Quinine Hydrochloride / Hcl CAS 60-93-5

Quinine hydrochlorideyog ib hom tshuaj lom neeg. Lwm lub npe yog quinine HCl. Nws yog xim tsis muaj xim lossis dawb koob siv lead ua nrog mercerization. Nws tsis muaj ntxhiab tsw thiab tsw qab heev. Nws hloov xim maj mam nyob rau hauv lub hnub. Nws yog weathered. Nws yog soluble nyob rau hauv dej, thiab soluble heev nyob rau hauv boiling dej, ethanol los yog chloroform. Kev ntsuas litmus ntawm cov tshuaj yog nruab nrab lossis alkaline, thiab qhov kev sib hloov kho qhov muag yog siab [ ] D{{0}} degree ~ - 258 degree (200mg yaj hauv 10ml ntawm 0.1mol / l hydrochloric acid) . LG yog soluble hauv 16ml dej, los yog LML ntawm ethanol, txog 7ml ntawm glycerol, los yog hais txog LML ntawm chloroform, uas yog heev yooj yim rau yaj nyob rau hauv ether. Odourless, nrog lub zog iab saj. GB 2760-2002 qhia tias quinine hcl hmoov raug tso cai siv los ua zaub mov tsw. Nws yog tsuas yog siv los npaj cov essence thiab iab tus neeg sawv cev rau iab dej qab zib.

Quinine hydrochloridemuaj cov yam ntxwv ntawm antipyretic, antimalarial, analgesic, anti-inflammatory thiab lwm yam. Cov txheej txheem hluavtaws ntawm quinine hcl: tom qab hloov quinine sulfate rau hauv quinine, quinine tau tawg mus rau hauv cov dispersant, ces hydrochloric acid lossis hydrogen chloride gas ntxiv, thiab tom qab ntawd nws tau los ntawm crystallization. Cov khoom tsim tam sim no tsuas yog siv cov kua qaub thiab cov hauv paus, cov kuab tshuaj uas muaj tshuaj lom thiab tus nqi qis, thiab tsis siv cov tshuaj reagents uas muaj toxicity. Cov tawm los yog siab, uas tuaj yeem ncav cuag lossis ze rau qhov theoretical yield. Nws tuaj yeem ncav cuag 110 - 115% los ntawm kev suav quinine, thiab txoj kev no yog ib puag ncig zoo. Tag nrho cov txheej txheem ntawm kev tsim khoom yog qhov yooj yim, yooj yim thiab tus nqi qis, uas yog qhov tsim nyog rau scale-up ntau lawm.

Nws yog ib qho tseem ceeb compound feem ntau siv nyob rau hauv kev npaj tshuaj.

1. Natural extraction method:

Txoj kev ntxov tshaj plaws rau synthesizingQuinine hydrochloridetau txais los ntawm ntuj rho tawm los ntawm cov nroj tsuag hauv genus Acacia. Cov nroj tsuag ntawm genus Albizia muaj cov ntsiab lus siab ntawm quinine, uas tuaj yeem muab rho tawm, ntxuav, thiab kho nrog hydrochloric acid kom tau cov khoom. Txawm hais tias txoj kev no tau txais cov tshuaj los ntawm cov peev txheej ntuj, nws muaj teeb meem xws li kev siv hluav taws xob tsawg thiab cov txheej txheem nyuaj.

2. Synthesis method:

Tam sim no, txoj kev tsim khoom tseem ceeb ntawm nws yog los ntawm cov tshuaj synthesis. Cov hauv qab no yog ob peb txoj hauv kev uas feem ntau siv synthesis:

2.1 Txoj kev Amoxidation:

Qhov no yog ib txoj kev sib xyaw ua ke, nrog rau cov kauj ruam hauv qab no:

-Cov quinoline tau hnov ​​​​mob nrog Ammoxidation tus neeg sawv cev (xws li hydrogen peroxide) kom tau quinoline N-oxide.

-Tom qab cov tshuaj tiv thaiv txo qis, N-oxide raug txo mus rau qhov sib thooj amine thib ob.

-React tus thib ob amine nrog hydrochloric acid los tsim.

2.2 Synthesis txoj kev ntawm o-nitrophenol:

Qhov no yog lwm txoj kev siv synthesis, nrog rau cov kauj ruam hauv qab no:

-O-nitrophenol reacts nrog acetic acid los tsim Nitrate ester.

-Tom qab cov tshuaj tiv thaiv txo qis, Nitrate ester ester raug txo rau cov amine sib raug.

-React amine nrog hydrochloric acid los tsim.

2.3 Indirect synthesis method of raw khoom:

Qhov no yog ib qho kev siv nyiaj txiag thiab siv tau zoo, nrog rau cov kauj ruam hauv qab no:

-Siv Sodium sulfite thiab qab zib ua raw cov ntaub ntawv, xanthic acid tau los ntawm Marga liquefaction nyob rau hauv alkaline tej yam kev mob.

-Nyob rau hauv lub catalysis ntawm sulfuric acid, xanthic acid thiab Aminoaldehydes thiab aminoketones undergo condensation cov tshuaj tiv thaiv kom tau quinoline compound.

-Tom qab cov kauj ruam tom ntej xws li oxidation, txo, thiab kev kho hydrochloric acid, nws tuaj yeem tau txais.

2.4 Conversion method rau synthesizing intermediates:

Qhov no yog ib txoj hauv kev tau txais cov khoom los ntawm kev hloov cov khoom sib xyaw ua ke rau hauv nruab nrab, thiab cov kauj ruam tshwj xeeb txawv nyob ntawm qhov nruab nrab. Cov tshuaj nruab nrab muaj xws li quinoline, butyraldehyde, thiab acetamide compounds.

Cov txheej txheem synthesis no tau siv dav hauv kev tsim khoom, thiab cov txheej txheem tsim nyog tuaj yeem xaiv raws li kev xav tau. Ntxiv rau cov txheej txheem synthesis saum toj no, kuj tseem muaj lwm txoj hauv kev, xws li enzymatic synthesis, microbial fermentation, thiab lwm yam, tab sis cov txheej txheem tam sim no tsis tshua siv hauv kev tsim khoom.

Melting point 158-160 C , Ceev 1.1206 ( kwv yees ntxhib ), FEMA 2976 , Refractive index 1.5400 ( kwv yees ), Cia tej yam kev mob nyob rau hauv inert gas ( nitrogen los yog Argon ) ntawm 2 - 8 degree , Dej solubility 549.7 mg / L ( 25 oC), Cov khoom txaus ntshai kos npe Xi Hazard qeb code 36 / 37 / 38, Cov lus qhia txog kev nyab xeeb 26-36-24 / 25, Kev Thauj Khoom Tsis Txaus Siab No. 1544, HazardClass 6.1 (b), Packing Group III

1. Molecular qauv thiab muaj pes tsawg leeg:

Cov tshuaj formula ntawm cov khoom yog C20H24N2O2 · HCl, thiab nws qhov hnyav molecular yog 396.88 g / mol. Nws yog Organic puag ntsev, muaj cov qauv quinoline thiab hydrochloric acid radical ion.

2. Solubility:

Quinine hydrochloridemuaj zoo solubility hauv dej thiab tuaj yeem yaj sai sai ntawm chav tsev kub. Nws tuaj yeem yaj hauv qee cov kuab tshuaj organic xws li ethanol, acetone, thiab ethers. Nws solubility feem ntau nce nrog nce kub.

3. pH tus nqi thiab acid-base zog:

Nws yog ib qho acidic compound tsim los ntawm kev sib xyaw ntawm hydrochloric acid ions thiab quinoline molecules. Hauv cov tshuaj aqueous, nws reacts nrog dej molecules, tso H + ions, ua rau cov kua qaub. Nws tus nqi pH feem ntau yog nyob rau hauv cov kua qaub, kwv yees li 2-4.

4. Optical zog:

Nws muaj cov khoom siv kho qhov muag, uas ua rau kev sib hloov ntawm qhov teeb meem polarized teeb. Nws qhov kev hloov kho qhov muag nyob ntawm qhov concentration ntawm cov tshuaj, qhov kub thiab txias, thiab wavelength ntawm lub teeb pom kev.

5. Infrared spectrum:

Lub infrared spectrum ntawm nws qhia nws cov qauv molecular thiab ua haujlwm pab pawg. Feem ntau infrared absorption ncov suav nrog C=O stretching vibration (1700-1650 cm ^ -1), CO stretching vibration (1300-1000 cm ^ -1), CC stretching vibration (1600-1400 cm ^ -1), thiab lwm yam.

6. Tshuaj tiv thaiv:

Nws tuaj yeem koom nrog ntau yam tshuaj lom neeg, xws li cov tshuaj tiv thaiv acid-puag, cov tshuaj tiv thaiv oxidation, thiab txo cov tshuaj tiv thaiv. Tsis tas li ntawd, vim nws cov qauv quinoline, nws kuj muaj qee yam kev hloov pauv ntawm electrophilic thiab tuaj yeem hnov ​​​​mob nrog nucleophilic reagents xws li amines, cawv, thiab carboxylic acids nyob rau hauv qhov tsim nyog.

7. Fluorescence yam ntxwv:

Nws yog ib qho fluorescent compound uas muaj zog fluorescence. Nyob rau hauv UV excitation, nws emits xiav rau ntshav fluorescence. Cov yam ntxwv fluorescence no ua rau nws tseem ceeb rau kev siv hauv thaj chaw xws li tshuaj xyuas tshuaj thiab tshuaj lom neeg.

1.Golden Chicken Reaction

Thaum nws cov koob tshuaj txhua hnub ntau dua 1g lossis siv tsis tu ncua ntev, nws feem ntau ua rau cov tshuaj tiv thaiv ntawm cinchona. Cov tshuaj tiv thaiv no zoo ib yam li cov tshuaj tiv thaiv salicylic acid, tshwj xeeb tshaj yog tshwm sim:

• tinnitus, mob taub hau, xeev siab, ntuav
• Tsis pom kev thiab hnov ​​​​lus, mob hnyav tuaj yeem ua rau lag ntseg ib ntus, tab sis feem ntau rov zoo tom qab tsis siv tshuaj.

2. Kev puas tsuaj rau lub paj hlwb

Nws tuaj yeem ua rau muaj kev puas tsuaj rau lub paj hlwb, tshwj xeeb tshaj yog tshwm sim xws li:

• Kev tsis pom kev pom xws li txo qhov pom, diplopia, thiab amblyopia
• Cov mob hnyav tuaj yeem muaj cov tsos mob ntawm lub paj hlwb xws li convulsions thiab coma

Tshwj xeeb tshaj yog thaum cov koob tshuaj ntau dua 4g hauv 24 teev, nws tuaj yeem ua rau cov paj hlwb ncaj qha thiab ua rau cov hlab ntsha ntawm lub qhov muag, ua rau qhov pom tau hais tseg.

3. Cov kab mob plawv teb

Nws kuj muaj qee yam cuam tshuam rau cov hlab plawv, thiab cov tsos mob hauv qab no yuav tshwm sim:

4.Hematological system cov tshuaj tiv thaiv

Lub sij hawm ntev los yog siv ntau dhau ntawm nws yuav ua rau thrombocytopenia thiab ua rau cov kab mob hemorrhagic. Tsis tas li ntawd, ib qho me me ntawm cov tshuaj no tuaj yeem ua rau mob hemolysis (mob zis dub) thiab tuag rau ob peb tus neeg mob uas mob malaria.

5.Digestive system teb
Quinine hydrochloride kuj tseem tuaj yeem ua rau tsis xis nyob hauv lub plab zom mov, tshwj xeeb tshaj yog tshwm sim:

xeev siab, ntuav, tsis qab los noj mov, tsam plab, raws plab, thiab lwm yam

6.Lwm cov tshuaj tiv thaiv

Ntxiv nrog rau cov tshuaj tiv thaiv saum toj no, nws kuj tseem tuaj yeem ua rau cov tsos mob hauv qab no:

• Kev ua xua xws li pob khaus, khaus, mob hawb pob, thiab lwm yam
• Thaum cov tshuaj lom, lub raum tsis ua haujlwm tuaj yeem tshwm sim, tej zaum vim kev ua haujlwm tsis zoo
• Cov poj niam cev xeeb tub uas siv nws tuaj yeem ua rau nchuav menyuam thiab tuaj yeem cuam tshuam rau lub cev tsis hnov ​​lus thiab lub paj hlwb hauv nruab nrab los ntawm cov placenta
• Nws kuj tseem tuaj yeem ua rau photosensitive, ua rau tawv nqaij ua xua rau hnub ci

7. Kev siv tshuaj yeeb
Nws tuaj yeem cuam tshuam nrog qee yam tshuaj thaum siv ua ke, xws li:

• Tom qab siv ua ke nrog mob plawv glycosides, qhov concentration ntawm cardiac glycosides hauv cov ntshav ntawm qee cov neeg mob nce ntxiv, ua rau lawv muaj kev cuam tshuam rau cov tshuaj lom.
• Kev sib xyaw nrog cov tshuaj hypoglycemic tuaj yeem ua rau mob hnyav heev
• Ua ke nrog cov leeg nqaij so, nws tuaj yeem ua rau ua pa nyuaj

1. Ua raws li tus kws kho mob cov lus qhia kom noj tshuaj

nruj me ntsis tswj cov koob tshuaj quinine thiab siv nws raws li kev pom zoo noj tshuaj uas kws kho mob lossis cov lus qhia tshuaj. Tsis txhob nce lossis txo qhov koob tshuaj lossis hloov cov tshuaj ntawm koj tus kheej.
Feem ntau nws yog qhov zoo dua los noj nws ntawm qhov ncauj thiab tsis txhob muab nws tso rau hauv cov hlab ntsha lossis sai sai.

2. Saib xyuas lub cev tiv thaiv

3.Cov neeg tshwj xeeb yuav tsum siv ceev faj

4. Ua tib zoo saib xyuas cov tshuaj sib cuam tshuam

• Nws yuav tsum tau siv nrog ceev faj thaum ua ke nrog cov tshuaj anticoagulants, vim tias nws tuaj yeem cuam tshuam cov synthesis ntawm prothrombin hauv daim siab thiab txhim kho cov txiaj ntsig ntawm anticoagulants.
• Thaum siv, tsis txhob sib koom nrog lwm cov tshuaj uas yuav ua rau xeev siab thiab ntuav.

5. Kev tswj hwm kev noj haus thiab kev ua neej

• Thaum noj tshuaj, haus dej kom txaus yuav tsum tau tswj kom txo tau nws cov tshuaj lom.
• Ua tib zoo saib xyuas kev noj zaub mov kom huv thiab tsis txhob noj cov zaub mov muaj roj ntau dhau thiab ua rau khaus kom tsis txhob ua rau lub nra hnyav rau ntawm txoj hnyuv.
• Tuav tus cwj pwm pw tsaug zog zoo thiab zam kom tsis txhob muaj qhov tsis zoo xws li pw tsaug zog thiab ua haujlwm dhau.

6.Lwm kev ceev faj

• Thoob plaws hauv tag nrho cov txheej txheem kho mob, cov ntshav qab zib yuav tsum tau saib xyuas txhua lub sijhawm, vim tias ob qho tib si malaria nws tus kheej thiab quinine tuaj yeem ua rau cov tshuaj insulin ntau ntxiv thiab ua rau cov ntshav qab zib tsawg.
• Yog tias koj xav siv nws ua ke nrog lwm cov tshuaj, koj yuav tsum sab laj nrog kws kho mob lossis kws muag tshuaj kom nkag siab txog kev sib cuam tshuam ntawm cov tshuaj thiab cov kev pheej hmoo.

Cim npe nrov: quinine hydrochloride/hcl cas 60-93-5, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom