Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm dimethylphosphine oxide cas 7211-39-4 nyob Suav teb. Txais tos rau cov lag luam wholesale bulk zoo dimethylphosphine oxide cas 7211-39-4 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Dimethylphosphine Oxide(DMPO) yog ib qho tseem ceeb organic phosphorus compound, nrog rau cov mis molecular (CH₃)₂P(O)H. Nws tuaj yeem suav tau tias yog ib qho derivative ntawm phosphorus oxide (PH₃O) uas ob lub hydrogen atoms tau hloov los ntawm pawg methyl. Cov yam ntxwv tseem ceeb ntawm cov molecule no yog nws cov polar phosphorus heev -oxygen ob daim ntawv cog lus (P=O), uas muaj lub zog siab zog thiab muaj zog polarity. Cov ntawv cog lus no tsis tsuas yog ua rau cov khoom sib xyaw nrog cov thermal stability siab heev thiab kub kub taw tes, tab sis kuj ua rau nws soluble hauv dej thiab ntau yam polar organic solvents. Lub molecule tag nrho muaj tetrahedral configuration. Vim muaj zog electronegativity ntawm cov pa atom, phosphorus atom nqa ib qho tseem ceeb ib feem zoo xwb, thaum lub hydrogen atom ncaj qha mus rau nws exhibits nws reactivity, ua rau nws ua raws li ib tug hydrogen daim ntawv cog lus pub thiab receptor. Cov qauv hluav taws xob tshwj xeeb no ua rau nws ua tau zoo heev Lewis puag thiab ligand, tshwj xeeb tshaj yog nyob rau hauv kev tsim cov complexes ruaj khov nrog kev hloov hlau. Yog li ntawd, nws yog dav siv nyob rau hauv homogeneous catalysis rau kev npaj ntawm ntau yam phosphorus ligands. Tsis tas li ntawd, nws yog ib qho tseem ceeb nruab nrab ntawm cov organic synthesis, siv nyob rau hauv cov synthesis ntawm phosphorus -muaj tshuaj, nplaim taws retardants, thiab cov khoom siv. Nws cov polarity tseem ceeb kuj ua rau nws tsim nyog raws li kev ntsuas tshuaj hnyav lossis cov khoom siv hauv kev tshawb fawb nuclear magnetic resonance (NMR).
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Tshuaj Formula |
C2H7OP, |
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Exact Mass |
78.05 |
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Molecular Luj |
78.05 |
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m/z |
78.02 (100.0%), 79.03 (2.2%) |
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Elemental Analysis |
C, 30.78; H, 9.04; O, 20.50; P, 39.68 |
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Thov xa mus rau peb tus qauv kev lag luam lossis COA. Yog tias koj xav tau cov ntsiab lus ntxiv, txais tos hu rau peb qhov muag.
Cov ntaub ntawv ntxiv ntawm cov tshuaj sib xyaw ua ke: Boiling point 65-67℃(Xovxwm: 6 Torr), Cia cov xwm txheej Khaws rau hauv qhov chaw tsaus, Inert cua, 2-8 degree, Cov tsos mob ua kua, Xim dawb khoom rau lub teeb daj, Sensibility Cua rhiab heev.
Nws cov molecules muaj zog P=O daim ntawv cog lus, uas muaj cov electronegativity siab, muab lawv ib co℃ntawm polarity. Yog li ntawd, solubility ntawm cov tshuaj no yog siab dua nyob rau hauv polar solvents, thaum nws yog qis dua nyob rau hauv tsis yog -polar solvents. Lub electronegativity ntawm P=O daim ntawv cog lus yog siab, thiab nws yog yooj yim oxidized los ntawm oxygen los tsim oxides, yog li cuam tshuam rau cov tshuaj thiab stability ntawm dimethyl phosphine oxide. Yog li ntawd, thaum siv cov tshuaj no, nws yog ib qho tsim nyog yuav tsum tsis txhob sib cuag nrog huab cua thiab khaws cia rau hauv lub thawv qhuav thiab kaw.
Dimethylphosphine oxide, tseem hu ua 2-cyano-3,3-diphenylacrylate isooctyl ester, yog cov roj soluble ultraviolet absorber dav siv hauv ntau yam.
Organic synthesis teb
Nyob rau hauv lub tshav pob ntawm organic synthesis, raws li ib tug organic phosphine compound, nws muaj ntau yam kev siv.
Daim ntawv thov nruab nrab:
Nws yog ib qho tseem ceeb nruab nrab ntawm ntau yam kev sib txuas ntawm cov organic. P=O daim ntawv cog lus nyob rau hauv nws cov molecule muaj ib tug high electronegativity, uas ua rau cov tshuaj ntau soluble nyob rau hauv polar solvents thiab yooj yim mus koom nyob rau hauv ntau yam nucleophilic hloov, ntxiv thiab lwm yam tshuaj.
Piv txwv li, nyob rau hauv cov synthesis ntawm qee cov organic tebchaw uas muaj phosphines, lawv tuaj yeem siv los ua cov ntaub ntawv pib los qhia phosphonyl pawg los ntawm ntau cov tshuaj tiv thaiv, yog li tau txais cov khoom lag luam.
Synthesis ntawm phosphine ligands:
Nyob rau hauv lub synthesis ntawm organic phosphine ligands, phosphonyl pawg tuaj yeem qhia los ntawm cov tshuaj tiv thaiv rau kev npaj ntawm chiral catalysts, hlau complexes, thiab lwm yam. Cov ligands ua lub luag haujlwm tseem ceeb hauv asymmetric synthesis, txhim kho stereoselectivity thiab tawm los ntawm cov tshuaj tiv thaiv.
Functional Material modification:
Raws li tus qauv hloov kho rau cov khoom siv ua haujlwm organic uas muaj phosphine, nws tuaj yeem txhim kho polarity, solubility, thiab lwm yam khoom ntawm cov khoom. Los ntawm kev qhia cov qauv ntawm dimethyl phosphine oxide, cov kev siv ntawm cov khoom siv hauv kev lag luam xws li electronics thiab optics tuaj yeem txhim kho.
Kev kho mob teb
Hauv kev lag luam tshuaj, dimethyl phosphine oxide thiab nws cov derivatives feem ntau yog siv hauv tshuaj synthesis thiab cov tshuaj hauv zos formulations.
Tshuaj intermediates:
Nws yog ib qho nruab nrab rau synthesizing qee yam tshuaj tiv thaiv - mob qog noj ntshav thiab tshuaj tiv thaiv kab mob. Piv txwv li, ARIAD Pharmaceutical Company tau siv nws los npaj cov tshuaj lymphoma tshiab Brigatinib. Los ntawm kev qhia cov qauv ntawm dimethyl phosphine oxide, kev ua haujlwm thiab kev xaiv ntawm cov tshuaj tau raug txhim kho.
Tshwj xeeb, brigatinib yog thib ob - tiam anaplastic lymphoma kinase (ALK) inhibitor uas tau pom zoo nyob rau ntau lub teb chaws thiab cheeb tsam rau kev kho mob ntawm ALK zoo uas tsis yog-mob qog noj ntshav hauv lub ntsws.
Hydrogen daim ntawv cog lus receptor:
Raws li hydrogen bond receptor, nws tuaj yeem koom nrog kev sib cuam tshuam ntawm cov tshuaj molecules thiab receptor proteins. Los ntawm kev qhia phosphine oxide qauv, LogD tus nqi ntawm cov compound tuaj yeem txo qis, solubility thiab metabolic stability tuaj yeem nce ntxiv.
Piv txwv li, nyob rau hauv kev hloov kho ntawm cov tshuaj antihypertensive xws li prazosin, kev taw qhia ntawm phosphine oxide qauv tuaj yeem txhim kho lawv cov dej solubility zoo thaum tswj kev siv tshuaj.
Dawb radical capture:
Nws muaj peev xwm los ntes cov dawb radicals. Cov dawb radicals yog ib hom tshuaj lom neeg nrog cov khoom siv hluav taws xob tsis sib xws uas ua lub luag haujlwm tseem ceeb hauv cov tshuaj tiv thaiv. Los ntawm reacting nrog dawb radicals, tus naj npawb ntawm cov dawb radicals yuav txo tau zoo, yog li hloov cov txheej txheem thiab cov khoom ntawm cov tshuaj tiv thaiv.
Cov yam ntxwv no ua rau nws muaj peev xwm siv tau rau hauv kev tsim cov tshuaj tua kab mob antioxidant thiab tshuaj tiv thaiv - mob.
Cov ntawv thov kev lag luam
Hauv kev lag luam,DIMETHYLPHOSPHINE OXIDEFeem ntau yog siv los ua qhov nruab nrab rau UV absorbers lossis nplaim hluav taws xob hauv cov ntaub ntawv xws li plastics, coatings, thiab dyes.
Plastics thiab Coatings:
Raws li qhov nruab nrab rau UV absorbers lossis nplaim hluav taws, nws tuaj yeem siv los npaj siab -cov khoom siv yas thiab txheej txheej, txhim kho lawv cov huab cua tiv thaiv thiab nplaim taws.
Piv txwv li, ntxiv bis (2-carboxyethyl) methyl phosphine oxide (CEMPO) rau cov nplaim hluav taws xob PA66 yas tuaj yeem txhim kho cov khoom siv hluav taws xob zoo.
Dyes thiab fragrances:
Nyob rau hauv kev lag luam dyeing, koom nyob rau hauv lub synthesis ntawm tej yam acidic dyes thiab haumxeeb dyes. Cov dyes muaj cov xim zoo nrawm thiab vividness, uas tuaj yeem ua tau raws li cov kev xav tau ntawm cov teb sib txawv.
Hauv kev lag luam txuj lom, cov derivatives ntawm cov tshuaj no tuaj yeem siv los npaj cov ntsiab lus tshwj xeeb. Cov essence no muaj cov tshuaj tsw qab tshwj xeeb thiab cov tshuaj tsw qab ntev, uas tuaj yeem txhim kho tus nqi ntxiv ntawm cov khoom.
Kev npaj catalyst:
Ligands uas tuaj yeem siv los npaj cov catalysts. Los ntawm kev qhia cov pab pawg phosphonyl, kev ua haujlwm thiab kev xaiv ntawm catalysts tuaj yeem txhim kho, yog li ua lub luag haujlwm tseem ceeb hauv thaj chaw xws li petrochemicals thiab tshuaj zoo.
Kev ua liaj ua teb thiab kev tiv thaiv ib puag ncig
Hauv kev ua liaj ua teb thiab kev tiv thaiv ib puag ncig, cov ntawv thov tau maj mam tau txais kev saib xyuas.
Tshuaj tua kab synthesis:
Derivatives ntawm dimethyl phosphine oxide tuaj yeem siv rau kev sib txuas ntawm cov tshuaj tua kab, tshuaj tua kab, thiab lwm yam tshuaj tua kab. Cov tshuaj tua kab no muaj cov tshuaj tua kab zoo thiab cov kab mob bactericidal, uas tuaj yeem txhim kho cov kab mob thiab kab tsuag ntawm cov qoob loo, yog li ua kom cov zaub mov ruaj ntseg thiab cov khoom ua liaj ua teb zoo.
Environmental Protection Treatment:
Yuav siv tau rau kev tshem tawm cov hlau hnyav ions hauv kev kho dej khib nyiab. Vim nws cov yam ntxwv tshwj xeeb, nws tuaj yeem ua rau muaj kev cuam tshuam nrog cov hlau hnyav ions, tsim cov precipitates uas yooj yim tshem tawm ntawm cov dej khib nyiab.
Tsis tas li ntawd, nws tseem tuaj yeem siv los ua photocatalyst kom degrade organic pollutants. Nyob rau hauv lub teeb pom kev zoo, active oxygen hom uas muaj zog oxidizing zog tuaj yeem tsim los oxidize thiab decompose organic pollutants rau hauv cov khoom tsis zoo.
Nws yog tsim los ntawm hydrolysis ntawm chlordimethylphosphine:
Me2PCl + H2O → Me2P(O)H + HCl
Methanol es tsis txhob ntawm ethanol kuj siv tau es tsis txhob dej, thiab cov byproduct yog chloromethane.
DMHO yog siv los ua ib qho nruab nrab hauv cov organic synthesis, xws li OLED.
Nyob rau hauv chav tsev kub, maj mam drip sodium bis (trimethylsilyl) amide (kev daws nyob rau hauv qhuav tetrahydrofuran) rau hauv ib tug degassed tov ntawm dimethyl phosphine oxide (50 mg, 0.64 mmol) nyob rau hauv qhuav tetrahydrofuran thaum stirring. Tom qab ntawd do cov tshuaj tiv thaiv sib tov ntawm chav tsev kub rau 15 feeb. Cov tshuaj pom tau dhau los ua turbid vim tsim ntawm phosphonyl anions. Maj mam ntxiv cov tshuaj sib xyaw ntawm 5-chloro-6- (chloromethyl) benzo [d] [1,3] dioxane (119.4 mg, 0.58 mmol) hauv cov tetrahydrofuran qhuav rau phosphonyl anion sib tov, ib qho dawb precipitate tuaj yeem pom maj mam tsim hauv cov tshuaj tiv thaiv sib tov. Do cov tshuaj tiv thaiv sib tov ntawm chav tsev kub rau 16 teev, tom qab ntawd ntxiv cov dej sib npaug rau cov tshuaj tiv thaiv sib tov kom tua nws. Extract cov sib tov tsib zaug nrog qhov sib npaug ntawm dichloromethane, qhuav thiab lim cov organic teeb meem ntawm Na2SO4, thiab mloog zoo rau qhov tshwm sim filtrate hauv lub tshuab nqus tsev kom tshem tawm cov kuab tshuaj. Cov khoom lag luam tuaj yeem tau txais los ntawm kev ntxuav cov khoom seem nrog chloroform / n-hexane kom tshem tawm impurities thiab ntsev.
Lus Cim: BLOOM TECH (Txij li xyoo 2008), ACHIEVE CHEM-TECH yog lub chaw pabcuam ntawm peb.
Dimethylphosphine oxideyog ib qho organic compound nrog ntau yam siv.
Thaum synthesizing dimethyl phosphine oxide, ob txoj hauv qab no feem ntau yog siv:
1. Methyl oxidation txoj kev
Methyl oxidation txoj kev yog ib txoj kev siv feem ntau rau synthesizing dimethyl phosphine oxide. Txoj kev no suav nrog cov tshuaj methanol thiab oxygen nyob rau hauv qhov kev txiav txim ntawm lub catalyst los tsim formaldehyde, uas tom qab ntawd reacts nrog sulfur trioxide los tsim dimethyl phosphine oxide. Qhov sib npaug ntawm cov tshuaj tiv thaiv yog raws li nram no:
2 CH UA3OH + O2→ 2 HHO + H2O
2 HHO + SO3→ CH3OCH2O2YOG3H
Cov tshuaj tiv thaiv tseem ceeb ntawm txoj kev no yog ib puag ncig acidic, yog li sulfuric acid yuav tsum tau ntxiv los ua cov catalyst thaum cov txheej txheem tshuaj tiv thaiv. Txawm li cas los xij, ntau dhau ntawm sulfuric acid tuaj yeem cuam tshuam cov tshuaj tiv thaiv, yog li nws yog ib qho tsim nyog los tswj cov tshuaj sulfuric acid. Tsis tas li ntawd, tus nqi ntawm methanol kuj qis, yog li txoj kev no yog kev lag luam ntau dua.
2. Oxidation phosphating txoj kev
Oxidative phosphating method yog lwm txoj hauv kev rau kev sib xyaw dimethyl phosphine oxide. Txoj kev no suav nrog reacting trichloromethane nrog phosphorus pentoxide hauv cov kuab tshuaj los tsim dimethyl phosphine oxide. Qhov sib npaug ntawm cov tshuaj tiv thaiv yog raws li nram no:
PCl3+2CHCl3→ CH3OCH2OPOCl2+2HCl
Lub ntsiab zoo ntawm txoj kev no yog cov tshuaj tiv thaiv me me thiab ua haujlwm yooj yim. Lub caij no, tus nqi ntawm trichloromethane kuj qis, uas yog qhov zoo rau kev txo cov nqi tsim khoom. Txawm li cas los xij, phosphorus pentoxide muaj toxicity thiab corrosiveness, yog li txoj kev no yuav tsum muaj kev xav tau siab rau cov neeg ua haujlwm thiab cov kev ntsuas kev nyab xeeb yuav tsum tau ua.
Zuag qhia tag nrho, ob txoj kev tuaj yeem siv los ua ke dimethyl phosphine oxide. Cov txheej txheem methyl oxidation reacts nyob rau hauv acidic ib puag ncig nrog kev ua haujlwm yooj yim thiab cov khoom siv tsis tshua muaj nqi; Txoj kev oxidative phosphating yuav tsum muaj cov tshuaj tiv thaiv hauv anhydrous chloride, nrog rau kev ua haujlwm me me thiab cov nqi raw khoom tsawg. Hauv cov txheej txheem tsim khoom tiag tiag, cov txheej txheem sib xyaw tsim nyog tuaj yeem xaiv raws li qhov xav tau ntau lawm thiab cov khoom siv. Nws tseem yuav tsum tau muab sau tseg tias cov kua khib nyiab, cov pa tso pa tawm, thiab cov khoom seem uas tsim los ntawm cov txheej txheem no yuav tsum tau kho kom tsim nyog kom muaj kev nyab xeeb ntawm ib puag ncig thiab kev tsim khoom.
Cim npe nrov: Dimethylphosphine Oxide CAS 7211-39-4, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom