4-Chlorobenzyl mercaptanyog ib qho organic compound nrog cov mis mos molecular C7H6ClS, CAS 6258-66-8. Tsawg melting point crystals muaj ib tug tshwj xeeb pungent tsw, uas yog tshwm sim los ntawm lub xub ntiag ntawm thiol pawg. Nws muaj peev xwm yaj nyob rau hauv dej los tsim ib lub teeb daj mus rau daj kua. Txawm li cas los xij, nws kuj muaj cov khoom uas me ntsis soluble hauv ethanol thiab ether. Nws qhov kub kub kub ua rau nws nyuaj rau evaporate ntawm chav tsev kub. Txawm li cas los xij, nyob rau hauv qhov kub thiab txias, nws tuaj yeem maj mam evaporate. Lub viscosity yog qhov qis, nrog rau qhov ntsuas viscosity ntawm 16.7, qhia tias qhov sib xyaw ua ke muaj qhov hloov pauv me me thaum lub sijhawm hloov pauv kub, uas yog qhov zoo rau nws daim ntawv thov kev lag luam. Nws muaj cov nqi siv dav hauv ntau qhov chaw. Vim nws cov qauv tshuaj lom neeg tshwj xeeb thiab cov khoom siv, nws ua lub luag haujlwm tseem ceeb hauv kev sib txuas ntawm cov khoom nruab nrab, tshuaj tua kab mob, tshuaj tua kab, tshuaj zawv plaub hau, tshuaj ntsuam xyuas, kev tshawb fawb hauv chav kuaj, thiab lwm yam.
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Tshuaj Formula |
C7H7Cls |
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Exact Mass |
158 |
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Molecular Luj |
159 |
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m/z |
158 (100.0%), 160 (32.0%), 159 (7.6%), 160 (4.5%), 161 (2.4%), 162 (1.4%) |
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Elemental Analysis |
C, 53.00 Nws; H, 4,45; 22,35; Kuv. Ib., 20.21 |
4-Chlorobenzyl mercaptanmuaj ntau yam kev siv nyob rau hauv cov synthesis ntawm intermediates. Cov ntawv thov no suav nrog ntau qhov chaw xws li tshuaj tua kab mob, tshuaj tua kab, tshuaj pleev xim, tshuaj intermediates, cov ntaub ntawv polymer, surfactants, thiab txuj lom. Kev nkag siab txog cov kev siv no yuav pab kom siv tau cov txiaj ntsig zoo thiab kev cia siab ntawm 4 chlorobenzyl mercaptan.
1. Synthesis ntawm aminoglycoside tshuaj tua kab mob: 4-chlorobenzylthiol yog ib qho tseem ceeb intermediate nyob rau hauv cov synthesis ntawm aminoglycoside tshuaj tua kab mob, xws li streptomycin, gentamicin, thiab lwm yam. Cov tshuaj tua kab mob no tsuas yog siv los kho cov kab mob thiab muaj broad-spectrum antibacterial teebmeem. Los ntawm kev siv 4-chlorobenzylthiol ua ib qho nruab nrab, cov tshuaj tua kab mob no tuaj yeem ua kom yooj yim dua, txhim kho kev tsim khoom thiab txo cov nqi.
2. Synthesis ntawm herbicides: 4-chlorobenzylthiol kuj siv tau los ua cov tshuaj tua kab mob. Herbicides yog cov tshuaj tua kab siv los tswj kev loj hlob ntawm cov nroj tsuag thiab ua lub luag haujlwm tseem ceeb hauv kev ua liaj ua teb. Siv 4 chlorobenzyl mercaptan ua ib qho nruab nrab tuaj yeem ua kom muaj txiaj ntsig zoo ntawm cov tshuaj tua kab mob thiab ua rau lawv nrog cov khoom tshiab thiab cov yam ntxwv.
3. Synthesis of insecticides: 4-chlorobenzylthiol kuj tuaj yeem siv los ua cov tshuaj tua kab. Cov tshuaj tua kab feem ntau yog siv los tswj cov kab mob thiab kab tsuag, thiab ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv qoob loo thiab hav zoov. Los ntawm kev siv 4 chlorobenzyl mercaptan ua ib qho nruab nrab, cov tshuaj tua kab tshiab tuaj yeem ua ke los txhim kho lawv txoj kev tswj hwm kev tiv thaiv kab mob tshwj xeeb.
4. Synthesis of Azo Dyes: 4-Chlorobenzylthiol feem ntau siv hauv kev lag luam dyeing los ua ke azo dyes. Azo dyes yog hom xim tseem ceeb, siv dav hauv kev lag luam xws li textile printing thiab dyeing, coatings, thiab lwm yam. Los ntawm kev siv 4-chlorobenzylthiol ua ib qho nruab nrab, azo dyes tuaj yeem ua kom yooj yim dua thiab muab cov xim tshiab thiab cov khoom.
5. Synthesis of pharmaceutical intermediates: 4-chlorobenzylthiol kuj siv tau los ua ke ntau yam tshuaj intermediates. Cov intermediates no tuaj yeem siv rau kev sib txuas ntxiv ntawm cov tshuaj, alkaloids, thiab lwm yam sib xyaw. Los ntawm kev siv 4-chlorobenzylthiol ua ib qho nruab nrab, cov tshuaj intermediates tuaj yeem ua kom zoo dua qub, muab kev txhawb nqa rau kev tshawb fawb thiab kev tsim tshuaj.
6. Synthesis ntawm cov ntaub ntawv polymer: 4 chlorobenzyl mercaptan kuj tuaj yeem siv los ua ke cov ntaub ntawv polymer. Cov ntaub ntawv Polymer yog cov chav kawm tseem ceeb ntawm cov ntaub ntawv siv dav hauv kev lag luam xws li tshuaj lom neeg engineering, lub teeb kev lag luam, thiab textiles. Los ntawm kev siv 4 chlorobenzyl mercaptan ua ib qho nruab nrab, cov ntaub ntawv polymer tshiab tuaj yeem ua ke thiab tau txais txiaj ntsig nrog cov khoom tshiab thiab cov yam ntxwv.
7. Synthesis ntawm surfactants: 4-chlorobenzylthiol kuj tuaj yeem siv los ua cov surfactants. Surfactants yog ib chav kawm ntawm cov khoom sib txuas nrog rau qhov chaw ua haujlwm, dav siv hauv thaj chaw xws li ntxuav thiab tshuaj pleev ib ce. Los ntawm kev siv 4 chlorobenzyl mercaptan ua ib qho nruab nrab, nws yooj yim dua los ua ke cov surfactants, txhim kho cov haujlwm saum npoo thiab siv cov nyhuv ntawm cov khoom.
8. Synthesis ntawm txuj lom:4-chlorobenzyl mercaptankuj tuaj yeem siv los ua ke cov txuj lom. Cov txuj lom yog ib hom kev sib xyaw ua ke uas tuaj yeem tsim cov tshuaj tsw qab thiab siv dav hauv thaj chaw xws li tshuaj lom neeg txhua hnub thiab zaub mov. Los ntawm kev siv 4 chlorobenzyl mercaptan ua ib qho nruab nrab, cov txuj lom tshiab tuaj yeem ua ke thiab muab cov tshuaj tsw qab thiab cov khoom tshiab.
Chemical Equation:
Cov tshuaj tiv thaiv phenol nrog sulfur chloride:
C6H5OH + 2NaOH + 2S2Cl2 → C6H5SCH2CH2CH2SCH2CH2C6H5 + 3NaCl + 3H2O
Hauv cov tshuaj tiv thaiv no, phenol tau hloov pauv cov tshuaj tiv thaiv nrog sulfur chloride nyob rau hauv qhov kev txiav txim ntawm sodium hydroxide, ua rau lub nruab nrab ntawm dichlorophenol pentasulfide thiab sodium chloride. Qhov nruab nrab ntawm dichlorophenol pentasulfide yog ntxiv rau hauv 4 chlorobenzyl mercaptan los ntawm cov kauj ruam tom ntej.
Synthesis cov tshuaj tiv thaiv ntawm chlorobenzyl mercaptan:
C6H5SCH2CH2CH2SCH2CH2C6H5 + 3NaOH → C6H4(Cl) CH2SH + 3NaCl + 3H2O
Hauv cov tshuaj tiv thaiv no, qhov nruab nrab ntawm dichlorophenol pentasulfide tau txais cov tshuaj tiv thaiv hydrolysis raws li kev ua ntawm sodium hydroxide, tshem tawm ob lub sulfur atoms los tsim 4 chlorobenzyl mercaptan. Ib txhij tsim sodium chloride thiab dej.
Txoj kev rau synthesizing4-chlorobenzyl mercaptanhauv chav kuaj tuaj yeem siv cov kauj ruam hauv qab no:
1. Npaj reagents thiab cov khoom siv: Npaj cov khoom siv raw thiab cov reagents tsim nyog, suav nrog phenol, sulfur chloride, sodium hydroxide, chloroform, magnetic stirrer, thermometer, drip funnel, round hauv qab khob, thiab lwm yam.
2. Dissolve phenol: Dissolve phenol hauv chloroform los ua chloroform tov ntawm phenol.
3. Ntxiv sodium hydroxide: Ntxiv sodium hydroxide rau chloroform tov ntawm phenol thiab do sib npaug.
4. Dropwise ntxiv ntawm sulfur chloride: Maj mam ntxiv sulfur chloride rau chloroform tov ntawm phenol, thiab tswj cov tshuaj tiv thaiv kub ntawm 50-60 degree.
5. Reaction stirring: Tom qab ntxiv sulfur chloride dropwise, txuas ntxiv stirring rau li 2 teev kom tso cai rau cov tshuaj tiv thaiv mus tas li.
6. Lim sib cais: Lim cov tshuaj tiv thaiv, tshem tawm cov khoom tsis zoo, thiab sau cov lim.
7. Kev ntxuav dej: ntxuav cov lim dej uas tsim nyog kom tshem tawm cov tshuaj phenol uas tsis muaj tshuaj lom.
8. Ua kom qhuav: Muab cov lim dej thiab cov tshuaj ntxuav, thiab qhuav nrog anhydrous sodium sulfate.
9. Distillation: Distilled lub qhuav filtrate kom tshem tawm chloroform thiab lwm yam volatile Cheebtsam.
10. Refining: Dissolve cov khoom distilled nyob rau hauv ethanol, ntxiv ib tug sodium hydroxide tov, tshav kub thiab reflux li 1 teev mus ntxiv purify cov khoom.
11. Kev lim dej txias: Tom qab txias, lim kom tshem tawm cov khoom tsis zoo.
12. Kev ziab: Ntxuav cov lim seem nrog cov dej kom tsim nyog kom tshem tawm cov tshuaj phenol uas tsis muaj kev cuam tshuam.
13. Purification: Muab cov filtrate thiab ntxuav, qhuav nrog anhydrous sodium sulfate, thiab tau cov crude 4 chlorobenzyl mercaptan.
14. Crystallization thiab kev sib cais: Cov khoom nyoos yog crystallized thiab sib cais kom tau txais siab -purity 4 chlorobenzyl mercaptan crystals.
Nyob rau hauv lub lig 19th thiab ntxov 20th centuries, chemists pib sim cov synthesis ntawm 4-chlorophenylmercaptan. Thawj txoj kev yog tsuas yog raws li cov tshuaj tiv thaiv ntawm chlorohydrazine chloride nrog sulfur-muaj cov tshuaj sib xyaw. Chlorobenzoyl chloride, raws li ib tug chlorinated aromatic hydrocarbon, muaj ib tug tej yam reactivity nrog cov tshuaj chlorine atom ntawm nws benzene nplhaib, uas muaj peev xwm hloov pauv cov tshuaj tiv thaiv nrog nucleophiles.
Cov kws tshawb fawb tau sim siv cov tshuaj inorganic sulfides xws li sodium sulfide thiab sodium sulfide los teb nrog 2-chlorophenylhydrazine chloride, vam tias yuav tau txais 4-chlorophenylhydrazine mercaptan. Txawm li cas los xij, vim qhov nyuaj ntawm kev tswj cov tshuaj tiv thaiv, ntau yam khoom siv los ntawm cov khoom feem ntau yog tsim nyob rau hauv cov khoom, uas ua rau tsis tshua muaj yield thiab purity. Txhawm rau txhim kho cov txiaj ntsig kev sib txuas thiab purity ntawm 4-chlorobenzenes, chemists tau tshawb xyuas qhov tob thiab ua kom zoo dua cov tshuaj tiv thaiv.
Lawv pom tias cov yam ntxwv xws li qhov kub thiab txias, lub sijhawm tshuaj tiv thaiv, kev xaiv hnyav, thiab cov khoom siv raw khoom muaj feem cuam tshuam rau cov txiaj ntsig ntawm cov tshuaj tiv thaiv. Piv txwv li, ntawm qhov kub thiab txias, cov tshuaj tiv thaiv qis dua, tab sis tus naj npawb ntawm cov tshuaj tiv thaiv sab yog tsawg dua; Thaum kub siab, cov tshuaj tiv thaiv tus nqi nrawm, tab sis tus naj npawb ntawm cov tshuaj tiv thaiv sab kuj nce raws li.
Los ntawm kev tshawb nrhiav dav dav, cov kws tshawb fawb maj mam pom qhov pom kev pom zoo. Piv txwv li, los ntawm reacting 2-chlorobenzoyl chloride nrog sodium thiosulfate nyob rau hauv ib tug tsim nyog hnyav thiab tom qab ntawd kho nrog acid, cov tawm los thiab purity ntawm 4-chlorophenylmercaptan tuaj yeem txhim kho tau zoo.
Qhov tseeb txheeb xyuas cov qauv ntawm 4-chlorophenylmercaptan ua qhov tseem ceeb tom qab nws txoj kev ua tiav tiav. Thaum pib ntawm lub xyoo pua 20th, nrog rau kev txhim kho spectroscopic tsom xam cov tswv yim xws li infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR), thiab huab hwm coj spectrometry (MS), chemists muaj peev xwm txiav txim siab ntau dua cov qauv ntawm cov organic tebchaw.
Los ntawm kev tshuaj xyuas infrared spectroscopy, cov pab pawg ua haujlwm tam sim no nyob rau hauv qhov sib xyaw ua ke, xws li lub zog ntawm kev vibration peaks ntawm thiol pawg, tuaj yeem txiav txim siab kom muaj tus cwj pwm nqus hauv infrared spectrum.
Nuclear magnetic resonance spectroscopy tuaj yeem muab tshuaj ib puag ncig cov ntaub ntawv ntawm hydrogen thiab carbon atoms hauv cov molecules, yog li inferring tus qauv ntawm molecules. Kev tsom xam spectrometry tuaj yeem txiav txim siab qhov txheeb ze molecular loj thiab cov ntaub ntawv tawg ion ntawm cov molecules, ntxiv xyuas lawv cov qauv. Tom qab txiav txim siab tus qauv ntawm 4-chlorophenylthiol, chemists tau tshawb xyuas qhov tob ntawm nws lub cev thiab tshuaj lom neeg. Kev tshawb fawb tau pom tias 4-chlorophenylmercaptan yog ib qho uas tsis muaj melting point siv lead ua nrog ib tug pungent tsw. Nws cov ntsiab lus melting yog 19-20 ° C, tus txheeb ze ntom ntom yog 1.202 g / mL (ntawm 25 ° C), kub taw tes yog 125 ° C (35mmHg), thiab flash point yog 76 ° C. Cov khoom siv lub cev no muab cov ntaub ntawv tseem ceeb rau kev khaws cia, kev thauj mus los, thiab kev siv 4-chlorophenyl mercaptan.
Tsis tas li ntawd, chemists tau kawm txog kev solubility, stability, thiab lwm yam khoom ntawm 4-chlorobenzenes thiab pom tias lawv muaj solubility zoo nyob rau hauv tej yam organic solvents, tab sis nws yog nquag decomposition nyob rau hauv lub teeb thiab kub tej yam kev mob.
kev phiv tshuaj
4-Chlorobenzyl Mercaptan (CAS naj npawb 6258-66-8) yog sulfur-muaj organic compound nrog cov mis molecular C ₇ H ₇ ClS. Nws zoo nkaus li cov kua dawb mus rau daj daj los yog khoom nyob rau hauv chav tsev kub thiab muaj ib tug muaj zog pungent tsw. Cov tshuaj chlorine atoms thiab thiol pawg (- SH) muaj nyob rau hauv nws cov qauv tshuaj endowed nrog nws reactivity, tab sis nyob rau tib lub sij hawm, nws kuj yuav ua rau ib tug series ntawm phiv tshuaj.
Toxicity mechanism thiab kev sib cuag
Toxicity mechanism
Cov tshuaj lom ntawm 4-Chlorobenzyl Mercaptan feem ntau yog los ntawm ob qhov tseem ceeb ntawm nws cov qauv tshuaj:
Chlorine atom (Cl): Chlorinated aromatic hydrocarbons tuaj yeem tsim cov khoom nruab nrab (xws li chloroquinones) los ntawm cov metabolism, ua rau muaj kev ntxhov siab oxidative thiab ua rau cov cell membranes, proteins, thiab DNA.
Thiol pab pawg (- SH): Thiol pab pawg muaj kev ua haujlwm siab thiab tuaj yeem khi rau cov hlau ions (xws li tooj liab thiab hlau), cuam tshuam nrog kev ua haujlwm enzyme; Nyob rau tib lub sijhawm, nws tuaj yeem cuam tshuam kev ua haujlwm ntawm tes los ntawm covalently hloov kho cysteine residues hauv cov protein.
Hu rau txoj kev
Inhalation: Nws volatility yuav ua rau muaj vapor nyob rau hauv cov huab cua, tshwj xeeb tshaj yog nyob rau hauv high kub los yog tsis zoo ventilated ib puag ncig uas cov concentration nce. Inhalation tuaj yeem ua rau lub ntsws ua pa ncaj qha.
Kev sib cuag ntawm daim tawv nqaij: Cov kua los yog cov khoom tuaj yeem nqus tau los ntawm daim tawv nqaij, tshwj xeeb tshaj yog ntawm daim tawv nqaij puas, ua rau lub zos lossis cov kab mob toxicity.
Kev sib cuag ntawm qhov muag: Kev sib tsoo ncaj qha rau hauv lub qhov muag yuav ua rau mob hnyav thiab txawm tias pob txha puas.
Kev noj tshuaj tsis haum: Txawm hais tias tsis yog ib txoj hauv kev, kev noj tshuaj tsis haum tuaj yeem ua rau mob plab hnyuv thiab ua rau lub cev muaj kuab lom.
Toxicity mechanism thiab kev sib cuag
Toxicity mechanism
Cov tshuaj lom ntawm 4-Chlorobenzyl Mercaptan feem ntau yog los ntawm ob qhov tseem ceeb ntawm nws cov qauv tshuaj:
Chlorine atom (Cl): Chlorinated aromatic hydrocarbons tuaj yeem tsim cov khoom nruab nrab (xws li chloroquinones) los ntawm cov metabolism, ua rau muaj kev ntxhov siab oxidative thiab ua rau cov cell membranes, proteins, thiab DNA.
Thiol pab pawg (- SH): Thiol pab pawg muaj kev ua haujlwm siab thiab tuaj yeem khi rau cov hlau ions (xws li tooj liab thiab hlau), cuam tshuam nrog kev ua haujlwm enzyme; Nyob rau tib lub sijhawm, nws tuaj yeem cuam tshuam kev ua haujlwm ntawm tes los ntawm covalently hloov kho cysteine residues hauv cov protein.
Hu rau txoj kev
Inhalation: Nws volatility yuav ua rau muaj vapor nyob rau hauv cov huab cua, tshwj xeeb tshaj yog nyob rau hauv high kub los yog tsis zoo ventilated ib puag ncig uas cov concentration nce. Inhalation tuaj yeem ua rau lub ntsws ua pa ncaj qha.
Kev sib cuag ntawm daim tawv nqaij: Cov kua los yog cov khoom tuaj yeem nqus tau los ntawm daim tawv nqaij, tshwj xeeb tshaj yog ntawm daim tawv nqaij puas, ua rau lub zos lossis cov kab mob toxicity.
Kev sib cuag ntawm qhov muag: Kev sib tsoo ncaj qha rau hauv lub qhov muag yuav ua rau mob hnyav thiab txawm tias pob txha puas.
Kev noj tshuaj tsis haum: Txawm hais tias tsis yog ib txoj hauv kev, kev noj tshuaj tsis haum tuaj yeem ua rau mob plab hnyuv thiab ua rau lub cev muaj kuab lom.
Cim npe nrov: 4-chlorobenzyl mercaptan cas 6258-66-8, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom