Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov khoom lag luam thiab cov khoom lag luam ntawm LOperamide Hmoov li 53179-11-6 nyob hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo nyob liploamide hmoov li 53179-11-6 kev muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Lageramide Hmoovyog ib tug artificially synthesized opioid derivative. Txawm li cas los xij, nws cov khoom siv hauv lub cev ua rau nws ua rau muaj kev sib tw ntawm lub cev, thaum nyuaj rau kev nkag mus rau hauv cov ntshav hauv lub cev, thaum lub sijhawm nyuaj siab. Cov xeeb ceem no tso cai rau nws los khaws lub zog anti- dogy nyhuv thaum yuav luag tsis muaj tshuaj ntsuab thiab kev ua kom muaj cov tshuaj opioid ib txwm muaj. Nws khi ncaj qha mus rau Opioid receptors ntawm lub plab hnyuv sab nrauv, ua haujlwm ntev dua ntawm lub plab zom mov, thiab ua kom nruj kev nro ntawm lub anal sphincter. Tseem ceeb tshaj, nws tuaj yeem txo plab hnyuv thiab elecolytes. Qhov no dual me ntsis kev txwv tsis pub muaj perovalsis thiab txo cov ntawv sau zais cia ua kom sai thiab tswj tau ntau yam tsos mob ntawm raws plab. Vim nws cov kev ua tau zoo thiab zoo peripheral xaiv, cov tshuaj hmoov nplej muaj dav yog qhov tseeb rau hauv cov cwm tsis yog xws li kev ua xua kev ua xua thiab kis rau kev sib xyaw. Txawm li cas los xij, nws yuav tsum siv raws li kev qhia kho mob kho mob nruj, tshwj xeeb tshaj yog rau daim ntawv hmoov, uas muaj cov kev coj dawb huv. Yog tias nws raug tsim txom lossis noj ntau dhau los, tshwj xeeb yog ua rau muaj kev cuam tshuam loj, tab sis kuj tseem muaj kev cuam tshuam nrog kev ua phem, tab sis kuj tseem muaj kev cuam tshuam nrog kev ua phem, tab sis kuj tseem muaj kev cuam tshuam nrog kev ua phem, tab sis kuj tseem muaj kev cuam tshuam nrog kev ua phem, tab sis kuj tseem tuaj yeem ua rau muaj kev phom sij heev thiab torsalal Yog li ntawd, txawm hais tias nws yog ib qho kev sib xyaw ua ke ntawm dhau- Cov tshuaj {14} {14}, thiab siv kev ceev faj kev ceev faj thiab kev tswj hwm zoo.
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Tshuaj Cov Qauv |
C29h33Cln2o2 |
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Muaj pes tsawg leej |
476 |
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Molecular hnyav |
477 |
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m/z |
476 (100.0%), 478 (32.0%), 477 (31.4%), 479 (10.0%), 478 (4.7%) |
|
Kev Ntsuam Xyuas |
C, 73.02; H, 6.97; Cl, 7.43; N, 5.87; O, 6.71 |
Synthetic LOperamide:
1. Nrog diphenylacetonitrile raws li cov khoom siv raw, nws rov qab ua rau cov pa dej, qhib nrog metylenyl ketone thiab sodium Cov pa roj carbonate los tsim cov lagopamate. Tag nrho cov txiaj ntsig yog 13.4% raws li diphenylacetrile.
2. Tom qab cov tshuaj tiv thaiv ntawm diphenylacetronitrile (i) thiab sodium amino, Ethylene oxide tau qhia thaum 5 ~ 10 degree. Tom qab dhau mus, cov tshuaj tiv thaiv tau nqa tawm ntawm chav tsev kub tom qab tiv thaiv cua sov tom qab kev tiv thaiv sov, thiab compound (II). Ntxiv 36% glacial acetic acid cov kua ntawm hydrogen bromide rau compound (i) thiab do ntawm 25 ~ 30 degree. Lim thiab ntxuav nrog dej mus rau pH. Compound (ⅲ) tau los ntawm kev ziab nrog cov txiaj ntsig ntawm 88%. Compound (III) yog chlorinated nrog thaleyl chloride rau compound (iv) hauv 95% tawm los. Compound (IV) thiab sodium carbonate yog yaj thiab dej, thiab dimethylamine tau qhia nyob rau hauv 0 ~ 5 teev rau kev tiv thaiv kom sov. Cov txheej dej txheej yog muab rho tawm nrog chloroform thiab cov extract yog feeb meej. Qhov seem yog recrystallized nrog methyl iSobutyl ketone kom tau txais cov compound (v) nyob rau hauv ib tug tawm los ntawm 56%. Compound (v), compound (vi), sodium carbonate thiab poov tshuaj Iodide tau yaj nyob rau hauv methylutyl ketone thiab lub cev qhuav dej los ntawm Reflux. Rov qab siv cov kuab tshuaj txo qis, ntxiv isopropanol kom muaj qhov hnyav li ntawm 2℃kom tau txais qhov hnyav rau pH 6.
Qhov kawg cov khoom lag luam ntawm cov tshuaj no feem ntau yog rau cov nyhuv ntawm cov leeg plab hnyuv, uas tuaj yeem inhibit qhov kev cog lus ducle thiab txo cov hnyuv. Nyob rau tib lub sijhawm, nws kuj tuaj yeem txo cov neurotransmitters tso tawm los ntawm cov hlab ntsha tawm ntawm cov hnyuv thiab ncaj qha inhibit reflex. Thiab cov tshuaj muaj peev xwm ncua sijhawm lub sijhawm nyob hauv txoj hnyuv, txhawb nqa cov pa dej, txhawb nqa cov pa roj av, yog li nws kuj muaj cov kev cuam tshuam zoo rau cov zawv plab. Txawm li cas los xij, cov tshuaj no tsis haum rau kev kis zawj yog, yog tias, thaum muaj mob raws plab, raws plab nyob rau lub sijhawm no yog qhov kev tiv thaiv ntawm lub cev. Yog tias muaj kev txwv tsis pub muaj mob raws plab, nws yuav ua rau qhov kev txom nyem ntawm kev ua pa thiab kub taub hau.
Pharmacological cuam tshuam: cov qauv siv tshuaj ntawmLageramide HmoovZoo ib yam li ntawd ntawm Haloperidol thiab pethidine thiab kho cov koob tshuaj tau tsis muaj kev cuam tshuam rau hauv nruab nrab lub paj hlwb. Cov nyhuv ntawm cov leeg plab hnyuv zoo ib yam li cov tshuaj opioid thiab diam tau interaction ntawm cov leeg plab hnyuv thiab txo cov hnyuv. Nws kuj tseem tuaj yeem txo cov kev tso tshuaj acetylcholine los ntawm cov hnyuv sab nrauv Cov khoom no tuaj yeem ncua sijhawm lub sijhawm nyob hauv cov hnyuv, txhawb kev nqus dej, thiab lwm yam enterotoxins, thiab lwm yam enterotoxins, tab sis cov tshuaj enterotoxins Cov khoom no tseem tuaj yeem nce cov kev tsis sib yeem ntawm cov leeg cov leeg nqaij, yog li txhaws kev zam kev txo qis tsis sib xws thiab kev kub ntxhov.
Pharmaconininet: Cov khoom no tau yooj yim nqus los ntawm cov hnyuv phab ntsa, thiab yuav luag txhua tus ntawm nws nkag mus rau lub siab metabolism. Vim nws lub horstfinity rau lub plab hnyuv thiab "thawj zaug kev sib tw ntawm cov ntshav hauv lub cev. Cov ntshav siab txog cov tshuaj muaj tshuaj muaj tsawg heev, thiab qhov siab tshaj plaws ntawm ntshav yog 5 teev tom qab kev tswj hwm qhov ncauj ntawm cov tshuaj ntsiav. Cov nyhuv ntev rau ntau tshaj 24 teev. T1 / 2 yog 10.8H nyob rau nruab nrab. Tus nqi protein khi yog 97%. Ua kom zoo los ntawm kua zaub thiab cov quav. Kev ua yeeb yam hauv zis rau txog 5% - 10%.
Cov tshuaj twg muaj kev nyab xeeb dua?
1.Tus neeg (YIMongting)
Mechanism ntawm Kev Ua:LOperamide feem ntau ua raws li tus antidoorHeal tus neeg sawv cev los ntawm kev khi rau cov plab hnyuv opesinal desility, maj mam nqes lub sijhawm ua haujlwm.
Kev Ruaj Ntseg:
- Ntawm cov kev pom zoo siv, LOperamide yog qhov muaj kev nyab xeeb thiab siv tshuaj tiv thaiv kab mob antidiarnrhant.
- Txawm li cas los xij, tshaj li qhov kev pom zoo ntau npaum li cas yuav ua rau muaj teeb meem loj, suav nrog tus xub tsim tiag tiag thiab tuag. Tshwj xeeb tshaj yog nyob rau hauv cov rooj plaub ntawm kev txhob txwm ua lossis kev tsim txom, kev pheej hmoo siab dua.
- LOperamide tseem yuav ua rau muaj kev nkag siab nruab nrab ua rau muaj kev tsaug zog, kiv taub hau, ua pa qeeb lossis tawv nqaij zoo li kev quav ntsej muag.
- Kev siv ntev dav dav yuav ua rau kev vam khom.
Cov teeb meem xav tau saib xyuas:
- Nruj me ntsis ua raws li cov kev qhia txog kev pab them nqi kho mob lossis cov lus qhia.
- Zam kev siv nws ua ke nrog lwm cov tshuaj uas yuav ua rau quav ntsej.
- Yog tias cov tsos mob hnyav xws li tsaus muag, lub plawv dhia ceev ceev, lossis lub plawv dhia sai sai.
2.mmoralonite hmoov
Mechanism ntawm Kev Ua:Montmorillonite hmoov tsuas yog muab tshem tawm cov kab mob, cov kab mob, thiab lawv cov co toxins los ntawm kev nkag mus rau lub plab hnyuv mucosa, ua tiav cov txiaj ntsig ntawm kev nres zawv plab.
Kev Ruaj Ntseg:
- Montmorillonite hmoov muaj ib tug zoo anti diatrheal effect thiab kuj muaj ob peb yam kev mob tshwm sim.
- Qhov tseem ceeb sab efficys yog concepation yog quav, tab sis nws feem ntau me me.
- Montmorillonite hmoov yuav tsum tau nkag mus rau hauv cov kab ncig, yog li nws cuam tshuam rau tag nrho lub cev yog qhov me me.
Cov teeb meem xav tau saib xyuas:
- Ua raws li cov lus qhia noj tshuaj rau ntawm kws kho mob cov lus qhia lossis lus qhia.
- Thaum muaj raws plab, kev noj haus yuav tsum yog lub teeb kom tsis txhob muaj mob plab zom zaws.
3.Geej taws
- Kev Nyab Xeeb:Under correct medication, the safety of montmorillonite powder is relatively high, with mild and rare side effects; Txawm hais tias LOperamide muaj cov tshuaj tiv thaiv zoo, muaj kev pheej hmoo ntawm kev tsim txom uas tuaj yeem ua rau muaj kev tsis zoo.
- Cov neeg muaj feem:Montmorillonite hmoov yog haum rau cov neeg mob nrog mob raws plab tshwm sim los ntawm cov kab mob hnyuv; LOperamide yog haum rau raws plab tshwm sim los ntawm mob siab thiab tus mob optitis.
- Cov lus qhia Medical:Thaum xaiv tshuaj tiv thaiv kab, kev xaiv yuav tsum yog raws tus neeg mob cov lus qhia tshwj xeeb thiab tus kws kho mob cov lus qhia. Txog kev zawv plab tshwm sim los ntawm kev cuam tshuam ib lub microbiota, cov hmoov montmorillonite yuav tau ntau dua; Txog kev zawv plab tshwm los ntawm mob siab thiab tus mob nkag mus ntev, LOperamide yuav ua tau zoo dua. Txawm li cas los xij, tsis hais cov tshuaj uas siv, nruj me ntsis rau cov lus qhia kho mob lossis cov lus qhia yuav tsum tau ua kom muaj kev tshuaj nyab xeeb.
Puas tuaj yeem muab cov compound no ua ke nrog cov probiotics?
Cov nyhuv ntawm probiotics ntawm kev quav ntsej muag
Ib txoj kev tshawb fawb tau tsim muaj tus nas cem quav qauv los ntawm cov kab ke no thiab cuam tshuam nrog kev npaj ua ntej npaj ua ntej. Cov txiaj ntsig tau pom tias kev npaj ua ke tsim tau muaj peev xwm txhim kho cov nqi ntawm cov nas, thiab cov protein rau hauv cov hnyuv nyog cov ntaub so ntswg, thiab ua kom muaj txiaj ntsig loj hauv plab zom mov.
Cov nyhuv ntawm probiotics ntawm LOperamide Tawg cem quav
Lwm txoj kev tshawb nrhiav kuj pom tias cov probietics tuaj yeem pab txhim kho lub sijhawm ntawm cov tawv nqaij, thiab iGA nyob rau lub sijhawm, thiab ua rau muaj kev cuam tshuam rau lub plab zom mov.
Zam kev siv nrog tshuaj tua kab mob
Nyob probiotic npaj yuav tsum tau zam ntawm kev siv ib txhij nrog tshuaj tua kab mob ntau li ntau tau.
Lub luag haujlwm ntawm Probiotics
Probiotics tsis yog tsuas muaj txiaj ntsig rau tib neeg kev noj qab haus huv, tab sis kuj tseem siv tau los kho zawv plab. Lawv tuaj yeem txo qis qhov tshwm sim ntawm cov tshuaj tua kab mob dogrreas (AAD).
Dab tsi yog cov kev ceev faj rauLageramide Hmoov, xws li yuav ua li cas khaws cia thiab khaws cia nws?
1. Intorage thiab cov txheej txheem khaws tseg
Qho so
Cov compound no yuav tsum tau muab cia rau hauv chav tsev kub, feem ntau ntawm 10℃thiab 30 degree, kom tsis txhob muaj ib puag ncig siab thiab tsawg dua los tiv thaiv cov tshuaj tsis zoo. Qee qhov chaw qhia tias qhov ntsuas kub yuav tsum qis dua 20 degree.
Kev vaum
Nws yuav tsum muab cia rau hauv qhov chaw nrog cov av noo tsawg los tiv thaiv kom noo los ntawm kev ua tau zoo ntawm cov tshuaj. Cov tshuaj ntub ntau dhau yuav ua rau cov tshuaj ntsiav ntau yuav ua rau cov tshuaj ntsiav kom mos muag, ua raws li, lossis ua rau cov kev hloov pauv ntawm cov tshuaj muaj pes tsawg leeg.
Daim duab
Zam kev tshav ntuj ncaj qha thiab khaws cia rau qhov chaw txias thiab tsaus. Lub teeb kis lub teeb tej zaum yuav cuam tshuam rau qhov ruaj khov thiab ua tau zoo ntawm cov tshuaj.
Ntim kev ncaj ncees
Nco ntsoov tias cov ntim tshuaj yog lawm thiab tiv thaiv huab cua, ya raws, thiab lwm yam los ntawm kev nkag mus thiab cuam tshuam cov tshuaj zoo. Muab ntim cia tuaj yeem txuas ntxiv rau lub neej txee ntawm cov tshuaj kom ntau li ntau tau.
Chaw Cia
Nws yuav tsum muab tso rau hauv qhov chaw siab lossis xauv cov txee uas tsis ncav cuag cov menyuam yaus thiab tsiaj kom tsis txhob muaj kev txwv tsis pub noj.
Zam kev sib xyaw nrog lwm cov tshuaj noj
Tiv thaiv kev sib raug zoo ntawm cov tshuaj sib txawv thiab ua kom muaj kev tshuaj noj muaj kev nyab xeeb.
2.Txoj kev tiv thaiv kev noj tshuaj
Lub sij hawm ntawm kev siv tau
Nquag xyuas cov hnub tas sij hawm ntawm cov tshuaj. Cov tshuaj uas nyob ze rau kev tas sij hawm lossis twb tas yuav tsum tau siv sijhawm.
Rational siv cov tshuaj
Nrawm ua raws li cov kws kho mob cov lus qhia thiab tsis nce lossis txo qis kev siv tshuaj lossis ua kom lub sijhawm ntev txog koj tus kheej.
Saib cov tshuaj uas tsis zoo
Yog tias muaj kev cuam tshuam tsis zoo xws li xeev siab, ntuav, cem, kev kho mob quav, nrhiav tus kws kho mob ntawm koj li kev kho mob.
Siv nrog ceev faj rau cov neeg tshwj xeeb
- Cev xeeb tub thiab lactating poj niam yuav tsum siv nrog kev ceev faj thiab ntsuas qhov zoo thiab kev ua tiav ua ntej siv.
- Siv nrog kev ceev faj rau cov neeg mob uas mob siab puas, vim tias nws yuav ua rau lub qhov ntswg kom haum.
Kev sib cuam tshuam yeeb tshuaj
Qhov no sib xyaw no yuav cuam tshuam nrog lwm cov tshuaj, xws li thaum siv cov tshuaj tua kab yees, tshuaj antichicgicergic, thiab lwm yam ceev faj yuav tsum tau siv.
TXUAG KAWG
Nquag tshuaj xyuas cov tsos thiab ntim ntawm cov tshuaj. Yog tias cov tsiav tshuaj pleev xim tso tawm, deformation, lossis tawg, lawv tsis tuaj yeem siv.
Cim npe nrov: LOperamide Hmoov Cas 53179-11-6, Chaw tsim khoom, chaw tsim khoom, Hoobkas, lag luam wholesale, yuav, nqe, loj, loj, rau muag