Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm 5-methyl-2-pyrazinecarboxylic acid cas 5521-55-1 nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale zoo 5-methyl-2-pyrazinecarboxylic acid cas 5521-55-1 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
5-Methyl-2-pyrazinecarboxylic Acidyog ib qho tseem ceeb nitrogen-muaj cov tshuaj heterocyclic organic. Nws cov qauv yog nyob nruab nrab ntawm ib lub nplhaib pyrazine - qhov no yog ib qho khoom siv hluav taws xob nplua nuj - nplua nuj aromatic system tsim los ntawm ob lub nitrogen atoms kos rau hauv rau - lub nplhaib koom hauv ib qho kev teeb tsa ortho. Cov qauv no txuas nrog pawg carboxyl (-COOH) ntawm 2- txoj haujlwm thiab methyl pawg (-CH3) ntawm 5-txoj haujlwm. Qhov kev tsim tshwj xeeb molecular no tso cai rau nws nrog kev nruj thiab kev sib luag ntawm lub nplhaib pyrazine, muaj peev xwm sib koom ua ke, muaj zog acidity ntawm pawg carboxyl, thiab zoo heev hydrogen daim ntawv cog lus muaj peev xwm.
Kev taw qhia ntawm pawg methyl ingeniously tswj cov huab cua electron ceev thiab liposolubility ntawm tag nrho cov molecule. Yog li ntawd, qhov sib xyaw no qhia txog tus nqi tseem ceeb hauv ntau qhov kev txiav- ntug kev tshawb fawb: hauv tshuaj chemistry, nws yog dav siv los ua cov tshuaj pharmacophore lossis organic synthesis tsev thaiv, tshwj xeeb tshaj yog tsim cov tshuaj molecules rau kev kho mob tuberculosis lossis ntshav qab zib; Hauv kev sib koom ua ke chemistry, nws pawg carboxyl thiab pyrazine nitrogen atom tuaj yeem ua haujlwm zoo heev bidentate ligands, nws tus kheej- sib dhos nrog cov hlau ions rau hauv cov tshiab thiab ua haujlwm tshwj xeeb hlau- cov ntaub ntawv organic; Tsis tas li ntawd, nws tseem yog qhov tseem ceeb tshaj plaws - tus nqi nruab nrab hauv kev sib txuas ntawm cov tshuaj zoo thiab cov ntaub ntawv tshawb fawb.
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Tshuaj Formula |
C6H6N2O2 |
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Exact Mass |
138 |
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Molecular Luj |
138 |
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m/z |
138 (100.0%), 139 (6.5%) |
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Elemental Analysis |
C, 52.17; H, 4.38; N, 20.28; O, 23.17 |
5-Methyl-2-pyrazinecarboxylic Acid, nrog rau cov mis molecular C6H6N5O2 thiab ib qho hnyav molecular ntawm 138.12, yog nitrogen-muaj cov tshuaj tsw qab heterocyclic. Nws zoo nkaus li dawb mus rau daj daj crystalline hmoov nrog lub melting point ntawm 166-169 degree. Nws ruaj khov ntawm chav tsev kub, me ntsis soluble hauv dej, thiab yooj yim soluble hauv cov kuab tshuaj organic. Cov qauv molecular sib xyaw ua ke peb pawg tseem ceeb ntawm methyl, carboxyl, thiab pyrazine rings, thiab tuaj yeem ua rau ntau yam kev cuam tshuam xws li esterification, amidation, condensation, thiab kev sib koom tes. Nws yog ib qho tseem ceeb nruab nrab hauv kev lag luam kws tshuaj, bioactive molecular skeleton, ib tug zoo tshuaj synthesis thaiv, thiab ib tug precursor rau functional khoom.
Cov ntawv thov tseem ceeb hauv thaj chaw kws tshuaj
Neuroprotective thiab Anti Alzheimer's Disease (AD) Tshuaj Intermediates
MPCA derivatives muaj inhibitory cuam tshuam rau - amyloid (A) ntau lawm, BACE1 inhibition, antioxidant, thiab tiv thaiv -kev ua ub no, uas yuav txo tau A deposition, inhibit neuroinflamation, thiab tiv thaiv neurons. Lawv siv rau kev kho mob ntawm AD, Parkinson's disease (PD), thiab mob stroke.
MPCA → 5-methylpyrazine-2-carboxylic acid ethyl ester → condensation nrog piperidine/pyrrolidine * * → BACE1 inhibitor, IC50 Tsawg dua los yog sib npaug rau 50 nM, Txo cov tiam ntawm A 42 los ntawm 70% +.
MPCA hlau complex (Zn ² ⁺ / Cu ² ⁺): tshem tawm cov dawb radicals, inhibits oxidative kev nyuaj siab, tiv thaiv hippocampal neurons, thiab txhim kho kev kawm thiab kev nco muaj peev xwm hauv AD qauv nas.
Lwm yam kev siv kho mob
Cov tshuaj tiv thaiv tuberculosis: MPCA derivatives txhim khu kev ua haujlwm ntawm pyrazinamide (PZA), txo cov kev kho mob los tiv thaiv tuberculosis, thiab txo cov tshuaj tiv thaiv.
Cov tshuaj diuretic: MPCA → Pyrazine diuretics, inhibit lub raum tubular sodium reabsorption, muaj cov nyhuv diuretic me me, thiab siv rau kev kub siab thiab edema.
Cov tshuaj tiv thaiv kab mob: MPCA derivatives inhibit NF - κ B txoj hauv kev thiab txo cov pro- cov kab mob inflammatory (TNF - , IL-6), siv rau kev mob caj dab rheumatoid thiab mob plab hnyuv.
Kev ua haujlwm lom neeg thiab cov tshuaj pharmacological
MPCA nws tus kheej muaj kev ua haujlwm lom neeg tsis muaj zog, thiab nws cov dej num derivative tau txhim kho zoo. Cov txiaj ntsig tseem ceeb ntawm pharmacological yog raws li hauv qab no:
Kev tswj hwm kev ua haujlwm ntawm metabolic
Hypoglycemia: Ua kom txoj hauv kev AMPK, txhawb nqa cov piam thaj, inhibit siab gluconeogenesis, thiab txo cov ntshav qabzib sai ntawm 15% -20%.
Txo cov ntshav lipids: activating PPAR, txhawb fatty acid - oxidation, txo TG/TC, thiab nce HDL-C.
Txhim kho insulin tsis kam: txhim kho cov tshuaj insulin, txhawb kev qhia cov tshuaj insulin, thiab txo qis cov tshuaj insulin los ntawm 20% -30%.
Antioxidant thiab tiv thaiv - cov haujlwm ua mob
Clearing dawb radicals: ncaj qha tshem tawm superoxide anions, hydroxyl radicals, lipid peroxides, inhibiting oxidative kev nyuaj siab, thiab txo cov cell puas.
Txhim khu antioxidant enzymes: nce SOD, GSH-PX, CAT kev ua, txo MDA cov ntsiab lus, thiab tiv thaiv cell membrane.
Inhibition of inflammatory: Thaiv cov NF - κ B thiab MAPK txoj hauv kev, txo qhov tso tawm ntawm TNF - , IL-1 , thiab IL-6, thiab txo cov mob ntev.
Kev ua haujlwm ntawm Neuroprotective
Inhibition of A aggregation: Ua ke A, tiv thaiv fibrosis deposition, thiab txo qhov tsim ntawm senile plaques.
Tiv thaiv neurons: Inhibiting glutamate excitotoxicity, txo cov neuronal apoptosis, thiab txhim kho neurological muaj nuj nqi.
Txhim kho kev paub: txhim kho kev kawm thiab kev nco muaj peev xwm, ua kom muaj sia nyob ntev, siv rau AD thiab vascular dementia.
Antibacterial thiab antifungal kev ua haujlwm
Tshuaj tua kab mob: Nws muaj cov tshuaj tiv thaiv nruab nrab tiv thaiv Escherichia coli, Staphylococcus aureus, Salmonella, thiab Streptococcus (MIC{0}} μ g / mL).
Antifungal: Inhibits Candida albicans thiab Aspergillus fumigatus, rhuav tshem cov kab mob ntawm tes, thiab inhibits spore germination.
Fine Chemicals thiab Materials Science Applications
Organic hluavtaws thaiv
MPCA yog ib tug multifunctional heterocyclic block uas yuav siv tau los tsim ib lub tsev qiv ntawv ntawm pyrazine nplhaib derivatives rau tshiab tshuaj tsim, tshuaj tua kab synthesis, thiab functional molecule tsim.
Esterification cov tshuaj tiv thaiv: nrog methanol / ethanol / ethylene glycol → 5-methylpyrazine-2-carboxylic acid ester, siv los ua tshuaj nruab nrab, tshuaj tsw qab, thiab plasticizer.
Amide cov tshuaj tiv thaiv: nrog ammonia / amine / hydrazine → 5-methylpyrazine-2-carboxamide / hydrazide, siv los ua cov tshuaj hypoglycemic, tshuaj tiv thaiv qog, thiab cog kev loj hlob regulator.
Cov tshuaj tiv thaiv condensation: cov khoom heterocyclic condensation nrog aldehydes / ketones / carboxylic acids, siv rau fluorescent dyes, optoelectronic cov ntaub ntawv, thiab catalyst ligands.
Hlau complexes thiab catalysts
Hlau organic moj khaum (MOFs) ligands
MPCA, raws li ib tug bidentate ligand (N, O coordination), ua hauj lwm nrog Zn ² ⁺, Cu ² ⁺, Co ² ⁺, Ni ² ⁺ los ua ke pyrazine raws li MOFs nrog siab porosity, loj tshwj xeeb deg cheeb tsam, thiab zoo thermal stability.
Gas adsorption: adsorbs CO ₂, CH ₄, H ₂, siv rau carbon capture, gas cais, thiab hydrogen cia.
Catalysis: MOF loaded Pd/Au yog siv rau Suzuki Miyaura coupling, hydrogenation cov tshuaj tiv thaiv, thiab oxidation cov tshuaj tiv thaiv, nrog rau cov catalytic siab thiab recyclability.
Cov khoom siv fluorescent: Zn MPCA MOFs nthuav tawm xiav fluorescence (λ em=450} nm) thiab siv rau fluorescence sensing, biological imaging, thiab lwm yam kev siv LED.
Homogeneous catalyst ligand
MPCA derivatives (xws li 5-methylpyrazine-2-carboxylic phosphine ligands) yog siv rau kev hloov pauv hlau catalysis los txhim kho cov tshuaj tiv thaiv thiab kev ua haujlwm.
Asymmetric catalysis: Chiral MPCA ligands yog siv rau asymmetric hydrogenation, epoxidation, Diels Alder cov tshuaj tiv thaiv, nrog rau cov txiaj ntsig ntau dua lossis sib npaug li 90%.
Cov khoom siv ua haujlwm polymer
Polyamide / polyester hloov monomer
MPCA yog copolymerized nrog hexamethylenediamine / ethylene glycol → muaj pyrazine nplhaib polyamide / polyester los txhim kho cov khoom siv hluav taws xob, kev siv lub zog, thiab tshuaj lom neeg corrosion.
Engineering plastics: siv rau cov khoom siv hauv tsheb, cov khoom siv hluav taws xob, thiab cov khoom siv tshuab, nrog rau qhov kub thiab txias nce ntawm 50℃thiab tensile zog nce ntawm 30%.
conductive polymer
MPCA doped polyaniline/polypyrrole → conductive composite khoom txhim khu conductivity, stability, thiab processability, siv nyob rau hauv sensors, electrode cov ntaub ntawv, thiab electromagnetic shielding.
Fluorescent dyes thiab optoelectronic cov ntaub ntawv
Fluorescent probes: MPCA derivatives yog siv los sau cov proteins/nucleic acids/cells rau biological imaging, fluorescence detection, thiab flow cytometry.
OLED cov ntaub ntawv: Pyrazine nplhaib derivatives pab raws li electron thauj / emission txheej los txhim kho luminescence efficiency thiab ua kom ntev lub neej ntawm cov cuab yeej.
Muaj peev xwm ua liaj ua teb thiab khoom noj khoom haus additives
cog kev loj hlob regulator
MPCA derivatives txhawb cov nroj tsuag kev loj hlob, nce yield, thiab txhim khu kev nyuaj siab.
Txhawb kev rooting:5-Methyl-2-pyrazinecarboxylic Acidmethyl ester yog siv rau kev txiav seedlings, nce rooting tus nqi los ntawm 40% thiab paus ntev los ntawm 50%.
Nce yield: foliar spraying txhawb photosynthesis thiab ua rau kom qhuav cov khoom tsub zuj zuj, ua rau 8% -12% nce nyob rau hauv nplej / nplej yield thiab 10% -15% nce zaub yield.
Txhim kho kev ntxhov siab: txhim kho drought-resistant, txias-resistant, thiab kab mob-resistant, txo qhov tshwm sim ntawm kab tsuag thiab kab mob los ntawm 30% -50%.
Khoom noj khoom haus txuj lom thiab tsw enhancers
Pyrazine tebchaw yog ib qho tseem ceeb tsw tebchaw nyob rau hauv cov zaub mov, thiab MPCA derivatives (xws li 5-methylpyrazine-2-carboxylic acid ethyl ester) muaj fruity, ci, thiab nqaij aromas, thiab yog siv los txhim kho cov aroma ntawm cov zaub mov, dej haus, haus luam yeeb, thiab nqaij.
Daim ntawv thov scenarios: kas fes, qhob noom xim kasfes, qhob cij, ncuav qab zib, nqaij ci, hnyuv ntxwm, txhim kho tsw, txhim kho saj, thiab txuas lub neej txee.
pub additive
MPCA derivatives txhawb cov tsiaj loj hlob, txhim khu kev tiv thaiv, thiab txhim kho nqaij zoo.
Cov tsiaj nyeg thiab nqaij qaib pub: Ntxiv 0.05% -0.1% tuaj yeem nce qhov hnyav txhua hnub los ntawm 5% -10%, txo kev noj zaub mov los ntawm 4% -8%, thiab txo cov neeg tuag los ntawm 30% -50%.
Aquatic feed: Ntxiv 0.08% -0.15% tuaj yeem nce tus nqi loj hlob los ntawm 8% -15%, txhim khu kev tiv thaiv kab mob, thiab txhim kho nqaij zoo.
Noj5-Methyl-2-pyrazinecarboxylic Acid(8.0g, 56.0 mmol) nyob rau hauv ntau tshaj methanol, ces ntxiv ob peb tee ntawm conical sulfuric acid (catalytic npaum li cas) rau cov sib tov, tshav kub cov tshuaj tiv thaiv sib tov rau reflux, thiab tswj lub reflux lub xeev rau 5 teev. Tom qab cov tshuaj tiv thaiv, evaporate cov kuab tshuaj nyob rau hauv lub tshuab nqus tsev rau dryness (ntawm ib tug rotating ntaus ntawv). Hloov cov seem mus rau hauv 1L beaker, ntxiv dej (400ml), thiab tom qab ntawd maj mam ntxiv NaHCO3 khoom kom txog thaum ua npuas dej nres. Lub sijhawm no, tus nqi pH ntawm cov tshuaj tiv thaiv yog hais txog 9. Extract qhov sib tov peb zaug nrog CHCl3 (3 x 400 mL), ua ke tag nrho cov txheej txheem organic, thiab tom qab ntawd evaporate cov kuab tshuaj kom tau cov khoom nyoos. Thaum kawg, 5-methylpyrazine-2-carboxylic acid methyl ester tuaj yeem tau los ntawm recrystallization (CH3Cl hauv roj av benzene) thiab purification.
Dissolve 5-methylpyrazine-2-carboxylic acid (0.1M) hauv methanol (2.0M), ntxiv ob peb tee ntawm cov concentrated sulfuric acid rau qhov sib tov, thiab do cov sib tov nyob rau hauv reflux rau 24 teev. Tom qab ntawd ntxiv hydrazine hydrate (3M) rau qhov sib tov thiab ua kom sov kom txog thaum cov tshuaj tiv thaiv reflux rau 8 teev. Tom qab cov tshuaj tiv thaiv tiav, cov tshuaj tiv thaiv sib tov yog concentrated nyob rau hauv lub siab txo, cov khoom yog txias, cov khoom tau yog ntxuav nrog dej txias, thiab thaum kawg cov ntshiab lub hom phiaj yog tau los ntawm recrystallization los ntawm ethanol.
1. Kev npaj ntawm A1 Cu Ag Zn catalyst immerses spherical Activated alumina rau hauv cov kua dej aqueous uas muaj qee qhov nyiaj nitrate, tooj liab nitrate, thiab zinc nitrate, tso cai rau cov tshuaj nitrate nkag mus rau hauv alumina. Qhuav alumina muaj nitrate ntawm 120-140℃C thiab calcine ntawm 500-550℃C rau 3 teev kom tau txais alumina A1-Cu-Ag-Zn carbides uas muaj 0.5% -3% nyiaj, 3% -8%, thiab 5% -10% tooj liab.
2. Kev npaj ntawm 2.5- Ertianji tshwj xeeb raug:
200g ntawm tus kheej- ua A1 Cu Ag Zn catalyst muaj 2% nyiaj, 7% zinc, thiab 8% tooj liab txhawb nqa ntawm aluminium oxide tau thauj khoom rau hauv lub tshuab hluav taws xob stainless hlau nrog lub taub sab hauv ntawm 025mm. Nitrogen roj tau qhia ntawm 30mL / mn, rhuab mus rau 200C, thiab cov roj hydrogen tau qhia ntawm 45mL / mn ntawm 200-280% C. Catalyst 2 raug txo kom tau txais cov catalyst thiab txias rau 200℃C. Isopropanolamine tau ntxiv ntawm 1g / min ntawm cov pa roj nitrogen, thaum cov pa roj nitrogen tau ntxiv ntawm 1g / min, thiab cov roj nitrogen tau ntxiv ntawm 1g / min. 45mL / min, thiab cov tshuaj tiv thaiv tau sau ntawm 200-280C. Cov khoom siv raw cov ntsiab lus tau txheeb xyuas los ntawm cov roj chromatography ntawm 94.5%, thiab tom qab ntawd raug rau qhov yooj yim atmospheric siab evaporation kom sau 152-154'C feem, ua rau muaj txiaj ntsig ntawm 91% thiab purity ntawm 99%.
3,5_ Kev npaj ntawm methyl-2-carboxylic acid yog ua los ntawm kev sib tov 21.6g (0.2mol) ntawm 2.5-dimethylbenzene, 4mL ntawm acetic acid, 2g ntawm acetophenone, 1g ntawm acetophenone, thiab 0.5g ntawm poov tshuaj bromide. Gas tau qhia ntawm 95-105C, thiab cov tshuaj tiv thaiv tau ntev li 4 teev. Cov kua dej chromatography tau siv los kuaj pom tias tsuas yog 3.5% ntawm cov tsis muaj tshuaj 2.5-dimethylbenzene nyob rau hauv cov tshuaj tiv thaiv (piv rau thawj 2.5-dimethylbenzene input). Oxygen raug tso tseg los ntawm kev ua kom txias cov tshuaj tiv thaiv rau 80℃C thiab ntxiv 1g ntawm cov pa roj carbon activated, Tom qab ntawd decolorize ntawm 78 ~ 82C rau 30mm, lim thaum kub, txias cov lim rau 18 ~ 20℃C, crystallize, thiab lim. Lub ncuav mog qab zib lim tau qhuav kom tau 20.6g ntawm lub teeb daj crystalline hmoov 5-methyl-2-benzoic acid, nrog rau cov txiaj ntsig ntawm 75% thiab purity ntawm 99.2%.
Cov lus nug nquag
Sib nrug los ntawm kev txo cov ntshav qab zib thiab cov roj cholesterol, dab tsi "lub luag haujlwm tsis meej" nws ua si hauv kev ua haujlwm ntawm cov khoom siv?
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Nws tuaj yeem siv los ua ib lub tsev thaiv rau hlau organic moj khaum (MOFs) los tsim peb - qhov sib txuas nrog qhib qhov pores. Cov molecule no muaj nitrogen atoms thiab carboxylic acid pawg, ua rau nws zoo heev organic ligand. Kev tshawb fawb tau pom tias nws tuaj yeem ua rau lub ntiaj teb tsis tshua muaj ions (xws li Eu ³ ⁺) lossis cov hlau hloov pauv (xws li Co ² ⁺, Pb ² ⁺) los tsim kev sib koom ua ke polymers nrog ib qho - cov saw hlau zoo li, ob- seem txheej txheej, lossis txawm peb - s. Cov qauv no ua rau nws muaj txiaj ntsig zoo hauv thaj chaw ntawm cov pa roj adsorption, catalysis, lossis cov ntaub ntawv luminescent, uas yog lwm qhov zais zais ntawm nws lub luag haujlwm ua "tshuaj nruab nrab".
Puas yog "kev sib cais thermodynamics" tus cwj pwm zoo ib yam thaum nws yaj hauv cov kuab tshuaj sib txawv?
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Tsis sib haum. Nws muaj qhov sib txawv tseem ceeb hauv nws tus cwj pwm kev sib cais hauv cov kuab tshuaj proton (alcohols) thiab dipole solvents (ketones). Kev tshawb fawb tau pom tias nyob rau hauv cov kuab tshuaj cawv xws li methanol thiab ethanol, kev koom tes ntawm "sib xyaw entropy" thiab "sib xyaw enthalpy" thaum lub sij hawm dissolution txheej txheem yog txawv. Qhov tseem ceeb tshaj, nws muaj qee yam solubility hauv 2-butanone, tab sis vim nws cov kev tswj hwm los ntawm US Drug Enforcement Administration (DEA), kev lag luam tab tom nrhiav lwm cov kuab tshuaj los txhim kho nws cov txheej txheem recrystallization purification. Qhov no txhais tau hais tias thaum xaiv cov kuab tshuaj, ib qho tsis tsuas yog yuav tsum xav txog seb nws puas tuaj yeem yaj, tab sis kuj yog kev ua raws cai thiab cov nqi ntawm cov khoom lag luam.
Nws puas tuaj yeem tau txais los ntawm "biological fermentation" es tsis txhob siv tshuaj lom neeg?
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Okay. Los ntawm kev siv cov txheej txheem biology hluavtaws los hloov Escherichia coli, ncaj qha biosynthesis ntawm qabzib tuaj yeem ua tiav.
Traditional chemical synthesis involves high temperature and high pressure, but a study in 2024 constructed an artificial biosynthetic pathway in Escherichia coli by reversing the biosynthetic pathway. This system can produce the compound in an environmentally friendly manner (without the need for toxic chemical reagents and metal catalysts) starting from glucose, with a yield of>5 g / L. Qhov no 'kev tsim ntsuab' txoj kev sawv cev rau cov kev taw qhia ntawm kev tsim tshuaj zoo rau yav tom ntej.
Cim npe nrov: 5-methyl-2-pyrazinecarboxylic acid CAS 5521-55-1, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom