Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm glycolchitosan cas 123938-86-3 nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo glycolchitosan cas 123938-86-3 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Glycolchitosanyog chitosan derivative nrog hydrophilic ethylene glycol ceg. Txhim kho daim nyias nyias permeability thiab to ntawm Glycine xHarosoy63W hlwb. Nws yog dej-soluble, biocompatible, thiab biodegradable. Nws tuaj yeem cuam tshuam kev loj hlob ntawm Escherichia coli, Staphylococcus aureus, thiab Streptococcus pneumoniae, nrog MIC qhov tseem ceeb ntawm 4 μ g / mL, 32 μ g / mL, thiab<0.5 μ g/mL, respectively. Molecular formula C24H47N3O16, CAS 123938-86-3. Chitosan is a high molecular weight compound composed of acetylated glucosamine units naturally present in crustaceans such as shrimp, crabs, and insects. It is obtained by deacetylation or enzymatic deacetylation of chitin under strong alkaline conditions. It is also a linear structure composed of a large number of glucosamine units and a small number of acetylated glucosamine units through 1,4-glycosidic bonds, and the only natural polysaccharide biopolymer compound with alkaline characteristics. Compared with chitosan, there are more polar amino groups that can be protonated in the molecular structure of chitosan. Therefore, while maintaining the good biodegradability, biocompatibility, and environmental friendliness of chitosan, its solubility in acidic media is also significantly improved compared to chitosan, and its application performance is also significantly improved.
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Hydroxyethyl deacetylated chitosan, tseem hu uaGlycolchitosan, yog ib qho derivative ntawm chitosan tau los ntawm kev hloov kho tshuaj, uas qhia txog hydrophilic ethylene glycol ceg rau hauv nws cov qauv. Qhov kev hloov kho no tsis tsuas yog txhim kho cov dej solubility ntawm chitosan, tab sis kuj tseem khaws nws cov qub biocompatibility thiab biodegradability, yog li nthuav dav daim ntawv thov kev cia siab hauv thaj chaw ntawm biology.
Nws muaj cov tshuaj tua kab mob tseem ceeb thiab tuaj yeem cuam tshuam kev loj hlob ntawm ntau yam kab mob. Kev tshawb fawb tau pom tias nws muaj txiaj ntsig zoo inhibitory cuam tshuam rau cov kab mob pathogenic xws li Escherichia coli, S. aureus, thiab S. enteritidis, nrog qhov tsawg kawg nkaus inhibitory concentrations (MICs) ntawm 4 μ g / mL, 32 μ g / mL, thiab<0.5 μ g/mL, respectively. This antibacterial property makes hydroxyethyl chitosan have potential application value in fields such as biomedicine, food preservation, and agriculture. For example, in the field of biomedicine, it can be used as an ingredient in wound dressings or antibacterial coatings to effectively prevent wound infections; In terms of food preservation, it can extend the shelf life of food and reduce food spoilage.
2. Cov neeg nqa tshuaj
Nws muaj biocompatibility zoo thiab degradability, ua rau nws yog cov khoom siv tshuaj zoo tagnrho. Nws tuaj yeem thauj cov khoom siv tau zoo xws li tshuaj molecules, noob, lossis photosensitizers rau hauv nws sab hauv lossis nto los ntawm lub cev encapsulation lossis tshuaj sib txuas, tsim cov complexes ruaj khov lossis nanoparticles. Cov complexes los yog nanoparticles muaj kev ruaj ntseg zoo heev thiab lub hom phiaj hauv vivo, uas tuaj yeem txhim kho bioavailability thiab kho cov txiaj ntsig ntawm cov tshuaj. Piv txwv li, hydroxyethyl chitosan nanoparticles (NPs) tuaj yeem ua tiav cov phiaj xwm xa tawm hauv cov ntaub so ntswg raws li kev txhim kho permeability thiab tuav (EPR), txo cov kev mob tshwm sim ntawm cov tshuaj ntawm cov ntaub so ntswg.
Cov nanoparticles ntawm cov tshuaj no kuj tau pom muaj peev xwm zoo hauv kev ua haujlwm ntawm tes. Vim lawv cov cytotoxicity qis thiab siab biocompatibility, cov nanoparticles no tuaj yeem nkag mus rau sab hauv ntawm cov hlwb kom nyab xeeb thiab ua tiav -lub sijhawm, tsis yog -kev saib xyuas ntawm cov hlwb los ntawm fluorescence labeling lossis lwm yam kev yees duab. Qhov no yog qhov tseem ceeb heev rau kev kawm txog cell biology, kab mob mechanisms, thiab kev siv tshuaj yeeb tshuaj. Tsis tas li ntawd, hydroxyethyl chitosan nanoparticles kuj tseem tuaj yeem ua cov tracers rau cov tshuab xa tshuaj, pab cov kws tshawb fawb saib xyuas kev faib thiab cov metabolism hauv cov tshuaj hauv lub cev.
4. Lub koom haum Engineering
Hauv kev lag luam ntawm cov ntaub so ntswg engineering, nws tau kawm dav vim nws cov biocompatibility zoo thiab degradability. Nws tuaj yeem ua cov khoom siv scaffold, muab qhov tsim nyog microenvironment rau kev loj hlob ntawm tes thiab kev sib txawv. Los ntawm kev khi nrog bioactive tshuaj xws li extracellular matrix proteins thiab loj hlob yam, hydroxyethyl chitosan scaffolds tuaj yeem simulate cov qauv thiab kev ua haujlwm ntawm cov ntaub so ntswg, txhawb kev kho thiab rov tsim cov ntaub so ntswg puas. Piv txwv li, hauv cov pob txha cov ntaub so ntswg engineering, hydroxyethyl chitosan scaffolds tuaj yeem coj cov pob txha loj hlob thiab kev sib txawv, txhawb kev kho pob txha thiab kho pob txha.
Nyob rau hauv xyoo tas los no, nrog rau kev xav tau ntau ntxiv rau cov tshuaj pleev ib ce ntuj, nws kuj tau txais kev saib xyuas thoob plaws hauv kev lag luam tshuaj pleev ib ce. Raws li lub ntuj moisturizer, antioxidant, thiab tshuaj tua kab mob, hydroxyethyl chitosan tuaj yeem txhim kho kev ua haujlwm thiab kev nyab xeeb ntawm cov tshuaj pleev ib ce. Nws zoo heev moisturizing kev ua tau zoo tuaj yeem pab cov tawv nqaij kaw hauv cov dej noo, tiv thaiv dryness thiab tsim cov kab zoo; Nws cov khoom antioxidant tuaj yeem tiv thaiv kev puas tsuaj ntawm cov dawb radicals rau ntawm daim tawv nqaij thiab ncua kev laus; Nws cov tshuaj tua kab mob tuaj yeem txo qhov khaus thiab kis kab mob ntawm cov tshuaj pleev ib ce ntawm daim tawv nqaij. Yog li ntawd, hydroxyethyl chitosan muaj dav daim ntawv thov kev cia siab nyob rau hauv kev tu tawv nqaij, tshuaj pleev ib ce, thiab kho qhov ncauj cov khoom.
6. Biomedical cov ntaub ntawv
Ntxiv nrog rau cov ntawv sau tseg saum toj no, nws tseem tuaj yeem ua lub substrate lossis additive rau biomedical cov ntaub ntawv. Piv txwv li, thaum npaj cov khoom siv kho mob xws li biomedical membranes, catheters, thiab cov tawv nqaij tsim, ntxiv ib qho tsim nyog ntawm hydroxyethyl chitosan tuaj yeem txhim kho biocompatibility thiab antibacterial thaj chaw ntawm cov ntaub ntawv; Thaum npaj biosensors, lub peev xwm paub txog qhov tshwj xeeb ntawm hydroxyethyl chitosan tuaj yeem siv los ua kom tau txais kev nkag siab zoo ntawm biomolecules. Tsis tas li ntawd, hydroxyethyl chitosan kuj tuaj yeem ua ke nrog lwm cov khoom siv biomaterials xws li collagen thiab hyaluronic acid los txhim kho kev ua haujlwm thiab kev siv ntau yam ntawm cov khoom.
Hauv kev tiv thaiv ib puag ncig, nws kuj muaj qee qhov peev xwm rau kev thov. Vim nws zoo heev biodegradability thiab ib puag ncig tus phooj ywg, nws tuaj yeem siv los ua cov khoom siv ntsuab rau kev kho dej khib nyiab, kho av, thiab lwm yam kev siv. Piv txwv li, hauv kev kho dej khib nyiab, hydroxyethyl chitosan tuaj yeem ua haujlwm zoo li adsorbent lossis flocculant kom tshem tawm cov khoom tsis zoo xws li cov hlau hnyav ions thiab cov kuab paug organic los ntawm cov dej khib nyiab; Hauv kev kho av, nws tuaj yeem txhawb nqa kev ua si thiab ntau haiv neeg ntawm cov kab mob hauv av, ua kom lub zog degradation thiab hloov pauv ntawm cov teeb meem hauv av.
Kev npaj ntawmGlycolchitosan(hydroxyethyl deacetylated chitosan):
Ntxiv cov tshuaj alkaline aqueous nrog rau qhov loj feem pua ntawm 20-50% rau chitosan hauv qhov sib piv loj ntawm 2.0-10: 1.0. Cov tshuaj alkaline aqueous yog tsim los ntawm kev sib xyaw ntawm sodium hydroxide, lithium hydroxide, thiab / lossis potassium hydroxide.
Tom qab sib tov thiab sib tov, alkalize ntawm -20 ~ 50℃rau 10 ~ 48 teev; Disperse alkalized chitosan hauv isopropanol hauv qhov sib piv loj ntawm 1.0: 10-100, thiab tom qab ntawd do ntawm qhov kub thiab txias ntawm 10-90℃rau 5-150 feeb;
Ntxiv cov tshuaj bromoethanol, epoxyethane, thiab / lossis chloroethanol hauv isopropanol hauv qhov piv ntawm 0.1-20 ntawm tus nqi ntawm bromoethanol, epoxyethane, thiab / lossis chloroethanol rau tus nqi ntawm chitosan glucosamine units hauv alkalized chitosan isopropanol system. Tom qab ntxiv, hnov mob ntawm qhov kub ntawm 10-100℃rau 2-48 teev;
Centrifuge lossis lim cov khoom siv tshuaj tiv thaiv, yaj lossis tawg cov khoom tau hauv dej, thiab tau txais cov tshuaj aqueous lossis slurry uas muaj hydroxyethyl chitosan (hydroxyethyl deacetylated chitosan);
Evaporate thiab mloog zoo rau cov tshuaj aqueous lossis slurry uas muaj hydroxyethyl chitosan (hydroxyethyl deacetylated chitosan) nyob rau hauv qhov tsis zoo, tom qab ntawd hloov cov tshuaj concentrated rau hauv lub hnab lim dej nrog lub qhov hnyav molecular txiav - tawm ntawm 500-50000, thiab dialyze hauv distilled lossis deionized-72 cov dej ntsev ntau dhau rau 12 teev. alkali los ntawm concentrated tov;
Tom qab theem nrab concentration ntawm cov tshuaj concentrated tom qab lim ntshav, maj mam ntxiv rau anhydrous ethanol thiab / los yog acetone nyob rau hauv ib tug ntim piv ntawm 1.0: 1.0-50 nyob rau hauv stirring rau precipitate hydroxyethyl chitosan (hydroxyethyl deacetylated chitosan);
Thaum kawg, lim thiab khov kom qhuav cov khoom tau txais los ntawm hydroxyethyl chitosan (hydroxyethyl deacetylated chitosan) nrog qhov nruab nrab grafting℃ntawm 5-300% glucosamine units.
Glycolchitosanyog ib qho hnyav molecular hnyav uas muaj li ntawm acetylated glucosamine units ib txwm muaj nyob rau hauv crustaceans xws li cws, crabs, thiab kab. Chitin yog tau los ntawm deacetylation los yog enzymatic deacetylation nyob rau hauv muaj zog alkaline tej yam kev mob. Nws tseem yog cov qauv linear tsim los ntawm ntau cov glucosamine units thiab tsawg tsawg ntawm acetylated glucosamine units los ntawm 1,4-glycosidic bonds, thiab yog tib lub ntuj polysaccharide biopolymer compound nrog alkaline yam ntxwv. Piv nrog rau chitosan, muaj ntau pawg polar amino pawg uas tuaj yeem protonated hauv cov qauv molecular ntawm chitosan. Yog li ntawd, thaum tswj xyuas qhov zoo biodegradability, biocompatibility, thiab ib puag ncig tus phooj ywg ntawm chitosan, nws solubility nyob rau hauv acidic media kuj tseem zoo dua piv rau chitosan, thiab nws daim ntawv thov kev ua tau zoo kuj tseem txhim kho.
Txawm li cas los xij, vim tias qhov hnyav molecular ntawm chitosan yog kaum txhiab lossis ntau pua txhiab tus, thiab muaj ntau ntawm hydroxyl thiab amino pawg hauv nws cov qauv, muaj zog hydrogen bonding kev sib cuam tshuam ntawm nws cov saw hlau molecular. Qhov kev sib txuas ntawm hydrogen no feem ntau ua rau nws zoo crystallinity, yog li nws cov solubility hauv dej ntshiab thiab alkaline xov xwm tseem tsis zoo heev, uas cuam tshuam thiab txwv nws cov ntawv thov ntxiv. Xav txog qhov tsis txaus ntawm chitosan nyob rau hauv cov nqe lus ntawm cov dej solubility, cov kws tshawb fawb tau npaj txoj hauv kev xws li grafting, catalytic hydrolysis, thiab tshuaj copolymerization los hloov chitosan los txhim kho nws cov dej solubility.
Piv txwv li, carboxymethyl chitosan tuaj yeem tau los ntawm kev qhia cov carboxymethyl pawg uas tuaj yeem sib cais hauv dej rau hauv cov qauv molecular ntawm chitosan, hydroxyethyl chitosan (hydroxyethyl deacetylated chitosan) tuaj yeem tau los ntawm kev qhia cov polar hydroxyethyl pawg uas tuaj yeem rhuav tshem nws cov crystallinity, 2-methychloridemonpropyl methyl chloride monopropylene. hydrophilicity tuaj yeem qhia tau kom tau 2-hydroxypropyl trimethylammonium chloride chitosan, thiab chitosan tuaj yeem oxidized thiab degraded rau hauv oligosaccharides nrog molecular hnyav hauv qab kaum tawm txhiab thiab crystallinity puas los ntawm hydrogen peroxide thiab lwm txoj kev. Vim yog kev qhia txog cov pab pawg hydrophilic thiab kev cuam tshuam ntawm hydrogen bonding qauv ntawm chitosan chains los yog qhov txo qis hauv molecular hnyav, cov chitosan derivatives feem ntau pom cov dej zoo solubility.
Cov kev mob tshwm sim ntawm cov tshuaj no yog dab tsi?
Kev ua xua
Rau qee tus neeg, cov tshuaj no tuaj yeem ua rau muaj kev tsis haum tshuaj, nrog rau cov tsos mob xws li pob khaus, khaus, liab, thiab o.
Hauv qhov xwm txheej hnyav, nws yuav ua rau muaj kev poob siab anaphylactic, uas yog ib qho kev tsis haum tshuaj loj heev uas yuav tsum tau kho mob tam sim ntawd.
Gastrointestinal tsis xis nyob
Tom qab noj cov tshuaj no, qee tus neeg yuav muaj cov tsos mob ntawm plab hnyuv xws li xeev siab, ntuav, raws plab, lossis cem quav.
Cov tsos mob no tuaj yeem tshwm sim los ntawm kev txhawb nqa ntawm plab hnyuv mucosa los ntawm kev noj tshuaj lossis cuam tshuam rau kev ua haujlwm ntawm lub plab zom mov.
Lub siab thiab lub raum puas
Lub sij hawm ntev los yog kev noj ntau dhau ntawm qee yam khoom siv bioactive yuav ua rau lub nra ntawm lub siab thiab lub raum, thiab tseem ua rau muaj kev puas tsuaj.
Txawm hais tias tsis muaj kev tshawb fawb txog cov teebmeem tshwj xeeb ntawm cov tshuaj no ntawm daim siab thiab ob lub raum, lub siab thiab lub raum toxicity tseem yuav tsum tau saib xyuas.
Lwm yam kev mob tshwm sim
Ntxiv nrog rau cov kev mob tshwm sim uas tau hais los saum toj no, cov tshuaj no kuj tseem yuav ua rau lwm yam tsis paub lossis tsis tshua muaj tshwm sim.
Cov kev mob tshwm sim no yuav txawv ntawm ib tus neeg mus rau ib tus neeg thiab tuaj yeem hloov pauv nrog rau yam xws li kev siv tshuaj ntev thiab ntau npaum li cas.
Cim npe nrov: Glycolchitosan CAS 123938-86-3, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom