Tom ntej: Triphenylmethyl Chloride CAS 76-83-5

Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm triphenylmethyl chloride cas 76-83-5 nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo triphenylmethyl chloride cas 76-83-5 muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Triphenylmethyl chloride hmoov, tshuaj formula C19H15Cl, CAS 76-83-5, yog ib tug dawb siv lead ua los yog crystalline hmoov uas yog insoluble nyob rau hauv dej tab sis yooj yim soluble nyob rau hauv organic solvents xws li benzene, carbon disulfide, thiab roj av ether. Nws yog me ntsis soluble hauv cawv thiab ethers thiab tuaj yeem hloov tau yooj yim rau triphenylmethanol thaum nqus dej. Nws cov ntsiab lus melting ntau yog 110-114 degree, thiab nws qhov kub kub tuaj yeem ncav cuag 374.3℃ntawm tus qauv atmospheric siab, qhia tias muaj kev ruaj ntseg thermal. Nyob rau hauv cov nqe lus ntawm tshuaj synthesis, nws yog ib qho tseem ceeb nruab nrab ntawm cov tshuaj cephalosporin thiab koom nyob rau hauv kev npaj ntawm antiviral tshuaj iodine glycosides. Nws cov derivatives kuj tau siv dav hauv kev tsim tshuaj thiab tshuaj tua kab. Ntxiv rau thaj chaw kws tshuaj, nws tseem tuaj yeem ua tus thawj coj rau cov khoom siv polymers, cov khoom siv rau cov tshuaj tiv thaiv kab mob, cov hmoov nplej txhim kho, fiber ntau decolorizer, thiab kev sib pauv rau cov khoom siv roj hmab, ua kom pom kev sib tw ntau yam.

Nws yog ib qho yooj yim siv cov organic raw khoom hauv kev lag luam tshuaj thiab tshuaj lom neeg, ua lub luag haujlwm tseem ceeb hauv cov organic synthesis thiab kev tsim tshuaj. Ib qho ntawm nws cov kev siv tseem ceeb yog ua ib pab pawg tiv thaiv rau thawj pawg hydroxyl hauv cov tebchaw xws li nucleosides, monosaccharides, lossis polysaccharides. Los ntawm kev tsim ib qho chaw ruaj khov triphenylmethyl ether, nws tiv thaiv cov pab pawg neeg los ntawm kev cuam tshuam thaum lub sijhawm sib txuas, thiab cov pab pawg tiv thaiv tuaj yeem raug tshem tawm zoo nyob rau hauv cov kua qaub tsis muaj zog, sib txuas ua haujlwm yooj yim thiab xaiv. Tsis tas li ntawd, nws tseem tuaj yeem siv rau kev tiv thaiv cov amino thiab thiol pawg, nrog rau kev hloov kho tshuaj hauv peptide synthesis, ua rau nws yog ib qho tseem ceeb rau kev tsim cov qauv molecular complex.

Triphenylmethyl Chloride(CAS naj npawb 76-83-5) yog dawb crystalline hmoov nrog cov mis mos molecular C ₁₉ H ₁₅ Cl thiab molecular hnyav 278.78. Nws cov qauv triphenylmethyl tshwj xeeb ua rau nws muaj kev ruaj ntseg zoo heev thiab cov nyhuv steric hindrance, ua rau nws yog ib qho tseem ceeb hauv cov teb xws li tshuaj, organic synthesis, thiab cov ntaub ntawv science.

Pharmaceutical and Chemical Industry: Ib Choj ntawm Raw Materials to Terminal Drugs

 

1. Qhov nruab nrab ntawm cov tshuaj tua kab mob cephalosporin
Nws yog cov khoom siv tseem ceeb ntawm cov khoom siv thib peb ntawm - tiam cephalosporins xws li ceftriaxone thiab cefotaxime. Cov qauv triphenylmethyl ua kom muaj kev ruaj ntseg ntawm cov tshuaj tua kab mob tiv thaiv - lactams los ntawm kev qhia txog kev cuam tshuam steric, yog li nthuav cov kab mob tua kab mob thiab ua kom ntev. Piv txwv li, nyob rau hauv cov synthesis ntawm ceftriaxone sodium, cov kev taw qhia ntawm cov tshuaj no ncua ib nrab ntawm - lub neej ntawm cov tshuaj mus rau 8 teev, thiab ib qho kev tswj xyuas muaj peev xwm tswj tau ib tug zoo concentration rau 24 teev, ua rau nws ib tug ntawm cov nyiam tshuaj rau kev kho mob ntawm zej zog - kis mob ntsws thiab urinary kab mob.

 

3. Polypeptides thiab nucleoside tshuaj tiv thaiv pawg
Nws yog ib qho kev xaiv tiv thaiv reagent rau thawj hydroxyl, amino, thiab thiol pawg, dav siv nyob rau hauv lub synthesis ntawm peptides, nucleosides, thiab carbohydrate compounds.
Kev tiv thaiv dej cawv thawj zaug: Hauv nucleoside chemistry, thawj pawg cawv tau yooj yim oxidized los yog koom nrog cov kev mob tshwm sim, tsim cov triphenylmethyl ether (TrO -) uas nyob ruaj khov nyob rau hauv nruab nrab thiab alkaline tej yam kev mob, thiab tuaj yeem raug tshem tawm zoo nyob rau hauv qis acidic tej yam kev mob (xws li 1% TFA / DCM) nrog 90% yield. Piv txwv li, nyob rau hauv cov synthesis ntawm cov tshuaj tiv thaiv kab mob khaub thuas Oseltamivir, nws muaj peev xwm tiv thaiv oxidation ntawm sab saw cawv pawg thaum lub sij hawm synthesis.

 

Kev tiv thaiv Amine: N-triphenylmethylation reagent (TrN) feem ntau yog siv los tiv thaiv thawj, theem nrab, thiab heterocyclic amines. Cov kev tiv thaiv kev tiv thaiv suav nrog kev siv cov tshuaj trifluoroacetic acid (TFA), acetic acid (AcOH), lossis hydrochloric acid (HCl), nrog cov tshuaj tiv thaiv me me thiab kev xaiv siab. Piv txwv li, nyob rau hauv synthesis ntawm cov tshuaj antidepressant Fluoxetine, lub triphenylmethyl tiv thaiv pab pawg neeg tuaj yeem tiv thaiv cov kev cuam tshuam ntawm cov amino pawg thaum lub sij hawm synthesis.
Thiol tiv thaiv: Triphenylmethyl sulfide (TrS -) los yog heterocyclic S- cov ntaub ntawv tiv thaiv yog dav siv nyob rau hauv tag nrho cov synthesis ntawm natural products, carbohydrate thiab nucleoside chemistry.

 

Piv txwv li, nyob rau hauv cov synthesis ntawm anti AIDS tshuaj Zidovudine, sulfhydryl tiv thaiv yuav tiv thaiv nws los ntawm oxidized rau disulfide.

4. Carbohydrate compound hloov kho
Nws tuaj yeem siv rau kev xaiv kev tiv thaiv thawj cov cawv hauv cov tshuaj carbohydrate, tshwj xeeb tshaj yog nyob rau hauv cov synthesis ntawm complex oligosaccharides, qhov twg nws steric hindrance nyhuv tuaj yeem ua tiav cheeb tsam xaiv kev hloov kho. Piv txwv li, nyob rau hauv kev sib txuas ntawm heparin analogs, triphenylmethyl tiv thaiv pab pawg tuaj yeem tiv thaiv cov pab pawg hydroxyl los ntawm kev ua sulfated, yog li tswj cov kev ua ntawm cov tshuaj anticoagulant.

Organic synthesis: ib lub thawv tshuaj rau cov khoom siv ntau yam

 

1. Wittig cov tshuaj tiv thaiv
Nws yog ib qho tseem ceeb reagent nyob rau hauv cov tshuaj tiv thaiv Wittig, siv los tsim inner onium ntsev (Ylide), yog li ua tiav kev tsim kho ntawm carbon carbon ob daim ntawv cog lus. Piv txwv li, nyob rau hauv cov synthesis ntawm vitamin A derivatives, Wittig cov tshuaj tiv thaiv yuav hloov aldehydes los yog ketones rau hauv olefins nrog ib tug tawm los ntawm ntau tshaj 85%.
2. Xaiv kev tiv thaiv ntawm pab pawg ua haujlwm
Kev tiv thaiv dej cawv thib ob: Thaum muaj cov cawv thib ob, cov cawv thawj zaug tuaj yeem xaiv cov tshuaj nrog triphenylchloromethane los ua triphenylmethyl ether. Piv txwv li, nyob rau hauv cov synthesis ntawm qab zib derivatives, xaiv kev tiv thaiv ntawm thawj cawv tuaj yeem ua tiav los ntawm kev tswj cov tshuaj tiv thaiv kab mob (xws li siv DMAP catalysts), thaum cov cawv thib ob tseem nyob hauv lub xeev tsis muaj kev cuam tshuam.

 

Propynyl cawv tiv thaiv: Nws tuaj yeem tiv thaiv propynyl cawv thiab tiv thaiv nws los ntawm kev poob protons uas nyob ib sab los tsim propadiene. Piv txwv li, nyob rau hauv synthesis ntawm anti- tshuaj mob cancer Paclitaxel, kev tiv thaiv ntawm propargyl cawv tuaj yeem tiv thaiv sab saw isomerization.
Kev tiv thaiv phenolic hydroxyl: Hauv cov tshuaj alkaline dichloromethane, phenolic hydroxyl pawg nrog me me steric hindrance tuaj yeem xaiv xaiv. Piv txwv li, nyob rau hauv cov synthesis ntawm anti- inflammatory tshuaj Ibuprofen, phenolic hydroxyl tiv thaiv yuav tiv thaiv nws los ntawm oxidized rau quinone tebchaw.

3. Analytical reagents
Triphenylmethyl chloride hmoovtuaj yeem siv los txheeb xyuas thawj cov cawv hauv cov suab thaj los ntawm kev tsim triphenylmethyl ether thiab ua kom muaj nuj nqis tsom xam siv cov txheej txheem chromatographic lossis spectroscopic. Tsis tas li ntawd, nws tseem tuaj yeem siv los ua tus qauv rau kev saib xyuas thiab ua kom cov organic synthesis zoo.

Materials Science: Los ntawm Polymers mus rau Kev Tsim Kho Cov Khoom Siv Ua Haujlwm

 

1. Resin polymer pib
Nws tuaj yeem siv los ua tus thawj coj rau cov tshuaj tiv thaiv dawb radical polymerization hauv kev sib txuas ntawm cov ntaub ntawv polymer xws li polystyrene thiab polymethyl methacrylate (PMMA). Nws muaj kev ua haujlwm siab ua haujlwm thiab tuaj yeem tswj tau qhov hnyav molecular faib ntawm polymers los ntawm kev kho cov tshuaj tiv thaiv. Piv txwv li, nyob rau hauv cov synthesis ntawm optical qib PMMA, cov neeg pib tuaj yeem ua tiav qhov ntsuas qhov hnyav molecular faib (PDI) hauv qab 1.2, ua tau raws li qhov yuav tsum tau muaj ntawm high -end optical devices.

 

2. Organic cov tshuaj tiv thaiv catalysts
Nws tuaj yeem siv los ua Lewis acid catalyst los txhawb esterification, etherification, condensation thiab lwm yam kev cuam tshuam. Piv txwv li, nyob rau hauv kev sib xyaw ntawm cov txuj lom vanillin, cov txiaj ntsig ntawm nws cov tshuaj tiv thaiv catalytic esterification tuaj yeem ncav cuag ntau dua 95%, thiab cov tshuaj tiv thaiv me me (tuaj yeem nqa tawm ntawm chav tsev kub).

3. Kev hloov kho cov khoom siv
Cov hmoov nplej txhim kho: Nws cov derivatives tuaj yeem khi nrog cov proteins hauv cov hmoov nplej, txhim kho cov khoom ntawm lub khob noom cookie, thiab txhim kho lub ntim thiab kev ntxhib los mos ntawm qhob cij. Piv txwv li, ntxiv 0.1% triphenylmethylation reagent hauv kev ua khob cij tuaj yeem ua rau lub khob cij nce ntxiv 15% thiab ua rau kev ntxhib los mos softer.

 

Fiber decolorizer: Nws tuaj yeem ua rau cov tshuaj tiv thaiv complexation nrog cov xim molecules hauv fibers kom ua tiav cov nyhuv decolorization. Piv txwv li, nyob rau hauv cov txheej txheem paj rwb fiber ntau bleaching, nws cov decolorization efficiency yog 30% siab dua li cov tshuaj sodium hypochlorite, thiab nws ua rau cov fibers tsawg dua.
Rubber khoom pauv tus neeg sawv cev: Nws cov derivatives tuaj yeem siv rau kev sib pauv hauv cov txheej txheem roj hmab vulcanization, txhim kho vulcanization efficiency thiab txhim kho cov khoom siv roj hmab. Piv txwv li, hauv kev tsim cov log tsheb, ntxiv 0.5% tuaj yeem ua rau cov roj hmab tensile zog los ntawm 20% thiab hnav tsis kam los ntawm 15%.

Kev Ua Liaj Ua Teb thiab Zaub Mov: Kev Tshaj Tawm los ntawm Tshuaj tua kab rau Additives

 

1. Cov tshuaj tua kab nruab nrab
Nws tuaj yeem siv los ua ib qho nruab nrab rau kev siv tshuaj tua kab, tshuaj tua kab, thiab lwm yam tshuaj tua kab. Piv txwv li, nws cov derivative Triphenylphosphine yog ib qho tseem ceeb raw khoom rau kev sib txuas ntawm herbicide glyphosate, uas yog zoo synthesized los ntawm catalytic tshua.

2. Khoom noj khoom haus additives
Txawm hais tias triphenylchloromethane nws tus kheej tsis tuaj yeem siv ncaj qha rau hauv cov khoom noj, nws cov derivatives (xws li triphenylmethylated starch) tuaj yeem siv los ua cov txheej txheem rau cov khoom ntim khoom noj los txhim kho cov khoom thaiv. Piv txwv li, hauv cov qos yaj ywm chips ntim, triphenylmethylated starch txheej tuaj yeem txo cov pa permeability los ntawm 50% thiab ua rau lub neej ntev.

Vimtriphenylmethyl chloridemuaj ntau yam kev siv hauv cov tshuaj organic thiab tshuaj synthesis, ntau cov kev tshawb fawb tau ua tiav ntawm nws cov synthesis hauv tsev thiab txawv teb chaws. Tam sim no, txoj hauv kev tseem ceeb rau kev sib xyaw triphenylmethane chloride yog raws li hauv qab no:

CR Hauser et al. (Organic Syntheses, Coll.31955) qhia txog cov txheej txheem ntawm kev sib txuas ntawm triphenylmethane chloride los ntawm benzene thiab carbon tetrachloride los ntawm Friedel-Cov tshuaj tiv thaiv hauv qab catalysis ntawm txhuas trichloride. Ntxiv 2kg ntawm benzene thiab 800g ntawm carbon tetrachloride rau hauv 5L peb- caj dab fwj nrog txhua yam nplawm, ntxiv 600g ntawm txhuas trichloride hauv cov khoom hauv qab dej khov, tom qab ntxiv txhuas trichloride, txuas ntxiv cov tshuaj tiv thaiv rau 2h, ntxiv cov tshuaj tiv thaiv rau hauv 1L ntawm benzene ntawm hydrochloride thiab 2L. 940g ua triphenylmethane chloride los ntawm txheej txheej, concentration thiab recrystallization, nrog rau 75%. Txoj kev no yog ib txoj kev sib xyaw ua ke ntawm triphenylmethane chloride, tab sis nws muaj qhov tsis zoo ntawm cov khoom loj ntawm peb cov khoom pov tseg thiab tsis tshua muaj txiaj ntsig.

CR Hauser et al. (Organic Syntheses, Coll. 31955) qhia tias triphenyl methyl chloride yog tsim los ntawm cov tshuaj tiv thaiv ntawm triphenyl methanol nrog acetyl chloride. Hauv 1L puag ncig hauv qab lub raj mis nrog reflux condenser raj, ntxiv 250g ntawm triphenyl methanol thiab 80ml ntawm benzene, cua sov, thiab ntxiv 150ml ntawm acetyl chloride hauv cov khoom siv. Tom qab ntxiv acetyl chloride, reflux rau 30min, txias nrog dej khov da dej, ntxiv 150ml ntawm roj av ether, lim, thiab qhuav kom tau 224g ntawm triphenylmethane chloride, nrog ib tug yield ntawm 83%. Txoj kev no muaj qhov tsis zoo ntawm tus nqi raw khoom siab.

Japanese patent JP63 - 57540 qhia txog ib txoj hauv kev ntxiv hydrogen chloride rau cov khoom nyoos ntawm triphenyl methyl chloride kom tshem tawm cov impurity triphenyl methanol. Ntxiv 139.2g ntawm crude triphenylmethane chloride thiab 164g ntawm carbon tetrachloride rau hauv cov tshuaj tiv thaiv lub khob, kub rau 55 degree, txhaj hydrogen chloride ntawm tus nqi ntws ntawm 0.72Nl / h, tom qab 3h, nres txhaj tshuaj hydrogen chloride, txias nws mus rau 5 degree, precipitate 10 tothyl methane thiab crystalline hmoov chloride, nrog purity ntawm 99.8%.

Lwm txoj kev npajtriphenylmethyl chloride:

1. Qhuav thiophene- dawb benzene thiab carbon tetrachloride yog tov thiab txias rau 0-5 degree, aluminium trichloride yog ntxiv, thiab ib tug loj npaum li cas ntawm hydrogen chloride gas raug tso tawm thaum lub sij hawm stirring cov tshuaj tiv thaiv. Cov reactant ntxiv rau qhov sib xyaw ua ntej ntawm benzene thiab hydrochloric acid thiab hydrolyzed ntawm 25 degree. Tom qab cov tshuaj tiv thaiv, cais cov benzene txheej. Thaum tshav kub kub thiab evaporate benzene, txias rau 40 degree, ntxiv me ntsis acetyl chloride, thiab cua sov thiab reflux rau ib pliag. Txias, lim niam cawv, ntxuav lub ncuav mog qab zib nrog roj av ether thiab benzene ib zaug, thiab qhuav kom tau triphenylmethane chloride.

2. Ntxiv anhydrous aluminium trichloride rau benzene yam tsis muaj dej thiab thiophene, sib tov kom zoo, ntxiv cov pa roj carbon tetrachloride qhuav hauv cov khoom thaum nplawm ntawm 30 ~ 40 degree, thiab tom qab ntawd txuas ntxiv stirring kom txog thaum cov tshuaj tiv thaiv tsis yog exothermic, cov chav khaws cia ntawm 70 ~ 80 degree, thiab cov sib tov rov qab mus kom txog thaum cov hydrogen chloride dim. Ntxiv 6mol / L ntawm hydrochloric acid rau benzene yam tsis muaj dej thiab thiophene, sib tov sib npaug, do sai, ntxiv cov sib tov saum toj no ob peb zaug, thiab nqa tawm cov tshuaj tiv thaiv hydrolysis, tswj cov dej kub hauv qab 40 degree. Cov benzene txheej yog sib cais, txheej dej yog diluted nrog dej khov, thiab ces muab rho tawm nrog benzene ob peb zaug. Cov tshuaj extraction yog ua ke, qhuav nrog anhydrous calcium chloride, decolored nrog activated carbon, lim thiab txias kom crystallize. Dissolve cov siv lead ua hauv cov kuab tshuaj tov ntawm benzene roj av ether nrog me ntsis chloroacetyl, thiab recrystallize kom tau purified triphenyl methyl chloride.

Cim npe nrov: Triphenylmethyl chloride CAS 76-83-5, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom