Streptozotocin uayog ib qho tshuaj lom neeg nrog ntau yam kev ua haujlwm lom neeg. Cov tsos yog lub teeb daj crystalline hmoov uas yooj yim soluble hauv dej. Nws yuav tsum tau muab cia rau hauv qhov chaw qhuav thiab tsaus ntawm 0 º C nrog argon filling. Nws tau pib cais tawm thiab muab rho tawm los ntawm qee hom Streptomyces, thiab nrog kev nce qib ntawm kev tshawb fawb thiab thev naus laus zis, tam sim no nws tuaj yeem npaj los ntawm cov txheej txheem tshuaj lom neeg. Raws li DNA methylation reagent, nws tuaj yeem ua rau muaj txiaj ntsig lom neeg hauv cov kab mob muaj sia. Nyob rau tib lub sijhawm, nws kuj muaj cov khoom tshwj xeeb xws li melting point thiab refractive index, uas yog qhov tseem ceeb rau kev txheeb xyuas nws cov purity thiab kev tswj kom zoo. Nws siv tuaj yeem ua rau DNA methylation hauv cov hlwb, yog li hloov kho cov qauv ntawm chromatin thiab kev nyeem tau ntawm cov noob, yog li cuam tshuam rau cov txheej txheem lom neeg xws li cell proliferation, sib txawv, thiab apoptosis; Hauv kev tshawb fawb txog kev kho mob, STZ feem ntau yog siv los ua tus qauv tsiaj los ua kom muaj kev sim ntshav qab zib. Nws kuj tseem muaj peev xwm ua kom muaj cell apoptosis thiab inhibit cell proliferation, uas ua rau nws muaj txiaj ntsig zoo hauv kev tshawb fawb ntawm cov tshuaj tiv thaiv kab mob.
Cov ntaub ntawv ntxiv ntawm chemical compound:
|
Tshuaj Formula |
C8H15N3O7 |
|
Exact Mass |
265.09 |
|
Molecular Luj |
265.22 |
|
m/z |
265.09 (100.0%), 266.09 (8.7%), 267.10 (1.4%), 266.09 (1.1%) |
|
Elemental Analysis |
C, 36.23; H, 5.70; N, 15.84; O, 42.23 |
|
Melting point |
121℃(lub kaum hli ntuj) (lit.) |
|
Boiling point |
408.44℃(kev kwv yees ntxhib) |
|
Qhov ntom |
1.4410 (kev kwv yees kwv yees) |
|
Cia tej yam kev mob |
-20 degree |
 |
 |
Streptozotocin uayog ib qho glucosamine nitrosourea derivative nrog ntau yam kev siv, tshwj xeeb hauv kev tshawb fawb biomedical. Lub ntsiab kev siv ntawm no compound yog raws li nram no:
STZ yog dav siv los ua kom muaj kev sim ntshav qab zib hauv cov qauv tsiaj. Los ntawm kev txhaj tshuaj STZ rau hauv cov tsiaj (xws li nas, nas, thiab lwm yam), lawv cov islet B hlwb tuaj yeem raug rhuav tshem, ua rau txo qis insulin secretion, yog li simulating pathogenesis ntawm tib neeg mob ntshav qab zib. Cov qauv no yog qhov tseem ceeb hauv kev kawm txog cov kab mob pathogenesis thiab cov teeb meem ntawm cov ntshav qab zib thiab ntsuas qhov ua tau zoo ntawm cov tshuaj tshiab.
Kev tshawb fawb txog tshuaj tiv thaiv -cov tshuaj qog nqaij hlav
STZ kuj tau pom tias muaj peev xwm ua rau cov cell apoptosis thiab inhibit cell proliferation, uas ua rau nws muaj txiaj ntsig zoo hauv kev tshawb fawb ntawm cov tshuaj tiv thaiv kab mob. Tam sim no, ntau pab pawg tshawb fawb tab tom tshawb nrhiav cov ntawv thov tshwj xeeb thiab cov txheej txheem ntawm STZ hauv kev kho mob qog noj ntshav, nrog rau lub hom phiaj los tsim cov tshuaj tiv thaiv kab mob tshiab. Nws yog ib qho tshuaj tiv thaiv - qog thiab cov tshuaj tiv thaiv kab mob tiv thaiv kab mob uas tuaj yeem cuam tshuam DNA synthesis hauv cov qog hlwb thiab qee cov enzymes tseem ceeb koom nrog hauv pyrimidine nucleoside metabolism thiab gluconeogenesis. Nyob rau hauv lub cev, nws muaj peev xwm spontaneously decompose thiab tsim methyl carbide ions uas ua rau DNA ob strand cross-txuas. Nws yog tsuas yog siv rau kev kho mob ntawm pancreatic cell carcinoma (beta cell lossis non beta cell carcinoma), uas tuaj yeem txo 50% mus rau 60% ntawm cov neeg mob pancreatic cell carcinoma. Thaum ua ke nrog 5-FU, qhov ua tau zoo tuaj yeem txhim kho.
Ntxiv nrog rau cov ntawv sau tseg, STZ kuj tau siv rau hauv lwm qhov kev tshawb fawb biomedical. Piv txwv li, nws tuaj yeem siv los ua DNA methylation reagent los cuam tshuam rau DNA methylation txheej txheem, yog li tswj cov noob qhia thiab kev coj tus cwj pwm ntawm tes. Tsis tas li ntawd, STZ tseem tuaj yeem ua tus pub dawb ntawm nitric oxide (NO) thiab vasodilator, nrog rau qee yam kev siv hauv kev tshawb fawb ntawm cov hlab plawv.
Cov kev mob tshwm sim ntawm cov tshuaj no yog dab tsi?
Cov teebmeem ntawmStreptozotocin uaFeem ntau koom nrog ntau yam, thiab cov hauv qab no yog cov ncauj lus kom ntxaws txog nws cov kev mob tshwm sim:
► Kev puas tsuaj ncaj qha rau cov tsiaj sim lossis cov neeg mob
STZ muaj tshuaj lom heev thiab yuav tsum muaj kev tswj hwm nruj ntawm kev siv tshuaj thiab kev tswj hwm kom tsis txhob muaj teeb meem tsis tsim nyog rau cov tsiaj sim lossis cov neeg mob. Tshwj xeeb tshaj yog, STZ tuaj yeem ua rau muaj kev cuam tshuam tsis zoo hauv cov tsiaj sim lossis cov neeg mob, suav nrog tab sis tsis txwv rau xeev siab, ntuav, raws plab, thiab lwm yam. Txawm hais tias cov tshuaj tiv thaiv no feem ntau me me thiab thim rov qab, lawv tseem yuav tsum tau saib xyuas los ntawm cov kws tshawb fawb thiab cov neeg ua haujlwm kho mob.
► Qhov cuam tshuam rau daim siab thiab lub raum ua haujlwm
Kev siv STZ mus ntev yuav muaj qee yam cuam tshuam rau lub siab thiab lub raum ua haujlwm. STZ muaj qee qib ntawm nephrotoxicity, uas tuaj yeem ua rau muaj qhov txawv txav ntawm lub raum tubules thiab glomeruli. Kev puas tsuaj loj tuaj yeem pom hauv qee feem ntawm cov neeg mob, ua rau cov tsos mob xws li proteinuria, ntshav qab zib, ketone zis, nce ntshav urea nitrogen, thiab ntshav creatinine. Yog li ntawd, nws yog ib qho tsim nyog yuav tsum tau saib xyuas lub siab thiab lub raum kev ua haujlwm ntsig txog cov cim qhia thaum siv los xyuas kom cov neeg mob muaj kev nyab xeeb.
► Lwm yam kev pheej hmoo
Ntxiv nrog rau cov kev mob tshwm sim saum toj no, STZ tseem ua rau muaj lwm yam kev pheej hmoo. Piv txwv li, STZ tuaj yeem ua rau cov cell apoptosis thiab inhibit cell proliferation, uas yuav ua rau nws muaj peev xwm los tiv thaiv -cov tshuaj qog nqaij hlav, tab sis nws kuj tuaj yeem ua rau kev puas tsuaj thiab kev tuag ntawm cov hlwb ib txwm. Tsis tas li ntawd, STZ kuj tseem tuaj yeem cuam tshuam rau cov txheej txheem methylation ntawm DNA, yog li tswj cov noob qhia thiab kev coj tus cwj pwm ntawm tes, uas yuav muaj kev cuam tshuam tsis zoo rau kev ua haujlwm ntawm tes thiab cov metabolism.
► Kev ceev faj rau kev siv
Kev tswj hwm nruj ntawm kev siv tshuaj thiab kev tswj hwm txoj kev: Vim muaj cov tshuaj lom neeg siab ntawm STZ, nws yog ib qho tsim nyog yuav tsum nruj me ntsis tswj cov tshuaj noj thiab kev tswj hwm txoj kev siv thaum siv kom tsis txhob muaj kev phiv thiab muaj feem cuam tshuam los ntawm kev siv ntau dhau.
Ua tib zoo saib xyuas cov ntsuas ntsuas: Thaum siv, nws yuav tsum ua tib zoo saib xyuas lub siab thiab lub raum kev ua haujlwm, cov ntshav qabzib, thiab lwm yam ntsuas ntsuas kom pom sai thiab tswj cov xwm txheej txawv txav.
Ua tib zoo saib xyuas kev ruaj ntseg ntawm cov tshuaj: STZ cov tshuaj yog qhov tsis ruaj tsis khov ntawm chav tsev kub thiab yooj yim decomposes rau hauv cov pa thiab evaporates, yog li nws yuav tsum tau siv thiab npaj rau ntawm qhov chaw kom ntseeg tau tias nws ua haujlwm tau zoo.
Kev muag khoom thiab kev txhim kho cov ntaub ntawv ntawm qhov sib xyaw no
Streptozotocin ua(streptozotocin) yog ib qho tseem ceeb ntawm biochemical reagent, uas yog siv los npaj tsiaj cov qauv ntawm ntshav qab zib. Nov yog cov ncauj lus kom ntxaws txog nws qhov muag:
1. Lub hom phiaj tseem ceeb
Streptozotocin tuaj yeem xaiv rhuav tshem cov kab mob pancreatic islet hlwb ntawm qee yam tsiaj thiab ua rau muaj ntshav qab zib hauv ntau tus tsiaj (xws li nas thiab nas), yog li nws tau siv dav los npaj cov tsiaj mob ntshav qab zib.
2.KEV
Hom thiab purity
Lub purity ntawm streptozotocin muab los ntawm ntau hom yuav txawv, thiab cov purity specifications muaj xws li ntau tshaj los yog sib npaug rau 98% (HPLC), Ntau tshaj los yog sib npaug rau 99% thiab hais txog.
Piv txwv li, Solarbio muab streptozotocin nrog ib tug purity ntawm Min.75% raws li alpha anomer, thaum Zeye Biotechnology muab cov khoom nrog ib tug purity ntawm Greater los yog sib npaug rau 98% (HPLC).
Nqe thiab ntim
Tus nqi ntawm streptozotocin sib txawv nyob ntawm seb yam khoom xws li hom, purity, ntim specifications, thiab lwm yam. Feem ntau hais lus, tus nqi ntawm cov pob me me (xws li 100mg) yog qis dua, thaum tus nqi ntawm cov pob loj (xws li 1g, 5g) kuj zoo dua. Piv txwv li, tus nqi ntau ntawm Solarbio hom tshuaj streptozotocin txawv ntawm 170 yuan mus rau 5000 yuan, nyob ntawm seb lub ntim specifications. Lub 100mg ntim specification ntawm streptozotocin muab los ntawm Zeye Biotechnology yog luv nqi ntawm 146 yuan / thawv (yam tsawg batch loj loj dua los yog sib npaug rau 1 lub thawv).
Tus neeg muab khoom
Muaj ntau tus neeg muag khoom hauv tsev thiab txawv teb chaws uas muab cov khoom lag luam streptozotocin, suav nrog-cov npe paub zoo xws li Solarbio, Zeye Biotechnology, Sigma, thiab lwm yam. Cov neeg muag khoom no feem ntau muaj qhov zoo - tsim kev muag khoom network thiab tom qab- muag kev pabcuam, uas tuaj yeem muab cov neeg siv khoom raws sijhawm thiab kev pabcuam kev pabcuam thiab kev daws teebmeem.
Shipping thiab Cia
Cov khoom Streptozotocin feem ntau yog xa los ntawm kev xa khoom xa tuaj lossis kev xa khoom, thiab lub sijhawm xa khoom tshwj xeeb nyob ntawm tus neeg muag khoom cov khoom muag thiab cov neeg siv khoom xav tau. Cov khoom yuav tsum tau khaws cia kom qhuav, kom deb ntawm lub teeb, thiab ua raws li cov tub yees sib xws los yog khov khov thaum lub sij hawm thauj mus los kom ntseeg tau cov khoom zoo. Tom qab tau txais cov khoom, tus neeg siv khoom yuav tsum khaws nws kom raug raws li qhov chaw cia khoom los ntawm tus neeg muag khoom kom tsis txhob muaj qhov tsis zoo xws li ya raws, cua sov, lossis lub teeb raug.
3. Ceev faj
Kev npaj thiab siv
Streptozotocin yuav tsum tau npaj rau hauv ib qho kev daws teeb meem nrog pH 4.2-4.5, uas yog tsim los ntawm citric acid thiab sodium citrate. Thaum npaj, coj cov txheej txheem kev khiav hauj lwm yuav tsum tau ua raws li kom ntseeg tau tias qhov tseeb thiab ruaj khov ntawm cov tshuaj npaj. Kev ntsuas qhov tseeb yuav tsum tau ua raws li kev sim ua thaum siv, thiab kev sib xyaw nrog lwm cov tshuaj yuav tsum zam.
Kev nyab xeeb
Streptozotocin yog cov tshuaj lom neeg uas yuav tsum tau siv cov cuab yeej tiv thaiv tsim nyog (xws li hnab looj tes, lub qhov ncauj qhov ntswg, thiab lwm yam) kom tsis txhob sib cuag ntawm daim tawv nqaij lossis nqus pa. Thaum lub sij hawm kev sim, kev soj ntsuam kev nyab xeeb yuav tsum tau ua raws li nruj me ntsis kom tsis txhob muaj xwm txheej tshwm sim.
Kev cai thiab ua raws cai
Kev muag thiab kev siv streptozotocin yuav tsum ua raws li cov kev cai lij choj, cov cai, thiab cov kev cai. Cov neeg siv khoom yuav tsum ua raws li cov cai hauv zos thiab cov kev cai thaum yuav khoom thiab siv cov khoom, thiab ua raws li cov txheej txheem kev khiav hauj lwm thiab cov qauv kev nyab xeeb.
Cov tshuaj tiv thaiv thiab contraindications
|
|
|
|
|
STZ cuam tshuam nrog ntau yam tshuaj, yuav tsum tau ceev faj hauv kev tswj hwm:
● Glucocorticoids: Potentiate STZ's hyperglycemic cuam tshuam, ua rau mob ntshav qab zib ntau ntxiv.
● Phenytoin: Txo STZ's -cell cytotoxicity, cuam tshuam nws cov nyhuv antitumor.
● Nephrotoxins (piv txwv li, cisplatin, aminoglycosides): kev siv sib xyaw ua rau muaj kev pheej hmoo ntawm lub raum tsis ua haujlwm.
● Immunosuppressants (xws li, cyclosporine): Tej zaum yuav txhim khu STZ's hepatotoxicity, txwv tsis pub siv rau cov neeg tau txais kev hloov pauv.
Cov neeg mob uas muaj lub raum lossis lub siab tsis zoo, cev xeeb tub, lossis tsis haum rau nitrosoureas yuav tsum zam STZ. Ua ntej- kev tshuaj ntsuam xyuas ntshav qabzib-6-phosphate dehydrogenase (G6PD) tsis txaus yog pom zoo, raws li STZ-induced oxidative stress yuav ua rau hemolysis hauv G6PD-tsis muaj cov neeg.
Streptozotocin tseem yog cov cuab yeej tseem ceeb hauv cov tshuaj thiab kev tshawb fawb, cuam tshuam qhov sib txawv ntawm cov tshuaj khomob khomob thiab kev kuaj kab mob. Nws lub peev xwm tshwj xeeb los xaiv ua kom puas tsuaj -cov cell tau hloov pauv kev tshawb fawb txog ntshav qab zib, thaum nws cov khoom antineoplastic muab kev cia siab rau cov neeg mob uas tsis tshua muaj qog nqaij hlav pancreatic. Txawm li cas los xij, STZ's toxicity xav tau cov txheej txheem kev nyab xeeb nruj thiab kev soj ntsuam tas li ntawm nws qhov kev pheej hmoo -cov txiaj ntsig profile. Raws li kev tshawb fawb tau nce qib, STZ cov keeb kwm yuav dhau los ntawm kev siv cov khoom siv kho kom zoo thiab cov khoom siv tshiab uas siv nws lub zog thaum txo qis kev puas tsuaj, thaum kawg pab txhim kho kev kho mob ntshav qab zib, mob qog noj ntshav, thiab kab mob neurodegenerative.
Cim npe nrov: streptozotocin stz cas 18883-66-4, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom