D-Salicin, tseem hu ua salicin, yog ib qho tshwm sim tshwm sim feem ntau pom hauv cov tawv ntoo ntawm cov ntoo dawb (Salix alba). Nws belongs rau ib chav kawm ntawm cov tebchaw hu ua phenolics thiab tshwj xeeb tshaj yog, raws li salicylates. Qhov sib xyaw no tau muaj txiaj ntsig zoo vim nws cov qauv zoo sib xws rau cov tshuaj aspirin, uas yog cov khoom siv hluavtaws ntawm salicylic acid.
Keeb kwm, nws tau siv rau hauv cov tshuaj ib txwm siv los txo qhov mob, txo qhov mob, thiab kho kub taub hau. Nws hom kev ua yog ntseeg tau tias yuav cuam tshuam rau kev tsim cov prostaglandins, uas yog cov tshuaj hormones uas ua rau mob thiab mob. Txawm li cas los xij, tsis zoo li cov tshuaj aspirin, nws tsis yog siv ncaj qha rau hauv kev npaj tshuaj niaj hnub no vim nws qhov nqus tau qeeb thiab cov metabolism.
Kev tshawb fawb tau txuas ntxiv mus, tshawb nrhiav nws cov txiaj ntsig muaj peev xwm hauv ntau qhov chaw kho mob, suav nrog ua cov tshuaj tiv thaiv -tus neeg mob inflammatory, analgesic (mob reliever), thiab txawm nyob rau hauv kev tswj ntawm tej yam mob. Cov kev tshawb fawb qhia tias nws tuaj yeem muab lwm txoj hauv kev rau cov tshuaj hluavtaws, nrog rau qhov sib piv me me ntawm qhov profile.
Txawm hais tias nws cov khoom muaj txiaj ntsig zoo, kev siv hauv kev kho mob tseem tsawg thiab feem ntau yuav tsum tau tshawb xyuas ntxiv los tsim kom muaj kev ua tau zoo thiab kev nyab xeeb, tshwj xeeb tshaj yog nyob rau hauv ntev - siv sijhawm ntev lossis hauv cov neeg mob tshwj xeeb. Txawm li cas los xij, nws cov kev siv ib txwm siv thiab kev tshawb fawb tsis tu ncua qhia txog lub peev xwm ntawm cov khoom siv ntuj no hauv cov tshuaj niaj hnub.
 |
 |
|
Tshuaj Formula |
C13H18O7 |
| Exact Mass | 286.11 |
| Molecular Luj | 286.28 |
|
m/z |
286.11 (100.0%), 287.11 (14.1%), 288.11 (1.4%) |
|
Elemental Analysis |
C, 54.54; H, 6.34; O, 39.12 |
|
Melting Point |
196-202 degree |
|
Boiling Point |
388.65℃(kev kwv yees kwv yees) |
|
Kev sib hloov tshwj xeeb |
-61.5 º (c{1}}, dej) |
|
Qhov ntom |
1.4340 |
|
Refractive Index |
-62℃(C{1}}, H2O) |
|
Kev cia khoom |
2-8 degree |
|
Solubility |
Solubility hauv dej yog 36 g / L |
|
Daim ntawv |
Dawb zoo crystalline hmoov |
|
Acidity Coefficient (pKa) |
12.80 ± 0.70 (Tshaj tawm) |
|
Dej Solubility |
36 g/L (15 ºC), 250 g/L (60 ºC) |
|
Kev ruaj ntseg |
Stable, tab sis rhiab rau lub teeb. Incompatible nrog muaj zog oxidizing neeg sawv cev. |
Synthesis ntawm Salicin ntawm Esterification thiab Glycosidation
- Kev Teeb Meem: Pib nrog salicylic acid thiab cawv (feem ntau methanol los yog ethanol) nyob rau hauv lub xub ntiag ntawm ib tug acid catalyst, xws li sulfuric acid los yog hydrochloric acid.
- Cov xwm txheej tshwm sim: Ua kom sov qhov sib xyaw kom sov li ntawm reflux mus txog 100 degree, nyob ntawm seb cov cawv siv. Khaws qhov kub no rau ob peb teev kom tso cai rau cov tshuaj tiv thaiv esterification mus ntxiv.
- Kev rho tawm ntawm Ester: Thaum cov tshuaj tiv thaiv tiav, neutralize cov kua qaub catalyst siv lub hauv paus zoo li sodium bicarbonate. Extract cov ester los ntawm cov tshuaj tiv thaiv sib tov siv cov kuab tshuaj haum. Concentrate thiab purify ester los ntawm distillation los yog crystallization.
- Kev npaj Reactant: Npaj cov piam thaj derivative, feem ntau yog cov piam thaj los yog galactose, nyob rau hauv daim ntawv ntawm activated qab zib ester los yog glycosyl halide. Cov activated intermediates no muaj ntau reactive rau nucleophilic hloov cov tshuaj tiv thaiv.
- Kev Teeb Meem: Muab cov ester uas tau txais los ntawm cov kauj ruam esterification nrog cov activated qab zib derivative nyob rau hauv lub xub ntiag ntawm ib tug catalyst, xws li nyiaj oxide los yog mercury (II) oxide.
- Cov xwm txheej tshwm sim: Ua kom sov qhov sib tov rau qhov kub ntawm 60℃txog 100℃rau ob peb teev kom tso cai rau cov tshuaj tiv thaiv glycosidation tshwm sim. Cov catalyst txhawb kev hloov ntawm ester pawg nrog cov suab thaj moiety.
- Kev cais tawm ntawm Salicin: Tom qab cov tshuaj tiv thaiv tiav, quench cov tshuaj tiv thaiv sib tov nrog dej thiab rho tawm cov khoom nrog cov organic hnyav. Purify salicin los ntawm crystallization lossis kem chromatography kom tau txais cov khoom kawg.
Kev Siv Tshuaj
Kev kho mob ua npaws, mob khaub thuas, thiab kis kab mob
Lub npe hu ua "natural aspirin" rau nws lub peev xwm los kho tus mob ua npaws, mob khaub thuas, thiab kab mob xws li mob khaub thuas. Nws muab kev pab ntawm qhov mob thiab tsis xis nyob los ntawm o.
Kev Kho Mob ntawm Mob caj dab thiab Back Pain
Ib qho txiaj ntsig zoo rau kev txo qhov mob cuam tshuam nrog kev mob caj dab thiab mob nraub qaum. Nws tau pom tias yuav txhim kho qhov mob nyem rau cov neeg mob caj dab thiab txo cov tsos mob ntawm kev mob caj dab thaum lub sijhawm.
Cov tshuaj tiv thaiv -Inflammatory and Analgesic Effects
Nws nthuav tawm los tiv thaiv- inflammatory thiab analgesic zog, ua rau nws muaj txiaj ntsig zoo hauv kev kho mob xws li mob taub hau thiab lwm yam mob.
Cosmetic & Skin Care
Exfoliation thiab daim tawv nqaij Brightening
D-Salicinmuaj me ntsis exfoliating zog, uas yuav pab kom maj mam tshem tawm cov tawv nqaij tuag ntawm daim tawv nqaij. Qhov no tsis tsuas yog nthuav tawm cov tawv nqaij smoother, ci dua tab sis kuj tso cai rau lwm cov khoom siv tawv nqaij kom nkag mus tob rau hauv daim tawv nqaij kom txhim kho kev ua tau zoo.
Txhim kho daim tawv nqaij elasticity thiab tiv thaiv -Kev laus
Nws paub tias muaj kev tiv thaiv- kev laus ntawm daim tawv nqaij. Nws txhawb kev tsim thiab kho ntawm collagen, ib qho tseem ceeb ntawm cov protein uas txhawb cov tawv nqaij elasticity. Los ntawm kev nce qib collagen, salicin tuaj yeem pab txo qis wrinkles, kab zoo, thiab sagging tawv nqaij, muab cov tawv nqaij zoo nkauj dua.
Kho cov tawv nqaij mob
Nws yog cov tshuaj tiv thaiv- cov khoom ua rau nws ua rau nws kho tau zoo rau ntau yam tawv nqaij. Nws tuaj yeem siv los soothe tawv nqaij khaus, txo qhov liab, thiab mob o ntawm pob txuv, rosacea, lossis eczema. Tsis tas li ntawd, salicin kuj tseem tuaj yeem pab txhim kho daim tawv nqaij rhiab heev thiab ua rau cov tawv nqaij ua rau muaj kev sib haum xeeb.
Balancing Skin Tone thiab Texture
Nws muaj peev xwm exfoliate cov tawv nqaij tuag thiab txhawb kev tsim collagen tuaj yeem pab kom sib npaug ntawm cov tawv nqaij tsis sib xws thiab kev ntxhib los mos. Los ntawm kev tshem tawm dull, tawv nqaij tsis muaj sia thiab txhawb kev rov ua dua tshiab ntawm tes, salicin tuaj yeem muab cov tawv nqaij ntau dua, ci ntsa iab.
Kev koom ua ke hauv cov khoom siv tshuaj pleev ib ce
Muaj nyob rau hauv ntau yam khoom tu tawv nqaij, xws li tshuaj ntxuav tes, toners, serums, moisturizers, thiab qhov ncauj qhov ntswg. Nws qhov mob me me tsis tau zoo tso cai rau nws siv rau ntau hom kev tsim, ua rau nws muaj ntau yam khoom siv rau ntau hom tawv nqaij thiab kev txhawj xeeb.
Salicylic acid yog ib txwm tshwm sim beta hydroxy acid (BHA) nrog cov qauv tshuaj ntawm ortho hydroxybenzoic acid thiab molecular hnyav ntawm 138.12.
Kev tswj hwm keratin: cov nyhuv bidirectional thiab meej nkag
1. Dissolve stratum corneum kev sib txuas
Los ntawm kev cuam tshuam cov desmosomes ntawm keratinocytes, txo qis intercellular adhesion, thiab txhawb cov shedding ntawm laus keratinocytes. Nws cov khoom lipophilic tso cai rau nws nkag mus rau hauv cov txheej txheem sebum, nkag mus tob rau hauv lub qhov hws, yaj cov keratin txuas ntxiv (blackheads / whiteheads), thiab tshem tawm cov plaub hau follicle ducts. Cov kev sim tau pom tias tom qab kev kho mob nrog 2% salicylic acid, lub thickness ntawm stratum corneum yog txo los ntawm 15% -20%, thiab lub voj voog rov ua dua ntawm keratinocytes yog luv los ntawm 30%.
2. Bidirectional tswj mechanism
Tsawg concentration (0.5% -2%): txhawb keratinization metabolism, txhim kho keratinization tsis tiav, haum rau keratosis ( nqaij qaib) thiab ichthyosis.
Nruab nrab concentration (3% -5%): ncaj qha dissolves keratin, softens tuab calluses thiab pob kws, kho mob siv rau kev kho mob ntawm palmar thiab plantar keratosis.
High concentration (10% -30%): Raws li ib tug tshuaj exfoliating tus neeg sawv cev, nws nkoos epidermal reconstruction los ntawm kev cuam tshuam cov kev ncaj ncees ntawm lub stratum corneum, thiab feem ntau yog siv rau pob txuv nti thiab kho photoaging.
Anti-inflammatory thiab antibacterial: multi-lub hom phiaj inhibition ntawm inflammatory cascade cov tshuaj tiv thaiv
1. Inhibition ntawm prostaglandin synthesis
Los ntawm kev thaiv cov kev ua ntawm cyclooxygenase (COX-1 / COX-2), kev tsim cov prostaglandin E2 (PGE2) txo qis, yog li txo cov vascular permeability thiab txo qhov liab, o, thiab mob. Nws cov kev xaiv inhibition ntawm COX-2 (IC50=0.8 μ M) ua rau nws muaj txiaj ntsig zoo hauv kev kho mob pob txuv, txo cov papules inflammatory mus txog 40%.
2. Broad spectrum antibacterial nyhuv
Propionibacterium acnes: Los ntawm kev cuam tshuam cov qauv ntawm cov kab mob ntawm tes thiab inhibiting lawv cov kev loj hlob, qhov tsawg kawg nkaus inhibitory concentration (MIC) yog 0.5% -1%.
Malassezia: Nrog rau tus nqi inhibition ntawm 85% tawm tsam cov kab mob pathogenic ntawm seborrheic dermatitis, ua ke nrog nws cov roj tswj cov nyhuv, nws tuaj yeem txo qhov tsim ntawm dandruff.
Kev tiv thaiv kev tiv thaiv: Tsis zoo li cov tshuaj tua kab mob, salicylic acid tua cov kab mob los ntawm kev ua haujlwm ntawm lub cev thiab tsis muaj qhov tshwm sim ntawm cov kab mob tiv thaiv kab mob.
Roj tswj thiab tiv thaiv seborrhea: tswj cov qog sebaceous
Los ntawm inhibiting kev ua ntawm 5 - reductase, kev hloov pauv ntawm testosterone rau dihydrotestosterone (DHT) txo, yog li txo qis qog sebaceous. Cov kev sim tshuaj pom tau tias tom qab 4 lub lis piam ntawm kev siv 2% salicylic acid gel, cov roj ntawm lub ntsej muag txo qis los ntawm 28%, thiab cov nyhuv tau mus txog 2 lub lis piam tom qab tshem tawm cov tshuaj. Nws lipophilicity tso cai rau nws nyob rau hauv cov hauv paus plaub hau ntev, tsis tu ncua exerting nws cov roj tswj cov nyhuv.
Whitening thiab photoprotection: Ntau txoj hauv kev inhibition ntawm pigment deposition
1. inhibit tyrosinase kev ua haujlwm
Los ntawm kev sib tw khi rau tooj liab ion active chaw ntawm tyrosinase, melanin synthesis raug txo. Tus nqi inhibition yog linearly ntsig txog qhov concentration, nrog tus nqi inhibition ntawm 35% ntawm qhov concentration ntawm 2%.
2. Ceev keratin metabolism
Txhawb nqa cov keratinocytes uas muaj melanin thiab txo lub voj voog thauj melanin. Kev siv cov tshuaj pleev thaiv hnub sib xyaw ua ke tuaj yeem txo qis UV induced pigmentation thiab ua kom cov txiaj ntsig ntawm kev kho melasma los ntawm 25%.
Cov ntaub ntawv noj tshuaj tshwj xeeb thiab cov tshuab xa khoom: txhim khu kev ua tau zoo thiab txo qhov khaus khaus
1. Supramolecular Salicylic Acid
Los ntawm kev siv cyclodextrin inclusion technology, salicylic acid molecules yog encapsulated nyob rau hauv polysaccharide lug tsim ib tug sustained - tso tawm system. Cov thev naus laus zis no txo nws txoj kev chim siab los ntawm 60% thiab ncua nws lub sijhawm ua haujlwm mus rau 8 teev, ua rau nws tsim nyog rau kev kho mob pob txuv.
2. Nano crystalline thaj
Siv lub microneedle array los tsoo los ntawm stratum corneum barrier thiab xa salicylic acid ncaj qha mus rau dermis txheej. Cov kev sim tsiaj tau pom tias cov cuab yeej no ua rau muaj kev nkag mus rau cov tshuaj ntau dua 12 zaug thiab muaj cov txiaj ntsig kho mob tseem ceeb ntawm cov pob txuv sib sib zog nqus.
faq ua
Dab tsi yog salicin siv rau?
Willow bark feem ntau yog sivkho mob thiab txo kub taub hau. Nws muaj cov tshuaj hu ua salicin uas tau pom tias muaj cov tshuaj tiv thaiv - mob.
Puas yog salicin thiab salicylic acid tib yam?
Hauv cov ntsiab lus, salicin feem ntau yog mob me me thiab tsis khaus rau lub plab hauv ob sab phlu vim nws xav tau kev hloov pauv hauv metabolic kom siv nws cov teebmeem. Salicylic acid, ntawm qhov tod tes, yog ib qho kev sib xyaw ua ke nrog lub zog muaj zog, feem ntau siv tshuaj pleev xim rau nws cov khoom kho mob tam sim ntawd.
Lwm lub npe rau salicylic acid yog dab tsi?
Salicylic acid tseem hu ua2-hydroxybenzoic acid(ib ntawm ob peb -hydroxy acids). Nws kho pob txuv los ntawm kev ua rau cov hlwb ntawm daim tawv nqaij slough tawm yooj yim dua, tiv thaiv cov pores los ntawm clogging li nws yog ib tug keratolytic neeg sawv cev. Salicylic acid 1% mus rau 2% kev npaj yog feem ntau ua tau zoo.
Dab tsi yog qhov txawv ntawm salicin thiab aspirin?
Cim npe nrov: d-salicin cas 138-52-3, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom