Adenosine hmoovyog cov hmoov hmoov uas muaj Adenosine, nucleotide uas muaj ribose, adenine thiab phosphate pawg, uas yog ib qho tseem ceeb ntawm ATP (adenosine triphosphate), cov khoom uas ncaj qha muab lub zog hauv cov kab mob uas muaj sia nyob, thiab hu ua "molecular txiaj" ntawm lub zog hauv cov hlwb. Adenosine yog ib qho purine nucleoside, ib qho sib xyaw ua ke ntawm N-9 ntawm adenine txuas rau C -1 ntawm D-ribose los ntawm -glycosidic daim ntawv cog lus, nrog rau cov tshuaj formula C10H13N5O4, thiab nws cov phosphate ester yog adenosine. . adenosine plays lub luag haujlwm tseem ceeb hauv biochemistry, suav nrog kev hloov pauv ntawm lub zog xws li hauv daim ntawv ntawm adenosine triphosphate (ATP) lossis adenosine dihydrogen diphosphate (ADP) lossis raws li cyclic adenosine monophosphate (cyclic adenosine monophosphate). D-adenosine (Nucleosid) yog ib chav kawm ntawm glycosChemicalbookylamine molecules uas muaj nucleic acid puag ntxiv rau ribose los yog deoxyribose, lub hauv paus yog Purine thiab Pyrimidine. Cov hauv paus muaj xws li Purine (Purine) thiab Pyrimidine (Pyrimidine), Purine suav nrog Guanine thiab Adenine, Pyrimidine suav nrog Cytosine, Thymine thiab Uracil, Ribose thiab nucleic acid bases yog tsim los ntawm -N glycosidic bonds.
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| Tshuaj Formula | C10H13N5O4 |
| Molecular Luj | 267.24 |
| Exact Mass | 267.1 |
| m/z | 267.10 (100.0%), 268.10 (10.8%), 268.09 (1.8%) |
| Elemental Analysis | C, 44.94; H, 4.90; N, 26.21; O, 23.95 |
| Melting point | 234-236 degree (lit.) |
| Boiling point | 410.43 degree (kev kwv yees ntxhib) |
| Qhov ntom | 1.3382 (zeeg) |
| Cia tej yam kev mob | 2-8 degree |
| Solubility | Me ntsis soluble hauv dej, soluble hauv dej kub, xyaum insoluble hauv ethanol (96 feem pua) thiab hauv methylene chloride. Nws dissolves nyob rau hauv dilute mineral acids. |
| Daim ntawv | Crystalline hmoov |
| Xim | Dawb |
| Acidity Coefficient (pKa) | 3.6, 12.4 (ntawm 25 degree) |
| Refractive Index | 1.7610 (kwv yees) |
| Dej solubility | Soluble hauv dej, ammonium hydroxide thiab dimethyl sulfoxide. Insoluble hauv ethanol. |
| Rotoriness (kev ua haujlwm kho qhov muag) | [ ]20 / D 70 ± 3 degree, c=2% hauv 5% NaOH |
| Kev ruaj ntseg | ruaj khov. Incompatible nrog muaj zog oxidizing neeg sawv cev. |
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Daim ntawv thov thaj chaw ntawmAdenosine hmoovfeem ntau yog tsom rau kev tshawb fawb tshuaj thiab kev tshawb fawb.
Pharmaceuticals
Kev kho mob plawv
Adenosine yog tus neeg saib xyuas kev tiv thaiv myocardial, uas tuaj yeem txo qis myocardial ischemia thiab reperfusion raug mob, yog li nws feem ntau siv los kho angina pectoris, myocardial infarction thiab lwm yam kab mob plawv.
Kev kho mob arrhythmia
Adenosine tuaj yeem ua rau ncua sijhawm atrioventricular block, uas tuaj yeem siv los txiav tawm atrioventricular nodal refractory tachycardia, thiab nws kuj tseem pab tau kom paub qhov txawv ntawm supraventricular tachycardia los ntawm ventricular tachycardia.
Vasodilatation
Adenosine dilates cov hlab ntsha, ua kom cov ntshav txaus rau myocardium thiab lwm yam ntaub so ntswg, yog li txhim kho cov ntaub so ntswg hypoxia.
Cov cheeb tsam ntawm Kev Tshawb Fawb Txog Kev Tshawb Fawb
Cell biology tshawb fawb
Adenosine yog ib feem ntawm ATP, ib qho tseem ceeb ntawm lub zog molecule nyob rau hauv cov hlwb, yog li ntawd, nyob rau hauv lub cell biology tshawb fawb, Adenosine hmoov kawg feem ntau yog siv los ua ib qho kev sim khoom siv los kawm cellular zog metabolism, teeb liab transduction thiab lwm yam txheej txheem.
Tshuaj nrhiav pom
Adenosine thiab nws cov derivatives muaj txiaj ntsig zoo hauv kev tshawb nrhiav thiab kev loj hlob ntawm cov tshuaj, raws li precursors lossis cov khoom xyaw nquag hauv kev tsim cov tshuaj tshiab rau kev kho mob plawv, kab mob paj hlwb, thiab lwm yam. Tsis tas li ntawd, Adenosine Powder tuaj yeem siv los ua cov khoom muaj nyob hauv kev kho mob ntawm cov kab mob plawv.
Tsis tas li ntawd, Adenosine Powder kuj tseem muaj peev xwm siv tau rau lwm qhov chaw, xws li cov khoom noj khoom haus, khoom noj khoom haus thiab lwm yam.
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Physiological teebmeem ntawmAdenosine hmoovFeem ntau suav nrog cov hauv qab no:
Lub zog metabolism
Adenosine yog ib qho tseem ceeb nruab nrab ntawm cov synthesis ntawm adenosine triphosphate (ATP), uas yog ib qho tseem ceeb rau cov khoom siv hluav taws xob ncaj qha hauv cov hlwb. Yog li, Adenosine plays lub luag haujlwm tseem ceeb hauv cellular zog metabolism, muab lub zog rau ntau yam kev ua ub no ntawm cov hlwb.
Cardioprotection
Adenosine muaj kev tiv thaiv ntawm cardiomyocytes, uas tuaj yeem txo qis myocardial ischemia-reperfusion raug mob thiab tiv thaiv cardiomyocytes los ntawm kev puas tsuaj.
Vasodilatation
Adenosine tuaj yeem nthuav cov hlab ntsha, ua kom cov ntshav txaus rau myocardium thiab lwm cov ntaub so ntswg, yog li txhim kho cov ntaub so ntswg hypoxic.
Neurotransmitter
Adenosine kuj ua raws li cov neeg xa xov liaison, tseem hu ua neurotransmitter, koom nrog kev xa xov hauv nruab nrab, pab kev sib txuas lus ntawm cov neurons sib txawv.
Tsis tas li ntawd, Adenosine muaj cov ntawv thov hauv cov tshuaj pleev ib ce. Nws tuaj yeem siv los ua moisturiser, antioxidant thiab cov tawv nqaij txias kom rov ua kom cov tawv nqaij lub zog, txhawb cov cell metabolism thiab inhibit melanin loj hlob. Adenosine kuj cuam tshuam nrog kev sib txuas ntawm cov kab mob nucleic acids hauv daim tawv nqaij, thiab muaj cov kab mob tua kab mob thiab tiv thaiv kab mob thaum cov ntaub so ntswg puas.
Lub synthesis ntawmAdenosine hmoovFeem ntau suav nrog ntau cov kauj ruam, suav nrog de novo synthesis ntawm nucleotides thiab txoj kev khaws cia. Txawm li cas los xij, cov txheej txheem synthesis tshwj xeeb yuav txawv ntawm kev lag luam nyob ntawm cov txheej txheem tsim khoom.
Feem ntau, adenosine synthesis suav nrog kev txuas ntawm ribose, phosphate thiab adenine bases.
(1) Phosphorylation ntawm ribose
Ua ntej, ribose (feem ntau D-ribose) yog phosphorylated los tsim ribose phosphate nyob rau hauv lub xub ntiag ntawm kinase.
(2) Kev sib txuas ntawm cov hauv paus rau ribose phosphate
Adenine bases txuas rau ribose phosphate los ntawm cov enzymes tshwj xeeb (xws li adenylate synthase) los tsim adenylate (AMP).
(3) Ntxiv phosphorylation
adenosine monophosphate (AMP) tuaj yeem ua tau ntxiv phosphorylated los tsim adenosine diphosphate (ADP) thiab adenosine triphosphate (ATP) los ntawm cov tshuaj tiv thaiv phosphorylation ntxiv nyob rau hauv lub xub ntiag ntawm adenylate kinase.
Txawm li cas los xij, qhov no yog cov lus piav qhia yooj yim heev thiab cov txheej txheem synthesis tiag tiag yuav koom nrog ntau theem nrab thiab cov enzymes.
Raws li cov qauv tshuaj tiv thaiv tshwj xeeb, nws yog ib qho nyuaj rau kev nthuav tawm ib qho tshuaj tiv thaiv kab mob vim tias cov txheej txheem synthesis nyuaj thiab muaj ntau yam tshuaj tiv thaiv. Tsis tas li ntawd, cov txheej txheem hluavtaws siv hauv kev lag luam tuaj yeem sib txawv nyob ntawm cov khoom tsim thiab cov khoom lag luam.
Cim npe nrov: adenosine hmoov cas 58-61-7, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom