Tert - butylisocyanate CAS 1609-86-5

Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov neeg muag khoom ntawm tert {}} butylisocyanate cas 1609- 86-5 nyob hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo tert-butylisocyanate CAS 1609-86-5 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Tert - butylisocyanate, tseem hu ua Tert Butyl Isocyanate, CAS 1609-}}}} {{{8 {{8 {{8 {{8 {{8 { Soluble me ntsis hauv dej, insoluble hauv ethanol, carbon disulfide, thiab feeb txog ammonia daws. Mas siv tau ua ib nrab hauv kev tsim cov tshuaj tua kab thiab kws tshuaj. The main preparation method is through the reaction of n-butylamine and phosgene. Cov kauj ruam tshwj xeeb suav nrog kev ntxiv N-butylamine thiab o-dichlorobenzene rau cov tshuaj reactor thaum 110-160 sension rau 20-30 feeb thiab sau distillate los ntawm distillate. Thaum kawg, sib tov thiab do distillate nrog anhydous sodium carbonate, cia nws sawv ntsug, thiab lim kom tau cov khoom tiav. Raws li ib qho khoom siv hluav taws xob organic nruab nrab, nws muaj ntau cov kev siv hauv cov liaj teb xws li tshuaj thiab tshuaj tua kab. Nws tuaj yeem siv tau los synthesize ntau pua cov lwg me me thiab tshuaj tua kab molecules nrog cov kev ua si lom neeg.

Tert - butylisocyanate, raws li cov organic siab heev, muaj cov ntawv thov dav dav hauv cov chaw muag tshuaj. Nws tsis yog tsuas yog ib qho tseem ceeb hauv cov lus qhia, tab sis kuj tseem siv tau los npaj ntau yam dlo me ntsis molecules.

Nws ua lub luag haujlwm tseem ceeb hauv cov synthesis thiab tuaj yeem koom nrog ntau yam kev tawm tsam raws li tus tseem ceeb nruab nrab, yog synthesizing tshuaj molecules nrog kev ua haujlwm lom neeg. Cov kev tawm tsam no suav nrog tab sis tsis txwv rau kev ua kom pom zoo ntawm cov amines thiab carboxylic acids, synthesis ntawm amino acids thiab peptides, thiab lwm yam.

(1) hluavtaws tshuaj tiv thaiv kab mob:
Nws tuaj yeem siv tau los synthesize ntau cov tshuaj tua kab mob ntau, uas muaj ntau cov kev siv hauv kev kho mob. Piv txwv li, los ntawm cov tshuaj lom neeg tshwj xeeb, Tert Butyl Isocyanate tuaj yeem sib txuas nrog lwm cov chaw sib txuas nrog cov khoom sib txuas nrog cov tshuaj tiv thaiv kab mob tshuaj tua kab mob. Cov lus sib txuas no ua si lub luag haujlwm tseem ceeb hauv kev kho kab mob.
(2) Kev npaj ntawm anti -} cov kua mis qog:
Nws kuj tseem siv tau los npaj anti - cov qog degs. Los ntawm reacting nrog lwm cov tebchaw, khawb molecules tuaj yeem suav tau tias inhibit txoj kev loj hlob thiab kis cov qog ntawm cov qog. Cov ntaub pua taw no muaj lub peev xwm kuaj mob hauv kev kho mob cancer.
(3) hluavtaws peptide tshuaj:
Peptide Dugs muaj ntau cov kev siv hauv cov ntaub ntawv hauv cov chaw muag tshuaj thiab tuaj yeem ua cov ntaub ntawv tseem ceeb rau synthesizing peptide dugs. Los ntawm cov tshuaj tiv thaiv tshwj xeeb, nws tuaj yeem khi nrog cov amino acids los tsim cov peptide bonds, yog li synthesizing peptide dugs nrog cov kev ua si lom.

Nws kuj tseem siv tau rau kev hloov kho cov txheej txheem ntawm cov qauv siv lwg me me, yog li kev txhim kho cov kev ua haujlwm roj ntsha, yog li kev txhim kho cov khoom siv roj ntsha

(1) txhim kho cov solubility ntawm cov khawb:
Qee cov ntaub pua taw yog qhov nyuaj los ua kom tau zoo nqus thiab faib rau hauv lub cev vim lawv cov tub tsis huv solubility. Los ntawm kev qhia nws cov pab pawg ua haujlwm, cov solubility ntawm cov khawb av tuaj yeem hloov kho, yog li txhim kho lawv cov khoom siv tsis zoo thiab kho tau.
(2) txhim kho kom ruaj khov ntawm cov tshuaj:
Cov lus qhia txog cov pab pawg ua haujlwm tseem tuaj yeem txhim kho cov tshuaj ruaj khov ntawm cov tshuaj thiab tiv thaiv kev ua kom muaj kev cuam tshuam lossis tsis zoo thaum lub sijhawm cia thiab siv. Qhov no pab tau txuas lub txee txee ntawm cov yeeb tshuaj thiab xyuas kom lawv cov txiaj ntsig zoo thaum lub sijhawm kho.
(3) Txo cov tshuaj tiv thaiv kab mob tshuaj lom:
Qee cov tshuaj muaj qee yam toxicity thiab yuav ua rau raug mob rau tib neeg lub cev. Los ntawm kev qhia nws cov pab pawg ua haujlwm, cov qauv ntawm cov tshuaj molecule tuaj yeem hloov kho, yog li txo nws cov tshuaj lom thiab kev txhim kho kev nyab xeeb ntawm cov tshuaj.

Nws tseem ua lub luag haujlwm tseem ceeb hauv kev npaj cov tshuaj molecules nrog cov kev ua haujlwm lom neeg. Cov tshuaj molecules no ua tiav lub luag haujlwm tseem ceeb hauv kev kho ntau yam kab mob.

(1) Kev npaj ntawm Melanin mloog cov Hormone Receptor-1 Wchschodist:

 

Melanin mloog cov hormone receptor-1 (MCR1) yog lub recep1) yog lub recept cuam tshuam rau kev rog, ntshav qab zib thiab lwm yam kab mob metabolic. Nws tuaj yeem siv tau los synthesize mchr1 antag antagonists, uas muaj lub peev xwm saib xyuas tus nqi hauv kev kho mob ntawm kev rog thiab mob ntshav qab zib. Los ntawm inhibiting txoj haujlwm ntawm MCHR1, qab thiab lub zog siv tuaj yeem raug txo kom tsawg, yog li tswj cov hnyav thiab cov ntshav qab zib.

(2) Kev npaj ntawm TrricClic nplhaib niki protein hloov inibitors:

 

Trricyclic Fartnesyl protein hloov chaw (FPSase) yog qhov tseem ceeb enzyme koom nrog ntawm tes teeb tsa ntawm tes thiab muaj peev xwm. Yuav siv tau los synthesize furthesize inibitors, uas ua lub luag haujlwm tseem ceeb hauv kev kho kab mob ntawm cov kab mob prolferative xws li mob cancer. Los ntawm inhibiting qhov kev ua ub no, cov phiajcim ntawm tes thiab muaj peev xwm thaiv tau, yog li inhibiting txoj kev loj hlob thiab kis cov qog ntawm cov qog nqaij hlav.

(3) Npaj lwm cov tshuaj siv yeeb yaj kiab

 

Ntxiv rau cov piv txwv saum toj no, nws tseem tuaj yeem siv los npaj ntau lwm biologically active cov tshuaj molecules. Cov tshuaj molecules no ua rau kev kho cov kab mob plawv, cov qauv tshuaj kis las, yog li cov tshuaj tua kab mob tuaj yeem hloov kho, yog li siv cov khoom siv roj ntsha tshwj xeeb.

Nws tseem ua lub luag haujlwm tseem ceeb hauv kev tsim cov tshuaj. Nws tuaj yeem siv los ua ke nrog cov neeg sib tw tshuaj tshiab caw cov tshuaj tshiab thiab ntsuas lawv cov khoom siv roj ntsha thiab cov chaw muag tshuaj los ntawm cov kev sim vitro thiab hauv Vivo kev sim.

(1) Cov neeg sib tw hluavtaws tshiab teb chaws:

 

Nyob rau hauv cov txheej txheem kev tsim tshuaj, nws tuaj yeem siv los ua synthesize cov neeg sib tw tshiab. Cov tebchaw muaj peev xwm thev naus laus zis thiab cov khoom siv pharmacological, thiab tuaj yeem siv los kho ntau yam kab mob. Los ntawm synthesizing thiab tshuaj ntsuam cov neeg tsim tshuaj tshiab tuaj yeem nrawm thiab muaj kev vam meej ntawm cov tshuaj tshiab tuaj yeem hloov kho.

(2) ntsuas cov khoom siv roj ntsha thiab cov khoom siv pharmacological ntawm cov tshuaj:

 

Cov tshuaj molecules synthesized los ntawm Tert Butyl Isocyanate tuaj yeem ntsuas los ntawm cov vitro thiab hauv Vivo kev sim. Nyob rau hauv cov kev sim vitro suav nrog cov haujlwm enzyme siv, thiab lwm yam los ntsuas qhov kev txwv tsis pub muaj cov tshuaj tiv thaiv cov hom phiaj. Hauv Vivo kev sim suav nrog cov kws sim tsiaj, uas tau siv los ntsuas cov chaw muag tshuaj thiab cov khoom siv tshuaj hauv Vivo. Cov kev sim no tuaj yeem muab cov txiaj ntsig tseem ceeb rau kev txhim kho cov tshuaj tshiab.

Purity thiab imprary tsom xam

 

Roj Chromatography (GC)

Cov mob kho kom zoo

Kab hom: tsis -} polar capillary kem (piv txwv li DB-1, 30 m × 0.25 μm).

Qhov kev pab cuam cua sov: pib kub 50℃(khaws cia rau 2 feeb), tom qab ntawd nce rau 200℃ntawm tus nqi ntawm 10℃ib feeb (khaws cia rau 5 feeb).

Ntes: FID (hydrogen nplaim ionization Ntes), nrog siab rhiab, haum rau cov tebchaw hloov sib txuas.

Kev txhais lus txhais lus

Lub sijhawm ua haujlwm ntawm lub ncov siab tseem ceeb yuav tsum muaj raws li ntawm cov qauv txheem (txog ntawm Ipiony Peak thaj chaw yuav tsum tsawg dua lossis sib npaug nrog cov qauv qib reugent).

Kev ua kom zoo ua kua chromatography (HPLC)

Muaj feem xyuam nrog cov xwm txheej: Kev tsom xam ntawm cov khoom tsis khov tsis khov lossis cov khoom siv hydrolysis.

Cov mob kho kom zoo

Kab hom: C18 thim rov qab -}} same kem (4.6mm М0mm, 5 μm).

Txawb theem: acetonitrile - dej (80:20, muaj 0.1% tfa), ntws tus nqi 1.0 ml / min.

Kev Tshawb Pom Wavelength: 220 NM (Ntau Ntau Ntau Pavetength Russength Ntawm Isocyanate Group).

Kev txhais lus txhais lus

Lub purity ntawm lub ntsiab siab tseem ceeb yuav tsum muaj ntau dua los yog sib npaug rau 98%, thiab impurity peaks yuav tsum tau qhia ntxiv los ntawm huab hwm coj los ntawm huab hwm coj (MS).

 

Tert Butyl Isocyanate(CAS naj npawb: 1609-86-5) yog cov organic heev compound tau siv dav siv cov tshuaj schthesis, thiab cov khoom siv tshuaj ntsuam. Txawm li cas los xij, nws muaj zog tsis muaj kuab, thiab cov nplaim hluav taws xob tuaj yeem ua rau muaj kev phom sij rau tib neeg, suav nrog kev phom sij hauv lub cev, suav nrog kev puas tsuaj rau kev mob nkeeg, thiab muaj kev phom sij ib puag ncig.

Cim npe nrov: tert - butylisocyanate CAS 1609-86-5, chaw tsim khoom, chaw tsim khoom, chaw tsim khoom, yuav khoom, rau muag