GLabridin Hmoov Li 59870-68-7

Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov khoom lag luam ntawm GLabridin Hmoov Li 59870-68-7 nyob hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo glabridin hmoov cas 59870-68-7 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Glabridin Hmoovyog ib hom flavonoids, nrog cov ntsiab lus me ntawm cov hmoov av xim av thiab cov ntsiab lus zoo ntawm hmoov dawb. Molecular Cov Qauv C20H20O4, CAS 59870 {- 68- 7. Insoluble hauv dej, soluble hauv butanediol, propylene glycol thiab lwm yam tshuaj kuab organic. Muab rho tawm los ntawm cov nroj tsuag muaj txiaj ntsig hu ua glycyrrhiza glycyrrhiza Glycyrhiza Glycyrhiza Glyitening kub "vim hais tias ntawm nws cov txiaj ntsig dawb. Nws tuaj yeem tshem tawm cov radicals dawb thiab melanin rau hauv qab ntawm cov leeg. Nws yog tus dawb huv rau cov tawv nqaij ntxuav hniav thiab anti -} kev laus. Glycyrrhizin muaj lub zog dawb radical ua rau muaj kev phom sij, vitamin C, Vitamin E thiab {{} Carotene raug lees paub ua tus huab tais ntawm antioxidant thiab anti-anti-laus. Glycyrrhizin muaj tib lub peev xwm los tiv thaiv cov vitamin E. Nws yog antioxidant. Nws tau tshaj tawm tias antioxidant nyhuv ntawm nws cov antioxidant yog qhov zoo dua li ntawm BHA thiab BHT. Nws tau tshaj tawm nyob rau hauv cov ntawv nyeem uas tau siv los txo qis corticosteroids ntawm cov kab mob sib kis thiab ntxiv dag zog rau lub luag haujlwm ntawm steroids.

Glabridin Hmoovyog flavonoid compound extracted los ntawm lub hauv paus ntawm glycyrrhiza Glycyrhiza Glycella Glycra L., nrog tshuaj lom neeg ntawm c ₂ ₀ ₀ ₄ ₄ ₄ thiab txoj kev molecular hnyav ntawm 324.37. Raws li cov nroj tsuag ua kom muaj zog, nws muaj ntau yam kev kho mob xws li ntxuav hniav dawb, anti {{ Cov hauv qab no muab cov ncauj lus kom ntxaws tshuaj xyuas los ntawm peb qhov ntev: Cov Txiaj Ntsim Ua Noj, Thov Kev Tso Cai Siv Hluav Taws Xob, thiab Kev Kawm Txuj Ci.

Cov Tub Ntxhais Txawj Ntsuag thiab Mechanism ntawm Kev Ua

 

1. Kev ntxuav hniav dawb thiab cov teeb pom kev zoo: lub "Golden Cast" uas inhibits melanin ntau lawm
Guanggacancao ding blocks lub melanin synthesis txoj kev los ntawm inhibiting Tyrosinase kev ua si. Tyrosinase yog tus tseem ceeb enzyme hauv melanin ntau lawm, thiab glycyrrhizin tuaj yeem txo nws cov haujlwm los ntawm ntau tshaj 50%. Nyob rau tib lub sijhawm, nws txo qhov kev qhia ntawm DOPA cov xim isomerase (trp - 2), yog li txo melanin deposition los ntawm qhov chaw. Nws cov kev ntxuav hniav dawb yog cov tawv me thiab ntev ntev. Cov ntaub ntawv kuaj mob qhia tau tias tom qab siv cov khoom lag luam tawv dawb Piv nrog cov neeg ua kom dawb xws li hydroquinone thiab arbutin, glycyrrhizin muaj cov teeb meem qis dua thiab cov teeb meem melamma xws li melasma thiab Sunspots.

 

2. Antioxidant Tiv Thaiv: Lub ntuj Scavenger ntawm Dawb Radicals
Lub antioxidant muaj peev xwm ntawm Guanggancao ding yog sib npaug ntawm vitamin E. Cov qauv molroxyl muaj peev xwm ntes dawb radicals thiab inhibit lipid peroxidation. Hauv kev sim ntawm tes, glycyrrhizin tuaj yeem txo cov qib oxyget, tiv thaiv hluav taws xob hluav taws xob, tiv thaiv kev ncaj ncees ntawm cov xov tooj ntawm tes. Cov kev sim tsiaj tau pom tias qhov kev coj ua ntawm Glycyrrhizin tuaj yeem ua rau muaj kev phom sij Superoxide los ntawm 35%) cov ntsiab lus ntawm daim tawv nqaij.

 

3. Anti Kev Kho Mob Raug Mob: Ib qho "cov tshuaj kho mob" rau cov kab mob tawv nqaij
Guanggancao ding txo qhov tso tawm cov kev tawm tsam (xws li inhus}}}}}}}}}}}}}}}}}}}} {}}} Cov kev tshawb fawb soj ntsuam tau pom tias tom qab kev kho mob nrog lub cream muaj 1% khaus ntawm cov neeg mob eczema txo qis los ntawm thaj chaw ntawm 67% thiab cov tawv nqaij lesion txo li 54%. Nws cov tshuaj tua hluav taws xob tawm tsam zoo ib yam li cov glucocorticoids, tab sis tsis muaj kev pheej hmoo ntawm cov nqaij daim tawv nqaij li xws li pob txuv thiab rosacea.

 

4. Lub cev tiv thaiv kab mob: "muaj kev tswj hwm roj ntsha" uas txhim kho lub cev tiv thaiv lub cev
Guanggancao ding tuaj yeem qhib macrophage phagocytic muaj nuj nqi, txhawb t lymphocyte proliferation, thiab txhim kho lub cev lub cev tsis muaj zog. Cov kev sim tau pom tias Guanggancao ding tuaj yeem nce cov ntshav qab zib iGG ntawm cov nas los ntawm 42% thiab txhim kho lawv tus kab mob khaub thuas. Hauv cov teb kho mob, nws yog siv los pab rau kev kho mob herpes Zoster, herpes yooj yim thiab lwm yam kab mob sib kis, ua rau muaj kev pheej hmoo ntawm cov kab ke.

 

5. Anti glycation thiab anti {-}}}}}} Cov khoom siv ntau yam rau kev ncua tawv nqaij
Guanggancao ding tuaj yeem inhibit tiam ntawm advanced glycation kawg cov khoom (hnub nyoog), txo cov ntoo khaub lig-}}}} txuas, thiab tswj cov tawv nqaij elasticity. Hauv cov kev sim vito tau pom tias tom qab kho nrog Glycyrrhizin, cov tawv nqaij fibrastes tau nce los ntawm cov nplais ywj uas tsawg ntawm 41%. Kev siv sijhawm ntev ntev ntawm cov khoom lag luam tawv nqaij tawv muaj glycyrrhizin muaj peev xwm txhim kho daim tawv nqaij sagging, kab zoo, thiab lwm yam teeb meem.

Daim Ntawv Thov Kev Ua Si thiab Cov Ntawv Khoom Khoom

 

1. Cov tshuaj pleev ib ce: Cov khoom xyaw tseem ceeb rau ntxuav hniav dawb thiab anti -}} kev laus
Khoom ntxuav ntxuav hniav dawb: Guangliquorice yog cov qauv kev sib xyaw ntawm high-}}} ess estence thiab lub ntsej muag kom pom zoo yog 0.001% -3%. Piv txwv li, ib hom thoob ntiaj teb "Photogenic Whitenic Whitening whitence" muaj 0.5% phosglycyrrhizin, uas ua haujlwm ua ke nrog nicotinamide kom ua tiav cov txiaj ntsig dawb huv si.
Cov khoom tiv thaiv tsom iav: Guanggancao ding tuaj yeem inhibit UV ntxias cov penanium dioxide thiab txo qis cov nqi sunscreen thiab txo qis "phototoxicity" kev tawm tsam.
Anti cov khoom lag luam: kev sib xyaw ua ke ntawm glycyrrhizin thiab cov khoom xyaw xws li hyaluronic acid thiab peptides tuaj yeem txhim kho cov tawv nqaij muaj nuj nqi thiab txo qhov tob tob. Ib qho anti -} Phosglycyrrhizin, thiab kuaj kuaj pom qhia tias lub ntsej muag pov tseg kom tiav los ntawm 18% tom qab 8 lub lis piam.

 

2. Kws ua teb cov chaw: multure - hom phiaj kho cov tshuaj
Cov tshuaj: guangliquiridine gel yog siv los kho eczema thiab hu rau eczema thiab arti {0} Hydrocortisone, tab sis tsis muaj tshuaj cuam tshuam dab tsi.
Kev kho mob daim siab thiab kho cov mob siab ua haujlwm, thiab kho mob siab rau kev kho kab mob siab thiab muaj rog. Cov ntaub ntawv kuaj mob qhia tau tias tom qab ua ke kev kho nrog Glycyrrhizin, cov neeg mob Al AL5% thiab lub siab cov qhab nia txhim kho los ntawm 21%.
Kev tiv thaiv kab mob plawv: Glycyrrhizin tuaj yeem txo qhov kev tsim cov ntshav atherosclerotic los ntawm inhibiting oxidation ntawm tsawg {{}} qhov lasprotein (LDL). Cov kev sim tsiaj tau qhia tias Glycyrrhizin tuaj yeem txo cov roj ntsha cholesterol ntau qib hauv nas los ntawm 22% thiab ncua kev nce qib ntawm arteriosclerosis.

 

3. Khoom noj thiab khoom noj qab haus huv: Cov ntaub ntawv nthuav tawm ntawm cov khoom xyaw ua haujlwm
Cov zaub mov ua haujlwm: Guanggancao ding tau tsim los rau hauv lub qhov ncauj ntxuav hniav, tiv thaiv cov dej qab zib glycation, thiab lwm yam khoom. Piv txwv li, qee hom tshuaj ntxuav hniav dawb "muaj 50mg ntawm glycyrhizic acid, thiab tom qab kev sib txuas lus rau 12 lub lis piam tsis zoo ntawm cov kev kawm nce los ntawm 19%.
Cov Khoom Noj Qab Haus Huv:Glabridin HmoovUralensis Extract yog sib xyaw ua ke nrog cov vitamins c thiab e tsim cov khoom siv tshuaj antioxidant, uas tau siv los ncua kev laus thiab txhim kho kev tiv thaiv kev laus. Cov kev sim tau pom tias Guanggancao ding tuaj yeem ua kom cov kua dej nag laus hauv cov laus los ntawm 28% thiab txo qis cov khoom siv tsawg los ntawm 34%.

Cov synthesis ntawmGlabridin HmoovFeem ntau pib los ntawm kev sib xyaw ua kom yooj yim lossis heterocyclic sib txuas. Ib txoj hauv kev, raws li tau piav qhia nyob rau hauv cov ntaub ntawv tsis ntev los no, koom nrog siv 2,4 {{{{}} dimethebobzene thiab diethyl malonate li cov khoom pib. Hom no lub hom phiaj los muab tus nqi -}} ua tau zoo thiab high-yielding txoj kev mus rau glabridin.

Iodide -} catalalyzed coupling kev tawm tsam:

Hauv cov huab cua argon, 2,4-Dimethebromobzene, piv txwv li cov kuab tshuaj ntsuab (piv txwv li (ib ncig ntawm 100 degree) rau ob peb teev. Cov kauj ruam no tau tshwm sim rau kev tsim tus lej tseem ceeb.

Cov Ntsiab Lus Tseem Ceeb:

Cov kuab tshuaj loj: 2-8 lub sij hawm qhov loj ntawm 2,4-dimethebromobzene.

Cov Lus Qhia Txog Cov Nyiaj Hniav: Catalyst rau Bromobenzene (1: 10-1: 1: 1: 1), Ntxiv rau Bromobenzene (1: 25-1: 5).

Txo cov tshuaj tiv thaiv:

Lub Intermediate tau los ntawm kev sib tw sib txuas yog tom qab ntawd raug rho tawm siv tus neeg sawv cev txo qis xws li lithium aluminium ALRUMINDRAN (THF) ntawm chav tsev kub. Cov kauj ruam no txuas ntxiv hloov kho cov qauv nruab nrab.

Qhov tseem ceeb taw tes:

Cov qauv nyiaj hniav mob ntawm txo tus neeg sawv cev rau nruab nrab (piv txwv li, 1: 1-4: 1).

Bromination tawm tsam:

Cov theem nrab tau txo qis yog tom qab brominated siv n- bromosuccinomide (pivs, tromhenyfrethans) hauv Dichhloromethane (0 Qib rau 50 degree). Cov kauj ruam no qhia txog lub bromine atom, uas yog qhov tseem ceeb rau kev hloov pauv tom ntej.

Qhov tseem ceeb taw tes:

Cov nyiaj maum liab ntawm NBS: Tripyenyfphh thaj: Nruab nrab (piv txwv li, 2-10: 1).

Nucleophilic hloov thiab friedel - sinquts kev tawm tsam:

Lub brominated Intermediate yog tom qab ntawd siv tau lwm qhov sib xyaw (piv txwv li ntawm potassyl {}}} ntau dua theem nrab.

Tom qab, tus friedel - cov tshuaj tiv thaiv siv cov acid catalyst (piv txwv li cov chloride) ntxiv hloov kho nruab nrab no.

Debromination thiab cov kauj ruam kawg:

Cov kauj ruam kawg muaj kev txiav tawm ntawm nruab nrab ntawm nruab nrab, feem ntau siv lub reagonent zoo li Boron Tribromide, kom tawm los GLabridin. Cov kauj ruam no yuav tsum ua tib zoo tswj hwm kev kub thiab cov tshuaj tiv thaiv ib zaug kom tsis txhob sab kev cawm seej.

Cim npe nrov: GLabridin Hmoov Li 59870-68-7, Cov Chaw Tsim Khoom, Chaw Tsim Tshuaj, Hoobkas, Muag Khoom Rhuav, Yuav, Nqe, Hlua, Rau Muag