Tshaj tawm
Peb tsis muab txhua yam tshuaj ntawm piperidine series, txawm tias muaj peev xwm tau txais piperidine los yog piperidone chemicals!
Txawm yuav txwv los tsis tau! Peb tsis muab!
Yog hais tias nws yog nyob rau hauv peb lub webiste, nws tsuas yog mus xyuas cov ntaub ntawv ntawm cov tshuaj compound.
Peb Hlis . 25th 2025
N-BOC-4-Hydroxypiperidine, muaj tus lej CAS 109384-19-2 thiab cov mis mos molecular ntawm C13H11Br. Nws feem ntau tshwm li cov hmoov dawb lossis greyish dawb crystalline hmoov thiab tej zaum yuav tshwm sim raws li cov khoom daj. Nws cov ntsiab lus kub kub yog siab heev, ntawm 292.3 ± 33.0℃C (ntawm 760 mmHg), thiab nws cov vapor siab tsawg heev, tsuas yog 0.000198 mmHg. Nws muaj zoo solubility nyob rau hauv cov organic solvents, tshwj xeeb tshaj yog polar solvents xws li chloroform thiab ethyl acetate. Lub solubility hauv dej yuav tsawg vim tias cov compound muaj ntau pawg hydrophobic. Nws yog ib qho tshuaj nruab nrab, thiab nws cov derivatives feem ntau yog siv rau kev sib txuas ntawm dipeptidyl peptidase DPP inhibitors. Cov DPP inhibitors tuaj yeem xaiv ua ke nrog DPP reversibly los tiv thaiv kev ua haujlwm ntawm cov enzyme no, ncua kev degradation ntawm glucagon zoo li peptide GLP-1, txhim khu kev ua haujlwm ntawm GLP, txhawb kev tsim cov tshuaj insulin hauv cov piam thaj, thiab txo cov qib glucagon, yog li tswj cov ntshav qab zib hom 2.
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Tshuaj Formula |
C10H19NO3 |
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Exact Mass |
201 |
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Molecular Luj |
201 |
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m/z |
201 (100.0%), 202 (10.8%) |
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Elemental Analysis |
C, 59.68; H, 9.52; N, 6.96; O, 23.85 |
N-Boc-4-hydroxypiperidine, raws li ib qho tseem ceeb ntawm cov organic compound, muaj ntau yam kev siv lub cev hauv kev tshawb fawb tshuaj thiab kev lag luam. Txawm li cas los xij, nws yuav tsum tau qhia meej tias cov khoom ntawm lub cev lawv tus kheej tsis ncaj qha txiav txim siab siv cov khoom sib xyaw ua ke, tab sis qhov tshwm sim ntawm kev sib xyaw ua ke ntawm cov khoom xws li nws cov khoom siv tshuaj lom neeg thiab cov tshuaj tiv thaiv.
Synthesis ntawm N-heterocyclic alkyl ethers:
Nws tuaj yeem siv los ua ke N-heterocyclic alkyl ethers los ntawm Mitsunobu cov tshuaj tiv thaiv. Cov tshuaj tiv thaiv Mitsunobu yog cov tshuaj lom neeg cov tshuaj tiv thaiv feem ntau siv los ua C-O daim ntawv cog lus, C-N daim ntawv cog lus, thiab C-S daim ntawv cog lus, nrog rau qhov zoo ntawm cov tshuaj tiv thaiv me me thiab cov txiaj ntsig siab. Raws li ib qho ntawm cov reactants, nws muaj peev xwm hnov mob nrog lwm yam cawv los yog amine tebchaw los tsim cov ether los yog amine compounds, uas muaj ntau yam kev siv tshuaj synthesis, cov ntaub ntawv science, thiab lwm yam.
Raws li biochemical reagent
Nws yog biochemical reagent uas tuaj yeem siv los ua biomaterial lossis organic compound rau kev tshawb fawb txog kev ua neej. Hauv kev sim tshuaj biochemical, nws yuav raug siv los simulate qee cov tshuaj tiv thaiv kab mob hauv cov kab mob, lossis ua cov substrate lossis inhibitor rau cov enzymes tshwj xeeb los kawm txog cov txheej txheem catalytic thiab substrate tshwj xeeb ntawm cov enzymes.
Tom qab xyoo ntawm kev tshawb nrhiav, tib neeg tau ua hauv - kev tshawb fawb tob rauN-Boc-4-hydroxypiperidine, thiab nws kuj tau pom muaj txiaj ntsig zoo hauv thaj chaw ntawm cov tshuaj synthesis. Txawm hais tias nws tuaj yeem ua ke los ntawm ntau txoj hauv kev, tseem muaj qee qhov teeb meem, xws li cov kauj ruam ntau dhau ntawm cov tshuaj synthesis, cov khoom tsis txaus siab thiab qhov muag purity, thiab kev siv tsawg ntawm cov khoom siv raw hauv chiral sib cais. Txawm li cas los xij, txoj kev hloov pauv lom neeg, txawm tias nws qhov zoo ntawm cov kauj ruam yooj yim, cov khoom siv raw khoom hloov pauv tau zoo, cov khoom zoo kho qhov muag purity, thiab cov txheej txheem kev npaj rau ib puag ncig, tau tsim kev loj hlob sai hauv xyoo tas los no. Txawm li cas los xij, tseem muaj qee qhov kev ncua deb ntawm kev tsim khoom lag luam. Yog li ntawd, cov neeg ua haujlwm tshuaj lom neeg tseem yuav tsum tau ua kom tsis muaj zog ntxiv.
Muaj ob txoj hauv kev sib xyaw ua ke, thiab cov txheej txheem sim tau piav qhia raws li hauv qab no:
Txoj Kev 1:
Ntxiv Boc2O (4.8g, 21.8mmol, 1.1 sib npaug) thiab Na2CO3 (4.4g, 41.52mmol, 2.1 sib npaug) H2O (70mL) cov kev daws teeb meem sequentially mus rau CH2Cl2 (55mL) tov ntawm 4-ine, 2mmol90 hydroxyper. 1.0 sib npaug). Do cov tshuaj tiv thaiv sib tov rau 72 teev. Cais cov theem thiab rho tawm cov theem aqueous nrog CH2Cl2. Lub merged organic theem tau qhuav nrog Na2SO4, lim, thiab concentrated nyob rau hauv txo siab. Thaum kawg, ib qho khoom siv dawb (4.3g, kom muaj nuj nqis) tau npaj. Txoj kev synthesis yog qhia hauv daim duab.
Txoj Kev 2:
Ntxiv 4.75 grams di tert butyl dicarbonate rau qhov sib tov ntawm 2 grams ntawm 4-hydroxypyridine hauv 4 milliliters dej thiab 13.8 milliliters ntawm 2N sodium hydroxide aqueous tov. Do cov tshuaj tiv thaiv nruab nrab ntawm qhov kub thiab txias rau 2 teev, tom qab ntawd ntxiv 50ml chloroform. Cais ob theem, ntxuav cov organic theem nrog ib tug 25% NH4OH aqueous tov, thiab ces ntxuav nrog ib tug saturated sodium chloride aqueous tov. Cov theem ntawm cov organic yog qhuav nrog magnesium sulfate, lim thiab evaporated kom tau N-Boc-4-hydroxypyridine nyob rau hauv ib tug yield ntawm 4g. Txoj kev synthesis yog qhia hauv daim duab.
Kauj Ruam 1: Ntawm 0℃C, ntxiv triethylamine (21.36 g, 211.5 mmol, 2.5 eq) thiab di tert butyl dicarbonate (27.67 g, 126.9 mmol, 1.5 eq) rau ib qho kev daws ntawm stirred piperidine-4-ib hydrochloride (14.0 mmol) hauv 14.0 mmol. 1,4-dioxane: dej (4:1130 ml). Do cov tshuaj tiv thaiv ib hmos ntawm chav tsev kub. TLC qhia tias cov khoom pib tau noj thiab pom cov khoom xav tau. Dilute cov tshuaj tiv thaiv sib tov los ntawm lub tshuab nqus tsev vacuum nrog CH2Cl2 (350ml) thiab ntxuav nrog dej (2 × 50ml). Cov txheej txheem organic yog qhuav nrog Na2SO4, lim, thiab evaporated nyob rau hauv lub siab txo. Purify cov crude residue los ntawm silica gel kem chromatography siv 1% methanol: dichloromethane ua tus eluent. Cov khoom xav tau (16.1g, 95% tawm los) yog cov khoom dawb.
Kauj Ruam 2: Synthesis ntawm 4-hydroxypiperidine-1-carboxylic acid tert butyl ester: Sodium borohydride (0.741 g, 19.59 mmol, 0.3 eq) tau ntxiv rau cov stirred 4-hydroxypiperidine-1-carboxylic 1 ester (1 stepyl. 65.32 mmol, 1.0 eq) nyob rau hauv ib qho kev daws ntawm methanol (130 ml) ntawm 0℃C. Sib tov cov tshuaj tiv thaiv ib hmos ntawm chav tsev kub. TLC qhia tias cov khoom pib tau noj thiab pom cov khoom xav tau. Evaporate cov tshuaj tiv thaiv sib tov nyob rau hauv lub siab txo, dilute nrog dej (200ml) thiab extract nrog CH2Cl2 (2 × 200ml). Cov txheej txheej organic sib xyaw yog qhuav nrog Na2SO4, lim, thiab evaporated nyob rau hauv qhov txo qis. Cov khoom tsim nyog (13.0g) yog cov khoom dawb N-Boc-4-hydroxypyridine. 1H NMR (300 MHz, CDCl3): δppm 3.90-3.78(m, 3H), 3.07-2.97(m, 2H), 1.92-1.80(m, 2-H1,10). ES MS: [M+Na]+224.1 (100%). Txoj kev synthesis yog qhia hauv daim duab saum toj no.
Ntxiv sodium borohydride (0.741 g, 19.59 mmol, 0.3 eq) rau ib qho kev daws ntawm 4-hydroxypiperidine-1-carboxylate tert butyl ester (13.0 g, 65.32 mmol, 1.0 eq) stirred ntawm 01℃C hauv methanol. Do cov tshuaj tiv thaiv ib hmos ntawm chav tsev kub. TLC qhia tias cov khoom pib tau noj thiab pom cov khoom xav tau. Evaporate cov tshuaj tiv thaiv sib tov nyob rau hauv lub siab txo, dilute nrog dej (200ml) thiab extract nrog CH2Cl2 (2 × 200ml). Cov txheej txheej organic sib xyaw yog qhuav nrog Na2SO4, lim, thiab evaporated nyob rau hauv qhov txo qis. Cov khoom tsim nyog (13.0g) yog cov khoom dawb N-Boc-4-hydroxypyridine. 1H NMR (300 MHz, CDCl3): δppm 3.90-3.78(m,3H), 3.07-2.97(m, 2H), 1.92-1.80(m, 1H1,10). ES MS: [M+Na]+224.1 (100%). Txoj kev synthesis yog qhia hauv daim duab saum toj no.
Cov txheej txheem synthesis ntawmN-Boc-4-hydroxypiperidinemuaj ntau haiv neeg, tab sis feem ntau yog raws li tert butoxycarbonylation cov tshuaj tiv thaiv ntawm 4-hydroxypiperidine. Ntxiv rau ob txoj hauv kev tau hais dhau los, peb kuj muab ntau txoj hauv kev sib xyaw ua ke rau kev siv:
Txoj Kev 1:
Los ntawm kev ntxiv cov tshuaj aqueous ntawm di tert butyl dicarbonate (Boc2O) thiab sodium carbonate rau cov tshuaj dichloromethane ntawm 4-hydroxypiperidine, nplawm cov tshuaj tiv thaiv, sib cais, rho tawm, ziab, lim, thiab ua kom pom tseeb, thaum kawg tau txais.
Txoj Kev 2:
Siv di tert butyl dicarbonate kom hnov mob nrog 4-hydroxypyridine hauv sodium hydroxide aqueous tov, ua raws li chloroform extraction, ua raws li kev ntxuav, ziab, pom, thiab evaporation kom tau cov khoom lag luam.
Lwm txoj hauv kev:
Pib los ntawm 4-piperidone, nws raug txo los ntawm sodium borohydride kom tau 4-hydroxypiperidine, uas yog ntxiv reacted nrog di tert butyl dicarbonate kom tau cov khoom. Cov txheej txheem no txhua tus muaj lawv tus kheej qhov zoo thiab qhov tsis zoo, tab sis lawv tuaj yeem ua tiav cov txiaj ntsig zoo thiab cov txiaj ntsig siab.
Kev siv hauv Pharmaceuticals
N-BOC-4-Hydroxypiperidine lub luag haujlwm tseem ceeb yog nyob rau hauv kev sib txuas ntawm cov neeg ua haujlwm neurologically thiab lwm cov tshuaj sib txuas. Nws cov qauv motif tshwm nyob rau hauv cov tshuaj tsom rau hauv nruab nrab paj hlwb (CNS) cov kab mob, kab mob plawv, thiab inflammatory mob.
CNS Tshuaj
Piperidine derivatives muaj nyob rau hauv CNS kev kho mob vim lawv muaj peev xwm cuam tshuam nrog neurotransmitter receptors. Piv txwv li, N-BOC-4-Hydroxypiperidine ua haujlwm ua ntej rau somatostatin receptor agonists, uas tswj hwm cov tshuaj hormone secretion thiab siv los kho cov qog acromegaly thiab neuroendocrine. Nws cov derivatives kuj muaj nyob rau hauv melatonin receptor modulators, uas hais txog kev pw tsaug zog thiab circadian atherosclerosis dysregulation.
Cardiovascular thiab Anti-Inflammatory Agents
Cov pab pawg hydroxyl pab txhawb kev sib txuas ntawm ethers thiab esters txuas rau cov tshuaj mob plawv. Piv txwv li, Mitsunobu cov tshuaj tiv thaiv nrog N-BOC-4-Hydroxypiperidine yield alkyl ethers uas inhibit phospholipase enzymes, txo qhov mob hauv atherosclerosis. Ib yam li ntawd, nws cov derivatives tau tshawb nrhiav raws li cov tshuaj tiv thaiv kab mob siab tsom rau cov tshuaj angiotensin receptors.
Anticancer thiab Antimicrobial Tshuaj
N-BOC-4-Hydroxypiperidine yog lub tsev thaiv kev tiv thaiv kab mob hauv cov tshuaj tiv thaiv kab mob sib xyaw (ADCs). Cov payloads no, tsim los tso tawm cov tshuaj cytotoxic thaum lub hom phiaj qog, cia siab rau qhov sib xyaw kom ruaj khov thaum lub sij hawm sib txuas thiab nws lub peev xwm los tswj kev tiv thaiv. Tsis tas li ntawd, nws cov derivatives nthuav tawm cov tshuaj tua kab mob los ntawm kev cuam tshuam cov kab mob cell phab ntsa synthesis.
N-BOC-4-Hydroxypiperidine yog lub hauv paus ntawm kev siv tshuaj niaj hnub, ua kom muaj kev tsim cov tshuaj cawm neeg txoj sia hla ntau thaj chaw kho mob. Nws cov tshuaj versatility, ua ke nrog kev nce qib hauv kev sib xyaw thiab kev tswj hwm kev tswj hwm, ua kom nws muaj feem cuam tshuam hauv kev lag luam dynamic. Raws li kev lag luam hloov mus rau kev coj noj coj ua ntsuab thiab cov tshuaj muaj tseeb, qhov sib xyaw no yuav txuas ntxiv mus ua lub luag haujlwm tseem ceeb hauv kev txhim kho kev noj qab haus huv yav tom ntej.
Los ntawm kev nkag siab txog nws cov khoom, kev siv, thiab kev xav txog kev nyab xeeb, cov kws tshawb fawb thiab cov chaw tsim khoom tuaj yeem siv N-BOC-4-Hydroxypiperidine lub peev xwm, tsav tsheb tshiab thiab txhim kho cov txiaj ntsig kev noj qab haus huv thoob ntiaj teb.
Cov lus nug nquag
piperidine cuam tshuam rau lub cev li cas?
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Kev raug Piperidine tuaj yeem ua rau xeev siab, ntuav, salivation thiab mob plab. * Kev raug mob tuaj yeem ua rau mob taub hau, kiv taub hau, leeg tsis muaj zog, qaug zog, kev nyuaj siab thiab chim siab. * Piperidine tuaj yeem cuam tshuam rau daim siab thiab lub raum.
Yam tshuaj twg yog piperidine?
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Piperidines yog ib chav kawm ntawmheterocycline aminesfeem ntau yog siv los ua scaffolds rau synthesis ntawm cov tshuaj tebchaw. Lawv yog ib tug derivative ntawm piperine, alkaloid lub luag hauj lwm rau lub tshav kub nyob rau hauv dub kua txob.
boc feem ntau siv nyob qhov twg?
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Pab pawg Boc tiv thaiv ib ntus ntawm pawg amino los ntawm cov kev xav tsis zoo, tso cai rau cov kws kho mob los tswj cov kab ke ntawm cov tshuaj tiv thaiv hauv ntau -qib syntheses. Boc chemistry tau siv dav hauvpeptide synthesis thiab synthesis ntawm complex organic molecules.
Cim npe nrov: n-boc-4-hydroxypiperidine cas 109384-19-2, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom