yog ua kom pom tseeb kev tshawb fawb thiab tsis paub tseeb ntawm kev tshawb fawb rau peb. Lawv lub hom phiaj thawj zaug tau tsim cov tshuaj los kho cov tshuaj kho plawv thiab cov kab mob cerebrovases thiab thaum kawg, lawv xav tsis tau tshuaj uas zoo rau kev kho ed. Qhov kev tshawb pom ntawm no hom "Yin thiab Yang thiab BANT tsuas yog nqa cov kev kho tshiab tshiab rau cov neeg mob, tab sis kuj qhib cov kev tshiab rau kev txhim kho cov kev kho mob ntawm tsev kho mob.
Hauv ntej, kev tshawb pom keeb kwm ntawmSildenafil citrate hmoovyog qhov nyuaj thiab kev tshawb fawb tshiab. Nws tsis yog tsuas yog qhia txog randomness thiab tsis paub meej ntawm kev tshawb fawb, tab sis kuj tseem qhia tus ntsuj plig kev tshawb nrhiav thiab kev tsim kho tshiab ntawm cov kws tshawb fawb. Nyob rau yav tom ntej, peb ntseeg tias muaj kev nce qib txuas ntxiv thiab thev naus laus zis, tib neeg yuav pom cov qauv tshuaj thiab kev kho mob, ua rau tib neeg kev noj qab haus huv.
Cim npe nrov: Sildenafil Citrate Hmoov CASRate CASATE 171599-83-0, tus neeg tsim khoom, chaw tsim khoom, chaw tsim khoom, lag luam, yuav, nqi, loj, rau muag